{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T23:59:55Z","timestamp":1789430395651,"version":"build-2803163510"},"reference-count":33,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2024,5,1]],"date-time":"2024-05-01T00:00:00Z","timestamp":1714521600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,5,1]],"date-time":"2024-05-01T00:00:00Z","timestamp":1714521600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,1,30]],"date-time":"2024-01-30T00:00:00Z","timestamp":1706572800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["jidinnovations.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["JID Innovations"],"published-print":{"date-parts":[[2024,5]]},"DOI":"10.1016\/j.xjidi.2024.100268","type":"journal-article","created":{"date-parts":[[2024,2,3]],"date-time":"2024-02-03T05:42:31Z","timestamp":1706938951000},"page":"100268","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"title":["NOD\/Scid IL2R\u03b3null Mice Reconstituted with PBMCs from Patients with Atopic Dermatitis or Psoriasis Vulgaris Reflect the Respective Phenotype"],"prefix":"10.1016","volume":"4","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-2271-3933","authenticated-orcid":false,"given":"Marietta","family":"Schindler","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6516-6912","authenticated-orcid":false,"given":"Paula","family":"Schuster-Winkelmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5072-8767","authenticated-orcid":false,"given":"Veronika","family":"We\u00df","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-2040-9361","authenticated-orcid":false,"given":"Sophia","family":"Czell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7109-8031","authenticated-orcid":false,"given":"Franziska","family":"Rueff","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0177-8722","authenticated-orcid":false,"given":"Andreas","family":"Wollenberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5290-5344","authenticated-orcid":false,"given":"Matthias","family":"Siebeck","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4756-261X","authenticated-orcid":false,"given":"Roswitha","family":"Gropp","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.xjidi.2024.100268_bib1","doi-asserted-by":"crossref","first-page":"1225","DOI":"10.1093\/ibd\/izy073","article-title":"CD1a-expressing monocytes as mediators of inflammation in ulcerative colitis","volume":"24","author":"Al-Amodi","year":"2018","journal-title":"Inflamm Bowel Dis"},{"key":"10.1016\/j.xjidi.2024.100268_bib2","doi-asserted-by":"crossref","first-page":"2203","DOI":"10.1084\/jem.20151093","article-title":"Melanocyte antigen triggers autoimmunity in human psoriasis","volume":"212","author":"Arakawa","year":"2015","journal-title":"J\u00a0Exp Med"},{"key":"10.1016\/j.xjidi.2024.100268_bib3","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1038\/s41573-021-00266-6","article-title":"Atopic dermatitis: an expanding therapeutic pipeline for a complex disease","volume":"21","author":"Bieber","year":"2022","journal-title":"Nat Rev Drug Discov"},{"key":"10.1016\/j.xjidi.2024.100268_bib4","first-page":"61","article-title":"Dimethyl sulfoxide (DMSO): a review","volume":"76","author":"Brayton","year":"1986","journal-title":"Cornell Vet"},{"key":"10.1016\/j.xjidi.2024.100268_bib5","doi-asserted-by":"crossref","first-page":"1682","DOI":"10.3389\/fimmu.2018.01682","article-title":"The IL-17 family of cytokines in psoriasis: il-17A and beyond","volume":"9","author":"Brembilla","year":"2018","journal-title":"Front Immunol"},{"key":"10.1016\/j.xjidi.2024.100268_bib6","doi-asserted-by":"crossref","first-page":"S65","DOI":"10.1016\/j.jaci.2017.01.011","article-title":"The immunology of atopic dermatitis and its reversibility with broad-spectrum and targeted therapies","volume":"139","author":"Brunner","year":"2017","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.xjidi.2024.100268_bib7","doi-asserted-by":"crossref","first-page":"1616","DOI":"10.1111\/jdv.14433","article-title":"The role of IL-23 and the IL-23\/TH 17 immune axis in the pathogenesis and treatment of psoriasis","volume":"31","author":"Girolomoni","year":"2017","journal-title":"J\u00a0Eur Acad Dermatol Venereol"},{"key":"10.1016\/j.xjidi.2024.100268_bib8","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1056\/NEJMoa1512711","article-title":"Phase 3 trials of ixekizumab in moderate-to-severe plaque psoriasis","volume":"375","author":"Gordon","year":"2016","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.xjidi.2024.100268_bib9","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1016\/S0140-6736(21)00126-4","article-title":"Bimekizumab efficacy and safety in moderate to severe plaque psoriasis (BE READY): a multicentre, double-blind, placebo-controlled, randomised withdrawal phase 3 trial","volume":"397","author":"Gordon","year":"2021","journal-title":"Lancet"},{"key":"10.1016\/j.xjidi.2024.100268_bib10","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.coi.2017.08.008","article-title":"Atopic dermatitis and psoriasis: two different immune diseases or one spectrum?","volume":"48","author":"Guttman-Yassky","year":"2017","journal-title":"Curr Opin Immunol"},{"key":"10.1016\/j.xjidi.2024.100268_bib11","doi-asserted-by":"crossref","first-page":"7061","DOI":"10.1073\/pnas.1415675112","article-title":"Th17 cells give rise to Th1 cells that are required for the pathogenesis of colitis","volume":"112","author":"Harbour","year":"2015","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.xjidi.2024.100268_bib12","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1038\/s41592-019-0470-3","article-title":"Moving beyond P values: data analysis with estimation graphics","volume":"16","author":"Ho","year":"2019","journal-title":"Nat Methods"},{"key":"10.1016\/j.xjidi.2024.100268_bib13","doi-asserted-by":"crossref","DOI":"10.1242\/dmm.036210","article-title":"Targeting ulcerative colitis by suppressing glucose uptake with ritonavir","volume":"11","author":"Jodeleit","year":"2018","journal-title":"Dis Model Mech"},{"key":"10.1016\/j.xjidi.2024.100268_bib14","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1093\/ibd\/izz284","volume":"26","author":"Jodeleit","year":"2020","journal-title":"Inflamm Bowel Dis"},{"key":"10.1016\/j.xjidi.2024.100268_bib15","doi-asserted-by":"crossref","DOI":"10.1242\/dmm.046995","article-title":"Head-to-head study of oxelumab and adalimumab in a mouse model of ulcerative colitis based on NOD\/Scid IL-2R\u03b3null mice reconstituted with peripheral blood mononuclear cells","volume":"14","author":"Jodeleit","year":"2021","journal-title":"Dis Models Mech"},{"key":"10.1016\/j.xjidi.2024.100268_bib16","doi-asserted-by":"crossref","first-page":"750","DOI":"10.1016\/j.jaci.2019.04.029","article-title":"IL-17A inhibition by secukinumab induces early clinical, histopathologic, and molecular resolution of psoriasis","volume":"144","author":"Krueger","year":"2019","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.xjidi.2024.100268_bib17","doi-asserted-by":"crossref","first-page":"5621","DOI":"10.1038\/ncomms6621","article-title":"The antimicrobial peptide LL37 is a T-cell autoantigen in psoriasis","volume":"5","author":"Lande","year":"2014","journal-title":"Nat Commun"},{"key":"10.1016\/j.xjidi.2024.100268_bib18","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1002\/eji.201344277","article-title":"Cationic antimicrobial peptides in psoriatic skin cooperate to break innate tolerance to self-DNA","volume":"45","author":"Lande","year":"2015","journal-title":"Eur J Immunol"},{"key":"10.1016\/j.xjidi.2024.100268_bib19","doi-asserted-by":"crossref","first-page":"1483","DOI":"10.4103\/0366-6999.183427","article-title":"Topical tetracycline improves MC903-induced atopic dermatitis in mice through inhibition of inflammatory cytokines and thymic stromal lymphopoietin expression","volume":"129","author":"Liu","year":"2016","journal-title":"Chin Med J (Engl)"},{"key":"10.1016\/j.xjidi.2024.100268_bib20","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1007\/s40257-018-0408-z","article-title":"Efficacy and safety of brodalumab in patients with moderate-to-severe plaque psoriasis and skin of color: results from the pooled AMAGINE-2\/-3 randomized trials","volume":"20","author":"McMichael","year":"2019","journal-title":"Am J Clin Dermatol"},{"key":"10.1016\/j.xjidi.2024.100268_bib21","doi-asserted-by":"crossref","first-page":"1110","DOI":"10.1016\/j.jid.2019.01.006","article-title":"Imiquimod-induced psoriasis in mice depends on the IL-17 signaling of keratinocytes","volume":"139","author":"Moos","year":"2019","journal-title":"J\u00a0Invest Dermatol"},{"key":"10.1016\/j.xjidi.2024.100268_bib22","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/j.alit.2020.01.001","article-title":"Anti-TSLP antibodies: targeting a master regulator of type 2 immune responses","volume":"69","author":"Nakajima","year":"2020","journal-title":"Allergol Int"},{"key":"10.1016\/j.xjidi.2024.100268_bib23","doi-asserted-by":"crossref","first-page":"1254","DOI":"10.1016\/j.jaci.2015.08.015","article-title":"The Asian atopic dermatitis phenotype combines features of atopic dermatitis and psoriasis with increased TH17 polarization","volume":"136","author":"Noda","year":"2015","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.xjidi.2024.100268_bib24","doi-asserted-by":"crossref","first-page":"1193","DOI":"10.1046\/j.1365-2133.2000.03887.x","article-title":"Phenotyping of epidermal dendritic cells allows the differentiation between extrinsic and intrinsic forms of atopic dermatitis","volume":"143","author":"Oppel","year":"2000","journal-title":"Br J Dermatol"},{"key":"10.1016\/j.xjidi.2024.100268_bib25","doi-asserted-by":"crossref","first-page":"2335","DOI":"10.1056\/NEJMoa1610020","article-title":"Two Phase 3 Trials of Dupilumab versus Placebo in Atopic Dermatitis","volume":"375","author":"Simpson","year":"2016","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.xjidi.2024.100268_bib26","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1016\/j.jaci.2013.04.046","article-title":"Intrinsic atopic dermatitis shows similar TH2 and higher TH17 immune activation compared with extrinsic atopic dermatitis","volume":"132","author":"Su\u00e1rez-Fari\u00f1as","year":"2013","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.xjidi.2024.100268_bib27","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1254\/jphs.10050FP","article-title":"Pharmacological characterization of itch-associated response induced by repeated application of oxazolone in mice","volume":"113","author":"Tsukumo","year":"2010","journal-title":"J\u00a0Pharmacol Sci"},{"key":"10.1016\/j.xjidi.2024.100268_bib28","doi-asserted-by":"crossref","first-page":"1943","DOI":"10.1093\/ecco-jcc\/jjab078","article-title":"Suppressing Kv1.3 ion channel activity with a novel small molecule inhibitor ameliorates inflammation in a humanised mouse model of ulcerative colitis","volume":"15","author":"Unterweger","year":"2021","journal-title":"J\u00a0Crohns Colitis"},{"key":"10.1016\/j.xjidi.2024.100268_bib29","doi-asserted-by":"crossref","first-page":"1631","DOI":"10.1002\/iid3.516","article-title":"NOD\/scid IL-2R\u03b3null mice reconstituted with peripheral blood mononuclear cells from patients with Crohn's disease reflect the human pathological phenotype","volume":"9","author":"Unterweger","year":"2021","journal-title":"Immun Inflamm Dis"},{"key":"10.1016\/j.xjidi.2024.100268_bib30","doi-asserted-by":"crossref","DOI":"10.3390\/ijms241512348","article-title":"Humanized NSG mouse models as a preclinical tool for translational research in inflammatory bowel diseases","volume":"24","author":"We\u00df","year":"2023","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.xjidi.2024.100268_bib31","doi-asserted-by":"crossref","first-page":"2717","DOI":"10.1111\/jdv.16892","article-title":"ETFAD\/EADV Eczema task force 2020 position paper on diagnosis and treatment of atopic dermatitis in adults and children","volume":"34","author":"Wollenberg","year":"2020","journal-title":"J\u00a0Eur Acad Dermatol Venereol"},{"key":"10.1016\/j.xjidi.2024.100268_bib32","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1111\/1523-1747.ep12343596","article-title":"Immunomorphological and ultrastructural characterization of Langerhans cells and a novel, inflammatory dendritic epidermal cell (IDEC) population in lesional skin of atopic eczema","volume":"106","author":"Wollenberg","year":"1996","journal-title":"J\u00a0Invest Dermatol"},{"key":"10.1016\/j.xjidi.2024.100268_bib33","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1046\/j.0022-202x.2001.01665.x","article-title":"Expression and function of the mannose receptor CD206 on epidermal dendritic cells in inflammatory skin diseases","volume":"118","author":"Wollenberg","year":"2002","journal-title":"J\u00a0Invest Dermatol"}],"container-title":["JID Innovations"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2667026724000146?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2667026724000146?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,11,10]],"date-time":"2024-11-10T00:54:29Z","timestamp":1731200069000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2667026724000146"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,5]]},"references-count":33,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2024,5]]}},"alternative-id":["S2667026724000146"],"URL":"https:\/\/doi.org\/10.1016\/j.xjidi.2024.100268","relation":{},"ISSN":["2667-0267"],"issn-type":[{"value":"2667-0267","type":"print"}],"subject":[],"published":{"date-parts":[[2024,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"NOD\/Scid IL2R\u03b3null Mice Reconstituted with PBMCs from Patients with Atopic Dermatitis or Psoriasis Vulgaris Reflect the Respective Phenotype","name":"articletitle","label":"Article Title"},{"value":"JID Innovations","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.xjidi.2024.100268","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Authors. Published by Elsevier Inc. on behalf of the Society for Investigative Dermatology.","name":"copyright","label":"Copyright"}],"article-number":"100268"}}