{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T21:09:24Z","timestamp":1788815364869,"version":"build-2803163510"},"reference-count":65,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,4,24]],"date-time":"2026-04-24T00:00:00Z","timestamp":1776988800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100006488","name":"Division of Agriculture and Natural Resources, University of California","doi-asserted-by":"publisher","award":["CA-D-ETX-2152-H"],"award-info":[{"award-number":["CA-D-ETX-2152-H"]}],"id":[{"id":"10.13039\/100006488","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009804","name":"Northern California Institute for Research and Education","doi-asserted-by":"publisher","award":["R21 AR082620"],"award-info":[{"award-number":["R21 AR082620"]}],"id":[{"id":"10.13039\/100009804","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009804","name":"Northern California Institute for Research and Education","doi-asserted-by":"publisher","award":["I01 BX006094"],"award-info":[{"award-number":["I01 BX006094"]}],"id":[{"id":"10.13039\/100009804","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100005595","name":"University of California","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100005595","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000199","name":"U.S. Department of Agriculture","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000199","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01 AR061106"],"award-info":[{"award-number":["R01 AR061106"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100005825","name":"National Institute of Food and Agriculture","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100005825","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000078","name":"Division of Materials Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000078","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jidinnovations.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["JID Innovations"],"published-print":{"date-parts":[[2026,7]]},"DOI":"10.1016\/j.xjidi.2026.100480","type":"journal-article","created":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T03:47:08Z","timestamp":1777607228000},"page":"100480","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Demographic factors associated with skin barrier function in a large population-based study"],"prefix":"10.1016","volume":"6","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7736-6946","authenticated-orcid":false,"given":"Katrina","family":"Abuabara","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6415-5034","authenticated-orcid":false,"given":"Benjamin","family":"Stroebel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6906-3593","authenticated-orcid":false,"given":"Shreya","family":"Sreekantaswamy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1924-6575","authenticated-orcid":false,"given":"Richard W.","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2677-7590","authenticated-orcid":false,"given":"Linda","family":"Zukley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5699-6500","authenticated-orcid":false,"given":"Noreen","family":"Karim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2058-4405","authenticated-orcid":false,"given":"Robert H.","family":"Rice","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3961-4136","authenticated-orcid":false,"given":"Blythe P.","family":"Durbin-Johnson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3958-7318","authenticated-orcid":false,"given":"David M.","family":"Rocke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3623-0070","authenticated-orcid":false,"given":"Theodora","family":"Mauro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.xjidi.2026.100480_bib1","first-page":"1396","article-title":"The skin and Inflamm-aging","volume":"12","author":"Agrawal","year":"2023","journal-title":"Biology (Basel)"},{"key":"10.1016\/j.xjidi.2026.100480_bib2","doi-asserted-by":"crossref","first-page":"1049","DOI":"10.1111\/bjd.17025","article-title":"Transepidermal water loss in healthy adults: a systematic review and meta-analysis update","volume":"179","author":"Akdeniz","year":"2018","journal-title":"Br J Dermatol"},{"key":"10.1016\/j.xjidi.2026.100480_bib3","doi-asserted-by":"crossref","first-page":"2295","DOI":"10.1016\/j.jid.2018.09.001","article-title":"Research techniques made simple: transepidermal water loss measurement as a research tool","volume":"138","author":"Alexander","year":"2018","journal-title":"J Invest Dermatol"},{"key":"10.1016\/j.xjidi.2026.100480_bib4","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1007\/978-1-4939-8672-9_3","article-title":"Phospholipases: an overview","volume":"1835","author":"Aloulou","year":"2018","journal-title":"Methods Mol Biol"},{"key":"10.1016\/j.xjidi.2026.100480_bib5","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1183\/09031936.95.08030483","article-title":"International Study of Asthma and Allergies in Childhood (ISAAC): rationale and methods","volume":"8","author":"Asher","year":"1995","journal-title":"Eur Respir J"},{"key":"10.1016\/j.xjidi.2026.100480_bib6","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1111\/j.2517-6161.1995.tb02031.x","article-title":"Controlling the false discovery rate: a practical and powerful approach to multiple testing","volume":"57","author":"Benjamini","year":"1995","journal-title":"J R Stat Soc Series B Stat Methodol"},{"key":"10.1016\/j.xjidi.2026.100480_bib7","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1007\/s12016-018-8702-3","article-title":"The immunologic role of IL-17 in psoriasis and psoriatic arthritis pathogenesis","volume":"55","author":"Blauvelt","year":"2018","journal-title":"Clin Rev Allergy Immunol"},{"key":"10.1016\/j.xjidi.2026.100480_bib8","article-title":"Skin of atopic dermatitis patients shows disturbed \u03b2-glucocerebrosidase and acid sphingomyelinase activity that relates to changes in stratum corneum lipid composition","volume":"1865","author":"Boer","year":"2020","journal-title":"Biochim Biophys Acta Mol Cell Biol Lipids"},{"key":"10.1016\/j.xjidi.2026.100480_bib9","doi-asserted-by":"crossref","first-page":"816","DOI":"10.1016\/j.jid.2019.08.444","article-title":"IL-36 promotes systemic IFN-I responses in severe forms of psoriasis","volume":"140","author":"Catapano","year":"2020","journal-title":"J Invest Dermatol"},{"key":"10.1016\/j.xjidi.2026.100480_bib10","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1038\/jid.2009.272","article-title":"The extent of orthorhombic lipid phases in the stratum corneum determines the barrier efficiency of human skin in vivo","volume":"130","author":"Damien","year":"2010","journal-title":"J Invest Dermatol"},{"key":"10.1016\/j.xjidi.2026.100480_bib11","doi-asserted-by":"crossref","first-page":"1289","DOI":"10.1001\/jamadermatol.2013.6101","article-title":"Accuracy of self-report in assessing Fitzpatrick skin phototypes I through VI","volume":"149","author":"Eilers","year":"2013","journal-title":"JAMA Dermatol"},{"key":"10.1016\/j.xjidi.2026.100480_bib13","doi-asserted-by":"crossref","first-page":"2281","DOI":"10.1172\/JCI117919","article-title":"The aged epidermal permeability barrier. Structural, functional, and lipid biochemical abnormalities in humans and a senescent murine model","volume":"95","author":"Ghadially","year":"1995","journal-title":"J Clin Invest"},{"key":"10.1016\/j.xjidi.2026.100480_bib14","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1111\/j.1468-3083.2009.03503.x","article-title":"The impact of obesity on skin disease and epidermal permeability barrier status","volume":"24","author":"Guida","year":"2010","journal-title":"J Eur Acad Dermatol Venereol"},{"key":"10.1016\/j.xjidi.2026.100480_bib15","doi-asserted-by":"crossref","first-page":"1719","DOI":"10.1038\/jid.2008.442","article-title":"pH-regulated mechanisms account for pigment-type differences in epidermal barrier function","volume":"129","author":"Gunathilake","year":"2009","journal-title":"J Invest Dermatol"},{"key":"10.1016\/j.xjidi.2026.100480_bib16","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1111\/j.0906-6705.2005.00265.x","article-title":"In vivo and in vitro evidence for autocrine DCoH\/HNF-1alpha transcription of albumin in the human epidermis","volume":"14","author":"Hasse","year":"2005","journal-title":"Exp Dermatol"},{"key":"10.1016\/j.xjidi.2026.100480_bib17","doi-asserted-by":"crossref","first-page":"45","DOI":"10.2165\/00128071-200809010-00005","article-title":"Comparison of skin hydration evaluation sites and correlations among skin hydration, transepidermal water loss, SCORAD index, Nottingham Eczema Severity Score, and quality of life in patients with atopic dermatitis","volume":"9","author":"Hon","year":"2008","journal-title":"Am J Clin Dermatol"},{"key":"10.1016\/j.xjidi.2026.100480_bib18","doi-asserted-by":"crossref","first-page":"1277","DOI":"10.1016\/j.jid.2017.01.007","article-title":"Epidermal dysfunction leads to an age-associated increase in levels of serum inflammatory cytokines","volume":"137","author":"Hu","year":"2017","journal-title":"J Invest Dermatol"},{"key":"10.1016\/j.xjidi.2026.100480_bib19","article-title":"Tape strips in dermatology research","author":"Hughes","year":"2020","journal-title":"Br J Dermatol"},{"key":"10.1016\/j.xjidi.2026.100480_bib20","doi-asserted-by":"crossref","first-page":"99","DOI":"10.5021\/ad.23.052","article-title":"Skin barrier function assessment: electrical impedance spectroscopy is less influenced by daily routine activities than transepidermal water loss","volume":"36","author":"Huygen","year":"2024","journal-title":"Ann Dermatol"},{"key":"10.1016\/j.xjidi.2026.100480_bib21","series-title":"Non invasive diagnostic techniques in clinical dermatology","first-page":"345","article-title":"TEWL, closed-chamber methods: aquaFlux and VapoMeter","author":"Imhof","year":"2014"},{"key":"10.1016\/j.xjidi.2026.100480_bib22","doi-asserted-by":"crossref","first-page":"1062","DOI":"10.1111\/j.0022-202X.2005.23699.x","article-title":"Late cornified envelope family in differentiating epithelia--response to calcium and ultraviolet irradiation","volume":"124","author":"Jackson","year":"2005","journal-title":"J Invest Dermatol"},{"key":"10.1016\/j.xjidi.2026.100480_bib23","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1111\/exd.13925","article-title":"Human stratum corneum proteomics reveals cross-linking of a broad spectrum of proteins in cornified envelopes","volume":"28","author":"Karim","year":"2019","journal-title":"Exp Dermatol"},{"key":"10.1016\/j.xjidi.2026.100480_bib24","doi-asserted-by":"crossref","first-page":"1085","DOI":"10.1016\/j.jid.2022.11.023","article-title":"Skin barrier function and cognition among older adults","volume":"143","author":"Kim","year":"2023","journal-title":"J Invest Dermatol"},{"key":"10.1016\/j.xjidi.2026.100480_bib25","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1007\/s00403-012-1313-6","article-title":"Transepidermal water loss in young and aged healthy humans: a systematic review and meta-analysis","volume":"305","author":"Kottner","year":"2013","journal-title":"Arch Dermatol Res"},{"key":"10.1016\/j.xjidi.2026.100480_bib26","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1038\/jid.2012.250","article-title":"Aloxe3 knockout mice reveal a function of epidermal lipoxygenase-3 as hepoxilin synthase and its pivotal role in barrier formation","volume":"133","author":"Krieg","year":"2013","journal-title":"J Invest Dermatol"},{"key":"10.1016\/j.xjidi.2026.100480_bib27","doi-asserted-by":"crossref","first-page":"1057","DOI":"10.1083\/jcb.201404147","article-title":"A keratin scaffold regulates epidermal barrier formation, mitochondrial lipid composition, and activity","volume":"211","author":"Kumar","year":"2015","journal-title":"J Cell Biol"},{"key":"10.1016\/j.xjidi.2026.100480_bib28","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1111\/joim.13024","article-title":"A roadmap to build a phenotypic metric of ageing: insights from the Baltimore Longitudinal Study of Aging","volume":"287","author":"Kuo","year":"2020","journal-title":"J Intern Med"},{"key":"10.1016\/j.xjidi.2026.100480_bib29","doi-asserted-by":"crossref","first-page":"R29","DOI":"10.1186\/gb-2014-15-2-r29","article-title":"voom: precision weights unlock linear model analysis tools for RNA-seq read counts","volume":"15","author":"Law","year":"2014","journal-title":"Genome Biol"},{"key":"10.1016\/j.xjidi.2026.100480_bib30","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/j.jconrel.2004.11.035","article-title":"The correlation between transepidermal water loss and percutaneous absorption: an overview","volume":"103","author":"Levin","year":"2005","journal-title":"J Control Release"},{"key":"10.1016\/j.xjidi.2026.100480_bib31","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1046\/j.0909-752x","article-title":"The influence of body mass index on skin susceptibility to sodium lauryl sulphate","volume":"8","author":"L\u00f6ffler","year":"2002","journal-title":"Skin Res Technol"},{"key":"10.1016\/j.xjidi.2026.100480_bib32","doi-asserted-by":"crossref","first-page":"2301","DOI":"10.2147\/CIA.S235595","article-title":"Could inflammaging and Its Sequelae Be Prevented or Mitigated?","volume":"14","author":"Man","year":"2019","journal-title":"Clin Interv Aging"},{"key":"10.1016\/j.xjidi.2026.100480_bib33","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1007\/978-1-0716-4298-6_6","article-title":"Proteomic analysis of single hairs","volume":"2884","author":"McLoughlin","year":"2025","journal-title":"Methods Mol Biol"},{"key":"10.1016\/j.xjidi.2026.100480_bib34","doi-asserted-by":"crossref","first-page":"37823","DOI":"10.1074\/jbc.M110.136408","article-title":"Phospholipid scramblase 1 is secreted by a lipid raft-dependent pathway and interacts with the extracellular matrix protein 1 in the dermal epidermal junction zone of human skin","volume":"285","author":"Merregaert","year":"2010","journal-title":"J Biol Chem"},{"key":"10.1016\/j.xjidi.2026.100480_bib35","doi-asserted-by":"crossref","first-page":"D204","DOI":"10.1093\/nar\/gkp1019","article-title":"PANTHER version 7: improved phylogenetic trees, orthologs and collaboration with the Gene Ontology Consortium","volume":"38","author":"Mi","year":"2010","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.xjidi.2026.100480_bib36","doi-asserted-by":"crossref","first-page":"D672","DOI":"10.1093\/nar\/gkad1025","article-title":"The reactome pathway knowledgebase 2024","volume":"52","author":"Milacic","year":"2024","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.xjidi.2026.100480_bib37","doi-asserted-by":"crossref","first-page":"2621","DOI":"10.1038\/jid.2010.175","article-title":"Interleukin-17A promotes IgE production in human B cells","volume":"130","author":"Milovanovic","year":"2010","journal-title":"J Invest Dermatol"},{"key":"10.1016\/j.xjidi.2026.100480_bib38","doi-asserted-by":"crossref","first-page":"1947","DOI":"10.1016\/j.jid.2021.11.036","article-title":"Antimicrobial late cornified envelope proteins: the psoriasis risk factor deletion of LCE3B\/C genes affects microbiota composition","volume":"142","author":"Niehues","year":"2022","journal-title":"J Invest Dermatol"},{"key":"10.1016\/j.xjidi.2026.100480_bib39","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1111\/j.1525-1470.2012.01738.x","article-title":"The effect of obesity on skin disease and epidermal permeability barrier status in children","volume":"29","author":"Nino","year":"2012","journal-title":"Pediatr Dermatol"},{"key":"10.1016\/j.xjidi.2026.100480_bib40","doi-asserted-by":"crossref","first-page":"1367","DOI":"10.1172\/JCI81522","article-title":"Involvement of activation-induced cytidine deaminase in skin cancer development","volume":"126","author":"Nonaka","year":"2016","journal-title":"J Clin Invest"},{"key":"10.1016\/j.xjidi.2026.100480_bib41","doi-asserted-by":"crossref","first-page":"7784","DOI":"10.3390\/ijms24097784","article-title":"Inflammaging and immunosenescence as part of skin aging-a narrative review","volume":"24","author":"Paj\u0105k","year":"2023","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.xjidi.2026.100480_bib42","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1016\/j.jaci.2016.07.019","article-title":"An IL-17-dominant immune profile is shared across the major orphan forms of ichthyosis","volume":"139","author":"Paller","year":"2017","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.xjidi.2026.100480_bib43","doi-asserted-by":"crossref","first-page":"1512","DOI":"10.1016\/j.jid.2024.12.010","article-title":"Epidermal penetration increases with age and may contribute to systemic inflammation","volume":"145","author":"Parenteau","year":"2025","journal-title":"J Invest Dermatol"},{"key":"10.1016\/j.xjidi.2026.100480_bib44","series-title":"Textbook of aging skin","first-page":"1729","article-title":"Gender differences in skin","author":"Phuong","year":"2017"},{"key":"10.1016\/j.xjidi.2026.100480_bib45","doi-asserted-by":"crossref","first-page":"1087","DOI":"10.1016\/j.jid.2020.11.006","article-title":"Inflammaging and the skin","volume":"141","author":"Pilkington","year":"2021","journal-title":"J Invest Dermatol"},{"key":"10.1016\/j.xjidi.2026.100480_bib46","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1007\/BF00788173","article-title":"Presence of serum albumin in normal human epidermis: possible implications for the nutrition and physiology of stratified epithelia. Presence of albumin in epidermis","volume":"13","author":"Rabilloud","year":"1989","journal-title":"Mol Biol Rep"},{"key":"10.1016\/j.xjidi.2026.100480_bib47","doi-asserted-by":"crossref","first-page":"1134","DOI":"10.1001\/archderm.1995.01690220040008","article-title":"Skin type, but neither race nor gender, influence epidermal permeability barrier function","volume":"131","author":"Reed","year":"1995","journal-title":"Arch Dermatol"},{"key":"10.1016\/j.xjidi.2026.100480_bib48","doi-asserted-by":"crossref","first-page":"3066","DOI":"10.1111\/all.14842","article-title":"Electrical impedance spectroscopy for the characterization of skin barrier in atopic dermatitis","volume":"76","author":"Rinaldi","year":"2021","journal-title":"Allergy"},{"key":"10.1016\/j.xjidi.2026.100480_bib49","doi-asserted-by":"crossref","first-page":"1934","DOI":"10.1111\/all.13824","article-title":"Direct assessment of skin epithelial barrier by electrical impedance spectroscopy","volume":"74","author":"Rinaldi","year":"2019","journal-title":"Allergy"},{"key":"10.1016\/j.xjidi.2026.100480_bib50","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.exger.2014.09.015","article-title":"Skin aging, gene expression and calcium","volume":"68","author":"Rinnerthaler","year":"2015","journal-title":"Exp Gerontol"},{"key":"10.1016\/j.xjidi.2026.100480_bib51","doi-asserted-by":"crossref","first-page":"e47","DOI":"10.1093\/nar\/gkv007","article-title":"limma powers differential expression analyses for RNA-sequencing and microarray studies","volume":"43","author":"Ritchie","year":"2015","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.xjidi.2026.100480_bib52","doi-asserted-by":"crossref","DOI":"10.1186\/gb-2010-11-3-r25","article-title":"A scaling normalization method for differential expression analysis of RNA-seq data","volume":"11","author":"Robinson","year":"2010","journal-title":"Genome Biol"},{"key":"10.1016\/j.xjidi.2026.100480_bib53","doi-asserted-by":"crossref","first-page":"1099","DOI":"10.1111\/pde.15772","article-title":"Changes in skin barrier function in neonates: daily variation and impact of bathing","volume":"41","author":"Tanaka","year":"2024","journal-title":"Pediatr Dermatol"},{"key":"10.1016\/j.xjidi.2026.100480_bib54","doi-asserted-by":"crossref","first-page":"2129","DOI":"10.1101\/gr.772403","article-title":"Panther: a library of protein families and subfamilies indexed by function","volume":"13","author":"Thomas","year":"2003","journal-title":"Genome Res"},{"key":"10.1016\/j.xjidi.2026.100480_bib55","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1159\/000441540","article-title":"Stratum corneum lipids: their role for the skin barrier function in healthy subjects and atopic dermatitis patients","volume":"49","author":"van Smeden","year":"2016","journal-title":"Curr Probl Dermatol"},{"key":"10.1016\/j.xjidi.2026.100480_bib56","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1093\/gerona\/glx161","article-title":"Relationship between homocysteine and muscle strength decline: the Baltimore longitudinal study of aging","volume":"73","author":"Vidoni","year":"2018","journal-title":"J Gerontol A Biol Sci Med Sci"},{"key":"10.1016\/j.xjidi.2026.100480_bib57","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1089\/wound.2013.0467","article-title":"The ontogeny of skin","volume":"3","author":"Visscher","year":"2014","journal-title":"Adv Wound Care (New Rochelle)"},{"key":"10.1016\/j.xjidi.2026.100480_bib58","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1016\/j.jaad.2024.08.044","article-title":"Clinical consequences of age-related skin barrier dysfunction-Part I: Structural, molecular, and physiologic changes with cutaneous aging","volume":"93","author":"Wahhab","year":"2025","journal-title":"J Am Acad Dermatol"},{"key":"10.1016\/j.xjidi.2026.100480_bib59","doi-asserted-by":"crossref","first-page":"5551","DOI":"10.18632\/aging.102946","article-title":"Aging-associated alterations in epidermal function and their clinical significance","volume":"12","author":"Wang","year":"2020","journal-title":"Aging"},{"key":"10.1016\/j.xjidi.2026.100480_bib60","doi-asserted-by":"crossref","first-page":"843","DOI":"10.2165\/00128071-200304120-00004","article-title":"Racial (ethnic) differences in skin properties: the objective data","volume":"4","author":"Wesley","year":"2003","journal-title":"Am J Clin Dermatol"},{"key":"10.1016\/j.xjidi.2026.100480_bib61","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.clindermatol.2010.07.005","article-title":"Dry skin in the elderly: complexities of a common problem","volume":"29","author":"White-Chu","year":"2011","journal-title":"Clin Dermatol"},{"key":"10.1016\/j.xjidi.2026.100480_bib62","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1007\/s11306-020-01762-3","article-title":"Plasma metabolites associated with chronic kidney disease and renal function in adults from the Baltimore Longitudinal Study of Aging","volume":"17","author":"Yamaguchi","year":"2021","journal-title":"Metabolomics"},{"key":"10.1016\/j.xjidi.2026.100480_bib63","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1007\/s40259-021-00490-x","article-title":"Novel targeted biological agents for the treatment of atopic dermatitis","volume":"35","author":"Yang","year":"2021","journal-title":"BioDrugs"},{"key":"10.1016\/j.xjidi.2026.100480_bib64","doi-asserted-by":"crossref","first-page":"2197","DOI":"10.1111\/jdv.15540","article-title":"Topical applications of an emollient reduce circulating pro-inflammatory cytokine levels in chronically aged humans: a pilot clinical study","volume":"33","author":"Ye","year":"2019","journal-title":"J Eur Acad Dermatol Venereol"},{"key":"10.1016\/j.xjidi.2026.100480_bib65","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1039\/C5MB00663E","article-title":"ReactomePA: an R\/Bioconductor package for reactome pathway analysis and visualization","volume":"12","author":"Yu","year":"2016","journal-title":"Mol Biosyst"},{"key":"10.1016\/j.xjidi.2026.100480_bib66","doi-asserted-by":"crossref","first-page":"1175","DOI":"10.1007\/s11357-020-00208-x","article-title":"Poor mitochondrial health and systemic inflammation? Test of a classic hypothesis in the Baltimore Longitudinal Study of Aging","volume":"42","author":"Zampino","year":"2020","journal-title":"GeroScience"}],"container-title":["JID Innovations"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2667026726000330?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2667026726000330?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T20:48:40Z","timestamp":1788814120000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2667026726000330"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7]]},"references-count":65,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2026,7]]}},"alternative-id":["S2667026726000330"],"URL":"https:\/\/doi.org\/10.1016\/j.xjidi.2026.100480","relation":{},"ISSN":["2667-0267"],"issn-type":[{"value":"2667-0267","type":"print"}],"subject":[],"published":{"date-parts":[[2026,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Demographic factors associated with skin barrier function in a large population-based study","name":"articletitle","label":"Article Title"},{"value":"JID Innovations","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.xjidi.2026.100480","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier Inc. on behalf of Society for Investigative Dermatology.","name":"copyright","label":"Copyright"}],"article-number":"100480"}}