{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T17:36:00Z","timestamp":1793381760907,"version":"4.5.0"},"reference-count":32,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,4,20]],"date-time":"2021-04-20T00:00:00Z","timestamp":1618876800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000968","name":"American Heart Association","doi-asserted-by":"publisher","award":["17GRNT33411154"],"award-info":[{"award-number":["17GRNT33411154"]}],"id":[{"id":"10.13039\/100000968","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["jtcvsopen.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["JTCVS Open"],"published-print":{"date-parts":[[2021,9]]},"DOI":"10.1016\/j.xjon.2021.04.009","type":"journal-article","created":{"date-parts":[[2021,4,27]],"date-time":"2021-04-27T14:51:40Z","timestamp":1619535100000},"page":"308-323","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":9,"special_numbering":"C","title":["Computational fluid dynamics investigation of the novel hybrid comprehensive stage II operation"],"prefix":"10.1016","volume":"7","author":[{"given":"Marwan","family":"Hameed","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ray","family":"Prather","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eduardo","family":"Divo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alain","family":"Kassab","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Nykanen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Farias","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William M.","family":"DeCampli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.xjon.2021.04.009_bib1","doi-asserted-by":"crossref","first-page":"644","DOI":"10.1161\/CIRCULATIONAHA.109.881904","article-title":"Mortality in first 5 years in infants with functional single ventricle born in Texas, 1996 to 2003","volume":"121","author":"Fixler","year":"2010","journal-title":"Circulation"},{"key":"10.1016\/j.xjon.2021.04.009_bib2","doi-asserted-by":"crossref","first-page":"1980","DOI":"10.1056\/NEJMoa0912461","article-title":"Comparison of shunt types in the Norwood procedure for single-ventricle lesions","volume":"362","author":"Ohye","year":"2010","journal-title":"New Engl J Med"},{"key":"10.1016\/j.xjon.2021.04.009_bib3","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1016\/j.jtcvs.2012.03.050","article-title":"Quality of life 4 years after complex heart surgery in infancy","volume":"145","author":"Garcia Guerra","year":"2013","journal-title":"J Thorac Cardiovasc Surg"},{"key":"10.1016\/j.xjon.2021.04.009_bib4","doi-asserted-by":"crossref","first-page":"e1181","DOI":"10.1542\/peds.2010-3742","article-title":"Inpatient costs and charges for surgical treatment of hypoplastic left heart syndrome","volume":"128","author":"Dean","year":"2011","journal-title":"Pediatrics"},{"issue":"1 Suppl","key":"10.1016\/j.xjon.2021.04.009_bib5","doi-asserted-by":"crossref","first-page":"S1","DOI":"10.1016\/j.jacc.2011.09.022","article-title":"Hypoplastic left heart syndrome: current considerations and expectations","volume":"59","author":"Feinstein","year":"2012","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.xjon.2021.04.009_bib6","doi-asserted-by":"crossref","first-page":"1070","DOI":"10.1067\/mtc.2003.183","article-title":"Outcomes after the Norwood operation in neonates with critical aortic stenosis or aortic valve atresia","volume":"125","author":"Ashburn","year":"2003","journal-title":"J Thorac Cardiovasc Surg"},{"key":"10.1016\/j.xjon.2021.04.009_bib8","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/j.jtcvs.2005.07.053","article-title":"Single-ventricle palliation for high-risk neonates: the emergence of an alternative hybrid stage I strategy","volume":"131","author":"Bacha","year":"2006","journal-title":"J Thorac Cardiovasc Surg"},{"key":"10.1016\/j.xjon.2021.04.009_bib9","doi-asserted-by":"crossref","first-page":"1211","DOI":"10.1016\/j.jtcvs.2009.11.037","article-title":"Hybrid procedure as an alternative to surgical palliation of high-risk infants with hypoplastic left heart syndrome and its variants","volume":"139","author":"Venugopal","year":"2010","journal-title":"J Thorac Cardiovasc Surg"},{"key":"10.1016\/j.xjon.2021.04.009_bib10","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1007\/s00246-004-0962-4","article-title":"Lessons learned from the development of a new hybrid strategy for the management of hypoplastic left heart syndrome","volume":"26","author":"Galantowicz","year":"2005","journal-title":"Pediatr Cardiol"},{"key":"10.1016\/j.xjon.2021.04.009_bib11","doi-asserted-by":"crossref","first-page":"2063","DOI":"10.1016\/j.athoracsur.2008.02.009","article-title":"Hybrid approach for hypoplastic left heart syndrome: intermediate results after the learning curve","volume":"85","author":"Galantowicz","year":"2008","journal-title":"Ann Thorac Surg"},{"issue":"11 Suppl 1","key":"10.1016\/j.xjon.2021.04.009_bib12","first-page":"S123","article-title":"Hybrid versus Norwood strategies for single-ventricle palliation","volume":"126","author":"Baba","year":"2012","journal-title":"Circulation"},{"key":"10.1016\/j.xjon.2021.04.009_bib13","doi-asserted-by":"crossref","first-page":"1095","DOI":"10.1016\/j.jtcvs.2014.11.081","article-title":"Hybrid approach to the comprehensive stage II operation in a subset of single-ventricle variants","volume":"149","author":"DeCampli","year":"2015","journal-title":"J Thorac Cardiovasc Surg"},{"key":"10.1016\/j.xjon.2021.04.009_bib15","doi-asserted-by":"crossref","first-page":"e1","DOI":"10.1016\/j.jtcvs.2005.06.010","article-title":"Main pulmonary artery to innominate artery shunt during hybrid palliation of hypoplastic left heart syndrome","volume":"130","author":"Caldarone","year":"2005","journal-title":"J Thorac Cardiovasc Surg"},{"key":"10.1016\/j.xjon.2021.04.009_bib16","doi-asserted-by":"crossref","first-page":"1540","DOI":"10.1016\/j.athoracsur.2012.06.043","article-title":"Computational analysis of hybrid Norwood circulation with distal aortic arch obstruction and reverse Blalock-Taussig shunt","volume":"94","author":"Ceballos","year":"2012","journal-title":"Ann Thorac Surg"},{"key":"10.1016\/j.xjon.2021.04.009_bib17","series-title":"Proceedings of the 4th International Conference on Computational and Mathematical Biomedical Engineering, Cachan, France, June 29 to July 1","article-title":"Hemodynamic analysis of the hybrid Norwood procedure for hypoplastic left heart syndrome using a coupled CFD-lumped parameter model [abstract]","author":"Ceballos","year":"2015"},{"key":"10.1016\/j.xjon.2021.04.009_bib18","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1007\/s13239-018-00396-w","article-title":"Patient-specific multi-scale model analysis of hemodynamics following the hybrid Norwood procedure for hypoplastic left heart syndrome: effects of reverse Blalock\u2013Taussig shunt diameter","volume":"10","author":"Ceballos","year":"2018","journal-title":"Cardiovasc Eng Technol"},{"issue":"11 Suppl 1","key":"10.1016\/j.xjon.2021.04.009_bib19","first-page":"S204","article-title":"Use of mathematical modeling to compare and predict hemodynamic effects between hybrid and surgical Norwood palliations for hypoplastic left heart syndrome","volume":"124","author":"Hsia","year":"2011","journal-title":"Circulation"},{"key":"10.1016\/j.xjon.2021.04.009_bib20","doi-asserted-by":"crossref","first-page":"1341","DOI":"10.1016\/j.jtcvs.2013.01.038","article-title":"Effects of pulmonary artery banding and retrograde aortic arch obstruction on the hybrid palliation of hypoplastic left heart syndrome","volume":"146","author":"Baker","year":"2013","journal-title":"J Thorac Cardiovasc Surg"},{"key":"10.1016\/j.xjon.2021.04.009_bib21","doi-asserted-by":"crossref","first-page":"648","DOI":"10.1016\/j.athoracsur.2014.04.047","article-title":"The effect of modified Blalock~Taussig shunt size and coarctation severity on coronary perfusion after the Norwood operation","volume":"98","author":"Corsini","year":"2014","journal-title":"Ann Thorac Surg"},{"key":"10.1016\/j.xjon.2021.04.009_bib22","doi-asserted-by":"crossref","first-page":"1550035","DOI":"10.1142\/S0219519415500359","article-title":"Medical image-based hemodynamic analysis for modified Blalock\u2013Taussig shunt","volume":"15","author":"Liu","year":"2015","journal-title":"J Mech Med Biol"},{"key":"10.1016\/j.xjon.2021.04.009_bib23","doi-asserted-by":"crossref","first-page":"051002","DOI":"10.1115\/1.4006814","article-title":"Optimization of shunt placement for the Norwood surgery using multi-domain modeling","volume":"134","author":"Esmaily Moghadam","year":"2012","journal-title":"J Biomech Eng"},{"key":"10.1016\/j.xjon.2021.04.009_bib24","doi-asserted-by":"crossref","first-page":"1019","DOI":"10.1007\/s10439-015-1370-z","article-title":"Hemodynamics in a pediatric ascending aorta using a viscoelastic pediatric blood model","volume":"44","author":"Good","year":"2015","journal-title":"Ann Biomed Eng"},{"key":"10.1016\/j.xjon.2021.04.009_bib25","series-title":"Fluid Mechanics","author":"Fox","year":"2016"},{"key":"10.1016\/j.xjon.2021.04.009_bib26","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1016\/j.jtcvs.2007.04.078","article-title":"Use of mathematic modeling to compare and predict hemodynamic effects of the modified Blalock\u2013Taussig and right ventricle\u2013pulmonary artery shunts for hypoplastic left heart syndrome","volume":"136","author":"Bove","year":"2008","journal-title":"J Thorac Cardiovasc Surg"},{"key":"10.1016\/j.xjon.2021.04.009_bib27","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/S1350-4533(96)00071-9","article-title":"A mathematical model of circulation in the presence of the bidirectional cavopulmonary anastomosis in children with a univentricular heart","volume":"19","author":"Pennati","year":"1997","journal-title":"Med Eng Phys"},{"key":"10.1016\/j.xjon.2021.04.009_bib28","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1006\/jsre.1999.5799","article-title":"Use of mathematical model to predict hemodynamics in cavopulmonary anastomosis with persistent forward flow","volume":"89","author":"Pennati","year":"2000","journal-title":"J Surg Res"},{"key":"10.1016\/j.xjon.2021.04.009_bib29","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1186\/1475-925X-10-86","article-title":"Mathematical multi-scale model of the cardiovascular system including mitral valve dynamics. Application to ischemic mitral insufficiency","volume":"10","author":"Paeme","year":"2011","journal-title":"Biomed Eng Online"},{"key":"10.1016\/j.xjon.2021.04.009_bib30","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2015\/987293","article-title":"Application of mathematical modeling for simulation and analysis of hypoplastic left heart syndrome (HLHS) in pre- and postsurgery conditions","volume":"2015","author":"Jalali","year":"2015","journal-title":"Biomed Res Int"},{"key":"10.1016\/j.xjon.2021.04.009_bib31","doi-asserted-by":"crossref","first-page":"1022","DOI":"10.1108\/HFF-10-2016-0378","article-title":"Multi-scale pulsatile CFD modeling of thrombus transport in a patient-specific LVAD implantation","volume":"27","author":"Prather","year":"2017","journal-title":"Int J Numer Methods Heat Fluid Flow"},{"key":"10.1016\/j.xjon.2021.04.009_bib32","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1080\/17415977.2012.667092","article-title":"A new control system for left ventricular assist devices based on patient-specific physiological demand","volume":"20","author":"Faragallah","year":"2012","journal-title":"Inverse Probl Sci Eng"},{"key":"10.1016\/j.xjon.2021.04.009_bib33","doi-asserted-by":"crossref","first-page":"2228","DOI":"10.1007\/s10439-012-0579-3","article-title":"Patient-specific multiscale modeling of blood flow for coronary artery bypass graft surgery","volume":"40","author":"Sankaran","year":"2012","journal-title":"Ann Biomed Eng"},{"key":"10.1016\/j.xjon.2021.04.009_bib34","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1016\/j.xjon.2021.04.019","article-title":"Clinical update on the hybrid comprehensive stage II operation","volume":"7","author":"Farias","year":"2021","journal-title":"JTCVS Open"}],"container-title":["JTCVS Open"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2666273621000905?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2666273621000905?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,12]],"date-time":"2025-11-12T20:46:18Z","timestamp":1762980378000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2666273621000905"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,9]]},"references-count":32,"alternative-id":["S2666273621000905"],"URL":"https:\/\/doi.org\/10.1016\/j.xjon.2021.04.009","relation":{},"ISSN":["2666-2736"],"issn-type":[{"value":"2666-2736","type":"print"}],"subject":[],"published":{"date-parts":[[2021,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Computational fluid dynamics investigation of the novel hybrid comprehensive stage II operation","name":"articletitle","label":"Article Title"},{"value":"JTCVS Open","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.xjon.2021.04.009","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 The Authors. Published by Elsevier Inc. on behalf of The American Association for Thoracic Surgery.","name":"copyright","label":"Copyright"}]}}