{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T06:05:34Z","timestamp":1793253934890,"version":"4.5.0"},"reference-count":67,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T00:00:00Z","timestamp":1675209600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T00:00:00Z","timestamp":1675209600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,1,11]],"date-time":"2023-01-11T00:00:00Z","timestamp":1673395200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100006108","name":"National Center for Advancing Translational Sciences","doi-asserted-by":"publisher","award":["UL1 TR002535"],"award-info":[{"award-number":["UL1 TR002535"]}],"id":[{"id":"10.13039\/100006108","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["F32HD091966"],"award-info":[{"award-number":["F32HD091966"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["K23HD092588"],"award-info":[{"award-number":["K23HD092588"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["U01HG0007587"],"award-info":[{"award-number":["U01HG0007587"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000011","name":"Howard Hughes Medical Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000011","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000051","name":"National Human Genome Research Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000051","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cell Genomics"],"published-print":{"date-parts":[[2023,2]]},"DOI":"10.1016\/j.xgen.2023.100259","type":"journal-article","created":{"date-parts":[[2023,2,8]],"date-time":"2023-02-08T10:40:35Z","timestamp":1675852835000},"page":"100259","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":78,"title":["The human inactive X chromosome modulates expression of the active X chromosome"],"prefix":"10.1016","volume":"3","author":[{"given":"Adrianna K.","family":"San Roman","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander K.","family":"Godfrey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helen","family":"Skaletsky","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel W.","family":"Bellott","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abigail F.","family":"Groff","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hannah L.","family":"Harris","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura V.","family":"Blanton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer F.","family":"Hughes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Brown","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sidaly","family":"Phou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashley","family":"Buscetta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Kruszka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicole","family":"Banks","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amalia","family":"Dutra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evgenia","family":"Pak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricia C.","family":"Lasutschinkow","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Colleen","family":"Keen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shanlee M.","family":"Davis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicole R.","family":"Tartaglia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carole","family":"Samango-Sprouse","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maximilian","family":"Muenke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9920-3411","authenticated-orcid":false,"given":"David C.","family":"Page","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.xgen.2023.100259_bib1","first-page":"541","article-title":"Allocycly of the X-chromosome in tumors and normal tissues","volume":"20","author":"Ohno","year":"1960","journal-title":"Cancer Res."},{"key":"10.1016\/j.xgen.2023.100259_bib2","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1038\/190372a0","article-title":"Gene action in the X-chromosome of the mouse (Mus musculus L.)","volume":"190","author":"Lyon","year":"1961","journal-title":"Nature"},{"key":"10.1016\/j.xgen.2023.100259_bib3","first-page":"135","article-title":"Sex chromatin and gene action in the mammalian X-chromosome","volume":"14","author":"Lyon","year":"1962","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/j.xgen.2023.100259_bib4","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1016\/S0140-6736(61)92457-6","article-title":"Nuclear sex in triploid XXY human cells","volume":"2","author":"Harnden","year":"1961","journal-title":"Lancet"},{"key":"10.1016\/j.xgen.2023.100259_bib5","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1007\/BF00289473","article-title":"The distribution of chromosomal genotypes associated with Turner's syndrome: livebirth prevalence rates and evidence for diminished fetal mortality and severity in genotypes associated with structural X abnormalities or mosaicism","volume":"64","author":"Hook","year":"1983","journal-title":"Hum. Genet."},{"key":"10.1016\/j.xgen.2023.100259_bib6","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1007\/s00439-014-1420-x","article-title":"Turner syndrome revisited: review of new data supports the hypothesis that all viable 45,X cases are cryptic mosaics with a rescue cell line, implying an origin by mitotic loss","volume":"133","author":"Hook","year":"2014","journal-title":"Hum. Genet."},{"key":"10.1016\/j.xgen.2023.100259_bib7","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1210\/endo-23-5-566","article-title":"A syndrome of infantilism, congenital webbed neck, and cubitus valgus","volume":"23","author":"Turner","year":"1938","journal-title":"Endocrinology"},{"key":"10.1016\/j.xgen.2023.100259_bib8","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1016\/S0140-6736(59)91893-8","article-title":"A sex-chromosome anomaly in a case of gonadal dysgenesis (turners syndrome)","volume":"1","author":"Ford","year":"1959","journal-title":"Lancet"},{"key":"10.1016\/j.xgen.2023.100259_bib9","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1186\/s13293-015-0053-7","article-title":"Derivation of consensus inactivation status for X-linked genes from genome-wide studies","volume":"6","author":"Balaton","year":"2015","journal-title":"Biol. Sex Differ."},{"key":"10.1016\/j.xgen.2023.100259_bib10","doi-asserted-by":"crossref","first-page":"6759","DOI":"10.1073\/pnas.77.11.6759","article-title":"Expression of an X-linked gene from an inactive human X chromosome in mouse-human hybrid cells: further evidence for the noninactivation of the steroid sulfatase locus in man","volume":"77","author":"Mohandas","year":"1980","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.xgen.2023.100259_bib11","doi-asserted-by":"crossref","first-page":"1333","DOI":"10.1086\/515488","article-title":"Expression of genes from the human active and inactive X chromosomes","volume":"60","author":"Brown","year":"1997","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/j.xgen.2023.100259_bib12","doi-asserted-by":"crossref","first-page":"14440","DOI":"10.1073\/pnas.96.25.14440","article-title":"A first-generation X-inactivation profile of the human X chromosome","volume":"96","author":"Carrel","year":"1999","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.xgen.2023.100259_bib13","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1038\/nature03479","article-title":"X-inactivation profile reveals extensive variability in X-linked gene expression in females","volume":"434","author":"Carrel","year":"2005","journal-title":"Nature"},{"key":"10.1016\/j.xgen.2023.100259_bib14","doi-asserted-by":"crossref","first-page":"R122","DOI":"10.1186\/gb-2013-14-11-r122","article-title":"Analysis of expressed SNPs identifies variable extents of expression from the human inactive X chromosome","volume":"14","author":"Cotton","year":"2013","journal-title":"Genome Biol."},{"key":"10.1016\/j.xgen.2023.100259_bib15","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1038\/nature24265","article-title":"Landscape of X chromosome inactivation across human tissues","volume":"550","author":"Tukiainen","year":"2017","journal-title":"Nature"},{"key":"10.1016\/j.xgen.2023.100259_bib16","doi-asserted-by":"crossref","first-page":"13015","DOI":"10.1073\/pnas.1806811115","article-title":"Extensive cellular heterogeneity of X inactivation revealed by single-cell allele-specific expression in human fibroblasts","volume":"115","author":"Garieri","year":"2018","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.xgen.2023.100259_bib17","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1186\/s12864-019-5507-6","article-title":"Human genes escaping X-inactivation revealed by single cell expression data","volume":"20","author":"Wainer Katsir","year":"2019","journal-title":"BMC Genom."},{"key":"10.1016\/j.xgen.2023.100259_bib18","doi-asserted-by":"crossref","first-page":"1629","DOI":"10.1101\/gr.275677.121","article-title":"Inferring genes that escape X-Chromosome inactivation reveals important contribution of variable escape genes to sex-biased diseases","volume":"31","author":"Sauteraud","year":"2021","journal-title":"Genome Res."},{"key":"10.1016\/j.xgen.2023.100259_bib19","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1093\/hmg\/10.1.77","article-title":"X chromosome-specific cDNA arrays: identification of genes that escape from X-inactivation and other applications","volume":"10","author":"Sudbrak","year":"2001","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.xgen.2023.100259_bib20","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1038\/sj.ejhg.5201212","article-title":"Application of microarrays to the analysis of the inactivation status of human X-linked genes expressed in lymphocytes","volume":"12","author":"Craig","year":"2004","journal-title":"Eur. J. Hum. Genet."},{"key":"10.1016\/j.xgen.2023.100259_bib21","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1016\/j.ygeno.2006.07.016","article-title":"X chromosome gene expression in human tissues: male and female comparisons","volume":"88","author":"Talebizadeh","year":"2006","journal-title":"Genomics"},{"key":"10.1016\/j.xgen.2023.100259_bib22","doi-asserted-by":"crossref","first-page":"e9","DOI":"10.1371\/journal.pgen.0040009","article-title":"Large-scale population study of human cell lines indicates that dosage compensation is virtually complete","volume":"4","author":"Johnston","year":"2008","journal-title":"PLoS Genet."},{"key":"10.1016\/j.xgen.2023.100259_bib23","doi-asserted-by":"crossref","DOI":"10.1038\/srep34220","article-title":"Widespread DNA hypomethylation and differential gene expression in Turner syndrome","volume":"6","author":"Trolle","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.xgen.2023.100259_bib24","doi-asserted-by":"crossref","first-page":"7398","DOI":"10.1073\/pnas.1802889115","article-title":"Sex-chromosome dosage effects on gene expression in humans","volume":"115","author":"Raznahan","year":"2018","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.xgen.2023.100259_bib25","doi-asserted-by":"crossref","first-page":"4864","DOI":"10.1073\/pnas.1910003117","article-title":"Integrated functional genomic analyses of Klinefelter and Turner syndromes reveal global network effects of altered X chromosome dosage","volume":"117","author":"Zhang","year":"2020","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.xgen.2023.100259_bib26","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1002\/ajmg.c.31799","article-title":"Epigenetic and transcriptomic consequences of excess X-chromosome material in 47,XXX syndrome-A comparison with Turner syndrome and 46,XX females","volume":"184","author":"Nielsen","year":"2020","journal-title":"Am. J. Med. Genet. C Semin. Med. Genet."},{"key":"10.1016\/j.xgen.2023.100259_bib27","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1038\/nature01722","article-title":"The male-specific region of the human Y chromosome is a mosaic of discrete sequence classes","volume":"423","author":"Skaletsky","year":"2003","journal-title":"Nature"},{"key":"10.1016\/j.xgen.2023.100259_bib28","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1038\/nature03440","article-title":"The DNA sequence of the human X chromosome","volume":"434","author":"Ross","year":"2005","journal-title":"Nature"},{"key":"10.1016\/j.xgen.2023.100259_bib29","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1038\/nature13206","article-title":"Mammalian Y chromosomes retain widely expressed dosage-sensitive regulators","volume":"508","author":"Bellott","year":"2014","journal-title":"Nature"},{"key":"10.1016\/j.xgen.2023.100259_bib30","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1038\/349038a0","article-title":"A gene from the region of the human X inactivation centre is expressed exclusively from the inactive X chromosome","volume":"349","author":"Brown","year":"1991","journal-title":"Nature"},{"key":"10.1016\/j.xgen.2023.100259_bib31","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1038\/379131a0","article-title":"Requirement for Xist in X chromosome inactivation","volume":"379","author":"Penny","year":"1996","journal-title":"Nature"},{"key":"10.1016\/j.xgen.2023.100259_bib32","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1093\/hmg\/9.3.395","article-title":"Differentially regulated and evolved genes in the fully sequenced Xq\/Yq pseudoautosomal region","volume":"9","author":"Ciccodicola","year":"2000","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.xgen.2023.100259_bib33","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1097\/GIM.0b013e3181b2e34c","article-title":"The 50th anniversary of the discovery of trisomy 21: the past, present, and future of research and treatment of Down syndrome","volume":"11","author":"M\u00e9garban\u00e9","year":"2009","journal-title":"Genet. Med."},{"key":"10.1016\/j.xgen.2023.100259_bib34","doi-asserted-by":"crossref","first-page":"e16220","DOI":"10.7554\/eLife.16220","article-title":"Trisomy 21 consistently activates the interferon response","volume":"5","author":"Sullivan","year":"2016","journal-title":"Elife"},{"key":"10.1016\/j.xgen.2023.100259_bib35","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1038\/s41586-020-2308-7","article-title":"The mutational constraint spectrum quantified from variation in 141,456 humans","volume":"581","author":"Karczewski","year":"2020","journal-title":"Nature"},{"key":"10.1016\/j.xgen.2023.100259_bib36","doi-asserted-by":"crossref","first-page":"e1003709","DOI":"10.1371\/journal.pgen.1003709","article-title":"Genic intolerance to functional variation and the interpretation of personal genomes","volume":"9","author":"Petrovski","year":"2013","journal-title":"PLoS Genet."},{"key":"10.1016\/j.xgen.2023.100259_bib37","doi-asserted-by":"crossref","first-page":"e1001154","DOI":"10.1371\/journal.pgen.1001154","article-title":"Characterising and predicting haploinsufficiency in the human genome","volume":"6","author":"Huang","year":"2010","journal-title":"PLoS Genet."},{"key":"10.1016\/j.xgen.2023.100259_bib38","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1101\/gr.082701.108","article-title":"Most mammalian mRNAs are conserved targets of microRNAs","volume":"19","author":"Friedman","year":"2009","journal-title":"Genome Res."},{"key":"10.1016\/j.xgen.2023.100259_bib39","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/j.cell.2009.01.002","article-title":"MicroRNAs: target recognition and regulatory functions","volume":"136","author":"Bartel","year":"2009","journal-title":"Cell"},{"key":"10.1016\/j.xgen.2023.100259_bib40","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1101\/gr.230433.117","article-title":"Conserved microRNA targeting reveals preexisting gene dosage sensitivities that shaped amniote sex chromosome evolution","volume":"28","author":"Naqvi","year":"2018","journal-title":"Genome Res."},{"key":"10.1016\/j.xgen.2023.100259_bib41","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1007\/BF00205079","article-title":"Sex chromosome aberrations and stature: deduction of the principal factors involved in the determination of adult height","volume":"91","author":"Ogata","year":"1993","journal-title":"Hum. Genet."},{"key":"10.1016\/j.xgen.2023.100259_bib42","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1038\/ng0597-54","article-title":"Pseudoautosomal deletions encompassing a novel homeobox gene cause growth failure in idiopathic short stature and Turner syndrome","volume":"16","author":"Rao","year":"1997","journal-title":"Nat. Genet."},{"key":"10.1016\/j.xgen.2023.100259_bib43","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1093\/hmg\/9.5.695","article-title":"The short stature homeobox gene SHOX is involved in skeletal abnormalities in Turner syndrome","volume":"9","author":"Clement-Jones","year":"2000","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.xgen.2023.100259_bib44","doi-asserted-by":"crossref","first-page":"1206","DOI":"10.1002\/ajmg.a.33334","article-title":"Increased number of sex chromosomes affects height in a nonlinear fashion: a study of 305 patients with sex chromosome aneuploidy","volume":"152A","author":"Ottesen","year":"2010","journal-title":"Am. J. Med. Genet."},{"key":"10.1016\/j.xgen.2023.100259_bib45","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1159\/000444596","article-title":"SHOX haploinsufficiency as a cause of syndromic and nonsyndromic short stature","volume":"7","author":"Fukami","year":"2016","journal-title":"Mol. Syndromol."},{"key":"10.1016\/j.xgen.2023.100259_bib46","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1016\/j.cell.2007.03.014","article-title":"Zfx controls the self-renewal of embryonic and hematopoietic stem cells","volume":"129","author":"Galan-Caridad","year":"2007","journal-title":"Cell"},{"key":"10.1016\/j.xgen.2023.100259_bib47","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1186\/1756-9966-30-114","article-title":"The Zfx gene is expressed in human gliomas and is important in the proliferation and apoptosis of the human malignant glioma cell line U251","volume":"30","author":"Zhou","year":"2011","journal-title":"J.\u00a0Exp. Clin. Cancer Res."},{"key":"10.1016\/j.xgen.2023.100259_bib48","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1016\/j.cancergen.2014.08.007","article-title":"Knockdown of ZFX suppresses renal carcinoma cell growth and induces apoptosis","volume":"207","author":"Fang","year":"2014","journal-title":"Cancer Genet."},{"key":"10.1016\/j.xgen.2023.100259_bib49","doi-asserted-by":"crossref","first-page":"7364","DOI":"10.1073\/pnas.96.13.7364","article-title":"Heterogeneous gene expression from the inactive X chromosome: an X-linked gene that escapes X inactivation in some human cell lines but is inactivated in others","volume":"96","author":"Carrel","year":"1999","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.xgen.2023.100259_bib50","doi-asserted-by":"crossref","first-page":"eabd8887","DOI":"10.1126\/science.abd8887","article-title":"The X chromosome dosage compensation program during the development of cynomolgus monkeys","volume":"374","author":"Okamoto","year":"2021","journal-title":"Science"},{"key":"10.1016\/j.xgen.2023.100259_bib51","series-title":"Sex Chromosomes and Sex-Linked Genes","author":"Ohno","year":"1967"},{"key":"10.1016\/j.xgen.2023.100259_bib54","doi-asserted-by":"crossref","first-page":"860","DOI":"10.1101\/gr.261248.120","article-title":"Quantitative analysis of Y-Chromosome gene expression across 36 human tissues","volume":"30","author":"Godfrey","year":"2020","journal-title":"Genome Res."},{"key":"10.1016\/j.xgen.2023.100259_bib60","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1038\/nature24277","article-title":"Genetic effects on gene expression across human tissues","volume":"550","year":"2017","journal-title":"Nature"},{"key":"10.1016\/j.xgen.2023.100259_bib56","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1038\/nbt.3519","article-title":"Near-optimal probabilistic RNA-seq quantification","volume":"34","author":"Bray","year":"2016","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.xgen.2023.100259_bib58","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1186\/s13059-014-0550-8","article-title":"Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2","volume":"15","author":"Love","year":"2014","journal-title":"Genome Biol."},{"key":"10.1016\/j.xgen.2023.100259_bib61","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1038\/nmeth.4324","article-title":"Differential analysis of RNA-seq incorporating quantification uncertainty","volume":"14","author":"Pimentel","year":"2017","journal-title":"Nat. Methods"},{"key":"10.1016\/j.xgen.2023.100259_bib67","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1093\/bioinformatics\/btq033","article-title":"BEDTools: a flexible suite of utilities for comparing genomic features","volume":"26","author":"Quinlan","year":"2010","journal-title":"Bioinformatics"},{"key":"10.1016\/j.xgen.2023.100259_bib62","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1038\/nbt.1754","article-title":"Integrative genomics viewer","volume":"29","author":"Robinson","year":"2011","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.xgen.2023.100259_bib52","first-page":"e3779","article-title":"Skin punch biopsy explant culture for derivation of primary human fibroblasts","author":"Vangipuram","year":"2013","journal-title":"JoVE"},{"key":"10.1016\/j.xgen.2023.100259_bib53","doi-asserted-by":"crossref","first-page":"eaaw7317","DOI":"10.1126\/science.aaw7317","article-title":"Conservation, acquisition, and functional impact of sex-biased gene expression in mammals","volume":"365","author":"Naqvi","year":"2019","journal-title":"Science"},{"key":"10.1016\/j.xgen.2023.100259_bib55","doi-asserted-by":"crossref","first-page":"1316","DOI":"10.1101\/gr.080531.108","article-title":"The consensus coding sequence (CCDS) project: identifying a common protein-coding gene set for the human and mouse genomes","volume":"19","author":"Pruitt","year":"2009","journal-title":"Genome Res."},{"key":"10.1016\/j.xgen.2023.100259_bib57","doi-asserted-by":"crossref","first-page":"1521","DOI":"10.12688\/f1000research.7563.1","article-title":"Differential analyses for RNA-seq: transcript-level estimates improve gene-level inferences","volume":"4","author":"Soneson","year":"2015","journal-title":"F1000Res."},{"key":"10.1016\/j.xgen.2023.100259_bib59","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1101\/gr.268516.120","article-title":"Dosage-sensitive functions in embryonic development drove the survival of genes on sex-specific chromosomes in snakes, birds, and mammals","volume":"31","author":"Bellott","year":"2021","journal-title":"Genome Res."},{"key":"10.1016\/j.xgen.2023.100259_bib63","doi-asserted-by":"crossref","first-page":"1083","DOI":"10.1038\/ng.2705","article-title":"Independent specialization of the human and mouse X chromosomes for the male germ line","volume":"45","author":"Mueller","year":"2013","journal-title":"Nat. Genet."},{"key":"10.1016\/j.xgen.2023.100259_bib64","doi-asserted-by":"crossref","first-page":"1337","DOI":"10.1101\/gr.275188.120","article-title":"Large palindromes on the primate X Chromosome are preserved by natural selection","volume":"31","author":"Jackson","year":"2021","journal-title":"Genome Res."},{"key":"10.1016\/j.xgen.2023.100259_bib65","series-title":"Online Mendelian Inheritance in Man","author":"McKusick-Nathans Institute of Genetic Medicine","year":"2022"},{"key":"10.1016\/j.xgen.2023.100259_bib66","series-title":"R: A Language and Environment for Statistical Computing","author":"R Development Core Team","year":"2020"}],"container-title":["Cell Genomics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2666979X23000150?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2666979X23000150?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,13]],"date-time":"2025-11-13T07:26:13Z","timestamp":1763018773000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2666979X23000150"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,2]]},"references-count":67,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2023,2]]}},"alternative-id":["S2666979X23000150"],"URL":"https:\/\/doi.org\/10.1016\/j.xgen.2023.100259","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2021.08.09.455676","asserted-by":"object"}]},"ISSN":["2666-979X"],"issn-type":[{"value":"2666-979X","type":"print"}],"subject":[],"published":{"date-parts":[[2023,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The human inactive X chromosome modulates expression of the active X chromosome","name":"articletitle","label":"Article Title"},{"value":"Cell Genomics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.xgen.2023.100259","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 The Authors.","name":"copyright","label":"Copyright"}],"article-number":"100259"}}