{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T07:39:36Z","timestamp":1773128376732,"version":"3.50.1"},"reference-count":163,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,1,31]],"date-time":"2025-01-31T00:00:00Z","timestamp":1738281600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000062","name":"NIDDK","doi-asserted-by":"publisher","award":["1R01DK140039-01"],"award-info":[{"award-number":["1R01DK140039-01"]}],"id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004354","name":"Svensk K\u00e4rnbr\u00e4nslehantering","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004354","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100003185","name":"National Psoriasis Foundation","doi-asserted-by":"publisher","award":["1062013"],"award-info":[{"award-number":["1062013"]}],"id":[{"id":"10.13039\/100003185","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["jidinnovations.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["JID Innovations"],"published-print":{"date-parts":[[2025,5]]},"DOI":"10.1016\/j.xjidi.2025.100354","type":"journal-article","created":{"date-parts":[[2025,2,5]],"date-time":"2025-02-05T11:43:26Z","timestamp":1738755806000},"page":"100354","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"title":["Antimicrobial Peptide Signaling in Skin Diseases"],"prefix":"10.1016","volume":"5","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-0469-6375","authenticated-orcid":false,"given":"Sharan Kumar","family":"Balaji","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2801-2068","authenticated-orcid":false,"given":"Bhavani","family":"Balasundarasekar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3397-5747","authenticated-orcid":false,"given":"Waris Muhammad","family":"Khuwaja","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-8050-5989","authenticated-orcid":false,"given":"Keean Michael","family":"Dolan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6887-8712","authenticated-orcid":false,"given":"Xintong","family":"Dong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.xjidi.2025.100354_bib1","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1111\/j.1468-3083.2009.03347.x","article-title":"Expression of human neutrophil proteins in acne vulgaris","volume":"24","author":"Adi\u015fen","year":"2010","journal-title":"J Eur Acad Dermatol Venereol"},{"key":"10.1016\/j.xjidi.2025.100354_bib2","doi-asserted-by":"crossref","first-page":"1118","DOI":"10.1002\/eji.200939275","article-title":"The antimicrobial peptide LL-37 modulates the inflammatory and host defense response of human neutrophils","volume":"40","author":"Alalwani","year":"2010","journal-title":"Eur J Immunol"},{"key":"10.1016\/j.xjidi.2025.100354_bib3","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1046\/j.0022-202x.2001.01401.x","article-title":"Expression of the peptide antibiotics human beta Defensin-1 and human beta Defensin-2 in normal human skin","volume":"117","author":"Ali","year":"2001","journal-title":"J Invest Dermatol"},{"key":"10.1016\/j.xjidi.2025.100354_bib165","first-page":"311","volume":"8","author":"Alkanfari","year":"2019"},{"key":"10.1016\/j.xjidi.2025.100354_bib4","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1111\/hel.12000","article-title":"Differential expression of human beta defensin 2 and 3 in gastric mucosa of Helicobacter pylori-infected individuals","volume":"18","author":"Bauer","year":"2013","journal-title":"Helicobacter"},{"key":"10.1016\/j.xjidi.2025.100354_bib5","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1016\/j.cell.2023.01.016","article-title":"Structures of LRP2 reveal a molecular machine for endocytosis","volume":"186","author":"Beenken","year":"2023","journal-title":"Cell"},{"key":"10.1016\/j.xjidi.2025.100354_bib6","doi-asserted-by":"crossref","first-page":"1100","DOI":"10.4049\/jimmunol.1403176","article-title":"TLR8 senses Staphylococcus aureus RNA in human primary monocytes and macrophages and induces IFN-\u03b2 production via a TAK1-IKK\u03b2-IRF5 signaling pathway","volume":"195","author":"Bergstr\u00f8m","year":"2015","journal-title":"J Immunol"},{"key":"10.1016\/j.xjidi.2025.100354_bib7","doi-asserted-by":"crossref","first-page":"876","DOI":"10.1007\/s00109-005-0688-7","article-title":"Understanding RAGE, the receptor for advanced glycation end products","volume":"83","author":"Bierhaus","year":"2005","journal-title":"J Mol Med (Berl)"},{"key":"10.1016\/j.xjidi.2025.100354_bib8","doi-asserted-by":"crossref","first-page":"492","DOI":"10.3390\/biomedicines10020492","article-title":"LL-37 and double-stranded RNA synergistically upregulate bronchial epithelial TLR3 involving enhanced import of double-stranded RNA and downstream TLR3 signaling","volume":"10","author":"Bodahl","year":"2022","journal-title":"Biomedicines"},{"key":"10.1016\/j.xjidi.2025.100354_bib9","doi-asserted-by":"crossref","first-page":"5497","DOI":"10.4049\/jimmunol.1002508","article-title":"Host Defense peptide LL-37 selectively reduces proinflammatory macrophage responses","volume":"186","author":"Brown","year":"2011","journal-title":"J Immunol"},{"key":"10.1016\/j.xjidi.2025.100354_bib10","doi-asserted-by":"crossref","first-page":"7369","DOI":"10.1074\/jbc.M114.626747","article-title":"Recognition of bacterial signal peptides by mammalian formyl peptide receptors: a new mechanism for sensing pathogens","volume":"290","author":"Bufe","year":"2015","journal-title":"J Biol Chem"},{"key":"10.1016\/j.xjidi.2025.100354_bib11","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1080\/08977190802312844","article-title":"EGFR family: structure physiology signalling and therapeutic targets","volume":"26","author":"Burgess","year":"2008","journal-title":"Growth Factors"},{"key":"10.1016\/j.xjidi.2025.100354_bib12","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1016\/j.micinf.2015.01.005","article-title":"The innate defense antimicrobial peptides hBD3 and RNase7 are induced in human umbilical vein endothelial cells by classical inflammatory cytokines but not Th17 cytokines","volume":"17","author":"Burgey","year":"2015","journal-title":"Microbes Infect"},{"key":"10.1016\/j.xjidi.2025.100354_bib13","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1038\/s41586-021-04126-6","article-title":"Structure, function and pharmacology of human itch GPCRs","volume":"600","author":"Cao","year":"2021","journal-title":"Nature"},{"key":"10.1016\/j.xjidi.2025.100354_bib14","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1111\/imm.12418","article-title":"Bright expression of CD91 identifies highly activated human dendritic cells that can be expanded by defensins","volume":"144","author":"Cappelletti","year":"2015","journal-title":"Immunology"},{"key":"10.1016\/j.xjidi.2025.100354_bib15","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1038\/sj.jid.5701043","article-title":"In vitro and in vivo wound healing-promoting activities of human cathelicidin LL-37","volume":"128","author":"Carretero","year":"2008","journal-title":"J Invest Dermatol"},{"key":"10.1016\/j.xjidi.2025.100354_bib16","doi-asserted-by":"crossref","first-page":"1778","DOI":"10.1182\/blood-2003-08-2820","article-title":"Direct bacterial protein PAMP recognition by human NK cells involves TLRs and triggers alpha-defensin production","volume":"104","author":"Chalifour","year":"2004","journal-title":"Blood"},{"key":"10.1016\/j.xjidi.2025.100354_bib17","doi-asserted-by":"crossref","first-page":"1709","DOI":"10.1053\/j.gastro.2020.12.076","article-title":"Inflamed ulcerative colitis regions associated with MRGPRX2-mediated mast cell degranulation and cell activation modules, defining a new therapeutic target","volume":"160","author":"Chen","year":"2021","journal-title":"Gastroenterology"},{"key":"10.1016\/j.xjidi.2025.100354_bib18","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1177\/1753425913490575","article-title":"Alarmin HNP-1 promotes pyroptosis and IL-1\u03b2 release through different roles of NLRP3 inflammasome via P2X7 in LPS-primed macrophages","volume":"20","author":"Chen","year":"2014","journal-title":"Innate Immun"},{"key":"10.1016\/j.xjidi.2025.100354_bib19","doi-asserted-by":"crossref","first-page":"3161","DOI":"10.1073\/pnas.1812947116","article-title":"Increased gene copy number of DEFA1\/DEFA3 worsens sepsis by inducing endothelial pyroptosis","volume":"116","author":"Chen","year":"2019","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.xjidi.2025.100354_bib20","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2022.109270","article-title":"Phellopterin alleviates atopic dermatitis-like inflammation and suppresses IL-4-induced STAT3 activation in keratinocytes","volume":"112","author":"Chen","year":"2022","journal-title":"Int Immunopharmacol"},{"key":"10.1016\/j.xjidi.2025.100354_bib21","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/j.jdermsci.2017.05.008","article-title":"The antimicrobial peptide derived from insulin-like growth factor-binding protein 5, AMP-IBP5, regulates keratinocyte functions through Mas-related gene X receptors","volume":"88","author":"Chieosilapatham","year":"2017","journal-title":"J Dermatol Sci"},{"key":"10.1016\/j.xjidi.2025.100354_bib22","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1016\/j.jdermsci.2020.07.003","article-title":"Involvement of the lipoprotein receptor LRP1 in AMP-IBP5-mediated migration and proliferation of human keratinocytes and fibroblasts","volume":"99","author":"Chieosilapatham","year":"2020","journal-title":"J Dermatol Sci"},{"key":"10.1016\/j.xjidi.2025.100354_bib23","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.jdermsci.2018.12.004","article-title":"Botulinum toxin blocks mast cells and prevents rosacea like inflammation","volume":"93","author":"Choi","year":"2019","journal-title":"J Dermatol Sci"},{"key":"10.1016\/j.xjidi.2025.100354_bib24","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1002\/mc.20728","article-title":"The prostaglandin E2 receptor, EP2, regulates survivin expression via an EGFR\/STAT3 pathway in UVB-exposed mouse skin","volume":"50","author":"Chun","year":"2011","journal-title":"Mol Carcinog"},{"key":"10.1016\/j.xjidi.2025.100354_bib25","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1111\/bjd.12419","article-title":"Human \u03b2-defensin-2 as a marker for disease severity and skin barrier properties in atopic dermatitis","volume":"169","author":"Clausen","year":"2013","journal-title":"Br J Dermatol"},{"key":"10.1016\/j.xjidi.2025.100354_bib26","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/0014-5793(95)00634-L","article-title":"hCAP-18, a cathelin\/pro-bactenecin-like protein of human neutrophil specific granules","volume":"368","author":"Cowland","year":"1995","journal-title":"FEBS Lett"},{"key":"10.1016\/j.xjidi.2025.100354_bib27","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1007\/s00011-020-01340-2","article-title":"Human host defense peptide LL-37 facilitates double-stranded RNA pro-inflammatory signaling through up-regulation of TLR3 expression in vascular smooth muscle cells","volume":"69","author":"Dahl","year":"2020","journal-title":"Inflamm Res"},{"key":"10.1016\/j.xjidi.2025.100354_bib28","doi-asserted-by":"crossref","first-page":"1146","DOI":"10.4049\/jimmunol.172.2.1146","article-title":"The cationic antimicrobial peptide LL-37 modulates dendritic cell differentiation and dendritic cell-induced T cell polarization","volume":"172","author":"Davidson","year":"2004","journal-title":"J Immunol"},{"key":"10.1016\/j.xjidi.2025.100354_bib29","doi-asserted-by":"crossref","DOI":"10.15252\/emmm.202013560","article-title":"A positive feedback loop between mTORC1 and cathelicidin promotes skin inflammation in rosacea","volume":"13","author":"Deng","year":"2021","journal-title":"EMBO Mol Med"},{"key":"10.1016\/j.xjidi.2025.100354_bib30","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1186\/s12974-020-01981-4","article-title":"Tanshinone IIA attenuates neuroinflammation via inhibiting RAGE\/NF-\u03baB signaling pathway in vivo and in vitro","volume":"17","author":"Ding","year":"2020","journal-title":"J Neuroinflammation"},{"key":"10.1016\/j.xjidi.2025.100354_bib31","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1016\/S0092-8674(01)00483-4","article-title":"A diverse family of GPCRs expressed in specific subsets of nociceptive sensory neurons","volume":"106","author":"Dong","year":"2001","journal-title":"Cell"},{"key":"10.1016\/j.xjidi.2025.100354_bib32","doi-asserted-by":"crossref","first-page":"1645","DOI":"10.1016\/j.immuni.2022.06.021","article-title":"Keratinocyte-derived defensins activate neutrophil-specific receptors Mrgpra2a\/b to prevent skin dysbiosis and bacterial infection","volume":"55","author":"Dong","year":"2022","journal-title":"Immunity"},{"key":"10.1016\/j.xjidi.2025.100354_bib33","doi-asserted-by":"crossref","first-page":"4987","DOI":"10.4049\/jimmunol.172.8.4987","article-title":"A novel P2X7 receptor activator, the human cathelicidin-derived peptide LL37, induces IL-1 beta processing and release","volume":"172","author":"Elssner","year":"2004","journal-title":"J Immunol"},{"key":"10.1016\/j.xjidi.2025.100354_bib34","doi-asserted-by":"crossref","first-page":"4578","DOI":"10.1111\/j.1742-4658.2010.07887.x","article-title":"Natural and amyloid self-assembly of S100 proteins: structural basis of functional diversity","volume":"277","author":"Fritz","year":"2010","journal-title":"FEBS J"},{"key":"10.1016\/j.xjidi.2025.100354_bib35","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1038\/nri3228","article-title":"Epithelial antimicrobial defence of the skin and intestine","volume":"12","author":"Gallo","year":"2012","journal-title":"Nat Rev Immunol"},{"key":"10.1016\/j.xjidi.2025.100354_bib36","doi-asserted-by":"crossref","first-page":"1488","DOI":"10.1111\/ced.14773","article-title":"NOD2 signalling in hidradenitis suppurativa","volume":"46","author":"Gambichler","year":"2021","journal-title":"Clin Exp Dermatol"},{"key":"10.1016\/j.xjidi.2025.100354_bib37","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1093\/icb\/43.2.300","article-title":"The role of antimicrobial peptides in innate Immunity","volume":"43","author":"Ganz","year":"2003","journal-title":"Integr Comp Biol"},{"key":"10.1016\/j.xjidi.2025.100354_bib38","doi-asserted-by":"crossref","first-page":"5613","DOI":"10.4049\/jimmunol.157.12.5613","article-title":"Human monocyte chemoattractant protein (MCP)-4 is a novel CC chemokine with activities on monocytes, eosinophils, and basophils induced in allergic and nonallergic inflammation that signals through the CC chemokine receptors (CCR)-2 and -3","volume":"157","author":"Garcia-Zepeda","year":"1996","journal-title":"J Immunol"},{"key":"10.1016\/j.xjidi.2025.100354_bib39","doi-asserted-by":"crossref","first-page":"1531","DOI":"10.1038\/s41401-020-00523-1","article-title":"Anti-inflammatory signaling through G protein-coupled receptors","volume":"41","author":"Ge","year":"2020","journal-title":"Acta Pharmacol Sin"},{"key":"10.1016\/j.xjidi.2025.100354_bib40","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1038\/jid.2008.268","article-title":"The antimicrobial protein psoriasin (S100A7) is upregulated in atopic dermatitis and after experimental skin barrier disruption","volume":"129","author":"Gl\u00e4ser","year":"2009","journal-title":"J Invest Dermatol"},{"key":"10.1016\/j.xjidi.2025.100354_bib41","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1073\/pnas.76.1.333","article-title":"Binding site on macrophages that mediates uptake and degradation of acetylated low density lipoprotein, producing massive cholesterol deposition","volume":"76","author":"Goldstein","year":"1979","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.xjidi.2025.100354_bib42","doi-asserted-by":"crossref","first-page":"5004","DOI":"10.1038\/s41467-023-40705-z","article-title":"Ligand recognition and G protein coupling of the human itch receptor MRGPRX1","volume":"14","author":"Guo","year":"2023","journal-title":"Nat Commun"},{"key":"10.1016\/j.xjidi.2025.100354_bib43","doi-asserted-by":"crossref","first-page":"1355","DOI":"10.1038\/jid.2009.432","article-title":"Enhanced expression and secretion of antimicrobial peptides in atopic dermatitis and after superficial skin injury","volume":"130","author":"Harder","year":"2010","journal-title":"J Invest Dermatol"},{"key":"10.1016\/j.xjidi.2025.100354_bib44","doi-asserted-by":"crossref","first-page":"46779","DOI":"10.1074\/jbc.M207587200","article-title":"RNase 7, a novel innate immune defense antimicrobial protein of healthy human skin","volume":"277","author":"Harder","year":"2002","journal-title":"J Biol Chem"},{"key":"10.1016\/j.xjidi.2025.100354_bib45","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1016\/j.chom.2019.04.004","article-title":"Resistin-like molecule \u03b1 provides vitamin-A-dependent antimicrobial protection in the skin","volume":"25","author":"Harris","year":"2019","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.xjidi.2025.100354_bib46","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1387\/ijdb.103254lh","article-title":"Expression of the Scavenger Receptor Class B type I (SR-BI) family in Drosophila melanogaster","volume":"55","author":"Herboso","year":"2011","journal-title":"Int J Dev Biol"},{"key":"10.1016\/j.xjidi.2025.100354_bib47","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1038\/s41467-019-13756-4","article-title":"Neutrophil extracellular trap-associated RNA and LL37 enable self-amplifying inflammation in psoriasis","volume":"11","author":"Herster","year":"2020","journal-title":"Nat Commun"},{"key":"10.1016\/j.xjidi.2025.100354_bib48","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1016\/S0092-8674(00)80801-6","article-title":"RAGE mediates a novel proinflammatory axis: a central cell surface receptor for S100\/Calgranulin polypeptides","volume":"97","author":"Hofmann","year":"1999","journal-title":"Cell"},{"key":"10.1016\/j.xjidi.2025.100354_bib49","doi-asserted-by":"crossref","first-page":"966","DOI":"10.1016\/j.jaad.2011.07.020","article-title":"Expression of innate defense antimicrobial peptides in hidradenitis suppurativa","volume":"66","author":"Hofmann","year":"2012","journal-title":"J Am Acad Dermatol"},{"key":"10.1016\/j.xjidi.2025.100354_bib50","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1016\/S0006-291X(03)01190-2","article-title":"Expression analysis of S100 proteins and RAGE in human tumors using tissue microarrays","volume":"307","author":"Hsieh","year":"2003","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.xjidi.2025.100354_bib51","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1007\/s10989-024-10609-7","article-title":"Antimicrobial peptides (AMPs): new perspectives on their function in dermatological diseases","volume":"30","author":"Hsu","year":"2024","journal-title":"Int J Pept Res Ther"},{"key":"10.1016\/j.xjidi.2025.100354_bib52","article-title":"Antimicrobial cathelicidin peptide LL-37 inhibits the LPS\/ATP-induced pyroptosis of macrophages by dual mechanism","volume":"9","author":"Hu","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.xjidi.2025.100354_bib53","doi-asserted-by":"crossref","first-page":"34457","DOI":"10.1074\/jbc.M801465200","article-title":"Interaction of the RAGE cytoplasmic domain with Diaphanous-1 is required for ligand-stimulated cellular migration through activation of Rac1 and Cdc42","volume":"283","author":"Hudson","year":"2008","journal-title":"J Biol Chem"},{"key":"10.1016\/j.xjidi.2025.100354_bib54","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1016\/j.abb.2008.10.026","article-title":"FPRL1-mediated induction of superoxide in LL-37-stimulated IMR90 human fibroblast","volume":"481","author":"Iaccio","year":"2009","journal-title":"Arch Biochem Biophys"},{"key":"10.1016\/j.xjidi.2025.100354_bib55","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1016\/j.jid.2022.10.020","article-title":"Cathelicidin LL-37 activates human keratinocyte autophagy through the P2X\u2087, mechanistic target of Rapamycin, and MAPK pathways","volume":"143","author":"Ikutama","year":"2023","journal-title":"J Invest Dermatol"},{"key":"10.1016\/j.xjidi.2025.100354_bib56","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2020.107911","article-title":"mTORC1 signaling controls TLR2-mediated T-cell activation by inducing TIRAP expression","volume":"32","author":"Imanishi","year":"2020","journal-title":"Cell Rep"},{"key":"10.1016\/j.xjidi.2025.100354_bib57","doi-asserted-by":"crossref","first-page":"4938","DOI":"10.1128\/JB.185.16.4938-4947.2003","article-title":"Conformation of a bactericidal domain of puroindoline a: structure and mechanism of action of a 13-residue antimicrobial peptide","volume":"185","author":"Jing","year":"2003","journal-title":"J Bacteriol"},{"key":"10.1016\/j.xjidi.2025.100354_bib58","doi-asserted-by":"crossref","first-page":"1146","DOI":"10.1016\/j.bbrc.2005.03.088","article-title":"Identification of MrgX2 as a human G-protein-coupled receptor for proadrenomedullin N-terminal peptides","volume":"330","author":"Kamohara","year":"2005","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.xjidi.2025.100354_bib59","doi-asserted-by":"crossref","first-page":"2936","DOI":"10.1182\/blood-2005-06-2314","article-title":"Human neutrophil peptides induce interleukin-8 production through the P2Y6 signaling pathway","volume":"107","author":"Khine","year":"2006","journal-title":"Blood"},{"key":"10.1016\/j.xjidi.2025.100354_bib60","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1016\/j.imbio.2019.05.004","article-title":"Human \u03b2-defensin 2 is involved in CCR2-mediated Nod2 signal transduction, leading to activation of the innate immune response in macrophages","volume":"224","author":"Kim","year":"2019","journal-title":"Immunobiology"},{"key":"10.1016\/j.xjidi.2025.100354_bib61","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0015985","article-title":"Activation of MyD88 signaling upon staphylococcal enterotoxin binding to MHC Class II molecules","volume":"6","author":"Kissner","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.xjidi.2025.100354_bib62","doi-asserted-by":"crossref","DOI":"10.1016\/j.jbc.2021.100828","article-title":"Sequence determinants in the cathelicidin LL-37 that promote inflammation via presentation of RNA to scavenger receptors","volume":"297","author":"Kulkarni","year":"2021","journal-title":"J Biol Chem"},{"key":"10.1016\/j.xjidi.2025.100354_bib63","doi-asserted-by":"crossref","first-page":"1585","DOI":"10.1016\/j.jaci.2023.01.029","article-title":"DOCK2 regulates MRGPRX2\/B2-mediated mast cell degranulation and drug-induced anaphylaxis","volume":"151","author":"Kunimura","year":"2023","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.xjidi.2025.100354_bib64","doi-asserted-by":"crossref","first-page":"6257","DOI":"10.4049\/jimmunol.174.10.6257","article-title":"Mouse cathelin-related antimicrobial peptide chemoattracts leukocytes using formyl peptide receptor-like 1\/mouse formyl peptide receptor-like 2 as the receptor and acts as an immune adjuvant","volume":"174","author":"Kurosaka","year":"2005","journal-title":"J Immunol"},{"key":"10.1016\/j.xjidi.2025.100354_bib65","doi-asserted-by":"crossref","first-page":"5621","DOI":"10.1038\/ncomms6621","article-title":"The antimicrobial peptide LL37 is a T-cell autoantigen in psoriasis","volume":"5","author":"Lande","year":"2014","journal-title":"Nat Commun"},{"key":"10.1016\/j.xjidi.2025.100354_bib66","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1038\/nature06116","article-title":"Plasmacytoid dendritic cells sense self-DNA coupled with antimicrobial peptide","volume":"449","author":"Lande","year":"2007","journal-title":"Nature"},{"key":"10.1016\/j.xjidi.2025.100354_bib67","doi-asserted-by":"crossref","first-page":"17810","DOI":"10.1074\/jbc.272.28.17810","article-title":"Activation of the receptor for advanced glycation end products triggers a p21(ras)-dependent mitogen-activated protein kinase pathway regulated by oxidant stress","volume":"272","author":"Lander","year":"1997","journal-title":"J Biol Chem"},{"key":"10.1016\/j.xjidi.2025.100354_bib68","doi-asserted-by":"crossref","first-page":"1985","DOI":"10.1016\/j.jid.2024.02.012","article-title":"S100A9 exacerbates the inflammation in rosacea through toll-like receptor 4\/MyD88\/NF-\u03baB signaling pathway","volume":"144","author":"Le","year":"2024","journal-title":"J Invest Dermatol"},{"key":"10.1016\/j.xjidi.2025.100354_bib69","doi-asserted-by":"crossref","first-page":"1863","DOI":"10.1038\/sj.jid.5701235","article-title":"Sebocytes express functional cathelicidin antimicrobial peptides and can act to kill Propionibacterium acnes","volume":"128","author":"Lee","year":"2008","journal-title":"J Invest Dermatol"},{"key":"10.1016\/j.xjidi.2025.100354_bib70","doi-asserted-by":"crossref","first-page":"12145","DOI":"10.1021\/acsnano.7b05234","article-title":"Crystallinity of double-stranded RNA-antimicrobial peptide complexes modulates toll-like receptor 3-mediated inflammation","volume":"11","author":"Lee","year":"2017","journal-title":"ACS Nano"},{"key":"10.1016\/j.xjidi.2025.100354_bib71","doi-asserted-by":"crossref","first-page":"1828","DOI":"10.1038\/jid.2014.28","article-title":"Transcriptome analysis of psoriasis in a large case-control sample: RNA-seq provides insights into disease mechanisms","volume":"134","author":"Li","year":"2014","journal-title":"J Invest Dermatol"},{"key":"10.1016\/j.xjidi.2025.100354_bib72","doi-asserted-by":"crossref","first-page":"2298","DOI":"10.3390\/cells12182298","article-title":"The role of NLRP3 in regulation of antimicrobial peptides and estrogen signaling in UPEC-infected bladder epithelial cells","volume":"12","author":"Lindblad","year":"2023","journal-title":"Cells"},{"key":"10.1016\/j.xjidi.2025.100354_bib73","doi-asserted-by":"crossref","first-page":"754","DOI":"10.3390\/nu15030754","article-title":"Altered expression of antimicrobial peptides in the upper gastrointestinal tract of patients with diabetes mellitus","volume":"15","author":"Linn","year":"2023","journal-title":"Nutrients"},{"key":"10.1016\/j.xjidi.2025.100354_bib74","doi-asserted-by":"crossref","first-page":"4438","DOI":"10.4049\/jimmunol.1401319","article-title":"Human \u03b2 Defensin-3 increases CD86 expression on monocytes by activating the ATP-gated channel P2X7","volume":"195","author":"Lioi","year":"2015","journal-title":"J Immunol"},{"key":"10.1016\/j.xjidi.2025.100354_bib75","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1038\/s41589-022-01173-6","article-title":"Ligand recognition and allosteric modulation of the human MRGPRX1 receptor","volume":"19","author":"Liu","year":"2023","journal-title":"Nat Chem Biol"},{"key":"10.1016\/j.xjidi.2025.100354_bib76","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.139932","article-title":"Immunopathogenesis of hidradenitis suppurativa and response to Anti-TNF-\u03b1 therapy","volume":"5","author":"Lowe","year":"2020","journal-title":"JCI Insight"},{"key":"10.1016\/j.xjidi.2025.100354_bib78","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1111\/1523-1747.ep12484041","article-title":"Molecular cloning, occurrence, and expression of a novel partially secreted protein \u201cpsoriasin\u201d that is highly up-regulated in psoriatic skin","volume":"97","author":"Madsen","year":"1991","journal-title":"J Invest Dermatol"},{"key":"10.1016\/j.xjidi.2025.100354_bib79","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-022-22498-1","article-title":"The LRP1\/CD91 ligands, tissue-type plasminogen activator, \u03b12-macroglobulin, and soluble cellular prion protein have distinct co-receptor requirements for activation of cell-signaling","volume":"12","author":"Mantuano","year":"2022","journal-title":"Sci Rep"},{"key":"10.1016\/j.xjidi.2025.100354_bib80","doi-asserted-by":"crossref","first-page":"1214","DOI":"10.1021\/acsinfecdis.9b00066","article-title":"Salmonella membrane structural remodeling increases resistance to antimicrobial peptide LL-37","volume":"5","author":"Martynowycz","year":"2019","journal-title":"ACS Infect Dis"},{"key":"10.1016\/j.xjidi.2025.100354_bib81","doi-asserted-by":"crossref","DOI":"10.1096\/fj.202001667RR","article-title":"Endogenous Mas-related G-protein-coupled receptor X1 activates and sensitizes TRPA1 in a human model of peripheral nerves","volume":"35","author":"McMillan","year":"2021","journal-title":"FASEB J"},{"key":"10.1016\/j.xjidi.2025.100354_bib82","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1038\/nature14022","article-title":"Identification of a mast-cell-specific receptor crucial for pseudo-allergic drug reactions","volume":"519","author":"McNeil","year":"2015","journal-title":"Nature"},{"key":"10.1016\/j.xjidi.2025.100354_bib83","doi-asserted-by":"crossref","first-page":"1938","DOI":"10.1016\/j.jid.2020.02.025","article-title":"Rosacea is characterized by a profoundly diminished skin barrier","volume":"140","author":"Medgyesi","year":"2020","journal-title":"J Invest Dermatol"},{"key":"10.1016\/j.xjidi.2025.100354_bib84","doi-asserted-by":"crossref","first-page":"2389","DOI":"10.1016\/j.jid.2017.05.033","article-title":"Hidradenitis suppurativa is characterized by dysregulation of the Th17:Treg cell axis, which is corrected by anti-TNF therapy","volume":"137","author":"Moran","year":"2017","journal-title":"J Invest Dermatol"},{"key":"10.1016\/j.xjidi.2025.100354_bib85","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1038\/jid.2011.259","article-title":"Cathelicidin antimicrobial peptide LL-37 in psoriasis enables keratinocyte reactivity against TLR9 ligands","volume":"132","author":"Morizane","year":"2012","journal-title":"J Invest Dermatol"},{"key":"10.1016\/j.xjidi.2025.100354_bib86","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1007\/s00018-019-03213-2","article-title":"Purinergic P2Y2 receptors modulate endothelial sprouting","volume":"77","author":"M\u00fchleder","year":"2020","journal-title":"Cell Mol Life Sci"},{"key":"10.1016\/j.xjidi.2025.100354_bib87","first-page":"4951","article-title":"MrgX2-mediated internalization of LL-37 and degranulation of human LAD2 mast cells","volume":"18","author":"Murakami","year":"2018","journal-title":"Mol Med Rep"},{"key":"10.1016\/j.xjidi.2025.100354_bib88","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1093\/intimm\/dxn012","article-title":"Evaluation of the effect of human beta-defensins on neutrophil apoptosis","volume":"20","author":"Nagaoka","year":"2008","journal-title":"Int Immunol"},{"key":"10.1016\/j.xjidi.2025.100354_bib89","doi-asserted-by":"crossref","DOI":"10.5402\/2012\/345791","article-title":"Modulation of neutrophil apoptosis by antimicrobial peptides","volume":"2012","author":"Nagaoka","year":"2012","journal-title":"ISRN Microbiol"},{"key":"10.1016\/j.xjidi.2025.100354_bib90","doi-asserted-by":"crossref","first-page":"3044","DOI":"10.4049\/jimmunol.176.5.3044","article-title":"An antimicrobial cathelicidin peptide, human CAP18\/LL-37, suppresses neutrophil apoptosis via the activation of formyl-peptide receptor-like 1 and P2X7","volume":"176","author":"Nagaoka","year":"2006","journal-title":"J Immunol"},{"key":"10.1016\/j.xjidi.2025.100354_bib91","doi-asserted-by":"crossref","first-page":"1274","DOI":"10.4049\/jimmunol.1402388","article-title":"Endogenous intracellular cathelicidin enhances TLR9 activation in dendritic cells and macrophages","volume":"194","author":"Nakagawa","year":"2015","journal-title":"J Immunol"},{"key":"10.1016\/j.xjidi.2025.100354_bib92","doi-asserted-by":"crossref","DOI":"10.1172\/JCI172578","article-title":"Increased LL37 in psoriasis and other inflammatory disorders promotes LDL uptake and atherosclerosis","volume":"134","author":"Nakamura","year":"2024","journal-title":"J Clin Invest"},{"key":"10.1016\/j.xjidi.2025.100354_bib93","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2023.112494","article-title":"Competition between skin antimicrobial peptides and commensal bacteria in type 2 inflammation enables survival of S. aureus","volume":"42","author":"Nakatsuji","year":"2023","journal-title":"Cell Rep"},{"key":"10.1016\/j.xjidi.2025.100354_bib94","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1038\/jid.2011.387","article-title":"Antimicrobial peptides: old molecules with new ideas","volume":"132","author":"Nakatsuji","year":"2012","journal-title":"J Invest Dermatol"},{"key":"10.1016\/j.xjidi.2025.100354_bib95","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1038\/jid.2009.384","article-title":"Sebum free fatty acids enhance the innate immune defense of human sebocytes by upregulating beta-Defensin-2 expression","volume":"130","author":"Nakatsuji","year":"2010","journal-title":"J Invest Dermatol"},{"key":"10.1016\/j.xjidi.2025.100354_bib96","doi-asserted-by":"crossref","first-page":"974","DOI":"10.1158\/0008-5472.CAN-14-2161","article-title":"RAGE mediates S100A7-induced breast cancer growth and metastasis by modulating the tumor microenvironment","volume":"75","author":"Nasser","year":"2015","journal-title":"Cancer Res"},{"key":"10.1016\/j.xjidi.2025.100354_bib97","doi-asserted-by":"crossref","first-page":"5200","DOI":"10.3390\/ijms24065200","article-title":"The antimicrobial peptide AMP-IBP5 suppresses dermatitis-like lesions in a mouse model of atopic dermatitis through the low-density lipoprotein receptor-related Protein-1 receptor","volume":"24","author":"Nguyen","year":"2023","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.xjidi.2025.100354_bib98","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-023-44889-8","article-title":"Regulation of dermal fibroblasts by human neutrophil peptides","volume":"13","author":"Niwetbowornchai","year":"2023","journal-title":"Sci Rep"},{"key":"10.1016\/j.xjidi.2025.100354_bib99","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1111\/all.13975","article-title":"Antimicrobial peptide derived from insulin-like growth factor-binding protein 5 activates mast cells via Mas-related G protein-coupled receptor X2","volume":"75","author":"Niyonsaba","year":"2020","journal-title":"Allergy"},{"key":"10.1016\/j.xjidi.2025.100354_bib100","doi-asserted-by":"crossref","first-page":"594","DOI":"10.1038\/sj.jid.5700599","article-title":"Antimicrobial peptides human beta-defensins stimulate epidermal keratinocyte migration, proliferation and production of proinflammatory cytokines and chemokines","volume":"127","author":"Niyonsaba","year":"2007","journal-title":"J Invest Dermatol"},{"key":"10.1016\/j.xjidi.2025.100354_bib101","doi-asserted-by":"crossref","first-page":"594","DOI":"10.1002\/path.1667","article-title":"C-C chemokine receptor 2 (CCR2) deficiency improves bleomycin-induced pulmonary fibrosis by attenuation of both macrophage infiltration and production of macrophage-derived matrix metalloproteinases","volume":"204","author":"Okuma","year":"2004","journal-title":"J Pathol"},{"key":"10.1016\/j.xjidi.2025.100354_bib102","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/j.bbi.2013.10.013","article-title":"Toll-like receptors 2 and 4 modulate autonomic control of heart rate and energy metabolism","volume":"36","author":"Okun","year":"2013","journal-title":"Brain Behav Immun"},{"key":"10.1016\/j.xjidi.2025.100354_bib103","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.abh1478","article-title":"Antimicrobial production by perifollicular dermal preadipocytes is essential to the pathophysiology of acne","volume":"14","author":"O\u2019Neill","year":"2022","journal-title":"Sci Transl Med"},{"key":"10.1016\/j.xjidi.2025.100354_bib104","doi-asserted-by":"crossref","first-page":"1151","DOI":"10.1056\/NEJMoa021481","article-title":"Endogenous antimicrobial peptides and skin infections in atopic dermatitis","volume":"347","author":"Ong","year":"2002","journal-title":"N Engl J Med"},{"key":"10.1016\/j.xjidi.2025.100354_bib105","doi-asserted-by":"crossref","first-page":"8500","DOI":"10.4049\/jimmunol.179.12.8500","article-title":"Monocyte chemoattractant protein-1\/CC chemokine ligand 2 controls microtubule-driven biogenesis and leukotriene B4-synthesizing function of macrophage lipid bodies elicited by innate immune response","volume":"179","author":"Pacheco","year":"2007","journal-title":"J Immunol"},{"key":"10.1016\/j.xjidi.2025.100354_bib106","doi-asserted-by":"crossref","DOI":"10.1172\/JCI156501","article-title":"Human \u03b2-defensin-3 attenuates atopic dermatitis-like inflammation through autophagy activation and the aryl hydrocarbon receptor signaling pathway","volume":"132","author":"Peng","year":"2022","journal-title":"J Clin Invest"},{"key":"10.1016\/j.xjidi.2025.100354_bib107","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1189\/jlb.0708412","article-title":"Human defensins activate monocyte-derived dendritic cells, promote the production of proinflammatory cytokines, and up-regulate the surface expression of CD91","volume":"86","author":"Presicce","year":"2009","journal-title":"J Leukoc Biol"},{"key":"10.1016\/j.xjidi.2025.100354_bib108","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1038\/s41467-023-36694-8","article-title":"Topical phage therapy in a mouse model of Cutibacterium acnes-induced acne-like lesions","volume":"14","author":"Rimon","year":"2023","journal-title":"Nat Commun"},{"key":"10.1016\/j.xjidi.2025.100354_bib109","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbamem.2020.183282","article-title":"Thrombocidin-1-derived antimicrobial peptide TC19 combats superficial multi-drug resistant bacterial wound infections","volume":"1862","author":"Riool","year":"2020","journal-title":"Biochim Biophys Acta Biomembr"},{"key":"10.1016\/j.xjidi.2025.100354_bib110","doi-asserted-by":"crossref","first-page":"7187","DOI":"10.3390\/ijms21197187","article-title":"Cross-talk between P2X and NMDA receptors","volume":"21","author":"Rodriguez","year":"2020","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.xjidi.2025.100354_bib111","doi-asserted-by":"crossref","first-page":"7028","DOI":"10.1074\/jbc.M109.091090","article-title":"Specific binding and chemotactic activity of mBD4 and its functional orthologue hBD2 to CCR6-expressing cells","volume":"285","author":"R\u00f6hrl","year":"2010","journal-title":"J Biol Chem"},{"key":"10.1016\/j.xjidi.2025.100354_bib112","doi-asserted-by":"crossref","first-page":"6688","DOI":"10.4049\/jimmunol.0903984","article-title":"Human beta-defensin 2 and 3 and their mouse orthologs induce chemotaxis through interaction with CCR2","volume":"184","author":"R\u00f6hrl","year":"2010","journal-title":"J Immunol"},{"key":"10.1016\/j.xjidi.2025.100354_bib113","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1016\/j.chom.2023.03.010","article-title":"Staphylococcal diversity in atopic dermatitis from an individual to a global scale","volume":"31","author":"Saheb Kashaf","year":"2023","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.xjidi.2025.100354_bib114","doi-asserted-by":"crossref","first-page":"1133","DOI":"10.1038\/ni732","article-title":"Dermcidin: a novel human antibiotic peptide secreted by sweat glands","volume":"2","author":"Schittek","year":"2001","journal-title":"Nat Immunol"},{"key":"10.1016\/j.xjidi.2025.100354_bib115","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1016\/S1097-2765(00)00073-3","article-title":"Crystal structure of a ternary FGF-FGFR-heparin complex reveals a dual role for heparin in FGFR binding and dimerization","volume":"6","author":"Schlessinger","year":"2000","journal-title":"Mol Cell"},{"key":"10.1016\/j.xjidi.2025.100354_bib116","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1038\/nature09674","article-title":"Reduction of disulphide bonds unmasks potent antimicrobial activity of human \u03b2-defensin 1","volume":"469","author":"Schroeder","year":"2011","journal-title":"Nature"},{"key":"10.1016\/j.xjidi.2025.100354_bib117","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.jdermsci.2014.12.001","article-title":"Human \u03b2-defensin-3 increases the expression of interleukin-37 through CCR6 in human keratinocytes","volume":"77","author":"Smithrithee","year":"2015","journal-title":"J Dermatol Sci"},{"key":"10.1016\/j.xjidi.2025.100354_bib118","doi-asserted-by":"crossref","first-page":"2796","DOI":"10.1182\/blood.V90.7.2796","article-title":"The human antibacterial cathelicidin, hCAP-18, is synthesized in myelocytes and metamyelocytes and localized to specific granules in neutrophils","volume":"90","author":"S\u00f8rensen","year":"1997","journal-title":"Blood"},{"key":"10.1016\/j.xjidi.2025.100354_bib119","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0031712","article-title":"Human alpha defensin 5 expression in the human kidney and urinary tract","volume":"7","author":"Spencer","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.xjidi.2025.100354_bib120","doi-asserted-by":"crossref","first-page":"236","DOI":"10.3390\/cells11020236","article-title":"S100A8\/A9 is a marker for the release of neutrophil extracellular traps and induces neutrophil activation","volume":"11","author":"Sprenkeler","year":"2022","journal-title":"Cells"},{"key":"10.1016\/j.xjidi.2025.100354_bib121","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1002\/jcb.22575","article-title":"Carboxylated N-glycans on RAGE promote S100A12 binding and signaling","volume":"110","author":"Srikrishna","year":"2010","journal-title":"J Cell Biochem"},{"key":"10.1016\/j.xjidi.2025.100354_bib122","doi-asserted-by":"crossref","first-page":"44739","DOI":"10.1074\/jbc.M111.277152","article-title":"Mas-related Gene X2 (MrgX2) is a novel G protein-coupled receptor for the antimicrobial peptide LL-37 in human mast cells: resistance to receptor phosphorylation, desensitization, and internalization","volume":"286","author":"Subramanian","year":"2011","journal-title":"J Biol Chem"},{"key":"10.1016\/j.xjidi.2025.100354_bib123","doi-asserted-by":"crossref","first-page":"345","DOI":"10.4049\/jimmunol.1300023","article-title":"\u03b2-Defensins activate human mast cells via Mas-Related Gene X2","volume":"191","author":"Subramanian","year":"2013","journal-title":"J Immunol"},{"key":"10.1016\/j.xjidi.2025.100354_bib124","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2021.712781","article-title":"The antimicrobial peptide human \u03b2-Defensin-3 accelerates wound healing by promoting angiogenesis, cell migration, and proliferation through the FGFR\/JAK2\/STAT3 signaling pathway","volume":"12","author":"Takahashi","year":"2021","journal-title":"Front Immunol"},{"key":"10.1016\/j.xjidi.2025.100354_bib125","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1111\/bjd.12942","article-title":"Cathelicidin antimicrobial peptide LL-37 augments interferon-\u03b2 expression and antiviral activity induced by double-stranded RNA in keratinocytes","volume":"171","author":"Takiguchi","year":"2014","journal-title":"Br J Dermatol"},{"key":"10.1016\/j.xjidi.2025.100354_bib126","doi-asserted-by":"crossref","first-page":"1417","DOI":"10.3390\/antibiotics11101417","article-title":"Antimicrobial peptides-mechanisms of action, antimicrobial effects and clinical applications","volume":"11","author":"Talapko","year":"2022","journal-title":"Antibiotics (Basel)"},{"key":"10.1016\/j.xjidi.2025.100354_bib127","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1016\/j.bcp.2011.11.013","article-title":"CCL2 increases MMP-9 expression and cell motility in human chondrosarcoma cells via the Ras\/Raf\/MEK\/ERK\/NF-\u03baB signaling pathway","volume":"83","author":"Tang","year":"2012","journal-title":"Biochem Pharmacol"},{"key":"10.1016\/j.xjidi.2025.100354_bib128","doi-asserted-by":"crossref","first-page":"1191","DOI":"10.4049\/jimmunol.1402845","article-title":"P2X7 receptor regulates internalization of antimicrobial peptide LL-37 by human macrophages that promotes intracellular pathogen clearance","volume":"195","author":"Tang","year":"2015","journal-title":"J Immunol"},{"key":"10.1016\/j.xjidi.2025.100354_bib129","doi-asserted-by":"crossref","first-page":"1322","DOI":"10.1016\/j.bbrc.2006.08.177","article-title":"Immunoglobulin E-independent activation of mast cell is mediated by Mrg receptors","volume":"349","author":"Tatemoto","year":"2006","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.xjidi.2025.100354_bib130","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1111\/exd.13482","article-title":"Elevated levels of the antimicrobial peptide LL-37 in hidradenitis suppurativa are associated with a Th1\/Th17 immune response","volume":"27","author":"Thomi","year":"2018","journal-title":"Exp Dermatol"},{"key":"10.1016\/j.xjidi.2025.100354_bib131","doi-asserted-by":"crossref","first-page":"4662","DOI":"10.4049\/jimmunol.175.7.4662","article-title":"Induction of keratinocyte migration via transactivation of the epidermal growth factor receptor by the antimicrobial peptide LL-371","volume":"175","author":"Tokumaru","year":"2005","journal-title":"J Immunol"},{"key":"10.1016\/j.xjidi.2025.100354_bib132","doi-asserted-by":"crossref","first-page":"5602","DOI":"10.1074\/jbc.M806664200","article-title":"SDF2L1, a component of the endoplasmic reticulum chaperone complex, differentially interacts with {alpha}-, {beta}-, and {theta}-defensin propeptides","volume":"284","author":"Tongaonkar","year":"2009","journal-title":"J Biol Chem"},{"key":"10.1016\/j.xjidi.2025.100354_bib133","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2022.1026304","article-title":"Mas-related G protein-coupled receptor MRGPRX2 in human basophils: expression and functional studies","volume":"13","author":"Toscano","year":"2023","journal-title":"Front Immunol"},{"key":"10.1016\/j.xjidi.2025.100354_bib134","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0133454","article-title":"Identifying the critical domain of LL-37 involved in mediating neutrophil activation in the presence of influenza virus: functional and structural analysis","volume":"10","author":"Tripathi","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.xjidi.2025.100354_bib135","doi-asserted-by":"crossref","first-page":"594","DOI":"10.1016\/j.jid.2021.07.178","article-title":"Specific \u03b2-defensins stimulate pruritus through activation of sensory neurons","volume":"142","author":"Tseng","year":"2022","journal-title":"J Invest Dermatol"},{"key":"10.1016\/j.xjidi.2025.100354_bib136","article-title":"MrgprX1 Mediates neuronal excitability and itch through tetrodotoxin-resistant sodium channels","volume":"4","author":"Tseng","year":"2019","journal-title":"Itch (Phila)"},{"key":"10.1016\/j.xjidi.2025.100354_bib137","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1080\/15384101.2018.1560205","article-title":"Ras signals principally via Erk in G1 but cooperates with PI3K\/Akt for cyclin D induction and S-phase entry","volume":"18","author":"Vasjari","year":"2019","journal-title":"Cell Cycle"},{"key":"10.1016\/j.xjidi.2025.100354_bib138","doi-asserted-by":"crossref","first-page":"1042","DOI":"10.1038\/nm1638","article-title":"Mrp8 and Mrp14 are endogenous activators of toll-like receptor 4, promoting lethal, endotoxin-induced shock","volume":"13","author":"Vogl","year":"2007","journal-title":"Nat Med"},{"key":"10.1016\/j.xjidi.2025.100354_bib139","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1007\/s00441-005-0127-7","article-title":"Antimicrobial peptides are present in immune and host defense cells of the human respiratory and gastrointestinal tracts","volume":"324","author":"Wah","year":"2006","journal-title":"Cell Tissue Res"},{"key":"10.1016\/j.xjidi.2025.100354_bib140","doi-asserted-by":"crossref","first-page":"72","DOI":"10.2174\/2211550111201010072","article-title":"Post-translational modifications of natural antimicrobial peptides and strategies for peptide engineering","volume":"1","author":"Wang","year":"2012","journal-title":"Curr Biotechnol"},{"key":"10.1016\/j.xjidi.2025.100354_bib141","doi-asserted-by":"crossref","first-page":"953","DOI":"10.3390\/cells11060953","article-title":"MRGPRX2-Mediated Degranulation of Human Skin Mast Cells Requires the Operation of G\u03b1i, G\u03b1q, Ca++ Channels, ERK1\/2 and PI3K-Interconnection between Early and Late Signaling","volume":"11","author":"Wang","year":"2022","journal-title":"Cells"},{"key":"10.1016\/j.xjidi.2025.100354_bib164","doi-asserted-by":"crossref","first-page":"1202","DOI":"10.1189\/jlb.0408234","article-title":"Evidence for PI-3K-dependent migration of Th17-polarized cells in response to CCR2 and CCR6 agonists","volume":"84","author":"Webb","year":"2008","journal-title":"J Leukoc Biol"},{"key":"10.1016\/j.xjidi.2025.100354_bib143","doi-asserted-by":"crossref","first-page":"18129","DOI":"10.1073\/pnas.0505256102","article-title":"Reduced Paneth cell alpha-defensins in ileal Crohn\u2019s disease","volume":"102","author":"Wehkamp","year":"2005","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.xjidi.2025.100354_bib144","doi-asserted-by":"crossref","first-page":"1252","DOI":"10.1111\/bjd.12234","article-title":"Myeloid marker S100A8\/A9 and lymphocyte marker, soluble interleukin 2 receptor: biomarkers of hidradenitis suppurativa disease activity?","volume":"168","author":"Wieland","year":"2013","journal-title":"Br J Dermatol"},{"key":"10.1016\/j.xjidi.2025.100354_bib145","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1016\/j.jaci.2020.12.655","article-title":"A group of cationic amphiphilic drugs activates MRGPRX2 and induces scratching behavior in mice","volume":"148","author":"Wolf","year":"2021","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.xjidi.2025.100354_bib146","doi-asserted-by":"crossref","first-page":"1499","DOI":"10.4049\/jimmunol.181.2.1499","article-title":"Chemotactic activity of S100A7 (psoriasin) is mediated by the receptor for advanced glycation end products and potentiates inflammation with highly homologous but functionally distinct S100A15","volume":"181","author":"Wolf","year":"2008","journal-title":"J Immunol"},{"key":"10.1016\/j.xjidi.2025.100354_bib147","doi-asserted-by":"crossref","first-page":"471","DOI":"10.3390\/molecules21040471","article-title":"Aberrant expression of bacterial pattern recognition receptor NOD2 of basophils and microbicidal peptides in atopic dermatitis","volume":"21","author":"Wong","year":"2016","journal-title":"Molecules"},{"key":"10.1016\/j.xjidi.2025.100354_bib148","doi-asserted-by":"crossref","first-page":"4218","DOI":"10.1074\/jbc.M608888200","article-title":"Hexameric calgranulin C (S100A12) binds to the receptor for advanced glycated end products (RAGE) using symmetric hydrophobic target-binding patches","volume":"282","author":"Xie","year":"2007","journal-title":"J Biol Chem"},{"key":"10.1016\/j.xjidi.2025.100354_bib149","doi-asserted-by":"crossref","first-page":"975","DOI":"10.1038\/nm1616","article-title":"Increased serine protease activity and cathelicidin promotes skin inflammation in rosacea","volume":"13","author":"Yamasaki","year":"2007","journal-title":"Nat Med"},{"key":"10.1016\/j.xjidi.2025.100354_bib150","doi-asserted-by":"crossref","first-page":"2068","DOI":"10.1096\/fj.06-6075com","article-title":"Kallikrein-mediated proteolysis regulates the antimicrobial effects of cathelicidins in skin","volume":"20","author":"Yamasaki","year":"2006","journal-title":"FASEB J"},{"key":"10.1016\/j.xjidi.2025.100354_bib151","doi-asserted-by":"crossref","first-page":"1069","DOI":"10.1084\/jem.192.7.1069","article-title":"LL-37, the neutrophil granule- and epithelial cell-derived cathelicidin, utilizes formyl peptide receptor-like 1 (FPRL1) as a receptor to chemoattract human peripheral blood neutrophils, monocytes, and T cells","volume":"192","author":"Yang","year":"2000","journal-title":"J Exp Med"},{"key":"10.1016\/j.xjidi.2025.100354_bib152","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1126\/science.286.5439.525","article-title":"Beta-Defensins: linking Innate and Adaptive Immunity through dendritic and T cell CCR6","volume":"286","author":"Yang","year":"1999","journal-title":"Science"},{"key":"10.1016\/j.xjidi.2025.100354_bib153","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1111\/imr.12577","article-title":"Alarmins and immunity","volume":"280","author":"Yang","year":"2017","journal-title":"Immunol Rev"},{"key":"10.1016\/j.xjidi.2025.100354_bib154","doi-asserted-by":"crossref","first-page":"15632","DOI":"10.18632\/oncotarget.6695","article-title":"CCL2-CCR2 axis promotes metastasis of nasopharyngeal carcinoma by activating ERK1\/2-MMP2\/9 pathway","volume":"7","author":"Yang","year":"2016","journal-title":"Oncotarget"},{"key":"10.1016\/j.xjidi.2025.100354_bib155","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1128\/IAI.05669-11","article-title":"The Staphylococcus aureus two-component regulatory system, GraRS, senses and confers resistance to selected cationic antimicrobial peptides","volume":"80","author":"Yang","year":"2012","journal-title":"Infect Immun"},{"key":"10.1016\/j.xjidi.2025.100354_bib156","doi-asserted-by":"crossref","first-page":"986","DOI":"10.1189\/jlb.69.6.986","article-title":"Proinflammatory properties of the human S100 protein S100A12","volume":"69","author":"Yang","year":"2001","journal-title":"J Leukoc Biol"},{"key":"10.1016\/j.xjidi.2025.100354_bib157","doi-asserted-by":"crossref","first-page":"2885","DOI":"10.1016\/j.jid.2021.02.745","article-title":"Antimicrobial peptide LL-37 drives rosacea-like skin inflammation in an NLRP3-dependent manner","volume":"141","author":"Yoon","year":"2021","journal-title":"J Invest Dermatol"},{"key":"10.1016\/j.xjidi.2025.100354_bib158","doi-asserted-by":"crossref","first-page":"1447","DOI":"10.3390\/molecules23061447","article-title":"4'-Methoxyresveratrol alleviated AGE-induced inflammation via RAGE-mediated NF-\u03baB and NLRP3 inflammasome pathway","volume":"23","author":"Yu","year":"2018","journal-title":"Molecules"},{"key":"10.1016\/j.xjidi.2025.100354_bib159","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1016\/j.yexcr.2018.09.024","article-title":"LL-37 inhibits LPS-induced inflammation and stimulates the osteogenic differentiation of BMSCs via P2X7 receptor and MAPK signaling pathway","volume":"372","author":"Yu","year":"2018","journal-title":"Exp Cell Res"},{"key":"10.1016\/j.xjidi.2025.100354_bib160","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1016\/j.intimp.2017.05.016","article-title":"LL-37-induced human mast cell activation through G protein-coupled receptor MrgX2","volume":"49","author":"Yu","year":"2017","journal-title":"Int Immunopharmacol"},{"key":"10.1016\/j.xjidi.2025.100354_bib161","doi-asserted-by":"crossref","first-page":"2343","DOI":"10.1016\/j.jid.2022.02.016","article-title":"IL-17A promotes psoriasis-associated keratinocyte proliferation through ACT1-dependent activation of YAP-AREG axis","volume":"142","author":"Yu","year":"2022","journal-title":"J Invest Dermatol"},{"key":"10.1016\/j.xjidi.2025.100354_bib162","article-title":"Small proline-rich proteins (SPRRs) are epidermally produced antimicrobial proteins that defend the cutaneous barrier by direct bacterial membrane disruption","volume":"11","author":"Zhang","year":"2022","journal-title":"Elife"},{"key":"10.1016\/j.xjidi.2025.100354_bib163","article-title":"Type I IFN promotes IL-10 production from T cells to suppress Th17 cells and Th17-associated autoimmune inflammation","volume":"6","author":"Zhang","year":"2011","journal-title":"PLoS One"}],"container-title":["JID Innovations"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2667026725000086?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2667026725000086?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,7,21]],"date-time":"2025-07-21T13:04:45Z","timestamp":1753103085000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2667026725000086"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5]]},"references-count":163,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2025,5]]}},"alternative-id":["S2667026725000086"],"URL":"https:\/\/doi.org\/10.1016\/j.xjidi.2025.100354","relation":{},"ISSN":["2667-0267"],"issn-type":[{"value":"2667-0267","type":"print"}],"subject":[],"published":{"date-parts":[[2025,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Antimicrobial Peptide Signaling in Skin Diseases","name":"articletitle","label":"Article Title"},{"value":"JID Innovations","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.xjidi.2025.100354","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier Inc. on behalf of the Society for Investigative Dermatology.","name":"copyright","label":"Copyright"}],"article-number":"100354"}}