{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,12]],"date-time":"2025-11-12T21:53:59Z","timestamp":1762984439505,"version":"3.45.0"},"reference-count":42,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,9,1]],"date-time":"2021-09-01T00:00:00Z","timestamp":1630454400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,6,5]],"date-time":"2021-06-05T00:00:00Z","timestamp":1622851200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100008667","name":"Senshin Medical Research Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008667","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["jtcvsopen.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["JTCVS Open"],"published-print":{"date-parts":[[2021,9]]},"DOI":"10.1016\/j.xjon.2021.06.008","type":"journal-article","created":{"date-parts":[[2021,6,9]],"date-time":"2021-06-09T13:18:02Z","timestamp":1623244682000},"page":"23-40","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Intravenous injection of adult human bone marrow mesenchymal stromal cells attenuates spinal cord ischemia\/reperfusion injury in a murine aortic arch crossclamping model"],"prefix":"10.1016","volume":"7","author":[{"given":"Hidekazu","family":"Nakai","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasuyuki","family":"Fujita","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Satoru","family":"Masuda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miki","family":"Komatsu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ayumi","family":"Tani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yutaka","family":"Okita","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenji","family":"Okada","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Atsuhiko","family":"Kawamoto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.xjon.2021.06.008_bib1","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1007\/s11748-010-0668-x","article-title":"Fighting spinal cord complication during surgery for thoracoabdominal aortic disease","volume":"59","author":"Okita","year":"2011","journal-title":"Gen Thorac Cardiovasc Surg"},{"key":"10.1016\/j.xjon.2021.06.008_bib2","doi-asserted-by":"crossref","first-page":"1258","DOI":"10.1016\/j.jvs.2017.05.082","article-title":"Effectiveness of surgical interventions for thoracic aortic aneurysms: a systematic review and meta-analysis","volume":"66","author":"Alsawas","year":"2017","journal-title":"J Vasc Surg"},{"key":"10.1016\/j.xjon.2021.06.008_bib3","first-page":"365","article-title":"Paraplegia after thoracoabdominal aortic surgery: not just assisted circulation, hypothermic arrest, clamp and sew, or TEVAR","volume":"1","author":"Acher","year":"2012","journal-title":"Ann Cardiothorac Surg"},{"key":"10.1016\/j.xjon.2021.06.008_bib4","doi-asserted-by":"crossref","first-page":"47","DOI":"10.3109\/08941939709032125","article-title":"Animal model for investigation of spinal cord injury caused by aortic cross-clamping","volume":"10","author":"Qayumi","year":"1997","journal-title":"J Invest Surg"},{"key":"10.1016\/j.xjon.2021.06.008_bib5","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1097\/00000658-198607000-00005","article-title":"Cross-clamping of the thoracic aorta. Influence of aortic shunts, laminectomy, papaverine, calcium channel blocker, allopurinol, and superoxide dismutase on spinal cord blood flow and paraplegia in baboons","volume":"204","author":"Svensson","year":"1986","journal-title":"Ann Surg"},{"key":"10.1016\/j.xjon.2021.06.008_bib6","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1097\/00000658-199205000-00002","article-title":"Protecting the ischemic spinal cord during aortic clamping. The influence of anesthetics and hypothermia","volume":"215","author":"Naslund","year":"1992","journal-title":"Ann Surg"},{"key":"10.1016\/j.xjon.2021.06.008_bib7","doi-asserted-by":"crossref","first-page":"1850","DOI":"10.1161\/01.STR.27.10.1850","article-title":"Effect of proximal arterial perfusion pressure on function, spinal cord blood flow, and histopathologic changes after increasing intervals of aortic occlusion in the rat","volume":"27","author":"Taira","year":"1996","journal-title":"Stroke"},{"key":"10.1016\/j.xjon.2021.06.008_bib8","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1161\/01.STR.31.1.208","article-title":"Spinal cord ischemia. Development of a model in the mouse","volume":"31","author":"Lang-Lazdunski","year":"2000","journal-title":"Stroke"},{"key":"10.1016\/j.xjon.2021.06.008_bib9","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1177\/1538574409333582","article-title":"Effect of PJ34 on spinal cord tissue viability and gene expression in a murine model of thoracic aortic reperfusion injury","volume":"43","author":"Stone","year":"2009","journal-title":"Vasc Endovasc Surg"},{"key":"10.1016\/j.xjon.2021.06.008_bib10","doi-asserted-by":"crossref","first-page":"2302","DOI":"10.1161\/STROKEAHA.110.600429","article-title":"Delayed paraplegia after spinal cord ischemic injury requires caspase-3 activation in mice","volume":"42","author":"Kakinohana","year":"2011","journal-title":"Stroke"},{"key":"10.1016\/j.xjon.2021.06.008_bib11","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1016\/j.jss.2010.12.025","article-title":"Ischemic dose-response in the spinal cord: both immediate and delayed paraplegia","volume":"174","author":"Smith","year":"2012","journal-title":"J Surg Res"},{"key":"10.1016\/j.xjon.2021.06.008_bib12","doi-asserted-by":"crossref","first-page":"S110","DOI":"10.1161\/CIRCULATIONAHA.111.080275","article-title":"The evolution of chemokine release supports a bimodal mechanism of spinal cord ischemia and reperfusion injury","volume":"126","author":"Smith","year":"2012","journal-title":"Circulation"},{"key":"10.1016\/j.xjon.2021.06.008_bib13","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1007\/s11748-016-0629-0","article-title":"Impact of acquired and innate immunity on spinal cord ischemia and reperfusion injury","volume":"64","author":"Yamanaka","year":"2016","journal-title":"Gen Thorac Cardiovasc Surg"},{"key":"10.1016\/j.xjon.2021.06.008_bib14","first-page":"393","article-title":"The development of fibroblast colonies in monolayer cultures of Guinea-pig bone marrow and spleen cells","volume":"3","author":"Friedenstein","year":"1970","journal-title":"Cell Tissue Kinet"},{"key":"10.1016\/j.xjon.2021.06.008_bib15","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1002\/sctm.18-0024","article-title":"Concise review: mesenchymal stem cell-based drug delivery: the good, the bad, the ugly, and the Promise","volume":"7","author":"Krueger","year":"2018","journal-title":"Stem Cells Transl Med"},{"key":"10.1016\/j.xjon.2021.06.008_bib16","doi-asserted-by":"crossref","first-page":"1434","DOI":"10.1002\/sctm.16-0434","article-title":"Concise review: innate and adaptive immune recognition of allogeneic and xenogeneic cell transplants in the central nervous system","volume":"6","author":"Hoornaert","year":"2017","journal-title":"Stem Cells Transl Med"},{"key":"10.1016\/j.xjon.2021.06.008_bib17","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1186\/s13287-015-0214-y","article-title":"Molecular signatures of mesenchymal stem cell-derived extracellular vesicle-mediated tissue repair","volume":"6","author":"Katsuda","year":"2015","journal-title":"Stem Cell Res Ther"},{"key":"10.1016\/j.xjon.2021.06.008_bib18","doi-asserted-by":"crossref","first-page":"1342","DOI":"10.1089\/scd.2016.0068","article-title":"Inactivated mesenchymal stem cells maintain immunomodulatory capacity","volume":"25","author":"Luk","year":"2016","journal-title":"Stem Cells Dev"},{"key":"10.1016\/j.xjon.2021.06.008_bib19","doi-asserted-by":"crossref","first-page":"824","DOI":"10.1016\/j.stem.2018.05.004","article-title":"Mesenchymal stromal cells: clinical challenges and therapeutic opportunities","volume":"22","author":"Galipeau","year":"2018","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.xjon.2021.06.008_bib20","doi-asserted-by":"crossref","first-page":"1523","DOI":"10.1016\/j.athoracsur.2017.12.014","article-title":"Mesenchymal stem cell-based therapy improves lower limb movement after spinal cord ischemia in rats","volume":"105","author":"Takahashi","year":"2018","journal-title":"Ann Thorac Surg"},{"key":"10.1016\/j.xjon.2021.06.008_bib21","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.brainres.2014.02.047","article-title":"Transplantation of mesenchymal stem cells exerts anti-apoptotic effects in adult rats after spinal cord ischemia-reperfusion injury","volume":"1561","author":"Yin","year":"2014","journal-title":"Brain Res"},{"key":"10.1016\/j.xjon.2021.06.008_bib22","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1089\/neu.2006.23.635","article-title":"Basso Mouse Scale for locomotion detects differences in recovery after spinal cord injury in five common mouse strains","volume":"23","author":"Basso","year":"2006","journal-title":"J Neurotrauma"},{"key":"10.1016\/j.xjon.2021.06.008_bib23","doi-asserted-by":"crossref","first-page":"e535","DOI":"10.1038\/cddis.2013.64","article-title":"Motor neuron degeneration in a mouse model of seipinopathy","volume":"4","author":"Guo","year":"2013","journal-title":"Cell Death Dis"},{"key":"10.1016\/j.xjon.2021.06.008_bib24","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1002\/stem.3016","article-title":"Concise review: mesenchymal stem cells: from roots to boost","volume":"37","author":"Andrzejewska","year":"2019","journal-title":"Stem Cells"},{"key":"10.1016\/j.xjon.2021.06.008_bib25","doi-asserted-by":"crossref","first-page":"2227","DOI":"10.1016\/j.athoracsur.2005.12.056","article-title":"Intrathecal injection of bone marrow stromal cells attenuates neurologic injury after spinal cord ischemia","volume":"81","author":"Shi","year":"2006","journal-title":"Ann Thorac Surg"},{"key":"10.1016\/j.xjon.2021.06.008_bib26","doi-asserted-by":"crossref","first-page":"1484","DOI":"10.1016\/j.athoracsur.2006.11.048","article-title":"Therapeutic benefit of intrathecal injection of marrow stromal cells on ischemia-injured spinal cord","volume":"83","author":"Shi","year":"2007","journal-title":"Ann Thorac Surg"},{"key":"10.1016\/j.xjon.2021.06.008_bib27","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1016\/j.jvs.2012.11.087","article-title":"Intrathecal transplantation of bone marrow stromal cells attenuates blood-spinal cord barrier disruption induced by spinal cord ischemia-reperfusion injury in rabbits","volume":"58","author":"Fang","year":"2013","journal-title":"J Vasc Surg"},{"key":"10.1016\/j.xjon.2021.06.008_bib28","doi-asserted-by":"crossref","first-page":"3300","DOI":"10.1007\/s11064-016-2062-2","article-title":"Cu, Zn-superoxide dismutase increases the therapeutic potential of adipose-derived mesenchymal stem cells by maintaining antioxidant enzyme levels","volume":"41","author":"Yoo","year":"2016","journal-title":"Neurochem Res"},{"key":"10.1016\/j.xjon.2021.06.008_bib29","doi-asserted-by":"crossref","first-page":"101601","DOI":"10.1016\/j.scr.2019.101601","article-title":"Simulated microgravity-cultured mesenchymal stem cells improve recovery following spinal cord ischemia in rats","volume":"41","author":"Kurose","year":"2019","journal-title":"Stem Cell Res"},{"key":"10.1016\/j.xjon.2021.06.008_bib30","doi-asserted-by":"crossref","first-page":"574","DOI":"10.2174\/156652412800619950","article-title":"Immunosuppressive properties of mesenchymal stem cells: advances and applications","volume":"12","author":"De Miguel","year":"2012","journal-title":"Curr Mol Med"},{"key":"10.1016\/j.xjon.2021.06.008_bib31","doi-asserted-by":"crossref","first-page":"14638","DOI":"10.1073\/pnas.0803670105","article-title":"Stem\/progenitor cells from bone marrow decrease neuronal death in global ischemia by modulation of inflammatory\/immune responses","volume":"105","author":"Ohtaki","year":"2008","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.xjon.2021.06.008_bib32","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12974-015-0252-5","article-title":"Human mesenchymal stem\/stromal cells suppress spinal inflammation in mice with contribution of pituitary adenylate cyclase-activating polypeptide (PACAP)","volume":"12","author":"Tsumuraya","year":"2015","journal-title":"J Neuroinflammation"},{"key":"10.1016\/j.xjon.2021.06.008_bib33","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1016\/j.jtcvs.2007.07.071","article-title":"Transplantation of hypoxia-preconditioned mesenchymal stem cells improves infarcted heart function via enhanced survival of implanted cells and angiogenesis","volume":"135","author":"Hu","year":"2008","journal-title":"J Thorac Cardiovasc Surg"},{"key":"10.1016\/j.xjon.2021.06.008_bib34","doi-asserted-by":"crossref","first-page":"1320","DOI":"10.3390\/ijms18061320","article-title":"Hypoxic preconditioning promotes the bioactivities of mesenchymal stem cells via the HIF-1alpha-GRP78-Akt axis","volume":"18","author":"Lee","year":"2017","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.xjon.2021.06.008_bib35","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1038\/cmi.2009.28","article-title":"Expression of IL-10 and TNF-alpha in rats with cerebral infarction after transplantation with mesenchymal stem cells","volume":"6","author":"Liu","year":"2009","journal-title":"Cell Mol Immunol"},{"key":"10.1016\/j.xjon.2021.06.008_bib36","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.brainres.2010.03.080","article-title":"Human mesenchymal stem cell transplantation protects against cerebral ischemic injury and upregulates interleukin-10 expression in Macacafascicularis","volume":"1334","author":"Li","year":"2010","journal-title":"Brain Res"},{"key":"10.1016\/j.xjon.2021.06.008_bibE1","doi-asserted-by":"crossref","first-page":"1098","DOI":"10.1016\/j.neuron.2014.07.027","article-title":"TNF and increased intracellular iron alter macrophage polarization to a detrimental M1 phenotype in the injured spinal cord","volume":"83","author":"Kroner","year":"2014","journal-title":"Neuron"},{"key":"10.1016\/j.xjon.2021.06.008_bibE2","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12974-015-0252-5","article-title":"Human mesenchymal stem\/stromal cells suppress spinal inflammation in mice with contribution of pituitary adenylate cyclase-activating polypeptide (PACAP)","volume":"12","author":"Tsumuraya","year":"2015","journal-title":"J Neuroinflammation"},{"key":"10.1016\/j.xjon.2021.06.008_bibE3","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1002\/stem.243","article-title":"Lnk deletion reinforces the function of bone marrow progenitors in promoting neovascularization and astrogliosis following spinal cord injury","volume":"28","author":"Kamei","year":"2010","journal-title":"Stem Cells"},{"key":"10.1016\/j.xjon.2021.06.008_bibE4","doi-asserted-by":"crossref","first-page":"e2817","DOI":"10.1038\/cddis.2017.168","article-title":"Restricting the induction of NGF in ovarian stroma engenders selective follicular activation through the mTOR signaling pathway","volume":"8","author":"He","year":"2017","journal-title":"Cell Death Dis"},{"key":"10.1016\/j.xjon.2021.06.008_bibE5","first-page":"3149","article-title":"The antiapoptotic protein Bcl-xL negatively regulates the bone-resorbing activity of osteoclasts in mice","volume":"119","author":"Iwasawa","year":"2009","journal-title":"J Clin Invest"},{"key":"10.1016\/j.xjon.2021.06.008_bibE6","doi-asserted-by":"crossref","first-page":"14547","DOI":"10.1038\/s41598-019-51020-3","article-title":"Low human and murine Mcl-1 expression leads to a pro-apoptotic plaque phenotype enriched in giant-cells","volume":"9","author":"Fontaine","year":"2019","journal-title":"Sci Rep"}],"container-title":["JTCVS Open"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2666273621001571?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2666273621001571?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,12]],"date-time":"2025-11-12T20:47:48Z","timestamp":1762980468000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2666273621001571"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,9]]},"references-count":42,"alternative-id":["S2666273621001571"],"URL":"https:\/\/doi.org\/10.1016\/j.xjon.2021.06.008","relation":{},"ISSN":["2666-2736"],"issn-type":[{"type":"print","value":"2666-2736"}],"subject":[],"published":{"date-parts":[[2021,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Intravenous injection of adult human bone marrow mesenchymal stromal cells attenuates spinal cord ischemia\/reperfusion injury in a murine aortic arch crossclamping model","name":"articletitle","label":"Article Title"},{"value":"JTCVS Open","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.xjon.2021.06.008","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 The Author(s). Published by Elsevier Inc. on behalf of The American Association for Thoracic Surgery.","name":"copyright","label":"Copyright"}]}}