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Dis."},{"key":"10.1016\/j.xgen.2025.101007_bib72","doi-asserted-by":"crossref","first-page":"e0234857","DOI":"10.1371\/journal.pone.0234857","article-title":"Control of the neuroprotective lipocalin apolipoprotein d expression by alternative promoter regions and differentially expressed mrna 5\u2019 utr variants","volume":"15","author":"Diez-Hermano","year":"2020","journal-title":"PLoS One"},{"key":"10.1016\/j.xgen.2025.101007_bib73","doi-asserted-by":"crossref","first-page":"1663","DOI":"10.1038\/s41593-023-01423-3","article-title":"Myelination-independent functions of oligodendrocyte precursor cells in health and disease","volume":"26","author":"Xiao","year":"2023","journal-title":"Nat. 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Sci."},{"key":"10.1016\/j.xgen.2025.101007_bib82","doi-asserted-by":"crossref","DOI":"10.1016\/j.gene.2022.146203","article-title":"A specific gene-splicing alteration in the snrnp70 gene as a hallmark of an als subtype","volume":"818","author":"Nakaya","year":"2022","journal-title":"Gene"},{"key":"10.1016\/j.xgen.2025.101007_bib83","doi-asserted-by":"crossref","first-page":"8755","DOI":"10.1038\/s41598-018-27136-3","article-title":"Interactome analyses revealed that the u1 snrnp machinery overlaps extensively with the rnap ii machinery and contains multiple als\/sma-causative proteins","volume":"8","author":"Chi","year":"2018","journal-title":"Sci. Rep."},{"key":"10.1016\/j.xgen.2025.101007_bib84","doi-asserted-by":"crossref","first-page":"6129","DOI":"10.1038\/s41467-020-19737-2","article-title":"Single cell RNA sequencing of human microglia uncovers a subset associated with alzheimer\u2019s disease","volume":"11","author":"Olah","year":"2020","journal-title":"Nat. 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