{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T09:21:36Z","timestamp":1773048096896,"version":"3.50.1"},"reference-count":44,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,2,26]],"date-time":"2025-02-26T00:00:00Z","timestamp":1740528000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002428","name":"FWF","doi-asserted-by":"publisher","award":["W1241"],"award-info":[{"award-number":["W1241"]}],"id":[{"id":"10.13039\/501100002428","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["jidinnovations.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["JID Innovations"],"published-print":{"date-parts":[[2025,5]]},"DOI":"10.1016\/j.xjidi.2025.100361","type":"journal-article","created":{"date-parts":[[2025,3,8]],"date-time":"2025-03-08T18:37:21Z","timestamp":1741459041000},"page":"100361","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"title":["Metabolomic and Lipidomic Alterations in Patients with Atopic Dermatitis with Dupilumab-Associated Ocular Surface Disease"],"prefix":"10.1016","volume":"5","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7161-7767","authenticated-orcid":false,"given":"VijayKumar","family":"Patra","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nora","family":"Woltsche","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9505-6271","authenticated-orcid":false,"given":"Natalie","family":"Bordag","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0704-5888","authenticated-orcid":false,"given":"Urban","family":"Cerpes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Danijela","family":"Bokanovic","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3978-7659","authenticated-orcid":false,"given":"Maria","family":"Repelnig","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9852-2856","authenticated-orcid":false,"given":"Yohann","family":"Clement","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Isabella","family":"Perchthaler","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2725-9616","authenticated-orcid":false,"given":"Harald","family":"K\u00f6feler","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manuela","family":"Fischl","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Franz","family":"Legat","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2533-7067","authenticated-orcid":false,"given":"Andreas","family":"Wedrich","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jutta","family":"Horwath-Winter","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4813-5900","authenticated-orcid":false,"given":"Sophie","family":"Ayciriex","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7777-9444","authenticated-orcid":false,"given":"Peter","family":"Wolf","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.xjidi.2025.100361_bib1","first-page":"4433","article-title":"Scientific Opinion on the re-evaluation of benzoic acid (E 210), sodium benzoate (E 211), potassium benzoate (E 212) and calcium benzoate (E 213) as food additives","volume":"14","author":"Aguilar","year":"2016","journal-title":"EFSA J"},{"key":"10.1016\/j.xjidi.2025.100361_bib2","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1007\/s00431-002-0962-4","article-title":"Two siblings with tyrosinaemia type 2","volume":"162","author":"Aydin","year":"2003","journal-title":"Eur J Pediatr"},{"key":"10.1016\/j.xjidi.2025.100361_bib3","doi-asserted-by":"crossref","first-page":"1519","DOI":"10.1016\/j.jaip.2017.08.005","article-title":"Expert perspectives on management of moderate-to-severe atopic dermatitis: a multidisciplinary consensus addressing current and emerging therapies","volume":"5","author":"Boguniewicz","year":"2017","journal-title":"J Allergy Clin Immunol Pract"},{"key":"10.1016\/j.xjidi.2025.100361_bib4","doi-asserted-by":"crossref","first-page":"S49","DOI":"10.1016\/j.ymgme.2010.02.020","article-title":"Creatine metabolism and the urea cycle","volume":"100","author":"Brosnan","year":"2010","journal-title":"Mol Genet Metab"},{"key":"10.1016\/j.xjidi.2025.100361_bib5","doi-asserted-by":"crossref","first-page":"1","DOI":"10.2165\/00128071-200102010-00001","article-title":"A role for leukotriene antagonists in atopic dermatitis?","volume":"2","author":"Chari","year":"2001","journal-title":"Am J Clin Dermatol"},{"key":"10.1016\/j.xjidi.2025.100361_bib7","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1016\/j.clindermatol.2013.11.007","article-title":"Atopic dermatitis as a systemic disease","volume":"32","author":"Darlenski","year":"2014","journal-title":"Clin Dermatol"},{"key":"10.1016\/j.xjidi.2025.100361_bib8","series-title":"Dupixent: EPAR - product information","year":"2023"},{"key":"10.1016\/j.xjidi.2025.100361_bib9","doi-asserted-by":"crossref","first-page":"3064","DOI":"10.1021\/acs.jproteome.3c00761","article-title":"Plasma instead of serum avoids critical confounding of clinical metabolomics studies by platelets","volume":"23","author":"Hagn","year":"2024","journal-title":"J Proteome Res"},{"key":"10.1016\/j.xjidi.2025.100361_bib10","doi-asserted-by":"crossref","first-page":"1171","DOI":"10.1038\/nmeth.4470","article-title":"Deciphering lipid structures based on platform-independent decision rules","volume":"14","author":"Hartler","year":"2017","journal-title":"Nat Methods"},{"key":"10.1016\/j.xjidi.2025.100361_bib11","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1093\/bioinformatics\/btq699","article-title":"Lipid data analyzer: unattended identification and quantitation of lipids in LC-MS data","volume":"27","author":"Hartler","year":"2011","journal-title":"Bioinformatics"},{"key":"10.1016\/j.xjidi.2025.100361_bib12","doi-asserted-by":"crossref","first-page":"1","DOI":"10.18637\/jss.v070.i01","article-title":"missMDA: a package for handling missing values in multivariate data analysis","volume":"70","author":"Josse","year":"2016","journal-title":"J Stat Softw"},{"key":"10.1016\/j.xjidi.2025.100361_bib13","doi-asserted-by":"crossref","DOI":"10.1016\/j.xjidi.2021.100042","article-title":"A literature review of real-world effectiveness and safety of dupilumab for atopic dermatitis","volume":"1","author":"Kamata","year":"2021","journal-title":"JID Innov"},{"key":"10.1016\/j.xjidi.2025.100361_bib14","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1038\/nmeth.4512","article-title":"Identifying metabolites by integrating metabolome databases with mass spectrometry cheminformatics","volume":"15","author":"Lai","year":"2018","journal-title":"Nat Methods"},{"key":"10.1016\/j.xjidi.2025.100361_bib15","doi-asserted-by":"crossref","first-page":"764","DOI":"10.1016\/j.jesp.2013.03.013","article-title":"Detecting outliers: do not use standard deviation around the mean, use absolute deviation around the median","volume":"49","author":"Leys","year":"2013","journal-title":"J Exp Soc Psychol"},{"key":"10.1016\/j.xjidi.2025.100361_bib16","doi-asserted-by":"crossref","first-page":"1523","DOI":"10.1194\/jlr.M033506","article-title":"Shorthand notation for lipid structures derived from mass spectrometry","volume":"54","author":"Liebisch","year":"2013","journal-title":"J Lipid Res"},{"key":"10.1016\/j.xjidi.2025.100361_bib17","doi-asserted-by":"crossref","first-page":"1137","DOI":"10.1194\/jlr.D700041-JLR200","article-title":"Lipid extraction by methyl-tert-butyl ether for high-throughput lipidomics","volume":"49","author":"Matyash","year":"2008","journal-title":"J Lipid Res"},{"key":"10.1016\/j.xjidi.2025.100361_bib18","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1007\/s40123-019-0191-9","article-title":"Ocular surface diseases induced by dupilumab in severe atopic dermatitis","volume":"8","author":"Maudinet","year":"2019","journal-title":"Ophthalmol Ther"},{"key":"10.1016\/j.xjidi.2025.100361_bib19","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1006\/exer.1996.0041","article-title":"Nitric oxide plays a role as a mediator of conjunctival edema in experimental allergic conjunctivitis","volume":"62","author":"Meijer","year":"1996","journal-title":"Exp Eye Res"},{"key":"10.1016\/j.xjidi.2025.100361_bib20","doi-asserted-by":"crossref","first-page":"1839","DOI":"10.1111\/bph.15477","article-title":"Nicotinamide adenine dinucleotide metabolism in the immune response, autoimmunity and inflammageing","volume":"179","author":"Navarro","year":"2022","journal-title":"Br J Pharmacol"},{"key":"10.1016\/j.xjidi.2025.100361_bib21","doi-asserted-by":"crossref","first-page":"186","DOI":"10.3390\/metabo10050186","article-title":"MetaboAnalystR 3.0: toward an optimized workflow for global metabolomics","volume":"10","author":"Pang","year":"2020","journal-title":"Metabolites"},{"key":"10.1016\/j.xjidi.2025.100361_bib22","article-title":"Persistent neutrophil infiltration and unique ocular surface microbiome typify dupilumab-associated conjunctivitis in patients with atopic dermatitis","volume":"0","author":"Patra","year":"2023","journal-title":"Ophthalmol Sci"},{"key":"10.1016\/j.xjidi.2025.100361_bib23","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1097\/ICO.0000000000002854","article-title":"Corneal perforation in patients under treatment with dupilumab for atopic dermatitis","volume":"41","author":"Phylactou","year":"2022","journal-title":"Cornea"},{"key":"10.1016\/j.xjidi.2025.100361_bib44","series-title":"Mixed-Effects Models in S and S-PLUS","author":"Pinheiro","year":"2000"},{"key":"10.1016\/j.xjidi.2025.100361_bib45","author":"Pinheiro","year":"2023","journal-title":"nlme: Linear and Nonlinear Mixed Effects Models. R package version 3.1-164"},{"key":"10.1016\/j.xjidi.2025.100361_bib28","series-title":"_R: A Language and Environment for Statistical Computing_","year":"2024"},{"key":"10.1016\/j.xjidi.2025.100361_bib24","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pcbi.1005752","article-title":"mixOmics: an R package for \u2019omics feature selection and multiple data integration","volume":"13","author":"Rohart","year":"2017","journal-title":"PLoS Comput Biol"},{"key":"10.1016\/j.xjidi.2025.100361_bib25","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1038\/nri2294","article-title":"Resolving inflammation: dual anti-inflammatory and pro-resolution lipid mediators","volume":"8","author":"Serhan","year":"2008","journal-title":"Nat Rev Immunol"},{"key":"10.1016\/j.xjidi.2025.100361_bib26","doi-asserted-by":"crossref","DOI":"10.1016\/j.exer.2023.109607","article-title":"Glutamine alleviates Lipopolysaccharide-induced corneal epithelial inflammation and oxidative stress in dogs","volume":"234","author":"Song","year":"2023","journal-title":"Exp Eye Res"},{"key":"10.1016\/j.xjidi.2025.100361_bib27","doi-asserted-by":"crossref","first-page":"1136","DOI":"10.1056\/NEJMra2023911","article-title":"Atopic dermatitis","volume":"384","author":"St\u00e4nder","year":"2021","journal-title":"N Engl J Med"},{"key":"10.1016\/j.xjidi.2025.100361_bib29","doi-asserted-by":"crossref","first-page":"937","DOI":"10.1111\/all.16045","article-title":"Dupilumab-associated ocular surface disease is characterized by a shift from Th2\/Th17 toward Th1\/Th17 inflammation","volume":"79","author":"Thormann","year":"2024","journal-title":"Allergy"},{"key":"10.1016\/j.xjidi.2025.100361_bib30","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.jchromb.2017.03.027","article-title":"Lipidomics by ultrahigh performance liquid chromatography-high resolution mass spectrometry and its application to complex biological samples","volume":"1053","author":"Triebl","year":"2017","journal-title":"J Chromatogr B Analyt Technol Biomed Life Sci"},{"key":"10.1016\/j.xjidi.2025.100361_bib31","doi-asserted-by":"crossref","first-page":"1159","DOI":"10.1038\/s41587-020-0531-2","article-title":"A lipidome atlas in MS-DIAL 4","volume":"38","author":"Tsugawa","year":"2020","journal-title":"Nat Biotechnol"},{"key":"10.1016\/j.xjidi.2025.100361_bib32","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1038\/s41592-019-0358-2","article-title":"A cheminformatics approach to characterize metabolomes in stable-isotope-labeled organisms","volume":"16","author":"Tsugawa","year":"2019","journal-title":"Nat Methods"},{"key":"10.1016\/j.xjidi.2025.100361_bib33","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/j.jtos.2020.05.008","article-title":"Ocular surface disease associated with dupilumab treatment for atopic diseases","volume":"19","author":"Utine","year":"2021","journal-title":"Ocul Surf"},{"key":"10.1016\/j.xjidi.2025.100361_bib34","doi-asserted-by":"crossref","first-page":"1109","DOI":"10.1016\/S0140-6736(15)00149-X","article-title":"Atopic dermatitis","volume":"387","author":"Weidinger","year":"2016","journal-title":"Lancet"},{"key":"10.1016\/j.xjidi.2025.100361_bib35","article-title":"Differences between human plasma and serum metabolite profiles","volume":"6","author":"Yu","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.xjidi.2025.100361_bib36","doi-asserted-by":"crossref","first-page":"291","DOI":"10.3390\/metabo12040291","article-title":"Changes in the cerebrospinal fluid and plasma lipidome in patients with Rett syndrome","volume":"12","author":"Zandl-Lang","year":"2022","journal-title":"Metabolites"},{"key":"10.1016\/j.xjidi.2025.100361_bib37","article-title":"Integrated metabolomics and lipidomics study of patients with atopic dermatitis in response to dupilumab","volume":"13","author":"Zhang","year":"2022","journal-title":"Front Immunol"},{"key":"10.1016\/j.xjidi.2025.100361_bib38","first-page":"229","article-title":"Progress of metabolomics in atopic dermatitis: a systematic review","volume":"21","author":"Zhang","year":"2023","journal-title":"J Dtsch Dermatol Ges"},{"key":"10.1016\/j.xjidi.2025.100361_bib39","doi-asserted-by":"crossref","first-page":"1074","DOI":"10.1038\/s41467-021-21016-7","article-title":"Asymmetric opening of the homopentameric 5-HT3A serotonin receptor in lipid bilayers","volume":"12","author":"Zhang","year":"2021","journal-title":"Nat Commun"},{"key":"10.1016\/j.xjidi.2025.100361_bib40","article-title":"Conjunctival microbiota in patients with type 2 diabetes mellitus and influences of perioperative use of topical levofloxacin in ocular surgery","volume":"8","author":"Zhu","year":"2021","journal-title":"Front Med (Lausanne)"},{"key":"10.1016\/j.xjidi.2025.100361_bib41","doi-asserted-by":"crossref","DOI":"10.1016\/j.waojou.2024.100894","article-title":"Genetically determined metabolites in allergic conjunctivitis: a Mendelian randomization study","volume":"17","author":"Zou","year":"2024","journal-title":"World Allergy Organ J"},{"key":"10.1016\/j.xjidi.2025.100361_bib42","doi-asserted-by":"crossref","first-page":"342","DOI":"10.3390\/metabo10090342","article-title":"A metabolomics workflow for analyzing complex biological samples using a combined method of untargeted and target-list based approaches","volume":"10","author":"Z\u00fcllig","year":"2020","journal-title":"Metabolites"},{"key":"10.1016\/j.xjidi.2025.100361_bib43","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1167\/iovs.62.10.8","article-title":"Understanding the Interactions between the ocular surface microbiome and the tear proteome","volume":"62","author":"Zysset-Burri","year":"2021","journal-title":"Invest Ophthalmol Vis Sci"}],"container-title":["JID Innovations"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2667026725000177?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2667026725000177?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,8]],"date-time":"2025-11-08T22:35:30Z","timestamp":1762641330000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2667026725000177"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5]]},"references-count":44,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2025,5]]}},"alternative-id":["S2667026725000177"],"URL":"https:\/\/doi.org\/10.1016\/j.xjidi.2025.100361","relation":{},"ISSN":["2667-0267"],"issn-type":[{"value":"2667-0267","type":"print"}],"subject":[],"published":{"date-parts":[[2025,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Metabolomic and Lipidomic Alterations in Patients with Atopic Dermatitis with Dupilumab-Associated Ocular Surface Disease","name":"articletitle","label":"Article Title"},{"value":"JID Innovations","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.xjidi.2025.100361","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier Inc. on behalf of the Society for Investigative Dermatology.","name":"copyright","label":"Copyright"}],"article-number":"100361"}}