{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T21:17:56Z","timestamp":1783718276784,"version":"3.55.0"},"reference-count":20,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2023,7,1]],"date-time":"2023-07-01T00:00:00Z","timestamp":1688169600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,7,1]],"date-time":"2023-07-01T00:00:00Z","timestamp":1688169600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T00:00:00Z","timestamp":1675209600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["jidinnovations.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["JID Innovations"],"published-print":{"date-parts":[[2023,7]]},"DOI":"10.1016\/j.xjidi.2023.100189","type":"journal-article","created":{"date-parts":[[2023,2,9]],"date-time":"2023-02-09T21:45:13Z","timestamp":1675979113000},"page":"100189","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"title":["IL17A mRNA Staining Distinguishes Palmoplantar Psoriasis from Hyperkeratotic Palmoplantar Eczema in Diagnostic Skin Biopsies"],"prefix":"10.1016","volume":"3","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7808-2670","authenticated-orcid":false,"given":"Jennifer S.","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6494-7250","authenticated-orcid":false,"given":"Michael J.","family":"Murphy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0120-4238","authenticated-orcid":false,"given":"Katelyn","family":"Singh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1771-2103","authenticated-orcid":false,"given":"Alice","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1872-6307","authenticated-orcid":false,"given":"Ryan D.","family":"Chow","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0345-7028","authenticated-orcid":false,"given":"Sa Rang","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7709-0548","authenticated-orcid":false,"given":"Jeffrey M.","family":"Cohen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2270-2524","authenticated-orcid":false,"given":"Christine J.","family":"Ko","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0975-4071","authenticated-orcid":false,"given":"William","family":"Damsky","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.xjidi.2023.100189_bib1","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1111\/jdv.16563","article-title":"Identification of a TH2-high psoriasis cluster based on skin biomarker analysis in a Chinese psoriasis population","volume":"35","author":"Chen","year":"2021","journal-title":"J\u00a0Eur Acad Dermatol Venereol"},{"key":"10.1016\/j.xjidi.2023.100189_bib2","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jaci.2018.10.032","article-title":"Atopic dermatitis endotypes and implications for targeted therapeutics","volume":"143","author":"Czarnowicki","year":"2019","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.xjidi.2023.100189_bib3","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1111\/cup.14105","article-title":"IL-36\u03b1 and IL-36\u03b3 expressions in the differential diagnosis of palmoplantar psoriasis and palmoplantar eczema: a retrospective histopathologic and immunohistochemical study","volume":"49","author":"Erdem","year":"2022","journal-title":"J\u00a0Cutan Pathol"},{"key":"10.1016\/j.xjidi.2023.100189_bib4","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/j.jaad.2020.03.050","article-title":"Progression of cutaneous T-cell lymphoma after dupilumab: case review of 7 patients","volume":"83","author":"Espinosa","year":"2020","journal-title":"J\u00a0Am Acad Dermatol"},{"key":"10.1016\/j.xjidi.2023.100189_bib5","doi-asserted-by":"crossref","first-page":"46","DOI":"10.3389\/fnana.2019.00046","article-title":"On the necessity of validating antibodies in the immunohistochemistry literature","volume":"13","author":"Gautron","year":"2019","journal-title":"Front Neuroanat"},{"key":"10.1016\/j.xjidi.2023.100189_bib6","doi-asserted-by":"crossref","first-page":"1344","DOI":"10.1016\/j.jaci.2012.07.012","article-title":"Progressive activation of T(H)2\/T(H)22 cytokines and selective epidermal proteins characterizes acute and chronic atopic dermatitis","volume":"130","author":"Gittler","year":"2012","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.xjidi.2023.100189_bib7","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.jaad.2016.07.058","article-title":"Secukinumab shows significant efficacy in palmoplantar psoriasis: results from GESTURE, a randomized controlled trial","volume":"76","author":"Gottlieb","year":"2017","journal-title":"J\u00a0Am Acad Dermatol"},{"key":"10.1016\/j.xjidi.2023.100189_bib8","doi-asserted-by":"crossref","first-page":"884","DOI":"10.1016\/j.jaad.2021.11.057","article-title":"Clustered intraepidermal lymphocytes and Langerhans cell microgranulomas are consistently observed in hyperkeratotic palmoplantar eczema compared with palmoplantar psoriasis and mycosis fungoides palmaris et plantaris","volume":"87","author":"Kim","year":"2022","journal-title":"J\u00a0Am Acad Dermatol"},{"key":"10.1016\/j.xjidi.2023.100189_bib9","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1056\/NEJMoa1314258","article-title":"Secukinumab in plaque psoriasis--results of two phase 3 trials","volume":"371","author":"Langley","year":"2014","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.xjidi.2023.100189_bib10","doi-asserted-by":"crossref","first-page":"1158","DOI":"10.1038\/s41467-022-28799-3","article-title":"Single-cell transcriptomics links malignant T cells to the tumor immune landscape in cutaneous T cell lymphoma","volume":"13","author":"Liu","year":"2022","journal-title":"Nat Commun"},{"key":"10.1016\/j.xjidi.2023.100189_bib11","doi-asserted-by":"crossref","first-page":"882","DOI":"10.1016\/j.jaci.2022.04.027","article-title":"Single-cell analysis implicates TH17-to-TH2 cell plasticity in the pathogenesis of palmoplantar pustulosis","volume":"150","author":"McCluskey","year":"2022","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.xjidi.2023.100189_bib12","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.159762","article-title":"Biogeographic and disease-specific alterations in epidermal lipid composition and single-cell analysis of acral keratinocytes","volume":"7","author":"Merleev","year":"2022","journal-title":"JCI Insight"},{"key":"10.1016\/j.xjidi.2023.100189_bib13","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1111\/1346-8138.14982","article-title":"Effect of dupilumab on hand eczema in patients with atopic dermatitis: an observational study","volume":"46","author":"Oosterhaven","year":"2019","journal-title":"J\u00a0Dermatol"},{"key":"10.1016\/j.xjidi.2023.100189_bib14","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1016\/j.jaad.2017.01.005","article-title":"The histopathological differentiation between palmar psoriasis and hand eczema: a retrospective review of 96 cases","volume":"77","author":"Park","year":"2017","journal-title":"J\u00a0Am Acad Dermatol"},{"key":"10.1016\/j.xjidi.2023.100189_bib15","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1016\/j.jaad.2022.05.047","article-title":"Secukinumab is effective and safe in the treatment of recalcitrant palmoplantar psoriasis and palmoplantar pustular psoriasis in a daily practice setting","volume":"87","author":"Reolid","year":"2022","journal-title":"J\u00a0Am Acad Dermatol"},{"key":"10.1016\/j.xjidi.2023.100189_bib16","doi-asserted-by":"crossref","first-page":"666935","DOI":"10.3389\/fimmu.2021.666935","article-title":"Single-cell RNA sequencing reveals tissue compartment-specific plasticity of mycosis fungoides tumor cells","volume":"12","author":"Rindler","year":"2021","journal-title":"Front Immunol"},{"key":"10.1016\/j.xjidi.2023.100189_bib17","doi-asserted-by":"crossref","DOI":"10.1016\/j.jaad.2022.12.052","article-title":"Skin cytokine profiles determined by RNA in situ hybridization correlate with response to dupilumab in patients with eczematous dermatitis","author":"Singh","year":"2023","journal-title":"J Am Acad Dermatol"},{"key":"10.1016\/j.xjidi.2023.100189_bib18","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0034594","article-title":"Heterogeneity of inflammatory and cytokine networks in chronic plaque psoriasis","volume":"7","author":"Swindell","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.xjidi.2023.100189_bib19","doi-asserted-by":"crossref","first-page":"100021","DOI":"10.1016\/j.xjidi.2021.100021","article-title":"Cytokine RNA in situ hybridization permits individualized molecular phenotyping in biopsies of psoriasis and atopic dermatitis","volume":"1","author":"Wang","year":"2021","journal-title":"JID Innov"},{"key":"10.1016\/j.xjidi.2023.100189_bib20","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1016\/j.jaci.2019.01.015","article-title":"Age-specific changes in the molecular phenotype of patients with moderate-to-severe atopic dermatitis","volume":"144","author":"Zhou","year":"2019","journal-title":"J\u00a0Allergy Clin Immunol"}],"container-title":["JID Innovations"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2667026723000103?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2667026723000103?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,13]],"date-time":"2025-11-13T08:03:35Z","timestamp":1763021015000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2667026723000103"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,7]]},"references-count":20,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2023,7]]}},"alternative-id":["S2667026723000103"],"URL":"https:\/\/doi.org\/10.1016\/j.xjidi.2023.100189","relation":{},"ISSN":["2667-0267"],"issn-type":[{"value":"2667-0267","type":"print"}],"subject":[],"published":{"date-parts":[[2023,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"IL17A mRNA Staining Distinguishes Palmoplantar Psoriasis from Hyperkeratotic Palmoplantar Eczema in Diagnostic Skin Biopsies","name":"articletitle","label":"Article Title"},{"value":"JID Innovations","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.xjidi.2023.100189","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 The Authors. Published by Elsevier Inc. on behalf of the Society for Investigative Dermatology.","name":"copyright","label":"Copyright"}],"article-number":"100189"}}