{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,6]],"date-time":"2026-02-06T00:17:33Z","timestamp":1770337053715,"version":"3.49.0"},"reference-count":24,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,4,25]],"date-time":"2025-04-25T00:00:00Z","timestamp":1745539200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000196","name":"Canada Foundation for Innovation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000196","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003579","name":"University of Toronto","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003579","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009326","name":"Cancer Research Society","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009326","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004376","name":"Terry Fox Research Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004376","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009812","name":"Princess Margaret Cancer Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009812","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["U01CA253383"],"award-info":[{"award-number":["U01CA253383"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007052","name":"Memorial Sloan-Kettering Cancer Center","doi-asserted-by":"publisher","award":["UL1TR00457"],"award-info":[{"award-number":["UL1TR00457"]}],"id":[{"id":"10.13039\/100007052","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["cell.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Human Genetics and Genomics Advances"],"published-print":{"date-parts":[[2025,7]]},"DOI":"10.1016\/j.xhgg.2025.100445","type":"journal-article","created":{"date-parts":[[2025,4,29]],"date-time":"2025-04-29T20:46:27Z","timestamp":1745959587000},"page":"100445","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"title":["Pathogenic germline variants in small cell lung cancer: A systematic review and meta-analysis"],"prefix":"10.1016","volume":"6","author":[{"given":"Sami","family":"Ul Haq","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aleem","family":"Aamir","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chloe","family":"Mighton","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katrina","family":"Hueniken","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vivek","family":"Philip","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raymond H.","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Geoffrey","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Sabatini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Scott V.","family":"Bratman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Benjamin H.","family":"Lok","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.xhgg.2025.100445_bib1","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1038\/s41572-020-00235-0","article-title":"Small-cell lung cancer","volume":"7","author":"Rudin","year":"2021","journal-title":"Nat. Rev. Dis. Primers"},{"key":"10.1016\/j.xhgg.2025.100445_bib2","doi-asserted-by":"crossref","first-page":"1677","DOI":"10.1016\/j.ebiom.2015.09.031","article-title":"Associated Links Among Smoking, Chronic Obstructive Pulmonary Disease, and Small Cell Lung Cancer: A Pooled Analysis in the International Lung Cancer Consortium","volume":"2","author":"Huang","year":"2015","journal-title":"EBioMedicine"},{"key":"10.1016\/j.xhgg.2025.100445_bib3","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.abc7488","article-title":"Whole-exome sequencing reveals germline-mutated small cell lung cancer subtype with favorable response to DNA repair-targeted therapies","volume":"13","author":"Tlemsani","year":"2021","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.xhgg.2025.100445_bib4","article-title":"Identifying novel germline mutations and copy number variations in patients with small cell lung cancer","volume":"5","author":"Haq","year":"2024","journal-title":"JTO Clin Res Rep"},{"key":"10.1016\/j.xhgg.2025.100445_bib5","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1038\/nature14664","article-title":"Comprehensive genomic profiles of small cell lung cancer","volume":"524","author":"George","year":"2015","journal-title":"Nature"},{"key":"10.1016\/j.xhgg.2025.100445_bib6","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1038\/nature12981","article-title":"Realizing the promise of cancer predisposition genes","volume":"505","author":"Rahman","year":"2014","journal-title":"Nature"},{"key":"10.1016\/j.xhgg.2025.100445_bib7","doi-asserted-by":"crossref","first-page":"2394","DOI":"10.1056\/NEJMoa2105215","article-title":"Adjuvant Olaparib for Patients with BRCA1- or BRCA2-Mutated Breast Cancer","volume":"384","author":"Tutt","year":"2021","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.xhgg.2025.100445_bib8","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1186\/s13073-020-0718-7","article-title":"The pan-cancer landscape of prognostic germline variants in 10,582 patients","volume":"12","author":"Chatrath","year":"2020","journal-title":"Genome Med."},{"key":"10.1016\/j.xhgg.2025.100445_bib9","article-title":"The PRISMA 2020 statement: an updated guideline for reporting systematic reviews","volume":"372","author":"Page","year":"2021","journal-title":"BMJ"},{"key":"10.1016\/j.xhgg.2025.100445_bib10","doi-asserted-by":"crossref","first-page":"2617","DOI":"10.1200\/JCO.20.03238","article-title":"Homologous Recombination Deficiency in Pancreatic Cancer: A Systematic Review and Prevalence Meta-Analysis","volume":"39","author":"Casolino","year":"2021","journal-title":"J. Clin. Oncol."},{"key":"10.1016\/j.xhgg.2025.100445_bib11","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1038\/gim.2016.139","article-title":"Mastering genomic terminology","volume":"19","author":"Jarvik","year":"2017","journal-title":"Genet. Med."},{"key":"10.1016\/j.xhgg.2025.100445_bib12","doi-asserted-by":"crossref","first-page":"21219","DOI":"10.1002\/cam4.6692","article-title":"Pathogenic germline variants in BRCA1 and TP53 increase lung cancer risk in Chinese","volume":"12","author":"Wei","year":"2023","journal-title":"Cancer Med."},{"key":"10.1016\/j.xhgg.2025.100445_bib13","doi-asserted-by":"crossref","first-page":"4486","DOI":"10.1002\/cam4.5148","article-title":"Mutational landscape of homologous recombination-related genes in small-cell lung cancer","volume":"12","author":"Wu","year":"2023","journal-title":"Cancer Med."},{"key":"10.1016\/j.xhgg.2025.100445_bib14","doi-asserted-by":"crossref","first-page":"1450","DOI":"10.1158\/1055-9965.EPI-21-1287","article-title":"Germline Pathogenic Variants Impact Clinicopathology of Advanced Lung Cancer","volume":"31","author":"Mukherjee","year":"2022","journal-title":"Cancer Epidemiol. Biomarkers Prev."},{"key":"10.1016\/j.xhgg.2025.100445_bib15","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1016\/j.cell.2018.03.039","article-title":"Pathogenic Germline Variants in 10,389 Adult Cancers","volume":"173","author":"Huang","year":"2018","journal-title":"Cell"},{"key":"10.1016\/j.xhgg.2025.100445_bib16","doi-asserted-by":"crossref","first-page":"1146","DOI":"10.1016\/j.jtho.2023.05.028","article-title":"The Role of Germline Mutations in Thoracic Malignancies: Between Myth and Reality","volume":"18","author":"Farinea","year":"2023","journal-title":"J. Thorac. Oncol."},{"key":"10.1016\/j.xhgg.2025.100445_bib17","doi-asserted-by":"crossref","first-page":"1943","DOI":"10.3748\/wjg.v27.i17.1943","article-title":"BRCA mutated pancreatic cancer: A change is coming","volume":"27","author":"Rosen","year":"2021","journal-title":"World J. Gastroenterol."},{"key":"10.1016\/j.xhgg.2025.100445_bib18","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1186\/s12885-021-09082-y","article-title":"Landscape of homologous recombination deficiencies in solid tumours: analyses of two independent genomic datasets","volume":"22","author":"Lai","year":"2022","journal-title":"BMC Cancer"},{"key":"10.1016\/j.xhgg.2025.100445_bib19","doi-asserted-by":"crossref","first-page":"2206","DOI":"10.1038\/s41467-020-16067-1","article-title":"Comprehensive germline genomic profiles of children, adolescents and young adults with solid tumors","volume":"11","author":"Akhavanfard","year":"2020","journal-title":"Nat. Commun."},{"key":"10.1016\/j.xhgg.2025.100445_bib20","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-023-46323-5","article-title":"Impact of germline DNA repair gene variants on prognosis and treatment of men with advanced prostate cancer","volume":"13","author":"Hansen","year":"2023","journal-title":"Sci. Rep."},{"key":"10.1016\/j.xhgg.2025.100445_bib21","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1001\/jamaoncol.2018.6760","article-title":"Prevalence of Germline Variants in Prostate Cancer and Implications for Current Genetic Testing Guidelines","volume":"5","author":"Nicolosi","year":"2019","journal-title":"JAMA Oncol."},{"key":"10.1016\/j.xhgg.2025.100445_bib22","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1007\/s10549-022-06776-0","article-title":"Prognostic impact of germline BRCA1\/2 pathogenic variants in breast cancer","volume":"197","author":"Corso","year":"2023","journal-title":"Breast Cancer Res. Treat."},{"key":"10.1016\/j.xhgg.2025.100445_bib23","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1038\/s41436-018-0009-5","article-title":"Germline cancer susceptibility gene variants, somatic second hits, and survival outcomes in patients with resected pancreatic cancer","volume":"21","author":"Yurgelun","year":"2019","journal-title":"Genet. Med."},{"key":"10.1016\/j.xhgg.2025.100445_bib24","article-title":"A germline heterozygous POLQ nonsense mutation causes hereditary colorectal cancer","author":"Xu","year":"2024","journal-title":"medRxiv"}],"container-title":["Human Genetics and Genomics Advances"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S266624772500048X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S266624772500048X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,8]],"date-time":"2025-11-08T21:34:55Z","timestamp":1762637695000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S266624772500048X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7]]},"references-count":24,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2025,7]]}},"alternative-id":["S266624772500048X"],"URL":"https:\/\/doi.org\/10.1016\/j.xhgg.2025.100445","relation":{},"ISSN":["2666-2477"],"issn-type":[{"value":"2666-2477","type":"print"}],"subject":[],"published":{"date-parts":[[2025,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Pathogenic germline variants in small cell lung cancer: A systematic review and meta-analysis","name":"articletitle","label":"Article Title"},{"value":"Human Genetics and Genomics Advances","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.xhgg.2025.100445","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier Inc. on behalf of American Society of Human Genetics.","name":"copyright","label":"Copyright"}],"article-number":"100445"}}