{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T07:07:33Z","timestamp":1793862453082,"version":"4.6.1"},"reference-count":32,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,4,22]],"date-time":"2025-04-22T00:00:00Z","timestamp":1745280000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100010551","name":"Texas Heart Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010551","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["T32HL139430"],"award-info":[{"award-number":["T32HL139430"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["jtcvsopen.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["JTCVS Open"],"published-print":{"date-parts":[[2025,6]]},"DOI":"10.1016\/j.xjon.2025.04.014","type":"journal-article","created":{"date-parts":[[2025,4,25]],"date-time":"2025-04-25T19:27:52Z","timestamp":1745609272000},"page":"280-293","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":7,"special_numbering":"C","title":["Association between timing of angiotensin II administration and outcomes in vasoplegia after cardiac surgery"],"prefix":"10.1016","volume":"25","author":[{"given":"Travis J.","family":"Miles","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael T.","family":"Guinn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Orlando R.","family":"Suero","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Todd K.","family":"Rosengart","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc R.","family":"Moon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph S.","family":"Coselli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ravi K.","family":"Ghanta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0803-8826","authenticated-orcid":false,"given":"Subhasis","family":"Chatterjee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.xjon.2025.04.014_bib1","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1186\/s13054-020-2743-8","article-title":"Vasoplegic syndrome following cardiothoracic surgery\u2014review of pathophysiology and update of treatment options","volume":"24","author":"Busse","year":"2020","journal-title":"Crit Care"},{"issue":"6","key":"10.1016\/j.xjon.2025.04.014_bib2","doi-asserted-by":"crossref","first-page":"838","DOI":"10.1093\/icvts\/ivy352","article-title":"Risk factors for vasoplegia after cardiac surgery: a meta-analysis","volume":"28","author":"Dayan","year":"2019","journal-title":"Interact Cardiovasc Thorac Surg"},{"issue":"1","key":"10.1016\/j.xjon.2025.04.014_bib3","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.ccc.2023.06.002","article-title":"Management of vasoplegic shock in the cardiovascular intensive care unit after cardiac surgery","volume":"40","author":"Suero","year":"2024","journal-title":"Crit Care Clin"},{"issue":"2","key":"10.1016\/j.xjon.2025.04.014_bib4","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1016\/j.chest.2017.12.021","article-title":"Management of refractory vasodilatory shock","volume":"154","author":"Jentzer","year":"2018","journal-title":"Chest"},{"issue":"5","key":"10.1016\/j.xjon.2025.04.014_bib5","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1056\/NEJMoa1704154","article-title":"Angiotensin II for the treatment of vasodilatory shock","volume":"377","author":"Khanna","year":"2017","journal-title":"N Engl J Med"},{"issue":"6","key":"10.1016\/j.xjon.2025.04.014_bib6","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1097\/CCM.0000000000003092","article-title":"Outcomes in patients with vasodilatory shock and renal replacement therapy treated with intravenous angiotensin II","volume":"46","author":"Tumlin","year":"2018","journal-title":"Crit Care Med"},{"key":"10.1016\/j.xjon.2025.04.014_bib7","first-page":"72","article-title":"Successful use of angiotensin II for vasoplegia after thoracoabdominal aortic aneurysm repair","volume":"4","author":"Chatterjee","year":"2020","journal-title":"J Thorac Cardiovasc Surg Tech"},{"issue":"4","key":"10.1016\/j.xjon.2025.04.014_bib8","doi-asserted-by":"crossref","first-page":"1407","DOI":"10.1016\/j.jtcvs.2021.02.097","article-title":"Evaluating the evidence for angiotensin II for the treatment of vasoplegia in critically ill cardiothoracic surgery patients","volume":"163","author":"Chow","year":"2022","journal-title":"J Thorac Cardiovasc Surg"},{"issue":"9","key":"10.1016\/j.xjon.2025.04.014_bib9","article-title":"Catecholamine-sparing effect of angiotensin II in an anephric patient with mixed shock after cardiac revascularization surgery: a case report","volume":"14","author":"Cutler","year":"2020","journal-title":"A A Pract"},{"issue":"9","key":"10.1016\/j.xjon.2025.04.014_bib10","doi-asserted-by":"crossref","first-page":"2756","DOI":"10.1053\/j.jvca.2020.07.087","article-title":"Angiotensin II for critically ill patients with shock after heart transplant","volume":"35","author":"Cutler","year":"2021","journal-title":"J Cardiothorac Vasc Anesth"},{"issue":"1","key":"10.1016\/j.xjon.2025.04.014_bib11","doi-asserted-by":"crossref","first-page":"e5","DOI":"10.1016\/j.athoracsur.2018.11.047","article-title":"Use of angiotensin II for post cardiopulmonary bypass vasoplegic syndrome","volume":"108","author":"Evans","year":"2019","journal-title":"Ann Thorac Surg"},{"issue":"11","key":"10.1016\/j.xjon.2025.04.014_bib12","doi-asserted-by":"crossref","first-page":"3080","DOI":"10.1053\/j.jvca.2019.03.004","article-title":"Synthetic human angiotensin II for postcardiopulmonary bypass vasoplegic shock","volume":"33","author":"Wieruszewski","year":"2019","journal-title":"J Cardiothorac Vasc Anesth"},{"issue":"1","key":"10.1016\/j.xjon.2025.04.014_bib13","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.athoracsur.2017.02.057","article-title":"Methylene blue for vasoplegic syndrome after cardiac operation: early administration improves survival","volume":"104","author":"Mehaffey","year":"2017","journal-title":"Ann Thorac Surg"},{"issue":"5","key":"10.1016\/j.xjon.2025.04.014_bib14","doi-asserted-by":"crossref","first-page":"1615","DOI":"10.1016\/j.athoracsur.2004.10.038","article-title":"Preoperative methylene blue administration in patients at high risk for vasoplegic syndrome during cardiac surgery","volume":"79","author":"Ozal","year":"2005","journal-title":"Ann Thorac Surg"},{"issue":"4 suppl","key":"10.1016\/j.xjon.2025.04.014_bib15","doi-asserted-by":"crossref","first-page":"S3","DOI":"10.1016\/j.athoracsur.2007.01.053","article-title":"Quality measurement in adult cardiac surgery: part 1\u2014conceptual framework and measure selection","volume":"83","author":"Shahian","year":"2007","journal-title":"Ann Thorac Surg"},{"issue":"3","key":"10.1016\/j.xjon.2025.04.014_bib16","doi-asserted-by":"crossref","first-page":"770","DOI":"10.1016\/j.athoracsur.2017.09.039","article-title":"Characterizing predictors and severity of vasoplegia syndrome after heart transplantation","volume":"105","author":"Chan","year":"2018","journal-title":"Ann Thorac Surg"},{"issue":"17","key":"10.1016\/j.xjon.2025.04.014_bib17","doi-asserted-by":"crossref","first-page":"1664","DOI":"10.1161\/CIRCULATIONAHA.108.814533","article-title":"Early on-cardiopulmonary bypass hypotension and other factors associated with vasoplegic syndrome","volume":"120","author":"Levin","year":"2009","journal-title":"Circulation"},{"issue":"1","key":"10.1016\/j.xjon.2025.04.014_bib18","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1186\/s13054-018-1995-z","article-title":"Angiotensin in critical care","volume":"22","author":"Hall","year":"2018","journal-title":"Crit Care"},{"issue":"1","key":"10.1016\/j.xjon.2025.04.014_bib19","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1186\/s13054-015-0802-3","article-title":"Angiotensin II in septic shock","volume":"19","author":"Correa","year":"2015","journal-title":"Crit Care"},{"issue":"1","key":"10.1016\/j.xjon.2025.04.014_bib20","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1053\/j.jvca.2020.08.001","article-title":"Treatment with angiotensin II is associated with rapid blood pressure response and vasopressor sparing in patients with vasoplegia after cardiac surgery: a post-hoc analysis of angiotensin II for the treatment of high-output shock (ATHOS-3) study","volume":"35","author":"Klijian","year":"2021","journal-title":"J Cardiothorac Vasc Anesth"},{"issue":"1","key":"10.1016\/j.xjon.2025.04.014_bib21","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1186\/s13054-018-2225-4","article-title":"Angiotensin in ECMO patients with refractory shock","volume":"22","author":"Ostermann","year":"2018","journal-title":"Crit Care"},{"issue":"3","key":"10.1016\/j.xjon.2025.04.014_bib22","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1016\/0888-6296(90)90046-I","article-title":"Low systemic vascular resistance during cardiac surgery: case reports, brief review, and management with angiotensin II","volume":"4","author":"Thaker","year":"1990","journal-title":"J Cardiothorac Anesth"},{"issue":"8","key":"10.1016\/j.xjon.2025.04.014_bib23","doi-asserted-by":"crossref","first-page":"2366","DOI":"10.1053\/j.jvca.2019.03.054","article-title":"Use of angiotensin II for vasoplegic shock in a combined heart and liver transplant recipient with systolic anterior motion physiology","volume":"33","author":"Wieruszewski","year":"2019","journal-title":"J Cardiothorac Vasc Anesth"},{"issue":"5","key":"10.1016\/j.xjon.2025.04.014_bib24","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1186\/s13054-014-0532-y","article-title":"Early versus delayed administration of norepinephrine in patients with septic shock","volume":"18","author":"Bai","year":"2014","journal-title":"Crit Care"},{"issue":"9","key":"10.1016\/j.xjon.2025.04.014_bib25","doi-asserted-by":"crossref","first-page":"1097","DOI":"10.1164\/rccm.201806-1034OC","article-title":"Early use of norepinephrine in septic shock resuscitation (CENSER): a randomized trial","volume":"199","author":"Permpikul","year":"2019","journal-title":"Am J Respir Crit Care Med"},{"issue":"5","key":"10.1016\/j.xjon.2025.04.014_bib26","doi-asserted-by":"crossref","DOI":"10.1016\/j.jacadv.2024.100916","article-title":"Predictors and impact of prolonged vasoplegia after continuous-flow left ventricular assist device implantation","volume":"3","author":"Lamba","year":"2024","journal-title":"JACC Adv"},{"issue":"9","key":"10.1016\/j.xjon.2025.04.014_bib27","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1056\/NEJMoa067373","article-title":"Vasopressin versus norepinephrine infusion in patients with septic shock","volume":"358","author":"Russell","year":"2008","journal-title":"N Engl J Med"},{"issue":"4","key":"10.1016\/j.xjon.2025.04.014_bib28","doi-asserted-by":"crossref","first-page":"614","DOI":"10.1097\/CCM.0000000000005317","article-title":"Association of catecholamine dose, lactate, and shock duration at vasopressin initiation with mortality in patients with septic shock","volume":"50","author":"Sacha","year":"2022","journal-title":"Crit Care Med"},{"issue":"2","key":"10.1016\/j.xjon.2025.04.014_bib29","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1016\/j.chest.2020.08.2074","article-title":"Angiotensin II infusion for shock: a multicenter study of postmarketing use","volume":"159","author":"Wieruszewski","year":"2021","journal-title":"Chest"},{"issue":"1","key":"10.1016\/j.xjon.2025.04.014_bib30","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1186\/s13054-022-03911-7","article-title":"Vasopressor choice and timing in vasodilatory shock","volume":"26","author":"Wieruszewski","year":"2022","journal-title":"Crit Care"},{"key":"10.1016\/j.xjon.2025.04.014_bib31","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/j.jcrc.2020.11.002","article-title":"Vasopressor dose equivalence: a scoping review and suggested formula","volume":"61","author":"Goradia","year":"2021","journal-title":"J Crit Care"},{"issue":"1","key":"10.1016\/j.xjon.2025.04.014_bib32","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/j.chest.2022.07.018","article-title":"The relationship between norepinephrine equivalent dose of vasopressors within 24 hours from the onset of septic shock and in-hospital mortality rate","volume":"163","author":"Sato","year":"2023","journal-title":"Chest"}],"container-title":["JTCVS Open"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2666273625001445?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2666273625001445?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,8]],"date-time":"2025-11-08T21:35:59Z","timestamp":1762637759000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2666273625001445"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6]]},"references-count":32,"alternative-id":["S2666273625001445"],"URL":"https:\/\/doi.org\/10.1016\/j.xjon.2025.04.014","relation":{},"ISSN":["2666-2736"],"issn-type":[{"value":"2666-2736","type":"print"}],"subject":[],"published":{"date-parts":[[2025,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Association between timing of angiotensin II administration and outcomes in vasoplegia after cardiac surgery","name":"articletitle","label":"Article Title"},{"value":"JTCVS Open","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.xjon.2025.04.014","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Author(s). Published by Elsevier Inc. on behalf of The American Association for Thoracic Surgery.","name":"copyright","label":"Copyright"}]}}