{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,9]],"date-time":"2026-04-09T07:06:15Z","timestamp":1775718375168,"version":"3.50.1"},"reference-count":28,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,10,20]],"date-time":"2021-10-20T00:00:00Z","timestamp":1634688000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100010648","name":"UZ Leuven","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100010648","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100001491","name":"Belgian American Educational Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001491","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003130","name":"Fonds Wetenschappelijk Onderzoek","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003130","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["jtcvsopen.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["JTCVS Open"],"published-print":{"date-parts":[[2021,12]]},"DOI":"10.1016\/j.xjon.2021.10.019","type":"journal-article","created":{"date-parts":[[2021,10,26]],"date-time":"2021-10-26T19:54:04Z","timestamp":1635278044000},"page":"301-312","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["The role of antiaggregant agents and anticoagulants in the prevention of aortic valve endocarditis: A double-cohort retrospective study"],"prefix":"10.1016","volume":"8","author":[{"given":"Hanne","family":"Theys","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5606-376X","authenticated-orcid":false,"given":"Jef","family":"Van den Eynde","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marie-Christine","family":"Herregods","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philippe","family":"Moreillon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruth","family":"Heying","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wouter","family":"Oosterlinck","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.xjon.2021.10.019_bib1","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1093\/eurheartj\/ehl427","article-title":"Infective endocarditis: changing epidemiology and predictors of 6-month mortality: a prospective cohort study","volume":"28","author":"Hill","year":"2006","journal-title":"Eur Heart J"},{"key":"10.1016\/j.xjon.2021.10.019_bib2","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/S0140-6736(03)15266-X","article-title":"Infective endocarditis","volume":"363","author":"Moreillon","year":"2004","journal-title":"Lancet"},{"key":"10.1016\/j.xjon.2021.10.019_bib3","doi-asserted-by":"crossref","first-page":"3075","DOI":"10.1093\/eurheartj\/ehv319","article-title":"2015 ESC guidelines for the management of infective endocarditis","volume":"36","author":"Habib","year":"2015","journal-title":"Eur Heart J"},{"key":"10.1016\/j.xjon.2021.10.019_bib4","doi-asserted-by":"crossref","first-page":"937","DOI":"10.1136\/heartjnl-2015-309102","article-title":"Antibiotic prophylaxis for infective endocarditis: a systematic review and meta-analysis","volume":"103","author":"Cahill","year":"2017","journal-title":"Heart"},{"key":"10.1016\/j.xjon.2021.10.019_bib5","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1186\/s12916-020-01531-y","article-title":"Investigation of the impact of the NICE guidelines regarding antibiotic prophylaxis during invasive dental procedures on the incidence of infective endocarditis in England: an electronic health records study","volume":"18","author":"Quan","year":"2020","journal-title":"BMC Med"},{"key":"10.1016\/j.xjon.2021.10.019_bib6","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1093\/femsre\/fuz030","article-title":"Development of a vaccine against Staphylococcus aureus invasive infections: evidence based on human immunity, genetics and bacterial evasion mechanisms","volume":"44","author":"Miller","year":"2019","journal-title":"FEMS Microbiol Rev"},{"key":"10.1016\/j.xjon.2021.10.019_bib7","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1111\/jth.13928","article-title":"Staphylococcus aureus, master manipulator of the human hemostatic system","volume":"16","author":"Liesenborghs","year":"2018","journal-title":"J Thromb Haemost"},{"key":"10.1016\/j.xjon.2021.10.019_bib8","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1093\/infdis\/jiu426","article-title":"Prophylaxis of experimental endocarditis with antiplatelet and antithrombin agents: a role for long-term prevention of infective endocarditis in humans?","volume":"211","author":"Veloso","year":"2015","journal-title":"J Infect Dis"},{"key":"10.1016\/j.xjon.2021.10.019_bib9","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1001\/jamacardio.2019.1189","article-title":"Antibacterial activity of ticagrelor in conventional antiplatelet dosages against antibiotic-resistant gram-positive bacteria","volume":"4","author":"Lancellotti","year":"2019","journal-title":"JAMA Cardiol"},{"key":"10.1016\/j.xjon.2021.10.019_bib10","doi-asserted-by":"crossref","first-page":"ftv060","DOI":"10.1093\/femspd\/ftv060","article-title":"Aspirin\u00a0plus ticlopidine prevented experimental endocarditis due to Enterococcus faecalis and Streptococcus gallolyticus","volume":"73","author":"Veloso","year":"2015","journal-title":"Pathog Dis"},{"key":"10.1016\/j.xjon.2021.10.019_bib11","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/S0924-8579(97)00056-3","article-title":"Influence of adjunctive ticlopidine on the treatment of experimental Staphylococcus aureus endocarditis","volume":"9","author":"Nicolau","year":"1998","journal-title":"Int J Antimicrob Agents"},{"key":"10.1016\/j.xjon.2021.10.019_bib12","doi-asserted-by":"crossref","first-page":"1748","DOI":"10.1128\/AAC.39.8.1748","article-title":"Influence of aspirin on development and treatment of experimental Staphylococcus aureus endocarditis","volume":"39","author":"Nicolau","year":"1995","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.xjon.2021.10.019_bib13","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/fcvm.2021.702780","article-title":"Antithrombotic treatment after surgical and transcatheter heart valve repair and replacement","volume":"8","author":"Verstraete","year":"2021","journal-title":"Front Cardiovasc Med"},{"key":"10.1016\/j.xjon.2021.10.019_bib14","doi-asserted-by":"crossref","first-page":"1151","DOI":"10.1016\/j.athoracsur.2004.11.001","article-title":"Prosthetic valve endocarditis","volume":"80","author":"Mahesh","year":"2005","journal-title":"Ann Thorac Surg"},{"key":"10.1016\/j.xjon.2021.10.019_bib15","doi-asserted-by":"crossref","first-page":"768","DOI":"10.1093\/ejcts\/ezx169","article-title":"Prosthetic valve endocarditis: predictors of early outcome of surgical therapy. A multicentric study","volume":"52","author":"Luciani","year":"2017","journal-title":"Eur J Cardiothorac Surg"},{"key":"10.1016\/j.xjon.2021.10.019_bib16","doi-asserted-by":"crossref","first-page":"2668","DOI":"10.1093\/eurheartj\/ehy153","article-title":"Incidence and factors associated with infective endocarditis in patients undergoing left-sided heart valve replacement","volume":"39","author":"\u00d8stergaard","year":"2018","journal-title":"Eur Heart J"},{"key":"10.1016\/j.xjon.2021.10.019_bib17","doi-asserted-by":"crossref","first-page":"2670","DOI":"10.1016\/j.jacc.2016.09.958","article-title":"Prosthetic heart valve thrombosis","volume":"68","author":"Dangas","year":"2016","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.xjon.2021.10.019_bib18","doi-asserted-by":"crossref","first-page":"31","DOI":"10.7861\/clinmed.cme.20.1.1","article-title":"Infective endocarditis: a contemporary update","volume":"20","author":"Rajani","year":"2020","journal-title":"Clin Med (Lond)"},{"key":"10.1016\/j.xjon.2021.10.019_bib19","doi-asserted-by":"crossref","first-page":"760","DOI":"10.1093\/eurheartj\/ehl486","article-title":"Definition, clinical profile, microbiological spectrum, and prognostic factors of early-onset prosthetic valve endocarditis","volume":"28","author":"Lopez","year":"2007","journal-title":"Eur Heart J"},{"key":"10.1016\/j.xjon.2021.10.019_bib20","doi-asserted-by":"crossref","first-page":"1354","DOI":"10.1001\/jama.297.12.1354","article-title":"Contemporary clinical profile and outcome of prosthetic valve endocarditis","volume":"297","author":"Wang","year":"2007","journal-title":"JAMA"},{"key":"10.1016\/j.xjon.2021.10.019_bib21","doi-asserted-by":"crossref","first-page":"1107","DOI":"10.1160\/TH11-12-0891","article-title":"Fibrin formation by staphylothrombin facilitates Staphylococcus aureus-induced platelet aggregation","volume":"107","author":"Vanassche","year":"2012","journal-title":"Thromb Haemost"},{"key":"10.1016\/j.xjon.2021.10.019_bib22","doi-asserted-by":"crossref","first-page":"e457","DOI":"10.1016\/j.jtcvs.2019.10.188","article-title":"Antiplatelet therapy abrogates platelet-assisted Staphylococcus aureus infectivity of biological heart valve conduits","volume":"161","author":"Ditkowski","year":"2021","journal-title":"J Thorac Cardiovasc Surg"},{"key":"10.1016\/j.xjon.2021.10.019_bib23","doi-asserted-by":"crossref","first-page":"e0215333","DOI":"10.1371\/journal.pone.0215333","article-title":"Adjunctive dabigatran therapy improves outcome of experimental left-sided Staphylococcus aureus endocarditis","volume":"14","author":"Lerche","year":"2019","journal-title":"PLoS One"},{"key":"10.1016\/j.xjon.2021.10.019_bib24","doi-asserted-by":"crossref","first-page":"e1159","DOI":"10.1161\/CIR.0000000000000503","article-title":"2017 AHA\/ACC focused update of the 2014 AHA\/ACC guideline for the management of patients with valvular heart disease: a report of the American College of Cardiology\/American Heart Association task force on clinical practice guidelines","volume":"135","author":"Nishimura","year":"2017","journal-title":"Circulation"},{"key":"10.1016\/j.xjon.2021.10.019_bib25","doi-asserted-by":"crossref","first-page":"761","DOI":"10.7326\/0003-4819-129-10-199811150-00002","article-title":"Dental and cardiac risk factors for infective endocarditis: a population-based, case-control study","volume":"129","author":"Strom","year":"1998","journal-title":"Ann Intern Med"},{"key":"10.1016\/j.xjon.2021.10.019_bib26","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1016\/S0140-6736(09)62191-7","article-title":"Comparison of ticagrelor with clopidogrel in patients with a planned invasive strategy for acute coronary syndromes (PLATO): a randomised double-blind study","volume":"375","author":"Cannon","year":"2010","journal-title":"Lancet"},{"issue":"2 Suppl","key":"10.1016\/j.xjon.2021.10.019_bib27","doi-asserted-by":"crossref","first-page":"e576S","DOI":"10.1378\/chest.11-2305","article-title":"Antithrombotic and thrombolytic therapy for valvular disease: antithrombotic therapy and prevention of thrombosis, 9th ed: American College of Chest Physicians evidence-based clinical practice guidelines","volume":"141","author":"Whitlock","year":"2012","journal-title":"Chest"},{"key":"10.1016\/j.xjon.2021.10.019_bib28","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1016\/j.jacc.2017.03.011","article-title":"2017 AHA\/ACC focused update of the 2014 AHA\/ACC guideline for the management of patients with valvular heart disease: a report of the American College of Cardiology\/American Heart Association task force on clinical practice guidelines","volume":"70","author":"Nishimura","year":"2017","journal-title":"J Am Coll Cardiol"}],"container-title":["JTCVS Open"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2666273621003739?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2666273621003739?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,12]],"date-time":"2025-11-12T20:48:56Z","timestamp":1762980536000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2666273621003739"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,12]]},"references-count":28,"alternative-id":["S2666273621003739"],"URL":"https:\/\/doi.org\/10.1016\/j.xjon.2021.10.019","relation":{},"ISSN":["2666-2736"],"issn-type":[{"value":"2666-2736","type":"print"}],"subject":[],"published":{"date-parts":[[2021,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The role of antiaggregant agents and anticoagulants in the prevention of aortic valve endocarditis: A double-cohort retrospective study","name":"articletitle","label":"Article Title"},{"value":"JTCVS Open","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.xjon.2021.10.019","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 The Author(s). Published by Elsevier Inc. on behalf of The American Association for Thoracic Surgery.","name":"copyright","label":"Copyright"}]}}