{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,11]],"date-time":"2026-11-11T16:28:08Z","timestamp":1794414488246,"version":"4.9.1"},"reference-count":86,"publisher":"Elsevier BV","issue":"11","license":[{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T00:00:00Z","timestamp":1788566400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000057","name":"National Institute of General Medical Sciences","doi-asserted-by":"publisher","award":["R35GM131726"],"award-info":[{"award-number":["R35GM131726"]}],"id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Cell Genomics"],"published-print":{"date-parts":[[2026,11]]},"DOI":"10.1016\/j.xgen.2026.101383","type":"journal-article","created":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T15:18:24Z","timestamp":1790695104000},"page":"101383","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"title":["Disease-associated loci share properties with response eQTLs under common environmental exposures"],"prefix":"10.1016","volume":"6","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-0476-9201","authenticated-orcid":false,"given":"Wenhe","family":"Lin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingyuan","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivia","family":"Allen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan","family":"Burnett","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joshua M.","family":"Popp","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew","family":"Stephens","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5287-627X","authenticated-orcid":false,"given":"Alexis","family":"Battle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8284-8926","authenticated-orcid":false,"given":"Yoav","family":"Gilad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.xgen.2026.101383_bib1","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1038\/nrg3891","article-title":"The role of regulatory variation in complex traits and disease","volume":"16","author":"Albert","year":"2015","journal-title":"Nat. Rev. Genet."},{"key":"10.1016\/j.xgen.2026.101383_bib2","doi-asserted-by":"crossref","first-page":"1318","DOI":"10.1126\/science.aaz1776","article-title":"The GTEx Consortium atlas of genetic regulatory effects across human tissues","volume":"369","author":"Aguet","year":"2020","journal-title":"Science"},{"key":"10.1016\/j.xgen.2026.101383_bib3","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1038\/s41586-022-04713-1","article-title":"Single-cell eQTL models reveal dynamic T cell state dependence of disease loci","volume":"606","author":"Nathan","year":"2022","journal-title":"Nature"},{"key":"10.1016\/j.xgen.2026.101383_bib4","doi-asserted-by":"crossref","first-page":"1287","DOI":"10.1126\/science.aaw0040","article-title":"Dynamic genetic regulation of gene expression during cellular differentiation","volume":"364","author":"Strober","year":"2019","journal-title":"Science"},{"key":"10.1016\/j.xgen.2026.101383_bib5","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.57345","article-title":"Dynamic effects of genetic variation on gene expression revealed following hypoxic stress in cardiomyocytes","volume":"10","author":"Ward","year":"2021","journal-title":"eLife"},{"key":"10.1016\/j.xgen.2026.101383_bib6","doi-asserted-by":"crossref","first-page":"3507","DOI":"10.1073\/pnas.1222878110","article-title":"Genomic responses in mouse models poorly mimic human inflammatory diseases","volume":"110","author":"Seok","year":"2013","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.xgen.2026.101383_bib7","doi-asserted-by":"crossref","first-page":"17224","DOI":"10.1073\/pnas.1413624111","article-title":"Comparison of the transcriptional landscapes between human and mouse tissues","volume":"111","author":"Lin","year":"2014","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.xgen.2026.101383_bib8","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1038\/nrg.2017.19","article-title":"Comparative transcriptomics in human and mouse","volume":"18","author":"Breschi","year":"2017","journal-title":"Nat. Rev. Genet."},{"key":"10.1016\/j.xgen.2026.101383_bib9","doi-asserted-by":"crossref","DOI":"10.1126\/science.1246949","article-title":"Innate immune activity conditions the effect of regulatory variants upon monocyte gene expression","volume":"343","author":"Fairfax","year":"2014","journal-title":"Science"},{"key":"10.1016\/j.xgen.2026.101383_bib10","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1038\/s41588-020-0579-4","article-title":"Allele-specific expression changes dynamically during T cell activation in HLA and other autoimmune loci","volume":"52","author":"Gutierrez-Arcelus","year":"2020","journal-title":"Nat. Genet."},{"key":"10.1016\/j.xgen.2026.101383_bib11","doi-asserted-by":"crossref","first-page":"3006","DOI":"10.1016\/j.cell.2021.03.056","article-title":"Dynamic landscape of immune cell-specific gene regulation in immune-mediated diseases","volume":"184","author":"Ota","year":"2021","journal-title":"Cell"},{"key":"10.1016\/j.xgen.2026.101383_bib12","doi-asserted-by":"crossref","DOI":"10.1126\/sciimmunol.abm2508","article-title":"Single-cell eQTL analysis of activated T cell subsets reveals activation and cell type\u2013dependent effects of disease-risk variants","volume":"7","author":"Schmiedel","year":"2022","journal-title":"Sci. Immunol."},{"key":"10.1016\/j.xgen.2026.101383_bib13","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1038\/s41588-022-01066-3","article-title":"Immune disease risk variants regulate gene expression dynamics during CD4+ T cell activation","volume":"54","author":"Soskic","year":"2022","journal-title":"Nat. Genet."},{"key":"10.1016\/j.xgen.2026.101383_bib14","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1038\/s41586-023-06422-9","article-title":"Dissecting human population variation in single-cell responses to SARS-CoV-2","volume":"621","author":"Aquino","year":"2023","journal-title":"Nature"},{"key":"10.1016\/j.xgen.2026.101383_bib15","doi-asserted-by":"crossref","first-page":"1066","DOI":"10.1038\/s41588-023-01421-y","article-title":"Mapping interindividual dynamics of innate immune response at single-cell resolution","volume":"55","author":"Kumasaka","year":"2023","journal-title":"Nat. Genet."},{"key":"10.1016\/j.xgen.2026.101383_bib16","doi-asserted-by":"crossref","first-page":"810","DOI":"10.1038\/s41467-020-14457-z","article-title":"Single-cell RNA-sequencing of differentiating iPS cells reveals dynamic genetic effects on gene expression","volume":"11","author":"Cuomo","year":"2020","journal-title":"Nat. Commun."},{"key":"10.1016\/j.xgen.2026.101383_bib17","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1038\/s41588-021-00801-6","article-title":"Population-scale single-cell RNA-seq profiling across dopaminergic neuron differentiation","volume":"53","author":"Jerber","year":"2021","journal-title":"Nat. Genet."},{"key":"10.1016\/j.xgen.2026.101383_bib18","article-title":"Multiomic QTL mapping reveals phenotypic complexity of GWAS loci and prioritizes putative causal variants","volume":"5","author":"Arthur","year":"2025","journal-title":"Cell Genom."},{"key":"10.1016\/j.xgen.2026.101383_bib19","doi-asserted-by":"crossref","first-page":"6928","DOI":"10.1038\/s41467-023-42560-4","article-title":"eQTL mapping in fetal-like pancreatic progenitor cells reveals early developmental insights into diabetes risk","volume":"14","author":"Nguyen","year":"2023","journal-title":"Nat. Commun."},{"key":"10.1016\/j.xgen.2026.101383_bib20","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.33480","article-title":"Determining the genetic basis of anthracycline-cardiotoxicity by molecular response QTL mapping in induced cardiomyocytes","volume":"7","author":"Knowles","year":"2018","journal-title":"eLife"},{"key":"10.1016\/j.xgen.2026.101383_bib21","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.ajhg.2022.12.005","article-title":"Leveraging drug perturbation to reveal genetic regulators of hepatic gene expression in African Americans","volume":"110","author":"Zhong","year":"2023","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/j.xgen.2026.101383_bib22","doi-asserted-by":"crossref","DOI":"10.1101\/2024.05.02.592174","article-title":"Cell type and dynamic state govern genetic regulation of gene expression in heterogeneous differentiating cultures","volume":"4","author":"Popp","year":"2024","journal-title":"Cell Genom."},{"key":"10.1016\/j.xgen.2026.101383_bib23","doi-asserted-by":"crossref","DOI":"10.1126\/science.aba7721","article-title":"A human cell atlas of fetal gene expression","volume":"370","author":"Cao","year":"2020","journal-title":"Science"},{"key":"10.1016\/j.xgen.2026.101383_bib24","doi-asserted-by":"crossref","DOI":"10.1126\/science.adf1226","article-title":"Comprehensive cell atlas of the first-trimester developing human brain","volume":"382","author":"Braun","year":"2023","journal-title":"Science"},{"key":"10.1016\/j.xgen.2026.101383_bib25","doi-asserted-by":"crossref","first-page":"1095","DOI":"10.1038\/s41587-021-00896-6","article-title":"Gene signature extraction and cell identity recognition at the single-cell level with Cell-ID","volume":"39","author":"Cortal","year":"2021","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.xgen.2026.101383_bib26","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1038\/nrn786","article-title":"Neural induction, the default model and embryonic stem cells","volume":"3","author":"Mu\u00f1oz-Sanju\u00e1n","year":"2002","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.xgen.2026.101383_bib27","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1016\/j.cell.2008.02.008","article-title":"Differentiation of Embryonic Stem Cells to Clinically Relevant Populations: Lessons from Embryonic Development","volume":"132","author":"Murry","year":"2008","journal-title":"Cell"},{"key":"10.1016\/j.xgen.2026.101383_bib28","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1038\/nature09726","article-title":"Intrinsic transition of embryonic stem-cell differentiation into neural progenitors","volume":"470","author":"Kamiya","year":"2011","journal-title":"Nature"},{"key":"10.1016\/j.xgen.2026.101383_bib29","doi-asserted-by":"crossref","first-page":"E8267","DOI":"10.1073\/pnas.1617802113","article-title":"Tet proteins influence the balance between neuroectodermal and mesodermal fate choice by inhibiting Wnt signaling","volume":"113","author":"Li","year":"2016","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.xgen.2026.101383_bib30","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1038\/s41587-021-01033-z","article-title":"Differential abundance testing on single-cell data using k-nearest neighbor graphs","volume":"40","author":"Dann","year":"2022","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.xgen.2026.101383_bib31","doi-asserted-by":"crossref","first-page":"19962","DOI":"10.1073\/pnas.0807758105","article-title":"Ethanol inhibits neuronal differentiation by disrupting activity-dependent neuroprotective protein signaling","volume":"105","author":"Chen","year":"2008","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.xgen.2026.101383_bib32","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1111\/j.1530-0277.2008.00867.x","article-title":"Long-Term Ethanol Exposure Impairs Neuronal Differentiation of Human Neuroblastoma Cells Involving Neurotrophin-Mediated Intracellular Signaling and in Particular Protein Kinase C","volume":"33","author":"Hellmann","year":"2009","journal-title":"Alcohol Clin. Exp. Res."},{"key":"10.1016\/j.xgen.2026.101383_bib33","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/j.brainresbull.2016.09.013","article-title":"Direct effects of ethanol on neuronal differentiation: An in vitro analysis of viability and morphology","volume":"127","author":"Guadagnoli","year":"2016","journal-title":"Brain Res. Bull."},{"key":"10.1016\/j.xgen.2026.101383_bib34","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1038\/s41587-019-0068-4","article-title":"Characterization of cell fate probabilities in single-cell data with Palantir","volume":"37","author":"Setty","year":"2019","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.xgen.2026.101383_bib35","doi-asserted-by":"crossref","first-page":"4363","DOI":"10.1242\/dev.02005","article-title":"Characterization of mesendoderm: a diverging point of the definitive endoderm and mesoderm in embryonic stem cell differentiation culture","volume":"132","author":"Tada","year":"2005","journal-title":"Development"},{"key":"10.1016\/j.xgen.2026.101383_bib36","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1038\/nbt1318","article-title":"Characterization of human embryonic stem cell lines by the International Stem Cell Initiative","volume":"25","author":"Adewumi","year":"2007","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.xgen.2026.101383_bib37","doi-asserted-by":"crossref","first-page":"1111","DOI":"10.1016\/j.stemcr.2019.11.001","article-title":"Transcriptomically Guided Mesendoderm Induction of Human Pluripotent Stem Cells Using a Systematically Defined Culture Scheme","volume":"13","author":"Carpenedo","year":"2019","journal-title":"Stem Cell Rep."},{"key":"10.1016\/j.xgen.2026.101383_bib38","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1002\/hep.23354","article-title":"Highly Efficient Generation of Human Hepatocyte\u2013like Cells from Induced Pluripotent Stem Cells","volume":"51","author":"Si-Tayeb","year":"2010","journal-title":"Hepatol. Baltim. Md"},{"key":"10.1016\/j.xgen.2026.101383_bib39","doi-asserted-by":"crossref","first-page":"e15","DOI":"10.1161\/CIRCRESAHA.110.235531","article-title":"Epicardial-derived cell epithelial-to-mesenchymal transition and fate specification require PDGF receptor signaling","volume":"108","author":"Smith","year":"2011","journal-title":"Circ. Res."},{"key":"10.1016\/j.xgen.2026.101383_bib40","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1530\/JOE-19-0066","article-title":"Prenatal caffeine exposure induces liver developmental dysfunction in offspring rats","volume":"242","author":"He","year":"2019","journal-title":"J. Endocrinol."},{"key":"10.1016\/j.xgen.2026.101383_bib41","doi-asserted-by":"crossref","first-page":"1056","DOI":"10.1136\/hrt.2005.087171","article-title":"Cigarette smoking induces atrial fibrosis in humans via nicotine","volume":"93","author":"Goette","year":"2007","journal-title":"Heart"},{"key":"10.1016\/j.xgen.2026.101383_bib42","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1159\/000301278","article-title":"Nicotine Promotes Cardiomyocyte Apoptosis via Oxidative Stress and Altered Apoptosis-Related Gene Expression","volume":"115","author":"Zhou","year":"2010","journal-title":"Cardiology"},{"key":"10.1016\/j.xgen.2026.101383_bib43","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1038\/s41588-018-0268-8","article-title":"Flexible statistical methods for estimating and testing effects in genomic studies with multiple conditions","volume":"51","author":"Urbut","year":"2019","journal-title":"Nat. Genet."},{"key":"10.1016\/j.xgen.2026.101383_bib44","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1016\/j.stem.2017.03.009","article-title":"Large-Scale Profiling Reveals the Influence of Genetic Variation on Gene Expression in Human Induced Pluripotent Stem Cells","volume":"20","author":"DeBoever","year":"2017","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.xgen.2026.101383_bib45","doi-asserted-by":"crossref","first-page":"1415","DOI":"10.1038\/s41588-021-00931-x","article-title":"A cross-population atlas of genetic associations for 220 human phenotypes","volume":"53","author":"Sakaue","year":"2021","journal-title":"Nat. Genet."},{"key":"10.1016\/j.xgen.2026.101383_bib46","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1038\/ng.3760","article-title":"Genome-wide association study implicates immune activation of multiple integrin genes in inflammatory bowel disease","volume":"49","author":"de Lange","year":"2017","journal-title":"Nat. Genet."},{"key":"10.1016\/j.xgen.2026.101383_bib47","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1186\/s13059-019-1836-7","article-title":"Scaling computational genomics to millions of individuals with GPUs","volume":"20","author":"Taylor-Weiner","year":"2019","journal-title":"Genome Biol."},{"key":"10.1016\/j.xgen.2026.101383_bib48","doi-asserted-by":"crossref","first-page":"D985","DOI":"10.1093\/nar\/gkw1055","article-title":"Open Targets: a platform for therapeutic target identification and validation","volume":"45","author":"Koscielny","year":"2016","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.xgen.2026.101383_bib49","doi-asserted-by":"crossref","first-page":"1866","DOI":"10.1038\/s41588-023-01529-1","article-title":"Systematic differences in discovery of genetic effects on gene expression and complex traits","volume":"55","author":"Mostafavi","year":"2023","journal-title":"Nat. Genet."},{"key":"10.1016\/j.xgen.2026.101383_bib50","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1038\/s41586-020-2493-4","article-title":"Expanded encyclopaedias of DNA elements in the human and mouse genomes","volume":"583","author":"Abascal","year":"2020","journal-title":"Nature"},{"key":"10.1016\/j.xgen.2026.101383_bib51","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1038\/nature09165","article-title":"Conserved role of intragenic DNA methylation in regulating alternative promoters","volume":"466","author":"Maunakea","year":"2010","journal-title":"Nature"},{"key":"10.1016\/j.xgen.2026.101383_bib52","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1038\/nature13182","article-title":"A promoter-level mammalian expression atlas","volume":"507","author":"Forrest","year":"2014","journal-title":"Nature"},{"key":"10.1016\/j.xgen.2026.101383_bib53","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1038\/ng.1064","article-title":"Tissue-specific analysis of chromatin state identifies temporal signatures of enhancer activity during embryonic development","volume":"44","author":"Bonn","year":"2012","journal-title":"Nat. Genet."},{"key":"10.1016\/j.xgen.2026.101383_bib54","doi-asserted-by":"crossref","first-page":"1010","DOI":"10.1126\/science.1259418","article-title":"Transcribed enhancers lead waves of coordinated transcription in transitioning mammalian cells","volume":"347","author":"Arner","year":"2015","journal-title":"Science"},{"key":"10.1016\/j.xgen.2026.101383_bib55","doi-asserted-by":"crossref","first-page":"1164","DOI":"10.1126\/science.abd4964","article-title":"Sexual dimorphism in body clocks","volume":"369","author":"Anderson","year":"2020","journal-title":"Science"},{"key":"10.1016\/j.xgen.2026.101383_bib56","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1038\/s41586-021-03446-x","article-title":"Genome-wide enhancer maps link risk variants to disease genes","volume":"593","author":"Nasser","year":"2021","journal-title":"Nature"},{"key":"10.1016\/j.xgen.2026.101383_bib57","doi-asserted-by":"crossref","first-page":"1358","DOI":"10.1038\/s41467-017-01467-7","article-title":"The effect of genetic variation on promoter usage and enhancer activity","volume":"8","author":"Garieri","year":"2017","journal-title":"Nat. Commun."},{"key":"10.1016\/j.xgen.2026.101383_bib58","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1038\/nature19057","article-title":"Analysis of protein-coding genetic variation in 60,706 humans","volume":"536","author":"Lek","year":"2016","journal-title":"Nature"},{"key":"10.1016\/j.xgen.2026.101383_bib59","doi-asserted-by":"crossref","first-page":"1851","DOI":"10.1038\/s41588-024-01872-x","article-title":"Global impact of unproductive splicing on human gene expression","volume":"56","author":"Fair","year":"2024","journal-title":"Nat. Genet."},{"key":"10.1016\/j.xgen.2026.101383_bib60","doi-asserted-by":"crossref","first-page":"764","DOI":"10.1038\/s41467-020-20885-8","article-title":"A fast and efficient colocalization algorithm for identifying shared genetic risk factors across multiple traits","volume":"12","author":"Foley","year":"2021","journal-title":"Nat. Commun."},{"key":"10.1016\/j.xgen.2026.101383_bib61","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1000888","article-title":"Trait-Associated SNPs Are More Likely to Be eQTLs: Annotation to Enhance Discovery from GWAS","volume":"6","author":"Nicolae","year":"2010","journal-title":"PLoS Genet."},{"key":"10.1016\/j.xgen.2026.101383_bib62","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1186\/s13072-017-0111-y","article-title":"In utero exposure to maternal smoking is associated with DNA methylation alterations and reduced neuronal content in the developing fetal brain","volume":"10","author":"Chatterton","year":"2017","journal-title":"Epigenetics Chromatin"},{"key":"10.1016\/j.xgen.2026.101383_bib63","doi-asserted-by":"crossref","DOI":"10.1042\/NS20170191","article-title":"LNX1\/LNX2 proteins: functions in neuronal signalling and beyond","volume":"2","author":"Young","year":"2018","journal-title":"Neuronal Signal."},{"key":"10.1016\/j.xgen.2026.101383_bib64","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1093\/emboj\/21.1.93","article-title":"LNX functions as a RING type E3 ubiquitin ligase that targets the cell fate determinant Numb for ubiquitin-dependent degradation","volume":"21","author":"Nie","year":"2002","journal-title":"EMBO J."},{"key":"10.1016\/j.xgen.2026.101383_bib65","doi-asserted-by":"crossref","first-page":"1640","DOI":"10.1016\/j.yexcr.2011.04.008","article-title":"Numb modulates intestinal epithelial cells toward goblet cell phenotype by inhibiting the Notch signaling pathway","volume":"317","author":"Yang","year":"2011","journal-title":"Exp. Cell Res."},{"key":"10.1016\/j.xgen.2026.101383_bib66","doi-asserted-by":"crossref","DOI":"10.3389\/fmed.2023.1333531","article-title":"The role of the Notch signalling pathway in the pathogenesis of ulcerative colitis: from the perspective of intestinal mucosal barrier","volume":"10","author":"Ning","year":"2024","journal-title":"Front. Med."},{"key":"10.1016\/j.xgen.2026.101383_bib67","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1038\/s41586-026-10627-z","article-title":"Cell-type-resolved genetic variation shapes inflammatory bowel disease risk","volume":"656","author":"Alegbe","year":"2026","journal-title":"Nature"},{"key":"10.1016\/j.xgen.2026.101383_bib68","doi-asserted-by":"crossref","first-page":"1309","DOI":"10.1101\/gr.190926.115","article-title":"Dynamics and function of distal regulatory elements during neurogenesis and neuroplasticity","volume":"25","author":"Thakurela","year":"2015","journal-title":"Genome Res."},{"key":"10.1016\/j.xgen.2026.101383_bib69","doi-asserted-by":"crossref","DOI":"10.15252\/msb.20209438","article-title":"Identification of genomic enhancers through spatial integration of single-cell transcriptomics and epigenomics","volume":"16","author":"Bravo Gonz\u00e1lez-Blas","year":"2020","journal-title":"Mol. Syst. Biol."},{"key":"10.1016\/j.xgen.2026.101383_bib70","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1038\/s41580-022-00507-5","article-title":"Context-specific regulation and function of mRNA alternative polyadenylation","volume":"23","author":"Mitschka","year":"2022","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.xgen.2026.101383_bib71","article-title":"Genetic regulatory effects in response to a high-cholesterol, high-fat diet in baboons","volume":"4","author":"Lin","year":"2024","journal-title":"Cell Genom."},{"key":"10.1016\/j.xgen.2026.101383_bib72","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1101\/gr.224436.117","article-title":"Impact of regulatory variation across human iPSCs and differentiated cells","volume":"28","author":"Banovich","year":"2018","journal-title":"Genome Res."},{"key":"10.1016\/j.xgen.2026.101383_bib73","doi-asserted-by":"crossref","first-page":"3426","DOI":"10.1016\/j.cell.2022.08.004","article-title":"High-coverage whole-genome sequencing of the expanded 1000 Genomes Project cohort including 602 trios","volume":"185","author":"Byrska-Bishop","year":"2022","journal-title":"Cell"},{"key":"10.1016\/j.xgen.2026.101383_bib74","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1038\/s41586-023-06045-0","article-title":"A genomic mutational constraint map using variation in 76,156 human genomes","volume":"625","author":"Chen","year":"2024","journal-title":"Nature"},{"key":"10.1016\/j.xgen.2026.101383_bib75","doi-asserted-by":"crossref","first-page":"650","DOI":"10.1016\/j.cell.2018.01.029","article-title":"The Human Transcription Factors","volume":"172","author":"Lambert","year":"2018","journal-title":"Cell"},{"key":"10.1016\/j.xgen.2026.101383_bib76","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1016\/j.cels.2015.12.004","article-title":"The Molecular Signatures Database Hallmark Gene Set Collection","volume":"1","author":"Liberzon","year":"2015","journal-title":"Cell Syst."},{"key":"10.1016\/j.xgen.2026.101383_bib77","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1186\/s13059-019-1865-2","article-title":"Vireo: Bayesian demultiplexing of pooled single-cell RNA-seq data without genotype reference","volume":"20","author":"Huang","year":"2019","journal-title":"Genome Biol."},{"key":"10.1016\/j.xgen.2026.101383_bib78","article-title":"Efficient differential expression analysis of large-scale single cell transcriptomics data using dreamlet","author":"Hoffman","year":"2024","journal-title":"BioRxiv"},{"key":"10.1016\/j.xgen.2026.101383_bib79","article-title":"Fast gene set enrichment analysis","author":"Korotkevich","year":"2021","journal-title":"bioRxiv"},{"key":"10.1016\/j.xgen.2026.101383_bib80","doi-asserted-by":"crossref","first-page":"1336","DOI":"10.1038\/s41592-023-01955-3","article-title":"Isolating salient variations of interest in single-cell data with contrastiveVI","volume":"20","author":"Weinberger","year":"2023","journal-title":"Nat. Methods"},{"key":"10.1016\/j.xgen.2026.101383_bib81","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1186\/s13059-017-1382-0","article-title":"SCANPY: large-scale single-cell gene expression data analysis","volume":"19","author":"Wolf","year":"2018","journal-title":"Genome Biol."},{"key":"10.1016\/j.xgen.2026.101383_bib82","doi-asserted-by":"crossref","first-page":"1353","DOI":"10.1093\/bioinformatics\/bts163","article-title":"Matrix eQTL: ultra fast eQTL analysis via large matrix operations","volume":"28","author":"Shabalin","year":"2012","journal-title":"Bioinformatics"},{"key":"10.1016\/j.xgen.2026.101383_bib83","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1016\/j.ajhg.2015.11.021","article-title":"An Efficient Multiple-Testing Adjustment for eQTL Studies that Accounts for Linkage Disequilibrium between Variants","volume":"98","author":"Davis","year":"2016","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/j.xgen.2026.101383_bib84","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1093\/bioinformatics\/btu655","article-title":"SNPsnap: a Web-based tool for identification and annotation of matched SNPs","volume":"31","author":"Pers","year":"2015","journal-title":"Bioinformatics"},{"key":"10.1016\/j.xgen.2026.101383_bib85","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1009666","article-title":"Single-cell sequencing reveals lineage-specific dynamic genetic regulation of gene expression during human cardiomyocyte differentiation","volume":"18","author":"Elorbany","year":"2022","journal-title":"PLoS Genet."},{"key":"10.1016\/j.xgen.2026.101383_bib86","series-title":"Quantitative Sociology International Perspectives on Mathematical and Statistical Modeling","first-page":"307","article-title":"Path Models with Latent Variables: The NIPALS Approach\u2217","author":"Wold","year":"1975"}],"container-title":["Cell Genomics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2666979X26002454?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2666979X26002454?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,11,11]],"date-time":"2026-11-11T16:03:27Z","timestamp":1794413007000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2666979X26002454"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,11]]},"references-count":86,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2026,11]]}},"alternative-id":["S2666979X26002454"],"URL":"https:\/\/doi.org\/10.1016\/j.xgen.2026.101383","relation":{},"ISSN":["2666-979X"],"issn-type":[{"value":"2666-979X","type":"print"}],"subject":[],"published":{"date-parts":[[2026,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Disease-associated loci share properties with response eQTLs under common environmental exposures","name":"articletitle","label":"Article Title"},{"value":"Cell Genomics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.xgen.2026.101383","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"101383"}}