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Plant Sci."},{"key":"10.1016\/j.xgen.2023.100349_bib161","doi-asserted-by":"crossref","first-page":"2516","DOI":"10.1093\/nar\/gkac1244","article-title":"The FANCC\u2013FANCE\u2013FANCF complex is evolutionarily conserved and regulates meiotic recombination","volume":"51","author":"Singh","year":"2023","journal-title":"Nucleic Acids Research"},{"key":"10.1016\/j.xgen.2023.100349_bib120","doi-asserted-by":"crossref","first-page":"1986","DOI":"10.1126\/science.281.5385.1986","article-title":"Why sex and recombination?","volume":"281","author":"Barton","year":"1998","journal-title":"Science"},{"key":"10.1016\/j.xgen.2023.100349_bib121","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1038\/ng917","article-title":"A high-resolution recombination map of the human genome","volume":"31","author":"Kong","year":"2002","journal-title":"Nat. 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