{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,8]],"date-time":"2025-11-08T21:41:26Z","timestamp":1762638086313,"version":"build-2065373602"},"reference-count":31,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,8,30]],"date-time":"2024-08-30T00:00:00Z","timestamp":1724976000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001711","name":"Schweizerischer Nationalfonds zur F\u00f6rderung der Wissenschaftlichen Forschung","doi-asserted-by":"publisher","award":["PP00P3_159269"],"award-info":[{"award-number":["PP00P3_159269"]}],"id":[{"id":"10.13039\/501100001711","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["jtcvsopen.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["JTCVS Open"],"published-print":{"date-parts":[[2024,12]]},"DOI":"10.1016\/j.xjon.2024.07.024","type":"journal-article","created":{"date-parts":[[2024,9,4]],"date-time":"2024-09-04T13:35:30Z","timestamp":1725456930000},"page":"491-503","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Intracavitary cisplatin-fibrin followed by irradiation improved tumor control compared to the single treatments in a mesothelioma rat model"],"prefix":"10.1016","volume":"22","author":[{"given":"Michaela B.","family":"Kirschner","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mayura","family":"Meerang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vanessa","family":"Orlowski","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katarzyna","family":"Furrer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fabienne","family":"Tschanz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ivo","family":"Grgic","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Virginia","family":"Cecconi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maries","family":"van den Broek","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthias","family":"Guckenberger","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martin","family":"Pruschy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Olivia","family":"Lauk","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Isabelle","family":"Opitz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"2","key":"10.1016\/j.xjon.2024.07.024_bib1","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1016\/j.lungcan.2013.11.026","article-title":"A systematic review and meta-analysis of surgical treatments for malignant pleural mesothelioma","volume":"83","author":"Cao","year":"2014","journal-title":"Lung Cancer"},{"issue":"Suppl 2","key":"10.1016\/j.xjon.2024.07.024_bib2","first-page":"S238","article-title":"Management of malignant pleural mesothelioma-The European experience","volume":"6","author":"Opitz","year":"2014","journal-title":"J Thorac Dis"},{"issue":"3","key":"10.1016\/j.xjon.2024.07.024_bib3","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1016\/j.suc.2020.02.009","article-title":"Peritoneal cancers and hyperthermic intraperitoneal chemotherapy","volume":"100","author":"Pletcher","year":"2020","journal-title":"Surg Clin North Am"},{"issue":"10","key":"10.1016\/j.xjon.2024.07.024_bib4","doi-asserted-by":"crossref","first-page":"1561","DOI":"10.1200\/JCO.2005.04.6813","article-title":"Phase I to II study of pleurectomy\/decortication and intraoperative intracavitary hyperthermic cisplatin lavage for mesothelioma","volume":"24","author":"Richards","year":"2006","journal-title":"J Clin Oncol"},{"issue":"4","key":"10.1016\/j.xjon.2024.07.024_bib5","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1093\/ejcts\/ezs418","article-title":"Cytoreductive surgery and hyperthermic intrathoracic chemotherapy perfusion for malignant pleural tumors: perioperative management and clinical experience","volume":"43","author":"Ried","year":"2013","journal-title":"Eur J Cardiothorac Surg"},{"issue":"6","key":"10.1016\/j.xjon.2024.07.024_bib6","doi-asserted-by":"crossref","first-page":"1156","DOI":"10.1200\/JCO.1994.12.6.1156","article-title":"A phase II trial of pleurectomy\/decortication followed by intrapleural and systemic chemotherapy for malignant pleural mesothelioma","volume":"12","author":"Rusch","year":"1994","journal-title":"J Clin Oncol"},{"issue":"2","key":"10.1016\/j.xjon.2024.07.024_bib7","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1016\/j.jtcvs.2009.02.046","article-title":"Extrapleural pneumonectomy followed by intracavitary intraoperative hyperthermic cisplatin with pharmacologic cytoprotection for treatment of malignant pleural mesothelioma: a phase II prospective study","volume":"138","author":"Tilleman","year":"2009","journal-title":"J Thorac Cardiovasc Surg"},{"issue":"2","key":"10.1016\/j.xjon.2024.07.024_bib8","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1245\/ASO.2003.03.022","article-title":"Cytoreductive surgery combined with intraoperative hyperthermic intrathoracic chemotherapy for stage I malignant pleural mesothelioma","volume":"10","author":"van Ruth","year":"2003","journal-title":"Ann Surg Oncol"},{"issue":"2","key":"10.1016\/j.xjon.2024.07.024_bib9","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1016\/j.jtcvs.2008.07.055","article-title":"A phase I study of extrapleural pneumonectomy and intracavitary intraoperative hyperthermic cisplatin with amifostine cytoprotection for malignant pleural mesothelioma","volume":"137","author":"Zellos","year":"2009","journal-title":"J Thorac Cardiovasc Surg"},{"issue":"3","key":"10.1016\/j.xjon.2024.07.024_bib10","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1016\/j.jtcvs.2005.08.012","article-title":"Intrapleural topical application of cisplatin with the surgical carrier Vivostat increases the local drug concentration in an immune-competent rat model with malignant pleuromesothelioma","volume":"131","author":"Lardinois","year":"2006","journal-title":"J Thorac Cardiovasc Surg"},{"issue":"1","key":"10.1016\/j.xjon.2024.07.024_bib11","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.jtcvs.2010.09.032","article-title":"Optimized intrapleural cisplatin chemotherapy with a fibrin carrier after extrapleural pneumonectomy: a preclinical study","volume":"141","author":"Opitz","year":"2011","journal-title":"J Thorac Cardiovasc Surg"},{"issue":"5","key":"10.1016\/j.xjon.2024.07.024_bib12","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1016\/j.ejcts.2007.01.047","article-title":"Local recurrence model of malignant pleural mesothelioma for investigation of intrapleural treatment","volume":"31","author":"Opitz","year":"2007","journal-title":"Eur J Cardiothorac Surg"},{"issue":"1","key":"10.1016\/j.xjon.2024.07.024_bib13","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1016\/j.jtcvs.2019.07.073","article-title":"Intracavitary cisplatin-fibrin chemotherapy after surgery for malignant pleural mesothelioma: a phase I trial","volume":"159","author":"Opitz","year":"2020","journal-title":"J Thorac Cardiovasc Surg"},{"issue":"5","key":"10.1016\/j.xjon.2024.07.024_bib14","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1158\/1541-7786.MCR-04-0032","article-title":"Cisplatin sensitizes cancer cells to ionizing radiation via inhibition of nonhomologous end joining","volume":"3","author":"Boeckman","year":"2005","journal-title":"Mol Cancer Res"},{"issue":"2","key":"10.1016\/j.xjon.2024.07.024_bib15","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1038\/ncponc0714","article-title":"The concurrent chemoradiation paradigm--general principles","volume":"4","author":"Seiwert","year":"2007","journal-title":"Nat Clin Pract Oncol"},{"issue":"2","key":"10.1016\/j.xjon.2024.07.024_bib16","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1016\/j.radonc.2014.04.001","article-title":"Cisplatin-mediated radiosensitization of non\u2013small cell lung cancer cells is stimulated by ATM inhibition","volume":"111","author":"Toulany","year":"2014","journal-title":"Radiother Oncol"},{"issue":"3","key":"10.1016\/j.xjon.2024.07.024_bib17","first-page":"448","article-title":"Characteristics of tumors and tumor cells cultured from experimental asbestos-induced mesotheliomas in rats","volume":"129","author":"Craighead","year":"1987","journal-title":"Am J Pathol"},{"issue":"3","key":"10.1016\/j.xjon.2024.07.024_bib18","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1016\/j.lungcan.2010.12.020","article-title":"Bioluminescence imaging for in\u00a0vivo monitoring of local recurrence mesothelioma model","volume":"71","author":"Shi","year":"2011","journal-title":"Lung Cancer"},{"issue":"1","key":"10.1016\/j.xjon.2024.07.024_bib19","doi-asserted-by":"crossref","first-page":"e34","DOI":"10.1093\/ejcts\/ezu393","article-title":"Evaluation of imaging techniques for the assessment of tumor progression in an orthotopic rat model of malignant pleural mesothelioma","volume":"47","author":"Meerang","year":"2015","journal-title":"Eur J Cardiothorac Surg"},{"issue":"9","key":"10.1016\/j.xjon.2024.07.024_bib20","doi-asserted-by":"crossref","first-page":"1413","DOI":"10.1200\/JCO.2008.17.5604","article-title":"Trimodality therapy with induction chemotherapy followed by extrapleural pneumonectomy and adjuvant high-dose hemithoracic radiation for malignant pleural mesothelioma","volume":"27","author":"de Perrot","year":"2009","journal-title":"J Clin Oncol"},{"issue":"5","key":"10.1016\/j.xjon.2024.07.024_bib21","doi-asserted-by":"crossref","first-page":"1685","DOI":"10.1016\/j.athoracsur.2007.04.076","article-title":"Outcomes after extrapleural pneumonectomy and intensity-modulated radiation therapy for malignant pleural mesothelioma","volume":"84","author":"Rice","year":"2007","journal-title":"Ann Thorac Surg"},{"issue":"6","key":"10.1016\/j.xjon.2024.07.024_bib22","doi-asserted-by":"crossref","first-page":"1362","DOI":"10.1183\/09031936.00039510","article-title":"Trimodality therapy for malignant pleural mesothelioma: results from an EORTC phase II multicentre trial","volume":"36","author":"Van Schil","year":"2010","journal-title":"Eur Respir J"},{"issue":"7","key":"10.1016\/j.xjon.2024.07.024_bib23","doi-asserted-by":"crossref","first-page":"1196","DOI":"10.1093\/annonc\/mdm093","article-title":"Multicenter trial of neo-adjuvant chemotherapy followed by extrapleural pneumonectomy in malignant pleural mesothelioma","volume":"18","author":"Weder","year":"2007","journal-title":"Ann Oncol"},{"issue":"3","key":"10.1016\/j.xjon.2024.07.024_bib24","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1016\/j.ijrobp.2015.06.029","article-title":"Radical radiation therapy after lung-sparing surgery for malignant pleural mesothelioma: survival, pattern of failure, and prognostic factors","volume":"93","author":"Minatel","year":"2015","journal-title":"Int J Radiat Oncol Biol Phys"},{"issue":"23","key":"10.1016\/j.xjon.2024.07.024_bib25","doi-asserted-by":"crossref","first-page":"2761","DOI":"10.1200\/JCO.2016.67.2675","article-title":"Phase II study of hemithoracic intensity-modulated pleural radiation therapy (IMPRINT) as part of lung-sparing multimodality therapy in patients with malignant pleural mesothelioma","volume":"34","author":"Rimner","year":"2016","journal-title":"J Clin Oncol"},{"issue":"2","key":"10.1016\/j.xjon.2024.07.024_bib26","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1016\/S1470-2045(20)30606-9","article-title":"Surgery for malignant pleural mesothelioma after radiotherapy (SMART): final results from a single-centre, phase 2 trial","volume":"22","author":"Cho","year":"2021","journal-title":"Lancet Oncol"},{"issue":"16","key":"10.1016\/j.xjon.2024.07.024_bib27","doi-asserted-by":"crossref","first-page":"1651","DOI":"10.1016\/S1470-2045(15)00208-9","article-title":"Neoadjuvant chemotherapy and extrapleural pneumonectomy of malignant pleural mesothelioma with or without hemithoracic radiotherapy (SAKK 17\/04): a randomised, international, multicentre phase 2 trial","volume":"16","author":"Stahel","year":"2015","journal-title":"Lancet Oncol"},{"issue":"11","key":"10.1016\/j.xjon.2024.07.024_bib28","doi-asserted-by":"crossref","first-page":"987","DOI":"10.1007\/s00066-014-0661-x","article-title":"Cisplatin- vs. oxaliplatin-based radiosensitizing chemotherapy for squamous cell carcinoma of the esophagus: a comparison of two preoperative radiochemotherapy regimens","volume":"190","author":"Fakhrian","year":"2014","journal-title":"Strahlenther Onkol"},{"issue":"3","key":"10.1016\/j.xjon.2024.07.024_bib29","first-page":"448","article-title":"Characteristics of tumors and tumor cells cultured from experimental asbestos-induced mesotheliomas in rats","volume":"129","author":"Craighead","year":"1987","journal-title":"Am J Pathol"},{"issue":"3","key":"10.1016\/j.xjon.2024.07.024_bib30","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1016\/j.lungcan.2010.12.020","article-title":"Bioluminescence imaging for in\u00a0vivo monitoring of local recurrence mesothelioma model","volume":"71","author":"Shi","year":"2011","journal-title":"Lung Cancer"},{"issue":"3","key":"10.1016\/j.xjon.2024.07.024_bib31","first-page":"319","article-title":"Body condition scoring: a rapid and accurate\u00a0method for assessing health status in mice","volume":"49","author":"Ullman-Culler\u00e9","year":"1999","journal-title":"Lab Anim Sci"}],"container-title":["JTCVS Open"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2666273624002419?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2666273624002419?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,8]],"date-time":"2025-11-08T21:36:35Z","timestamp":1762637795000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2666273624002419"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12]]},"references-count":31,"alternative-id":["S2666273624002419"],"URL":"https:\/\/doi.org\/10.1016\/j.xjon.2024.07.024","relation":{},"ISSN":["2666-2736"],"issn-type":[{"type":"print","value":"2666-2736"}],"subject":[],"published":{"date-parts":[[2024,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Intracavitary cisplatin-fibrin followed by irradiation improved tumor control compared to the single treatments in a mesothelioma rat model","name":"articletitle","label":"Article Title"},{"value":"JTCVS Open","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.xjon.2024.07.024","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Author(s). Published by Elsevier Inc. on behalf of The American Association for Thoracic Surgery.","name":"copyright","label":"Copyright"}]}}