{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,23]],"date-time":"2026-02-23T18:17:47Z","timestamp":1771870667200,"version":"3.50.1"},"reference-count":35,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,11,25]],"date-time":"2025-11-25T00:00:00Z","timestamp":1764028800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000050","name":"National Heart Lung and Blood Institute","doi-asserted-by":"publisher","award":["1R56HL169501-01"],"award-info":[{"award-number":["1R56HL169501-01"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart Lung and Blood Institute","doi-asserted-by":"publisher","award":["T32HL160517"],"award-info":[{"award-number":["T32HL160517"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart Lung and Blood Institute","doi-asserted-by":"publisher","award":["1R01HL176640-01"],"award-info":[{"award-number":["1R01HL176640-01"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart Lung and Blood Institute","doi-asserted-by":"publisher","award":["R01HL128831"],"award-info":[{"award-number":["R01HL128831"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart Lung and Blood Institute","doi-asserted-by":"publisher","award":["1RO1HL127072-01A1"],"award-info":[{"award-number":["1RO1HL127072-01A1"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart Lung and Blood Institute","doi-asserted-by":"publisher","award":["R01HL46716"],"award-info":[{"award-number":["R01HL46716"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart Lung and Blood Institute","doi-asserted-by":"publisher","award":["RO1HL136347-04S1"],"award-info":[{"award-number":["RO1HL136347-04S1"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006418","name":"Brown University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006418","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["jtcvsopen.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["JTCVS Open"],"published-print":{"date-parts":[[2026,2]]},"DOI":"10.1016\/j.xjon.2025.10.039","type":"journal-article","created":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T16:19:53Z","timestamp":1764605993000},"page":"101541","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Uncontrolled hypertension contributes to vascular permeability after cardioplegic arrest and cardiopulmonary bypass"],"prefix":"10.1016","volume":"29","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-7581-0555","authenticated-orcid":false,"given":"Meghamsh","family":"Kanuparthy","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christopher R.","family":"Stone","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rishik","family":"Manthana","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Himanshu","family":"Kaushik","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kelsey C.","family":"Muir","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jad","family":"Hamze","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Afshin","family":"Ehsan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Neel","family":"Sodha","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun","family":"Feng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frank W.","family":"Sellke","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.xjon.2025.10.039_bib1","series-title":"StatPearls","first-page":"1","article-title":"Cardioplegia","author":"Carvajal","year":"2023"},{"key":"10.1016\/j.xjon.2025.10.039_bib2","doi-asserted-by":"crossref","DOI":"10.3389\/fsurg.2024.1224068","article-title":"Strategies to attenuate maladaptive inflammatory response associated with cardiopulmonary bypass","volume":"11","author":"Banerjee","year":"2024","journal-title":"Front Surg"},{"issue":"4","key":"10.1016\/j.xjon.2025.10.039_bib3","doi-asserted-by":"crossref","first-page":"1222","DOI":"10.1016\/0003-4975(96)00538-3","article-title":"Endothelial cell injury in cardiovascular surgery: the pathophysiology of vasomotor dysfunction","volume":"62","author":"Sellke","year":"1996","journal-title":"Ann Thorac Surg"},{"issue":"1","key":"10.1016\/j.xjon.2025.10.039_bib4","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1161\/CIRCRESAHA.116.306534","article-title":"Protein interactions at endothelial junctions and signaling mechanisms regulating endothelial permeability","volume":"120","author":"Komarova","year":"2017","journal-title":"Circ Res"},{"issue":"2","key":"10.1016\/j.xjon.2025.10.039_bib5","doi-asserted-by":"crossref","first-page":"409","DOI":"10.3390\/biomedicines13020409","article-title":"Microvascular dysfunction following cardioplegic arrest and cardiopulmonary bypass: impacts of diabetes and hypertension","volume":"13","author":"Kanuparthy","year":"2025","journal-title":"Biomedicines"},{"issue":"4","key":"10.1016\/j.xjon.2025.10.039_bib6","doi-asserted-by":"crossref","first-page":"292","DOI":"10.2174\/157016108785909779","article-title":"The cardiac microvasculature in hypertension, cardiac hypertrophy and diastolic heart failure","volume":"6","author":"Hoenig","year":"2008","journal-title":"Curr Vasc Pharmacol"},{"issue":"3","key":"10.1016\/j.xjon.2025.10.039_bib7","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1016\/j.surg.2016.08.057","article-title":"Effects of diabetes and cardiopulmonary bypass on expression of adherens junction proteins in human peripheral tissue","volume":"161","author":"Feng","year":"2017","journal-title":"Surgery"},{"issue":"2","key":"10.1016\/j.xjon.2025.10.039_bib8","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1016\/j.surg.2024.03.052","article-title":"Patients with uncontrolled hypertension subjected to cardiopulmonary bypass have altered coronary vasomotor responses to serotonin","volume":"176","author":"Harris","year":"2024","journal-title":"Surgery"},{"key":"10.1016\/j.xjon.2025.10.039_bib9","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/j.jss.2023.10.004","article-title":"Increased coronary contraction to thromboxane A2 in cardiac surgery patients with poorly controlled hypertension","volume":"294","author":"Sabe","year":"2024","journal-title":"J Surg Res"},{"issue":"6","key":"10.1016\/j.xjon.2025.10.039_bib10","doi-asserted-by":"crossref","first-page":"e256","DOI":"10.1016\/j.jtcvs.2022.07.022","article-title":"Poorly controlled hypertension is associated with increased coronary myogenic tone in patients undergoing cardiac surgery with cardiopulmonary bypass","volume":"165","author":"Sabe","year":"2023","journal-title":"J Thorac Cardiovasc Surg"},{"key":"10.1016\/j.xjon.2025.10.039_bib11","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.jss.2018.04.045","article-title":"Impaired coronary contraction to phenylephrine after cardioplegic arrest in diabetic patients","volume":"230","author":"Sellke","year":"2018","journal-title":"J Surg Res"},{"issue":"2","key":"10.1016\/j.xjon.2025.10.039_bib12","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1016\/j.surg.2018.03.007","article-title":"Decreased contractile response of peripheral arterioles to serotonin after CPB in patients with diabetes","volume":"164","author":"Sabe","year":"2018","journal-title":"Surgery"},{"issue":"6","key":"10.1016\/j.xjon.2025.10.039_bib13","doi-asserted-by":"crossref","first-page":"2098","DOI":"10.1016\/j.jtcvs.2018.05.090","article-title":"Enhanced coronary arteriolar contraction to vasopressin in patients with diabetes after cardiac surgery","volume":"156","author":"Sellke","year":"2018","journal-title":"J Thorac Cardiovasc Surg"},{"issue":"2","key":"10.1016\/j.xjon.2025.10.039_bib14","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1016\/j.ab.2004.02.049","article-title":"A high-affinity reversible protein stain for Western blots","volume":"329","author":"Antharavally","year":"2004","journal-title":"Anal Biochem"},{"issue":"1","key":"10.1016\/j.xjon.2025.10.039_bib15","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41598-017-17204-5","article-title":"QuPath: open source software for digital pathology image analysis","volume":"7","author":"Bankhead","year":"2017","journal-title":"Sci Rep"},{"issue":"1","key":"10.1016\/j.xjon.2025.10.039_bib16","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.mvr.2008.10.005","article-title":"Regulation of endothelial barrier function by reactive oxygen and nitrogen species","volume":"77","author":"Boueiz","year":"2009","journal-title":"Microvasc Res"},{"key":"10.1016\/j.xjon.2025.10.039_bib17","doi-asserted-by":"crossref","first-page":"472","DOI":"10.3389\/fphys.2020.00472","article-title":"Oxidative stress and microvessel barrier dysfunction","volume":"11","author":"He","year":"2020","journal-title":"Front Physiol"},{"issue":"s12","key":"10.1016\/j.xjon.2025.10.039_bib18","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1111\/j.1524-6175.2006.06032.x","article-title":"Nitric oxide in hypertension","volume":"8","author":"Hermann","year":"2006","journal-title":"J Clin Hypertens"},{"issue":"4","key":"10.1016\/j.xjon.2025.10.039_bib19","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1111\/j.1751-7176.2012.00606.x","article-title":"Impaired vasodilation in the pathogenesis of hypertension: focus on nitric oxide, endothelial-derived hyperpolarizing factors, and prostaglandins","volume":"14","author":"Giles","year":"2012","journal-title":"J Clin Hypertens"},{"issue":"7","key":"10.1016\/j.xjon.2025.10.039_bib20","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1016\/j.freeradbiomed.2010.12.018","article-title":"Pathogenetic role of eNOS uncoupling in cardiopulmonary disorders","volume":"50","author":"Gielis","year":"2011","journal-title":"Free Radic Biol Med"},{"issue":"2","key":"10.1016\/j.xjon.2025.10.039_bib21","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1124\/mol.63.2.325","article-title":"Akt-dependent phosphorylation of serine 1179 and mitogen-activated protein kinase kinase\/extracellular signal-regulated kinase 1\/2 cooperatively mediate activation of the endothelial nitric-oxide synthase by hydrogen peroxide","volume":"63","author":"Cai","year":"2003","journal-title":"Mol Pharmacol"},{"issue":"2","key":"10.1016\/j.xjon.2025.10.039_bib22","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/j.yjmcc.2006.05.023","article-title":"Regulation of endothelial and myocardial NO synthesis by multi-site eNOS phosphorylation","volume":"42","author":"Mount","year":"2007","journal-title":"J Mol Cell Cardiol"},{"issue":"4","key":"10.1016\/j.xjon.2025.10.039_bib23","doi-asserted-by":"crossref","first-page":"1085","DOI":"10.3390\/biomedicines11041085","article-title":"Nitric oxide in cardiac surgery: a review article","volume":"11","author":"Kamenshchikov","year":"2023","journal-title":"Biomedicines"},{"issue":"9","key":"10.1016\/j.xjon.2025.10.039_bib24","doi-asserted-by":"crossref","first-page":"3026","DOI":"10.3390\/jcm9093026","article-title":"ADMA: a key player in the relationship between vascular dysfunction and inflammation in atherosclerosis","volume":"9","author":"Dowsett","year":"2020","journal-title":"J Clin Med"},{"issue":"3","key":"10.1016\/j.xjon.2025.10.039_bib25","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1038\/ni.2825","article-title":"VE-cadherin phosphorylation decides: vascular permeability or diapedesis","volume":"15","author":"Sidib\u00e9","year":"2014","journal-title":"Nat Immunol"},{"issue":"2","key":"10.1016\/j.xjon.2025.10.039_bib26","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.tcm.2005.11.008","article-title":"Angiogenesis: the VE-cadherin switch","volume":"16","author":"Wallez","year":"2006","journal-title":"Trends Cardiovasc Med"},{"issue":"2","key":"10.1016\/j.xjon.2025.10.039_bib27","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1093\/cvr\/cvq086","article-title":"Role of GTPases in control of microvascular permeability","volume":"87","author":"Spindler","year":"2010","journal-title":"Cardiovasc Res"},{"issue":"1","key":"10.1016\/j.xjon.2025.10.039_bib28","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1113\/jphysiol.2001.013117","article-title":"Rho and rho kinase modulation of barrier properties: cultured endothelial cells and intact microvessels of rats and mice","volume":"539","author":"Adamson","year":"2002","journal-title":"J Physiol"},{"issue":"11","key":"10.1016\/j.xjon.2025.10.039_bib29","doi-asserted-by":"crossref","first-page":"2332","DOI":"10.1161\/ATVBAHA.107.152322","article-title":"Involvement of Rho kinase in endothelial barrier maintenance","volume":"27","author":"van Nieuw Amerongen","year":"2007","journal-title":"Arterioscler Thromb Vasc Biol"},{"issue":"3","key":"10.1016\/j.xjon.2025.10.039_bib30","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1080\/10739680600556944","article-title":"Rho and ROCK signaling in VEGF-induced microvascular endothelial hyperpermeability","volume":"13","author":"Sun","year":"2006","journal-title":"Microcirculation"},{"issue":"3","key":"10.1016\/j.xjon.2025.10.039_bib31","doi-asserted-by":"crossref","first-page":"716","DOI":"10.1002\/jcp.21819","article-title":"Role of Rac 1 and cAMP in endothelial barrier stabilization and thrombin-induced barrier breakdown","volume":"220","author":"Baumer","year":"2009","journal-title":"J Cell Physiol"},{"issue":"1","key":"10.1016\/j.xjon.2025.10.039_bib32","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/j.jtcvs.2008.12.024","article-title":"Increased vascular permeability after cardiopulmonary bypass in patients with diabetes is associated with increased expression of vascular endothelial growth factor and hepatocyte growth factor","volume":"138","author":"Emani","year":"2009","journal-title":"J Thorac Cardiovasc Surg"},{"issue":"1","key":"10.1016\/j.xjon.2025.10.039_bib33","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1080\/14628840500480449","article-title":"Systemic VEGF levels after coronary artery bypass graft surgery reflects the extent of inflammatory response","volume":"8","author":"Kusumanto","year":"2006","journal-title":"Acute Card Care"},{"issue":"3","key":"10.1016\/j.xjon.2025.10.039_bib34","doi-asserted-by":"crossref","first-page":"C695","DOI":"10.1152\/ajpcell.00322.2010","article-title":"Regulation of VEGF-induced endothelial cell migration by mitochondrial reactive oxygen species","volume":"301","author":"Wang","year":"2011","journal-title":"Am J Physiol Cell Physiol"},{"issue":"38","key":"10.1016\/j.xjon.2025.10.039_bib35","doi-asserted-by":"crossref","first-page":"25602","DOI":"10.1074\/jbc.M109.009894","article-title":"The regulation of vascular endothelial growth factor-induced microvascular permeability requires rac and reactive oxygen species","volume":"284","author":"Monaghan-Benson","year":"2009","journal-title":"J Biol Chem"}],"container-title":["JTCVS Open"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2666273625004334?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2666273625004334?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,2,23]],"date-time":"2026-02-23T17:31:03Z","timestamp":1771867863000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2666273625004334"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2]]},"references-count":35,"alternative-id":["S2666273625004334"],"URL":"https:\/\/doi.org\/10.1016\/j.xjon.2025.10.039","relation":{},"ISSN":["2666-2736"],"issn-type":[{"value":"2666-2736","type":"print"}],"subject":[],"published":{"date-parts":[[2026,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Uncontrolled hypertension contributes to vascular permeability after cardioplegic arrest and cardiopulmonary bypass","name":"articletitle","label":"Article Title"},{"value":"JTCVS Open","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.xjon.2025.10.039","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Author(s). Published by Elsevier Inc. on behalf of The American Association for Thoracic Surgery.","name":"copyright","label":"Copyright"}],"article-number":"101541"}}