{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,3]],"date-time":"2025-09-03T10:30:42Z","timestamp":1756895442758,"version":"3.40.4"},"reference-count":35,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,1,15]],"date-time":"2025-01-15T00:00:00Z","timestamp":1736899200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["P30CA016056"],"award-info":[{"award-number":["P30CA016056"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["jtcvsopen.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["JTCVS Open"],"published-print":{"date-parts":[[2025,4]]},"DOI":"10.1016\/j.xjon.2024.12.012","type":"journal-article","created":{"date-parts":[[2025,1,21]],"date-time":"2025-01-21T00:20:56Z","timestamp":1737418856000},"page":"484-495","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Preclinical experience with cisplatin, gemcitabine, and doxorubicin in pulmonary suffusion"],"prefix":"10.1016","volume":"24","author":[{"given":"Lindsay J.","family":"Nitsche","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leslie","family":"Curtin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sandra","family":"Sexton","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thaer","family":"Khoury","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joshua D.","family":"Prey","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sai","family":"Yendamuri","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4800-2297","authenticated-orcid":false,"given":"Todd L.","family":"Demmy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.xjon.2024.12.012_bib1","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1038\/s41571-023-00798-3","article-title":"The global burden of lung cancer: current status and future trends","volume":"20","author":"Leiter","year":"2023","journal-title":"Nat Rev Clin Oncol"},{"key":"10.1016\/j.xjon.2024.12.012_bib2","doi-asserted-by":"crossref","first-page":"209","DOI":"10.3322\/caac.21660","article-title":"Global Cancer Statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"71","author":"Sung","year":"2021","journal-title":"CA Cancer J Clin"},{"key":"10.1016\/j.xjon.2024.12.012_bib3","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/S0960-7404(03)00039-2","article-title":"Isolated lung perfusion for the treatment of pulmonary metastases current mini-review of work in progress","volume":"12","author":"Van Putte","year":"2003","journal-title":"Surg Oncol"},{"volume":"17","year":"2020","key":"10.1016\/j.xjon.2024.12.012_bib4"},{"key":"10.1016\/j.xjon.2024.12.012_bib5","doi-asserted-by":"crossref","first-page":"1314","DOI":"10.1111\/codi.15113","article-title":"Pulmonary metastasectomy in colorectal cancer: updated analysis of 93 randomized patients\u2014control survival is much better than previously assumed","volume":"22","author":"Milosevic","year":"2020","journal-title":"Colorectal Dis"},{"key":"10.1016\/j.xjon.2024.12.012_bib6","doi-asserted-by":"crossref","first-page":"21","DOI":"10.21037\/asj-21-54","article-title":"Lung metastases from hepatocellular carcinoma: multidisciplinary approach\u2014narrative review","volume":"2","author":"Comacchio","year":"2022","journal-title":"AME Surg J"},{"key":"10.1016\/j.xjon.2024.12.012_bib7","doi-asserted-by":"crossref","first-page":"1484","DOI":"10.1200\/JCO.2015.63.4543","article-title":"Detection of occult micrometastases in patients with clinical stage I non\u2013small-cell lung cancer: a prospective analysis of mature results of CALGB 9761 (Alliance)","volume":"34","author":"Martin","year":"2016","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.xjon.2024.12.012_bib8","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1136\/bmj.311.7010.899","article-title":"Chemotherapy in non\u2013small-cell lung cancer: a meta-analysis using updated data on individual patients from 52 randomised clinical trials. Non\u2013small-Cell Lung Cancer Collaborative Group","volume":"311","year":"1995","journal-title":"BMJ"},{"key":"10.1016\/j.xjon.2024.12.012_bib9","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.critrevonc.2007.12.002","article-title":"Identifying an optimum treatment strategy for patients with advanced non\u2013small-cell lung cancer","volume":"67","author":"Grossi","year":"2008","journal-title":"Crit Rev Oncol Hematol"},{"key":"10.1016\/j.xjon.2024.12.012_bib10","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2021.119527","article-title":"A comprehensive review on time-tested anticancer drug doxorubicin","volume":"278","author":"Sritharan","year":"2021","journal-title":"Life Sci"},{"key":"10.1016\/j.xjon.2024.12.012_bib11","doi-asserted-by":"crossref","first-page":"177","DOI":"10.4137\/CMO.S6252","article-title":"Gemcitabine: efficacy in the treatment of advanced stage nonsquamous non\u2013small-cell lung cancer","volume":"5","author":"Hayashi","year":"2011","journal-title":"Clin Med Insights Oncol"},{"key":"10.1016\/j.xjon.2024.12.012_bib12","doi-asserted-by":"crossref","first-page":"598","DOI":"10.1038\/bjc.1995.116","article-title":"Factors affecting platinum concentrations in human surgical tumour specimens after cisplatin","volume":"71","author":"Stewart","year":"1995","journal-title":"Br J Cancer"},{"key":"10.1016\/j.xjon.2024.12.012_bib13","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1200\/JCO.1999.17.1.150","volume":"17","author":"Van Glabbeke","year":"1999","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.xjon.2024.12.012_bib16","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1097\/imi.0b013e31820b1e63","article-title":"Regional lung chemotherapy techniques","volume":"6","author":"Mallick","year":"2011","journal-title":"Innovations (Phila)"},{"key":"10.1016\/j.xjon.2024.12.012_bib17","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/j.thorsurg.2015.09.013","article-title":"Thoracoscopic lung suffusion","volume":"26","author":"Demmy","year":"2016","journal-title":"Thorac Surg Clin"},{"key":"10.1016\/j.xjon.2024.12.012_bib18","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1016\/j.athoracsur.2009.04.101","article-title":"Thoracoscopic organ suffusion for regional lung chemotherapy (preliminary results)","volume":"88","author":"Demmy","year":"2009","journal-title":"Ann Thorac Surg"},{"first-page":"1","year":"2011","series-title":"Committee for the Update of the Guide for the Care and Use of Laboratory Animals, National Research Council of the National Academies. Guide for the Care and Use of Laboratory Animals","key":"10.1016\/j.xjon.2024.12.012_bib19"},{"key":"10.1016\/j.xjon.2024.12.012_bib20","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1007\/BF02256589","article-title":"Isolated lung chemotherapeutic infusions for treatment of pulmonary metastases: a pilot study","volume":"9","author":"Demmy","year":"2002","journal-title":"J Biomed Sci"},{"key":"10.1016\/j.xjon.2024.12.012_bib21","doi-asserted-by":"crossref","first-page":"3617","DOI":"10.1002\/rcm.2235","article-title":"Pharmacokinetic measurements of IDN 5390 using electrospray ionization tandem mass spectrometry: structure characterization and quantification in dog plasma","volume":"19","author":"Song","year":"2005","journal-title":"Rapid Commun Mass Spectrom"},{"key":"10.1016\/j.xjon.2024.12.012_bib22","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1177\/0192623320968181","article-title":"International harmonization of nomenclature and diagnostic Criteria (INHAND): nonproliferative and proliferative lesions of the dog","volume":"49","author":"Woicke","year":"2021","journal-title":"Toxicol Pathol"},{"key":"10.1016\/j.xjon.2024.12.012_bib23","unstructured":"Cypel M. In\u00a0vivo lung perfusion with oxaloplatin for patients with bilateral colorectal lung metastases: interim results of a clinical trial. Presented at International Thoracic Surgical Oncology Summit; September 28, 2024; New York, NY."},{"key":"10.1016\/j.xjon.2024.12.012_bib24","series-title":"Pharmacology and Therapeutics for Dentistry","first-page":"15","article-title":"Pharmacokinetics: the absorption, distribution, and fate of drugs","author":"Dowd","year":"2017"},{"key":"10.1016\/j.xjon.2024.12.012_bib25","doi-asserted-by":"crossref","first-page":"1320","DOI":"10.1002\/1097-0142(19880401)61:7<1320::AID-CNCR2820610708>3.0.CO;2-J","article-title":"Pulmonary toxicity of doxorubicin administered by in situ isolated lung perfusion in dogs","volume":"61","author":"Minchin","year":"1988","journal-title":"Cancer"},{"key":"10.1016\/j.xjon.2024.12.012_bib26","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1097\/00000658-195810000-00009","article-title":"Chemotherapy of cancer: regional perfusion utilizing an extracorporeal circuit","volume":"148","author":"Creech","year":"1958","journal-title":"Ann Surg"},{"key":"10.1016\/j.xjon.2024.12.012_bib27","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/S0022-5223(19)32665-0","article-title":"Lung perfusion with chemotherapeutic agents","volume":"39","author":"Pierpont","year":"1960","journal-title":"J Thorac Cardiovasc Surg"},{"key":"10.1016\/j.xjon.2024.12.012_bib28","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1177\/0267659106073984","article-title":"Isolated lung perfusion for pulmonary metastases, a review and work in progress","volume":"21","author":"Grootenboers","year":"2006","journal-title":"Perfusion"},{"key":"10.1016\/j.xjon.2024.12.012_bib29","doi-asserted-by":"crossref","first-page":"2244","DOI":"10.3390\/cancers15082244","article-title":"Innovative invasive loco-regional techniques for the treatment of lung cancer","volume":"15","author":"Claes","year":"2023","journal-title":"Cancers (Basel)"},{"key":"10.1016\/j.xjon.2024.12.012_bib30","doi-asserted-by":"crossref","first-page":"1542","DOI":"10.1016\/S0003-4975(00)01131-0","article-title":"Isolated lung perfusion for patients with unresectable metastases from sarcoma: a phase I trial","volume":"69","author":"Burt","year":"2000","journal-title":"Ann Thorac Surg"},{"key":"10.1016\/j.xjon.2024.12.012_bib31","doi-asserted-by":"crossref","first-page":"1919","DOI":"10.1016\/j.athoracsur.2004.05.058","article-title":"Isolated lung perfusion with melphalan for resectable lung metastases: a phase I clinical trial","volume":"78","author":"Hendriks","year":"2004","journal-title":"Ann Thorac Surg"},{"key":"10.1016\/j.xjon.2024.12.012_bib32","doi-asserted-by":"crossref","first-page":"1547","DOI":"10.1097\/JTO.0000000000000279","article-title":"Phase II multicenter clinical trial of pulmonary metastasectomy and isolated lung perfusion with melphalan in patients with resectable lung metastases","volume":"9","author":"den Hengst","year":"2014","journal-title":"J Thorac Oncol"},{"key":"10.1016\/j.xjon.2024.12.012_bib33","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.athoracsur.2019.02.071","article-title":"Multicenter phase II clinical trial of isolated lung perfusion in patients with lung metastases","volume":"108","author":"Beckers","year":"2019","journal-title":"Ann Thorac Surg"},{"key":"10.1016\/j.xjon.2024.12.012_bib34","doi-asserted-by":"crossref","first-page":"1626","DOI":"10.1016\/j.jtcvs.2020.03.033","article-title":"A model to assess acute and delayed lung toxicity of oxaliplatin during in\u00a0vivo lung perfusion","volume":"161","author":"Ramadan","year":"2021","journal-title":"J Thorac Cardiovasc Surg"},{"key":"10.1016\/j.xjon.2024.12.012_bib35","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.thorsurg.2015.09.008","article-title":"Isolated lung perfusion for pulmonary metastases","volume":"26","author":"Ward","year":"2016","journal-title":"Thorac Surg Clin"},{"key":"10.1016\/j.xjon.2024.12.012_bib36","doi-asserted-by":"crossref","first-page":"774","DOI":"10.1016\/j.jtcvs.2013.10.009","article-title":"Modified in\u00a0vivo lung perfusion allows for prolonged perfusion without acute lung injury","volume":"147","author":"dos Santos","year":"2014","journal-title":"J Thorac Cardiovasc Surg"},{"key":"10.1016\/j.xjon.2024.12.012_bib37","doi-asserted-by":"crossref","first-page":"8598","DOI":"10.3390\/ijms24108598","article-title":"The synergistic effect of interventional locoregional treatments and immunotherapy for the treatment of hepatocellular carcinoma","volume":"24","author":"Brandi","year":"2023","journal-title":"Int J Mol Sci"}],"container-title":["JTCVS Open"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2666273625000257?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2666273625000257?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,4,22]],"date-time":"2025-04-22T00:36:02Z","timestamp":1745282162000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2666273625000257"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4]]},"references-count":35,"alternative-id":["S2666273625000257"],"URL":"https:\/\/doi.org\/10.1016\/j.xjon.2024.12.012","relation":{},"ISSN":["2666-2736"],"issn-type":[{"type":"print","value":"2666-2736"}],"subject":[],"published":{"date-parts":[[2025,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Preclinical experience with cisplatin, gemcitabine, and doxorubicin in pulmonary suffusion","name":"articletitle","label":"Article Title"},{"value":"JTCVS Open","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.xjon.2024.12.012","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Author(s). Published by Elsevier Inc. on behalf of The American Association for Thoracic Surgery.","name":"copyright","label":"Copyright"}]}}