{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T03:50:52Z","timestamp":1782186652969,"version":"3.54.5"},"reference-count":40,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,8,28]],"date-time":"2025-08-28T00:00:00Z","timestamp":1756339200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000738","name":"US Department of Veterans Affairs","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000738","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000057","name":"National Institute of General Medical Sciences","doi-asserted-by":"publisher","award":["R01GM130583"],"award-info":[{"award-number":["R01GM130583"]}],"id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["jidinnovations.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["JID Innovations"],"published-print":{"date-parts":[[2025,11]]},"DOI":"10.1016\/j.xjidi.2025.100409","type":"journal-article","created":{"date-parts":[[2025,9,2]],"date-time":"2025-09-02T15:21:52Z","timestamp":1756826512000},"page":"100409","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"title":["Translesion Synthesis DNA Polymerase Gene Expression Is Impacted by Age and IGF-1 in Epidermal Human Skin"],"prefix":"10.1016","volume":"5","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5792-3768","authenticated-orcid":false,"suffix":"Jr.","given":"Stanley D.","family":"Rider","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6427-6522","authenticated-orcid":false,"given":"Madison S.","family":"Owens","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4268-4311","authenticated-orcid":false,"given":"Craig A.","family":"Rohan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7232-1039","authenticated-orcid":false,"given":"Jeffrey B.","family":"Travers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8203-0745","authenticated-orcid":false,"given":"Michael G.","family":"Kemp","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.xjidi.2025.100409_bib1","doi-asserted-by":"crossref","first-page":"1332","DOI":"10.1111\/php.13279","article-title":"Insulin-like growth Factor-1 impacts p53 target gene induction in UVB-irradiated keratinocytes and human skin","volume":"96","author":"Alkawar","year":"2020","journal-title":"Photochem Photobiol"},{"key":"10.1016\/j.xjidi.2025.100409_bib2","doi-asserted-by":"crossref","first-page":"12188","DOI":"10.1093\/nar\/gkaa974","article-title":"Multiple biochemical properties of the p53 molecule contribute to activation of polymerase iota-dependent DNA damage tolerance","volume":"48","author":"Biber","year":"2020","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.xjidi.2025.100409_bib3","doi-asserted-by":"crossref","first-page":"2360","DOI":"10.1038\/jid.2012.164","article-title":"NF-\u03baB accumulation associated with COL1A1 transactivators defects during chronological aging represses type I collagen expression through a -112\/-61-bp region of the COL1A1 promoter in human skin fibroblasts","volume":"132","author":"Bigot","year":"2012","journal-title":"J Invest Dermatol"},{"key":"10.1016\/j.xjidi.2025.100409_bib4","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1007\/128_2014_553","article-title":"Solar UV radiation-induced DNA Bipyrimidine photoproducts: formation and mechanistic insights","volume":"356","author":"Cadet","year":"2015","journal-title":"Top Curr Chem"},{"key":"10.1016\/j.xjidi.2025.100409_bib5","doi-asserted-by":"crossref","first-page":"3740","DOI":"10.1093\/nar\/gkae061","article-title":"The levels of p53 govern the hierarchy of DNA damage tolerance pathway usage","volume":"52","author":"Casta\u00f1o","year":"2024","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.xjidi.2025.100409_bib6","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1038\/nchembio.139","article-title":"DNA damage tolerance: when it\u2019s OK to make mistakes","volume":"5","author":"Chang","year":"2009","journal-title":"Nat Chem Biol"},{"key":"10.1016\/j.xjidi.2025.100409_bib7","doi-asserted-by":"crossref","first-page":"1172","DOI":"10.1016\/j.jid.2023.10.020","article-title":"Effects of age and sex on the expression of core circadian clock genes in human skin epidermis","volume":"144","author":"Cvammen","year":"2024","journal-title":"J Invest Dermatol"},{"key":"10.1016\/j.xjidi.2025.100409_bib8","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1186\/2046-2395-3-8","article-title":"The secreted protein S100A7 (psoriasin) is induced by telomere dysfunction in human keratinocytes independently of a DNA damage response and cell cycle regulators","volume":"3","author":"de Castro","year":"2014","journal-title":"Longev Healthspan"},{"key":"10.1016\/j.xjidi.2025.100409_bib9","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1038\/jid.2011.426","article-title":"Shining a light on xeroderma pigmentosum","volume":"132","author":"DiGiovanna","year":"2012","journal-title":"J Invest Dermatol"},{"key":"10.1016\/j.xjidi.2025.100409_bib10","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1111\/exd.12637","article-title":"Insulin-like growth factor-I and UVB photoprotection in human keratinocytes","volume":"24","author":"Fernandez","year":"2015","journal-title":"Exp Dermatol"},{"key":"10.1016\/j.xjidi.2025.100409_bib11","doi-asserted-by":"crossref","first-page":"666","DOI":"10.1001\/archderm.144.5.666","article-title":"Looking older: fibroblast collapse and therapeutic implications","volume":"144","author":"Fisher","year":"2008","journal-title":"Arch Dermatol"},{"key":"10.1016\/j.xjidi.2025.100409_bib12","doi-asserted-by":"crossref","first-page":"814","DOI":"10.1111\/1523-1747.ep12462039","article-title":"Variations in excision repair of UVB-induced pyrimidine dimers in DNA of human skin in situ","volume":"90","author":"Freeman","year":"1988","journal-title":"J Invest Dermatol"},{"key":"10.1016\/j.xjidi.2025.100409_bib13","article-title":"Wounding therapies for prevention of photocarcinogenesis","volume":"11","author":"Frommeyer","year":"2021","journal-title":"Front Oncol"},{"key":"10.1016\/j.xjidi.2025.100409_bib14","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1093\/geronj\/38.2.137","article-title":"Age-associated changes in human epidermal cell renewal","volume":"38","author":"Grove","year":"1983","journal-title":"J Gerontol"},{"key":"10.1016\/j.xjidi.2025.100409_bib15","doi-asserted-by":"crossref","first-page":"E4311","DOI":"10.1073\/pnas.1605828113","article-title":"DNA damage tolerance pathway involving DNA polymerase \u03b9 and the tumor suppressor p53 regulates DNA replication fork progression","volume":"113","author":"Hampp","year":"2016","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.xjidi.2025.100409_bib16","doi-asserted-by":"crossref","DOI":"10.1016\/j.jbc.2021.100570","article-title":"Age and insulin-like growth factor-1 impact PCNA monoubiquitination in UVB-irradiated human skin","volume":"296","author":"Hutcherson","year":"2021","journal-title":"J Biol Chem"},{"key":"10.1016\/j.xjidi.2025.100409_bib17","doi-asserted-by":"crossref","first-page":"7457","DOI":"10.1093\/nar\/gkab526","article-title":"Impact of the interplay between stemness features, p53 and pol iota on replication pathway choices","volume":"49","author":"Ihle","year":"2021","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.xjidi.2025.100409_bib18","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1016\/j.molcel.2007.11.005","article-title":"Send in the clamps: control of DNA translesion synthesis in eukaryotes","volume":"28","author":"Jansen","year":"2007","journal-title":"Mol Cell"},{"key":"10.1016\/j.xjidi.2025.100409_bib19","first-page":"82","article-title":"Regulation of DNA damage tolerance in mammalian cells by post-translational modifications of PCNA","volume":"803\u2013805","author":"Kanao","year":"2017","journal-title":"Mutat Res"},{"key":"10.1016\/j.xjidi.2025.100409_bib20","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/bs.enz.2019.06.001","article-title":"Damage removal and gap filling in nucleotide excision repair","volume":"45","author":"Kemp","year":"2019","journal-title":"Enzymes"},{"key":"10.1016\/j.xjidi.2025.100409_bib21","doi-asserted-by":"crossref","first-page":"1231","DOI":"10.1074\/jbc.M116.765883","article-title":"Insulin-like growth factor 1 receptor signaling is required for optimal ATR-CHK1 kinase signaling in ultraviolet B (UVB)-irradiated human keratinocytes","volume":"292","author":"Kemp","year":"2017","journal-title":"J Biol Chem"},{"key":"10.1016\/j.xjidi.2025.100409_bib22","doi-asserted-by":"crossref","first-page":"356","DOI":"10.3390\/molecules22030356","article-title":"Impact of age and insulin-like growth Factor-1 on DNA damage responses in UV-irradiated human skin","volume":"22","author":"Kemp","year":"2017","journal-title":"Molecules"},{"key":"10.1016\/j.xjidi.2025.100409_bib23","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1073\/pnas.94.1.11","article-title":"Sunlight and skin cancer: another link revealed","volume":"94","author":"Kraemer","year":"1997","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.xjidi.2025.100409_bib24","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1002\/(SICI)1097-0215(19990129)80:3<431::AID-IJC16>3.0.CO;2-5","article-title":"Activation of the insulin-like growth factor-1 receptor promotes the survival of human keratinocytes following ultraviolet B irradiation","volume":"80","author":"Kuhn","year":"1999","journal-title":"Int J Cancer"},{"key":"10.1016\/j.xjidi.2025.100409_bib25","doi-asserted-by":"crossref","first-page":"1270","DOI":"10.1093\/nar\/gkw1196","article-title":"Predominant role of DNA polymerase eta and p53-dependent translesion synthesis in the survival of ultraviolet-irradiated human cells","volume":"45","author":"Lerner","year":"2017","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.xjidi.2025.100409_bib26","doi-asserted-by":"crossref","first-page":"1475","DOI":"10.1038\/onc.2009.440","article-title":"The IGF-1\/IGF-1R signaling axis in the skin: a new role for the dermis in aging-associated skin cancer","volume":"29","author":"Lewis","year":"2010","journal-title":"Oncogene"},{"key":"10.1016\/j.xjidi.2025.100409_bib27","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1038\/jid.2008.293","article-title":"A new paradigm for the role of aging in the development of skin cancer","volume":"129","author":"Lewis","year":"2009","journal-title":"J Invest Dermatol"},{"key":"10.1016\/j.xjidi.2025.100409_bib28","doi-asserted-by":"crossref","first-page":"1346","DOI":"10.1091\/mbc.e07-10-1041","article-title":"UVB-induced senescence in human keratinocytes requires a functional insulin-like growth factor-1 receptor and p53","volume":"19","author":"Lewis","year":"2008","journal-title":"Mol Biol Cell"},{"key":"10.1016\/j.xjidi.2025.100409_bib29","doi-asserted-by":"crossref","first-page":"1398","DOI":"10.1128\/MCB.26.4.1398-1413.2006","article-title":"DNA polymerase eta, the product of the xeroderma pigmentosum variant gene and a target of p53, modulates the DNA damage checkpoint and p53 activation","volume":"26","author":"Liu","year":"2006","journal-title":"Mol Cell Biol"},{"key":"10.1016\/j.xjidi.2025.100409_bib30","doi-asserted-by":"crossref","first-page":"1245","DOI":"10.1016\/j.molonc.2016.06.002","article-title":"Insulin-like growth factor-1 receptor regulates repair of ultraviolet B-induced DNA damage in human keratinocytes in vivo","volume":"10","author":"Loesch","year":"2016","journal-title":"Mol Oncol"},{"key":"10.1016\/j.xjidi.2025.100409_bib31","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1007\/978-0-387-09599-8_10","article-title":"Xeroderma pigmentosum variant, XP-V: its product and biological roles","volume":"637","author":"Masutani","year":"2008","journal-title":"Adv Exp Med Biol"},{"key":"10.1016\/j.xjidi.2025.100409_bib32","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0004066","article-title":"Aging alters functionally human dermal papillary fibroblasts but not reticular fibroblasts: a new view of skin morphogenesis and aging","volume":"3","author":"Mine","year":"2008","journal-title":"PLoS One"},{"key":"10.1016\/j.xjidi.2025.100409_bib33","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a012708","article-title":"Translesion DNA synthesis and mutagenesis in eukaryotes","volume":"5","author":"Sale","year":"2013","journal-title":"Cold Spring Harb Perspect Biol"},{"key":"10.1016\/j.xjidi.2025.100409_bib34","doi-asserted-by":"crossref","first-page":"8502","DOI":"10.1002\/anie.201601524","article-title":"Mechanisms of DNA repair by photolyase and excision nuclease (nobel lecture)","volume":"55","author":"Sancar","year":"2016","journal-title":"Angew Chem Int Ed Engl"},{"key":"10.1016\/j.xjidi.2025.100409_bib35","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/j.molcel.2018.03.027","article-title":"Coordinated activity of Y Family TLS polymerases and EXO1 protects non-S phase cells from UV-induced cytotoxic lesions","volume":"70","author":"Sertic","year":"2018","journal-title":"Mol Cell"},{"key":"10.1016\/j.xjidi.2025.100409_bib36","doi-asserted-by":"crossref","DOI":"10.1172\/JCI150972","article-title":"Randomized controlled trial of fractionated laser resurfacing on aged skin as prophylaxis against actinic neoplasia","volume":"131","author":"Spandau","year":"2021","journal-title":"J Clin Invest"},{"key":"10.1016\/j.xjidi.2025.100409_bib37","doi-asserted-by":"crossref","first-page":"1591","DOI":"10.1038\/jid.2012.29","article-title":"Fractionated laser resurfacing corrects the inappropriate UVB response in geriatric skin","volume":"132","author":"Spandau","year":"2012","journal-title":"J Invest Dermatol"},{"key":"10.1016\/j.xjidi.2025.100409_bib38","doi-asserted-by":"crossref","first-page":"967","DOI":"10.1111\/dsu.12138","article-title":"Fibroblast senescence and squamous cell carcinoma: how wounding therapies could be protective","volume":"39","author":"Travers","year":"2013","journal-title":"Dermatol Surg"},{"key":"10.1016\/j.xjidi.2025.100409_bib39","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/S0921-8777(99)00069-5","article-title":"Effect of age on the formation and repair of UV photoproducts in human skin in situ","volume":"459","author":"Xu","year":"2000","journal-title":"Mutat Res"},{"key":"10.1016\/j.xjidi.2025.100409_bib40","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1007\/s00403-005-0618-0","article-title":"Aged human skin removes UVB-induced pyrimidine dimers from the epidermis more slowly than younger adult skin in vivo","volume":"297","author":"Yamada","year":"2006","journal-title":"Arch Dermatol Res"}],"container-title":["JID Innovations"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2667026725000657?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2667026725000657?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,3,7]],"date-time":"2026-03-07T21:48:57Z","timestamp":1772920137000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2667026725000657"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11]]},"references-count":40,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2025,11]]}},"alternative-id":["S2667026725000657"],"URL":"https:\/\/doi.org\/10.1016\/j.xjidi.2025.100409","relation":{},"ISSN":["2667-0267"],"issn-type":[{"value":"2667-0267","type":"print"}],"subject":[],"published":{"date-parts":[[2025,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Translesion Synthesis DNA Polymerase Gene Expression Is Impacted by Age and IGF-1 in Epidermal Human Skin","name":"articletitle","label":"Article Title"},{"value":"JID Innovations","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.xjidi.2025.100409","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Published by Elsevier Inc. on behalf of the Society for Investigative Dermatology.","name":"copyright","label":"Copyright"}],"article-number":"100409"}}