{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,12]],"date-time":"2025-11-12T21:54:03Z","timestamp":1762984443555,"version":"3.45.0"},"reference-count":22,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T00:00:00Z","timestamp":1654041600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T00:00:00Z","timestamp":1654041600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,4,18]],"date-time":"2022-04-18T00:00:00Z","timestamp":1650240000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["jtcvsopen.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["JTCVS Open"],"published-print":{"date-parts":[[2022,6]]},"DOI":"10.1016\/j.xjon.2022.04.011","type":"journal-article","created":{"date-parts":[[2022,4,20]],"date-time":"2022-04-20T21:55:00Z","timestamp":1650491700000},"page":"113-120","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"special_numbering":"C","title":["Aortic root dilation in adult patients with Marfan syndrome: Does aortic root stiffness matter?"],"prefix":"10.1016","volume":"10","author":[{"given":"Kelly","family":"Cox","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yousi A.","family":"Oquendo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Liang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elif Seda","family":"Selamet Tierney","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.xjon.2022.04.011_bib1","doi-asserted-by":"crossref","first-page":"1965","DOI":"10.1016\/S0140-6736(05)67789-6","article-title":"Marfan's syndrome","volume":"366","author":"Judge","year":"2005","journal-title":"Lancet"},{"key":"10.1016\/j.xjon.2022.04.011_bib2","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1136\/jmg.2009.072785","article-title":"The revised Ghent nosology for the Marfan syndrome","volume":"47","author":"Loeys","year":"2010","journal-title":"J Med Genet"},{"key":"10.1016\/j.xjon.2022.04.011_bib3","doi-asserted-by":"crossref","first-page":"e150","DOI":"10.1161\/01.CIR.0000155243.70456.F4","article-title":"Treatment of aortic disease in patients with Marfan syndrome","volume":"111","author":"Milewicz","year":"2005","journal-title":"Circulation"},{"key":"10.1016\/j.xjon.2022.04.011_bib4","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1161\/CIRCULATIONAHA.111.054676","article-title":"Aortic event rate in the Marfan population: a cohort study","volume":"125","author":"Jondeau","year":"2012","journal-title":"Circulation"},{"key":"10.1016\/j.xjon.2022.04.011_bib5","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1136\/postgradmedj-2013-305132rep","article-title":"Republished review: surgical management of aortic root disease in Marfan syndrome and other congenital disorders associated with aortic root aneurysms","volume":"92","author":"Treasure","year":"2016","journal-title":"Postgrad Med J"},{"key":"10.1016\/j.xjon.2022.04.011_bib6","doi-asserted-by":"crossref","first-page":"1978","DOI":"10.1016\/S0140-6736(05)66995-4","article-title":"Marfan's syndrome","volume":"366","author":"Ho","year":"2005","journal-title":"Lancet"},{"key":"10.1016\/j.xjon.2022.04.011_bib7","first-page":"E43","volume":"76","author":"Hiratzka","year":"2010","journal-title":"Catheter Cardiovasc Interv"},{"key":"10.1016\/j.xjon.2022.04.011_bib8","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1093\/eurheartj\/ehl457","article-title":"Relation of aortic root dilatation and age in Marfan's syndrome","volume":"28","author":"Aburawi","year":"2007","journal-title":"Eur Heart J"},{"key":"10.1016\/j.xjon.2022.04.011_bib9","doi-asserted-by":"crossref","first-page":"1307","DOI":"10.1056\/NEJM199904293401702","article-title":"Replacement of the aortic root in patients with Marfan's syndrome","volume":"340","author":"Gott","year":"1999","journal-title":"N Engl J Med"},{"key":"10.1016\/j.xjon.2022.04.011_bib10","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1016\/j.ejcts.2008.04.035","article-title":"Prophylactic aortic root surgery in patients with Marfan syndrome: 10 years' experience with a protocol based on body surface area","volume":"34","author":"Aalberts","year":"2008","journal-title":"Eur J Cardiothorac Surg"},{"key":"10.1016\/j.xjon.2022.04.011_bib11","doi-asserted-by":"crossref","first-page":"924","DOI":"10.1161\/CIRCULATIONAHA.110.949131","article-title":"What is new in dilatation of the ascending aorta? Review of current literature and practical advice for the cardiologist","volume":"123","author":"Cozijnsen","year":"2011","journal-title":"Circulation"},{"key":"10.1016\/j.xjon.2022.04.011_bib12","doi-asserted-by":"crossref","first-page":"1094","DOI":"10.1016\/j.amjcard.2018.01.016","article-title":"Influence of aortic stiffness on aortic-root growth rate and outcome in patients with the Marfan syndrome","volume":"121","author":"Selamet Tierney","year":"2018","journal-title":"Am J Cardiol"},{"key":"10.1016\/j.xjon.2022.04.011_bib13","doi-asserted-by":"crossref","first-page":"926","DOI":"10.1093\/ejcts\/ezy168","article-title":"Aortic stiffness in adolescent Turner and Marfan syndrome patients","volume":"54","author":"Schafer","year":"2018","journal-title":"Eur J Cardiothorac Surg"},{"key":"10.1016\/j.xjon.2022.04.011_bib14","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1038\/ajh.2009.115","article-title":"Augmentation index relates to progression of aortic disease in adults with Marfan syndrome","volume":"22","author":"Mortensen","year":"2009","journal-title":"Am J Hypertens"},{"key":"10.1016\/j.xjon.2022.04.011_bib15","doi-asserted-by":"crossref","first-page":"1146","DOI":"10.1016\/j.ehj.2004.04.033","article-title":"Aortic stiffness and diameter predict progressive aortic dilatation in patients with Marfan syndrome","volume":"25","author":"Nollen","year":"2004","journal-title":"Eur Heart J"},{"key":"10.1016\/j.xjon.2022.04.011_bib16","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1161\/CIRCULATIONAHA.114.014934","article-title":"Segmental aortic stiffness in children and young adults with connective tissue disorders: relationships with age, aortic size, rate of dilation, and surgical root replacement","volume":"132","author":"Prakash","year":"2015","journal-title":"Circulation"},{"key":"10.1016\/j.xjon.2022.04.011_bib17","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1016\/S0002-9149(02)03330-1","article-title":"Comparison of aortic elasticity in patients with the marfan syndrome with and without aortic root replacement","volume":"91","author":"Nollen","year":"2003","journal-title":"Am J Cardiol"},{"issue":"Suppl 1","key":"10.1016\/j.xjon.2022.04.011_bib18","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.ijcard.2004.08.014","article-title":"What is new in the Marfan syndrome?","volume":"97","author":"Nollen","year":"2004","journal-title":"Int J Cardiol"},{"key":"10.1016\/j.xjon.2022.04.011_bib19","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1177\/1358863X15569868","article-title":"Distinct effects of losartan and atenolol on vascular stiffness in Marfan syndrome","volume":"20","author":"Bhatt","year":"2015","journal-title":"Vasc Med"},{"key":"10.1016\/j.xjon.2022.04.011_bib20","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1161\/01.CIR.80.1.78","article-title":"Stiffness of systemic arteries in patients with myocardial infarction. A noninvasive method to predict severity of coronary atherosclerosis","volume":"80","author":"Hirai","year":"1989","journal-title":"Circulation"},{"key":"10.1016\/j.xjon.2022.04.011_bib21","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1093\/cvr\/12.7.401","article-title":"Evaluation of the elasticity and characteristic impedance of the ascending aorta in man","volume":"12","author":"Merillon","year":"1978","journal-title":"Cardiovasc Res"},{"key":"10.1016\/j.xjon.2022.04.011_bib22","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1148\/radiology.219.2.r01ma01535","article-title":"Biophysical properties of the normal-sized aorta in patients with Marfan syndrome: evaluation with MR flow mapping","volume":"219","author":"Groenink","year":"2001","journal-title":"Radiology"}],"container-title":["JTCVS Open"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2666273622001632?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2666273622001632?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,12]],"date-time":"2025-11-12T20:47:56Z","timestamp":1762980476000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2666273622001632"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,6]]},"references-count":22,"alternative-id":["S2666273622001632"],"URL":"https:\/\/doi.org\/10.1016\/j.xjon.2022.04.011","relation":{},"ISSN":["2666-2736"],"issn-type":[{"type":"print","value":"2666-2736"}],"subject":[],"published":{"date-parts":[[2022,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Aortic root dilation in adult patients with Marfan syndrome: Does aortic root stiffness matter?","name":"articletitle","label":"Article Title"},{"value":"JTCVS Open","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.xjon.2022.04.011","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 The Author(s). Published by Elsevier Inc. on behalf of The American Association for Thoracic Surgery.","name":"copyright","label":"Copyright"}]}}