{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,2]],"date-time":"2026-11-02T18:29:51Z","timestamp":1793644191494,"version":"4.5.1"},"reference-count":64,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T00:00:00Z","timestamp":1711929600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,4,1]],"date-time":"2024-04-01T00:00:00Z","timestamp":1711929600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,3,6]],"date-time":"2024-03-06T00:00:00Z","timestamp":1709683200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004622","name":"KWF Kankerbestrijding","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004622","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cell Genomics"],"published-print":{"date-parts":[[2024,4]]},"DOI":"10.1016\/j.xgen.2024.100528","type":"journal-article","created":{"date-parts":[[2024,3,28]],"date-time":"2024-03-28T12:09:27Z","timestamp":1711627767000},"page":"100528","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":14,"title":["Whole-genome mapping of APOBEC mutagenesis in metastatic urothelial carcinoma identifies driver hotspot mutations and a novel mutational signature"],"prefix":"10.1016","volume":"4","author":[{"given":"J. Alberto","family":"Nakauma-Gonz\u00e1lez","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maud","family":"Rijnders","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minouk T.W.","family":"Noordsij","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John W.M.","family":"Martens","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Astrid A.M.","family":"van der Veldt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martijn P.J.","family":"Lolkema","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joost L.","family":"Boormans","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9794-1477","authenticated-orcid":false,"given":"Harmen J.G.","family":"van de Werken","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.xgen.2024.100528_bib1","doi-asserted-by":"crossref","first-page":"970","DOI":"10.1038\/ng.2702","article-title":"An APOBEC cytidine deaminase mutagenesis pattern is widespread in human cancers","volume":"45","author":"Roberts","year":"2013","journal-title":"Nat. Genet."},{"key":"10.1016\/j.xgen.2024.100528_bib2","doi-asserted-by":"crossref","first-page":"D941","DOI":"10.1093\/nar\/gky1015","article-title":"COSMIC: The Catalogue Of Somatic Mutations In Cancer","volume":"47","author":"Tate","year":"2019","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.xgen.2024.100528_bib3","doi-asserted-by":"crossref","DOI":"10.1080\/2162402X.2018.1550341","article-title":"APOBEC-related mutagenesis and neo-peptide hydrophobicity: implications for response to immunotherapy","volume":"8","author":"Boichard","year":"2019","journal-title":"OncoImmunology"},{"key":"10.1016\/j.xgen.2024.100528_bib4","doi-asserted-by":"crossref","first-page":"1349","DOI":"10.1038\/s41467-024-45714-0","article-title":"Gene-expression-based T-Cell-to-Stroma Enrichment (TSE) score predicts response to immune checkpoint inhibitors in urothelial cancer","volume":"15","author":"Rijnders","year":"2024","journal-title":"Nat. Commun."},{"key":"10.1016\/j.xgen.2024.100528_bib5","doi-asserted-by":"crossref","DOI":"10.1084\/jem.20200261","article-title":"APOBEC3A catalyzes mutation and drives carcinogenesis in\u00a0vivo","volume":"217","author":"Law","year":"2020","journal-title":"J.\u00a0Exp. Med."},{"key":"10.1016\/j.xgen.2024.100528_bib6","doi-asserted-by":"crossref","first-page":"e4136","DOI":"10.7717\/peerj.4136","article-title":"Stem-loop structure preference for site-specific RNA editing by APOBEC3A and APOBEC3G","volume":"5","author":"Sharma","year":"2017","journal-title":"PeerJ"},{"key":"10.1016\/j.xgen.2024.100528_bib7","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1016\/j.cell.2020.01.032","article-title":"Passenger Mutations in More Than 2,500 Cancer Genomes: Overall Molecular Functional Impact and Consequences","volume":"180","author":"Kumar","year":"2020","journal-title":"Cell"},{"key":"10.1016\/j.xgen.2024.100528_bib8","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1186\/s13073-020-00781-y","article-title":"Identification of new driver and passenger mutations within APOBEC-induced hotspot mutations in bladder cancer","volume":"12","author":"Shi","year":"2020","journal-title":"Genome Med."},{"key":"10.1016\/j.xgen.2024.100528_bib9","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1038\/s41467-021-27792-6","article-title":"Association of mutation signature effectuating processes with mutation hotspots in driver genes and non-coding regions","volume":"13","author":"Wong","year":"2022","journal-title":"Nat. Commun."},{"key":"10.1016\/j.xgen.2024.100528_bib10","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/j.eururo.2022.01.026","article-title":"Comprehensive Molecular Characterization Reveals Genomic and Transcriptomic Subtypes of Metastatic Urothelial Carcinoma","volume":"81","author":"Nakauma-Gonz\u00e1lez","year":"2022","journal-title":"Eur. Urol."},{"key":"10.1016\/j.xgen.2024.100528_bib11","doi-asserted-by":"crossref","first-page":"1067","DOI":"10.1038\/ng.3378","article-title":"An APOBEC3A hypermutation signature is distinguishable from the signature of background mutagenesis by APOBEC3B in human cancers","volume":"47","author":"Chan","year":"2015","journal-title":"Nat. Genet."},{"key":"10.1016\/j.xgen.2024.100528_bib12","doi-asserted-by":"crossref","first-page":"1185","DOI":"10.3390\/cells12081185","article-title":"Aberrant APOBEC3B Expression in Breast Cancer Is Linked to Proliferation and Cell Cycle Phase","volume":"12","author":"Roelofs","year":"2023","journal-title":"Cells"},{"key":"10.1016\/j.xgen.2024.100528_bib13","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1016\/j.bbrc.2021.02.008","article-title":"APOBEC3B is preferentially expressed at the G2\/M phase of cell cycle","volume":"546","author":"Hirabayashi","year":"2021","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.xgen.2024.100528_bib14","doi-asserted-by":"crossref","first-page":"e1008545","DOI":"10.1371\/journal.pgen.1008545","article-title":"APOBEC3A is a prominent cytidine deaminase in breast cancer","volume":"15","author":"Cortez","year":"2019","journal-title":"PLoS Genet."},{"key":"10.1016\/j.xgen.2024.100528_bib15","doi-asserted-by":"crossref","first-page":"4537","DOI":"10.18632\/oncotarget.23344","article-title":"APOBEC-mediated mutagenesis in urothelial carcinoma is associated with improved survival, mutations in DNA damage response genes, and immune response","volume":"9","author":"Glaser","year":"2018","journal-title":"Oncotarget"},{"key":"10.1016\/j.xgen.2024.100528_bib16","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1016\/j.cell.2017.09.007","article-title":"Comprehensive Molecular Characterization of Muscle-Invasive Bladder Cancer","volume":"171","author":"Robertson","year":"2017","journal-title":"Cell"},{"key":"10.1016\/j.xgen.2024.100528_bib17","doi-asserted-by":"crossref","first-page":"2971","DOI":"10.1038\/s41467-020-16802-8","article-title":"Quantification of ongoing APOBEC3A activity in tumor cells by monitoring RNA editing at hotspots","volume":"11","author":"Jalili","year":"2020","journal-title":"Nat. Commun."},{"key":"10.1016\/j.xgen.2024.100528_bib45","doi-asserted-by":"crossref","first-page":"D794","DOI":"10.1093\/nar\/gkx1081","article-title":"The Encyclopedia of DNA elements (ENCODE): data portal update","volume":"46","author":"Davis","year":"2018","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.xgen.2024.100528_bib18","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1016\/j.eururo.2013.08.052","article-title":"Telomerase reverse transcriptase promoter mutations in bladder cancer: High frequency across stages, detection in urine, and lack of association with outcome","volume":"65","author":"Allory","year":"2014","journal-title":"Eur. Urol."},{"key":"10.1016\/j.xgen.2024.100528_bib19","doi-asserted-by":"crossref","first-page":"1746","DOI":"10.1016\/j.ygeno.2019.09.017","article-title":"Telomerase reverse transcriptase promoter mutations in cancers derived from multiple organ sites among middle eastern population","volume":"112","author":"Siraj","year":"2020","journal-title":"Genomics"},{"key":"10.1016\/j.xgen.2024.100528_bib20","doi-asserted-by":"crossref","first-page":"eaaw2872","DOI":"10.1126\/science.aaw2872","article-title":"Passenger hotspot mutations in cancer driven by APOBEC3A and mesoscale genomic features","volume":"364","author":"Buisson","year":"2019","journal-title":"Science"},{"key":"10.1016\/j.xgen.2024.100528_bib21","doi-asserted-by":"crossref","first-page":"1602","DOI":"10.1038\/s41467-021-21891-0","article-title":"An extended APOBEC3A mutation signature in cancer","volume":"12","author":"Langenbucher","year":"2021","journal-title":"Nat. Commun."},{"key":"10.1016\/j.xgen.2024.100528_bib22","doi-asserted-by":"crossref","first-page":"720","DOI":"10.1038\/s41467-019-08576-5","article-title":"Whole-genome sequencing identifies ADGRG6 enhancer mutations and FRS2 duplications as angiogenesis-related drivers in bladder cancer","volume":"10","author":"Wu","year":"2019","journal-title":"Nat. Commun."},{"key":"10.1016\/j.xgen.2024.100528_bib23","doi-asserted-by":"crossref","first-page":"E8286","DOI":"10.1073\/pnas.1804823115","article-title":"RNF169 limits 53BP1 deposition at DSBs to stimulate single-strand annealing repair","volume":"115","author":"An","year":"2018","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.xgen.2024.100528_bib24","doi-asserted-by":"crossref","first-page":"1046","DOI":"10.1038\/s41419-020-03248-5","article-title":"Loss of the tumor suppressor BTG3 drives a pro-angiogenic tumor microenvironment through HIF-1 activation","volume":"11","author":"Cheng","year":"2020","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.xgen.2024.100528_bib25","doi-asserted-by":"crossref","DOI":"10.1016\/j.peptides.2020.170347","article-title":"Adrenomedullin\u00a0\u2013 Current perspective on a peptide hormone with significant therapeutic potential","volume":"131","author":"Fischer","year":"2020","journal-title":"Peptides"},{"key":"10.1016\/j.xgen.2024.100528_bib26","doi-asserted-by":"crossref","first-page":"1069","DOI":"10.4161\/cc.5.10.2771","article-title":"GDF3 at the crossroads of TGF-beta signaling","volume":"5","author":"Levine","year":"2006","journal-title":"Cell Cycle"},{"key":"10.1016\/j.xgen.2024.100528_bib27","doi-asserted-by":"crossref","first-page":"762","DOI":"10.1016\/j.str.2017.03.008","article-title":"Structural Analysis Reveals Features of Ribosome Assembly Factor Nsa1\/WDR74 Important for Localization and Interaction with Rix7\/NVL2","volume":"25","author":"Lo","year":"2017","journal-title":"Structure"},{"key":"10.1016\/j.xgen.2024.100528_bib28","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1038\/s41586-020-1969-6","article-title":"Pan-cancer analysis of whole genomes","volume":"578","author":"Campbell","year":"2020","journal-title":"Nature"},{"key":"10.1016\/j.xgen.2024.100528_bib29","doi-asserted-by":"crossref","first-page":"1450","DOI":"10.1038\/s41588-019-0507-7","article-title":"The genomic landscape of metastatic breast cancer highlights changes in mutation and signature frequencies","volume":"51","author":"Angus","year":"2019","journal-title":"Nat. Genet."},{"key":"10.1016\/j.xgen.2024.100528_bib30","doi-asserted-by":"crossref","first-page":"1029","DOI":"10.1016\/j.cell.2017.09.042","article-title":"Universal Patterns of Selection in Cancer and Somatic Tissues","volume":"171","author":"Martincorena","year":"2017","journal-title":"Cell"},{"key":"10.1016\/j.xgen.2024.100528_bib31","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1038\/s41525-021-00197-6","article-title":"The landscape and driver potential of site-specific hotspots across cancer genomes","volume":"6","author":"Juul","year":"2021","journal-title":"NPJ Genom. Med."},{"key":"10.1016\/j.xgen.2024.100528_bib32","doi-asserted-by":"crossref","first-page":"1273","DOI":"10.1016\/j.celrep.2016.01.021","article-title":"APOBEC3A and APOBEC3B Preferentially Deaminate the Lagging Strand Template during DNA Replication","volume":"14","author":"Hoopes","year":"2016","journal-title":"Cell Rep."},{"key":"10.1016\/j.xgen.2024.100528_bib33","doi-asserted-by":"crossref","first-page":"1103","DOI":"10.1016\/j.celrep.2015.09.077","article-title":"APOBEC-Induced Cancer Mutations Are Uniquely Enriched in Early-Replicating, Gene-Dense, and Active Chromatin Regions","volume":"13","author":"Kazanov","year":"2015","journal-title":"Cell Rep."},{"key":"10.1016\/j.xgen.2024.100528_bib34","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1038\/s41586-022-04972-y","article-title":"Mechanisms of APOBEC3 mutagenesis in human cancer cells","volume":"607","author":"Petljak","year":"2022","journal-title":"Nature"},{"key":"10.1016\/j.xgen.2024.100528_bib35","doi-asserted-by":"crossref","first-page":"1282","DOI":"10.1016\/j.cell.2019.02.012","article-title":"Characterizing Mutational Signatures in Human Cancer Cell Lines Reveals Episodic APOBEC Mutagenesis","volume":"176","author":"Petljak","year":"2019","journal-title":"Cell"},{"key":"10.1016\/j.xgen.2024.100528_bib36","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1038\/s41586-020-1943-3","article-title":"The repertoire of mutational signatures in human cancer","volume":"578","author":"Alexandrov","year":"2020","journal-title":"Nature"},{"key":"10.1016\/j.xgen.2024.100528_bib37","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1038\/nrg3729","article-title":"Mechanisms underlying mutational signatures in human cancers","volume":"15","author":"Helleday","year":"2014","journal-title":"Nat. Rev. Genet."},{"key":"10.1016\/j.xgen.2024.100528_bib38","doi-asserted-by":"crossref","DOI":"10.1016\/j.dnarep.2020.102905","article-title":"Molecular origins of APOBEC-associated mutations in cancer","volume":"94","author":"Petljak","year":"2020","journal-title":"DNA Repair"},{"key":"10.1016\/j.xgen.2024.100528_bib39","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1186\/s13578-020-00390-7","article-title":"The role of poly(ADP-ribose) polymerase inhibitors in the treatment of cancer and methods to overcome resistance: a review","volume":"10","author":"Patel","year":"2020","journal-title":"Cell Biosci."},{"key":"10.1016\/j.xgen.2024.100528_bib40","doi-asserted-by":"crossref","DOI":"10.3389\/fonc.2014.00086","article-title":"Chemotherapeutic Compounds Targeting the DNA Double-Strand Break Repair Pathways: The Good, the Bad, and the Promising","volume":"4","author":"Jekimovs","year":"2014","journal-title":"Front. Oncol."},{"key":"10.1016\/j.xgen.2024.100528_bib41","series-title":"International Review of Cell and Molecular Biology","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/bs.ircmb.2021.06.003","article-title":"Chapter Two - DNA double-strand break repair in cancer: A path to achieving precision medicine","author":"Gillyard","year":"2021"},{"key":"10.1016\/j.xgen.2024.100528_bib42","doi-asserted-by":"crossref","first-page":"1353","DOI":"10.1016\/S1470-2045(20)30445-9","article-title":"Association of tumour mutational burden with outcomes in patients with advanced solid tumours treated with pembrolizumab: prospective biomarker analysis of the multicohort, open-label, phase 2 KEYNOTE-158 study","volume":"21","author":"Marabelle","year":"2020","journal-title":"Lancet Oncol."},{"key":"10.1016\/j.xgen.2024.100528_bib43","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1126\/science.aba8347","article-title":"Extensive heterogeneity in somatic mutation and selection in the human bladder","volume":"370","author":"Lawson","year":"2020","journal-title":"Science"},{"key":"10.1016\/j.xgen.2024.100528_bib44","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1038\/s41588-022-01296-5","article-title":"APOBEC mutagenesis is a common process in normal human small intestine","volume":"55","author":"Wang","year":"2023","journal-title":"Nat. Genet."},{"key":"10.1016\/j.xgen.2024.100528_bib61","doi-asserted-by":"crossref","first-page":"W160","DOI":"10.1093\/nar\/gkw257","article-title":"deepTools2: a next generation web server for deep-sequencing data analysis","volume":"44","author":"Ram\u00edrez","year":"2016","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.xgen.2024.100528_bib62","series-title":"R Core Team (2017). R: A Language and Environment for Statistical Computing","author":"Team","year":"2017"},{"key":"10.1016\/j.xgen.2024.100528_bib63","author":"Hartig"},{"key":"10.1016\/j.xgen.2024.100528_bib64","doi-asserted-by":"crossref","first-page":"844","DOI":"10.1093\/bioinformatics\/btab709","article-title":"Rediscover: an R package to identify mutually exclusive mutations","volume":"38","author":"Ferrer-Bonsoms","year":"2022","journal-title":"Bioinformatics"},{"key":"10.1016\/j.xgen.2024.100528_bib51","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1186\/s13073-018-0539-0","article-title":"MutationalPatterns: Comprehensive genome-wide analysis of mutational processes","volume":"10","author":"Blokzijl","year":"2018","journal-title":"Genome Med."},{"key":"10.1016\/j.xgen.2024.100528_bib52","doi-asserted-by":"crossref","first-page":"giad081","DOI":"10.1093\/gigascience\/giad081","article-title":"Katdetectr: an R\/bioconductor package utilizing unsupervised changepoint analysis for robust kataegis detection","volume":"12","author":"Hazelaar","year":"2022","journal-title":"GigaScience"},{"key":"10.1016\/j.xgen.2024.100528_bib46","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1038\/nature11247","article-title":"An integrated encyclopedia of DNA elements in the human genome","volume":"489","author":"Dunham","year":"2012","journal-title":"Nature"},{"key":"10.1016\/j.xgen.2024.100528_bib47","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1038\/nature14248","article-title":"Integrative analysis of 111 reference human epigenomes","volume":"518","author":"Kundaje","year":"2015","journal-title":"Nature"},{"key":"10.1016\/j.xgen.2024.100528_bib48","article-title":"Whole-genome mapping of APOBEC mutagenesis in metastatic urothelial carcinoma identifies driver hotspot mutations and a novel mutational signature","author":"Nakauma-Gonz\u00e1lez","year":"2023","journal-title":"Zenodo"},{"key":"10.1016\/j.xgen.2024.100528_bib49","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1038\/s41586-019-1689-y","article-title":"Pan-cancer whole-genome analyses of metastatic solid tumours","volume":"575","author":"Priestley","year":"2019","journal-title":"Nature"},{"key":"10.1016\/j.xgen.2024.100528_bib50","doi-asserted-by":"crossref","first-page":"5251","DOI":"10.1038\/s41467-019-13084-7","article-title":"The genomic landscape of metastatic castration-resistant prostate cancers reveals multiple distinct genotypes with potential clinical impact","volume":"10","author":"van Dessel","year":"2019","journal-title":"Nat. Commun."},{"key":"10.1016\/j.xgen.2024.100528_bib53","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1038\/nature11017","article-title":"The landscape of cancer genes and mutational processes in breast cancer","volume":"486","author":"Stephens","year":"2012","journal-title":"Nature"},{"key":"10.1016\/j.xgen.2024.100528_bib54","doi-asserted-by":"crossref","first-page":"2997","DOI":"10.1038\/ncomms3997","article-title":"Heterogeneity of genomic evolution and mutational profiles in multiple myeloma","volume":"5","author":"Bolli","year":"2014","journal-title":"Nat. Commun."},{"key":"10.1016\/j.xgen.2024.100528_bib55","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1038\/nature14347","article-title":"The evolutionary history of lethal metastatic prostate cancer","volume":"520","author":"Gundem","year":"2015","journal-title":"Nature"},{"key":"10.1016\/j.xgen.2024.100528_bib56","doi-asserted-by":"crossref","first-page":"1460","DOI":"10.1073\/pnas.95.4.1460","article-title":"A unified view of polymer, dumbbell, and oligonucleotide DNA nearest-neighbor thermodynamics","volume":"95","author":"SantaLucia","year":"1998","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.xgen.2024.100528_bib57","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1146\/annurev.biophys.32.110601.141800","article-title":"The Thermodynamics of DNA Structural Motifs","volume":"33","author":"SantaLucia","year":"2004","journal-title":"Annu. Rev. Biophys. Biomol. Struct."},{"key":"10.1016\/j.xgen.2024.100528_bib58","doi-asserted-by":"crossref","first-page":"3406","DOI":"10.1093\/nar\/gkg595","article-title":"Mfold web server for nucleic acid folding and hybridization prediction","volume":"31","author":"Zuker","year":"2003","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.xgen.2024.100528_bib59","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1038\/nature14221","article-title":"Cell-of-origin chromatin organization shapes the mutational landscape of cancer","volume":"518","author":"Polak","year":"2015","journal-title":"Nature"},{"key":"10.1016\/j.xgen.2024.100528_bib60","article-title":"Tumor mutational landscape is a record of the pre-malignant state","author":"K\u00fcbler","year":"2019","journal-title":"bioRxiv"}],"container-title":["Cell Genomics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2666979X24000703?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2666979X24000703?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,12,19]],"date-time":"2024-12-19T19:51:46Z","timestamp":1734637906000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2666979X24000703"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,4]]},"references-count":64,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2024,4]]}},"alternative-id":["S2666979X24000703"],"URL":"https:\/\/doi.org\/10.1016\/j.xgen.2024.100528","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2023.08.09.23293865","asserted-by":"object"}]},"ISSN":["2666-979X"],"issn-type":[{"value":"2666-979X","type":"print"}],"subject":[],"published":{"date-parts":[[2024,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Whole-genome mapping of APOBEC mutagenesis in metastatic urothelial carcinoma identifies driver hotspot mutations and a novel mutational signature","name":"articletitle","label":"Article Title"},{"value":"Cell Genomics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.xgen.2024.100528","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Authors.","name":"copyright","label":"Copyright"}],"article-number":"100528"}}