{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T22:34:01Z","timestamp":1793226841334,"version":"4.5.0"},"reference-count":38,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,4,14]],"date-time":"2026-04-14T00:00:00Z","timestamp":1776124800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000050","name":"National Heart Lung and Blood Institute","doi-asserted-by":"publisher","award":["T32HL139430"],"award-info":[{"award-number":["T32HL139430"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart Lung and Blood Institute","doi-asserted-by":"publisher","award":["R01HL176883"],"award-info":[{"award-number":["R01HL176883"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.jp","jtcvsopen.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["JTCVS Open"],"published-print":{"date-parts":[[2026,8]]},"DOI":"10.1016\/j.xjon.2026.101826","type":"journal-article","created":{"date-parts":[[2026,4,20]],"date-time":"2026-04-20T07:53:14Z","timestamp":1776671594000},"page":"101826","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Predicting acute kidney injury in adults after cardiac surgery with a novel clinical metric: The cardiac diuretic-responsiveness index"],"prefix":"10.1016","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7891-8765","authenticated-orcid":false,"given":"Michael Tyler","family":"Guinn","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Travis J.","family":"Miles","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel T.","family":"Engelman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc R.","family":"Moon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph S.","family":"Coselli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Todd K.","family":"Rosengart","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Subhasis","family":"Chatterjee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ravi K.","family":"Ghanta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"2","key":"10.1016\/j.xjon.2026.101826_bib1","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1016\/j.athoracsur.2005.07.047","article-title":"Acute renal failure after cardiac surgery: evaluation of the RIFLE classification","volume":"81","author":"Kuitunen","year":"2006","journal-title":"Ann Thorac Surg"},{"issue":"4","key":"10.1016\/j.xjon.2026.101826_bib2","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1016\/j.jcrc.2012.12.008","article-title":"Acute kidney injury after cardiac surgery according to risk\/injury\/failure\/loss\/end-stage, acute kidney injury network, and kidney disease: improving global outcomes classifications","volume":"28","author":"Bastin","year":"2013","journal-title":"J Crit Care"},{"issue":"11","key":"10.1016\/j.xjon.2026.101826_bib3","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.118.008834","article-title":"Cardiac and vascular surgery-associated acute kidney injury: the 20th international consensus conference of the ADQI (Acute Disease Quality Initiative) Group","volume":"7","author":"Nadim","year":"2018","journal-title":"J Am Heart Assoc"},{"issue":"1","key":"10.1016\/j.xjon.2026.101826_bib4","doi-asserted-by":"crossref","first-page":"19","DOI":"10.2215\/CJN.00240605","article-title":"Acute kidney injury associated with cardiac surgery","volume":"1","author":"Rosner","year":"2006","journal-title":"Clin J Am Soc Nephrol"},{"issue":"3","key":"10.1016\/j.xjon.2026.101826_bib5","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1016\/j.kint.2017.02.021","article-title":"Cardiac surgery in patients with congenital heart disease is associated with acute kidney injury and the risk of chronic kidney disease","volume":"92","author":"Madsen","year":"2017","journal-title":"Kidney Int"},{"issue":"3","key":"10.1016\/j.xjon.2026.101826_bib6","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1016\/j.athoracsur.2014.05.008","article-title":"Clinical impact of mild acute kidney injury after cardiac surgery","volume":"98","author":"Elmistekawy","year":"2014","journal-title":"Ann Thorac Surg"},{"issue":"6","key":"10.1016\/j.xjon.2026.101826_bib7","doi-asserted-by":"crossref","first-page":"1970","DOI":"10.1093\/ndt\/gfm908","article-title":"Costs and outcomes of acute kidney injury (AKI) following cardiac surgery","volume":"23","author":"Dasta","year":"2008","journal-title":"Nephrol Dial Transplant"},{"issue":"18","key":"10.1016\/j.xjon.2026.101826_bib8","doi-asserted-by":"crossref","first-page":"2444","DOI":"10.1161\/CIRCULATIONAHA.108.800011","article-title":"Acute kidney injury is associated with increased long-term mortality after cardiothoracic surgery","volume":"119","author":"Hobson","year":"2009","journal-title":"Circulation"},{"issue":"4","key":"10.1016\/j.xjon.2026.101826_bib9","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1016\/j.ccc.2020.07.002","article-title":"Prevention of acute kidney injury","volume":"36","author":"Kullmar","year":"2020","journal-title":"Crit Care Clin"},{"issue":"5","key":"10.1016\/j.xjon.2026.101826_bib10","doi-asserted-by":"crossref","first-page":"R207","DOI":"10.1186\/cc13015","article-title":"Development and standardization of a furosemide stress test to predict the severity of acute kidney injury","volume":"17","author":"Chawla","year":"2013","journal-title":"Crit Care"},{"issue":"6","key":"10.1016\/j.xjon.2026.101826_bib11","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1007\/s40620-019-00614-1","article-title":"Furosemide as a functional marker of acute kidney injury in ICU patients: a new role for an old drug","volume":"32","author":"Mariano","year":"2019","journal-title":"J Nephrol"},{"issue":"1","key":"10.1016\/j.xjon.2026.101826_bib12","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1186\/s13054-020-02912-8","article-title":"Furosemide stress test as a predictive marker of acute kidney injury progression or renal replacement therapy: a systemic review and meta-analysis","volume":"24","author":"Chen","year":"2020","journal-title":"Crit Care"},{"issue":"4","key":"10.1016\/j.xjon.2026.101826_bib13","doi-asserted-by":"crossref","first-page":"1388","DOI":"10.1016\/j.athoracsur.2017.03.015","article-title":"Lack of furosemide responsiveness predicts acute kidney injury in infants after cardiac surgery","volume":"104","author":"Kakajiwala","year":"2017","journal-title":"Ann Thorac Surg"},{"issue":"6","key":"10.1016\/j.xjon.2026.101826_bib14","doi-asserted-by":"crossref","first-page":"2444","DOI":"10.1016\/j.jtcvs.2018.12.076","article-title":"Furosemide response predicts acute kidney injury in children after cardiac surgery","volume":"157","author":"Penk","year":"2019","journal-title":"J Thorac Cardiovasc Surg"},{"issue":"2","key":"10.1016\/j.xjon.2026.101826_bib15","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1016\/j.athoracsur.2023.07.011","article-title":"Furosemide responsiveness predicts acute kidney injury progression after cardiac surgery","volume":"117","author":"Su","year":"2024","journal-title":"Ann Thorac Surg"},{"issue":"1","key":"10.1016\/j.xjon.2026.101826_bib16","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1186\/s13613-024-01387-y","article-title":"Modified furosemide responsiveness index and biomarkers for AKI progression and prognosis: a prospective observational study","volume":"14","author":"Su","year":"2024","journal-title":"Ann Intensive Care"},{"issue":"4","key":"10.1016\/j.xjon.2026.101826_bib17","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1016\/j.athoracsur.2025.02.022","article-title":"A novel clinical risk score to predict vasoplegia after adult cardiac surgery","volume":"120","author":"Miles","year":"2025","journal-title":"Ann Thorac Surg"},{"key":"10.1016\/j.xjon.2026.101826_bib18","first-page":"280","article-title":"Association between timing of angiotensin II administration and outcomes in vasoplegia after cardiac surgery","volume":"25","author":"Miles","year":"2025","journal-title":"J Thorac Cardiovasc Surg Open"},{"issue":"2","key":"10.1016\/j.xjon.2026.101826_bib19","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1016\/j.jtcvs.2025.07.009","article-title":"Tissue perfusion pressure: a novel hemodynamic measure to assess risk of acute kidney injury after cardiac surgery","volume":"171","author":"Miles","year":"2026","journal-title":"J Thorac Cardiovasc Surg"},{"issue":"2","key":"10.1016\/j.xjon.2026.101826_bib20","first-page":"85","article-title":"Acute kidney injury: definition, pathophysiology and clinical phenotypes","volume":"37","author":"Makris","year":"2016","journal-title":"Clin Biochem Rev"},{"key":"10.1016\/j.xjon.2026.101826_bib21","doi-asserted-by":"crossref","DOI":"10.1155\/2019\/9810675","article-title":"Segmented linear regression models for assessing change in retrospective studies in healthcare","volume":"2019","author":"Valsamis","year":"2019","journal-title":"Comput Math Methods Med"},{"key":"10.1016\/j.xjon.2026.101826_bib22","doi-asserted-by":"crossref","DOI":"10.1038\/sdata.2016.35","article-title":"MIMIC-III, a freely accessible critical care database","volume":"3","author":"Johnson","year":"2016","journal-title":"Sci Data"},{"issue":"8","key":"10.1016\/j.xjon.2026.101826_bib23","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1056\/NEJMoa2403769","article-title":"A randomized trial of intravenous amino acids for kidney protection","volume":"391","author":"Landoni","year":"2024","journal-title":"N Engl J Med"},{"issue":"12","key":"10.1016\/j.xjon.2026.101826_bib24","doi-asserted-by":"crossref","first-page":"3076","DOI":"10.1053\/j.jvca.2024.08.033","article-title":"Amino acid infusion for perioperative functional renal protection: a meta-analysis","volume":"38","author":"Pruna","year":"2024","journal-title":"J Cardiothorac Vasc Anesth"},{"issue":"7","key":"10.1016\/j.xjon.2026.101826_bib25","doi-asserted-by":"crossref","first-page":"1","DOI":"10.22514\/sv.2024.079","article-title":"The renal effects of amino acids infusion","volume":"20","author":"Losiggio","year":"2024","journal-title":"Signa Vitae"},{"issue":"2","key":"10.1016\/j.xjon.2026.101826_bib26","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1016\/j.athoracsur.2024.11.020","article-title":"Intravenous amino-acid infusion to prevent acute kidney injury after cardiac surgery: a review of the evidence","volume":"120","author":"Losiggio","year":"2025","journal-title":"Ann Thorac Surg"},{"issue":"11","key":"10.1016\/j.xjon.2026.101826_bib27","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1038\/nrneph.2017.119","article-title":"Cardiac surgery-associated acute kidney injury: risk factors, pathophysiology and treatment","volume":"13","author":"Wang","year":"2017","journal-title":"Nat Rev Nephrol"},{"issue":"21","key":"10.1016\/j.xjon.2026.101826_bib28","doi-asserted-by":"crossref","first-page":"2208","DOI":"10.1161\/CIRCULATIONAHA.106.635573","article-title":"Bedside tool for predicting the risk of postoperative dialysis in patients undergoing cardiac surgery","volume":"114","author":"Mehta","year":"2006","journal-title":"Circulation"},{"issue":"16","key":"10.1016\/j.xjon.2026.101826_bib29","doi-asserted-by":"crossref","first-page":"1801","DOI":"10.1001\/jama.297.16.1801","article-title":"Derivation and validation of a simplified predictive index for renal replacement therapy after cardiac surgery","volume":"297","author":"Wijeysundera","year":"2007","journal-title":"JAMA"},{"issue":"1","key":"10.1016\/j.xjon.2026.101826_bib30","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1681\/ASN.2004040331","article-title":"A clinical score to predict acute renal failure after cardiac surgery","volume":"16","author":"Thakar","year":"2005","journal-title":"J Am Soc Nephrol"},{"issue":"2","key":"10.1016\/j.xjon.2026.101826_bib31","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1016\/j.athoracsur.2011.09.073","article-title":"Risk factors for perioperative acute kidney injury after adult cardiac surgery: role of perioperative management","volume":"93","author":"Parolari","year":"2012","journal-title":"Ann Thorac Surg"},{"key":"10.1016\/j.xjon.2026.101826_bib32","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1016\/j.jcrc.2021.10.015","article-title":"Prediction of cardiac surgery associated\u2013acute kidney injury (CSA-AKI) by healthcare professionals and urine cell cycle arrest AKI biomarkers [TIMP-2]\u2217[IGFBP7]: a single center prospective study (the PREDICTAKI trial)","volume":"67","author":"Vandenberghe","year":"2022","journal-title":"J Crit Care"},{"issue":"11","key":"10.1016\/j.xjon.2026.101826_bib33","doi-asserted-by":"crossref","first-page":"1020","DOI":"10.1038\/ki.2010.25","article-title":"Early intervention with erythropoietin does not affect the outcome of acute kidney injury (the EARLYARF trial)","volume":"77","author":"Endre","year":"2010","journal-title":"Kidney Int"},{"issue":"8","key":"10.1016\/j.xjon.2026.101826_bib34","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1001\/jamasurg.2019.1153","article-title":"Guidelines for perioperative care in cardiac surgery: enhanced recovery after surgery society recommendations","volume":"154","author":"Engelman","year":"2019","journal-title":"JAMA Surg"},{"issue":"6","key":"10.1016\/j.xjon.2026.101826_bib35","doi-asserted-by":"crossref","first-page":"e551","DOI":"10.1016\/j.jtcvs.2022.09.045","article-title":"Machine learning for dynamic and early prediction of acute kidney injury after cardiac surgery","volume":"166","author":"Ryan","year":"2023","journal-title":"J Thorac Cardiovasc Surg"},{"issue":"4","key":"10.1016\/j.xjon.2026.101826_bib36","doi-asserted-by":"crossref","first-page":"2644","DOI":"10.21037\/jtd-23-1659","article-title":"Machine learning in cardiac surgery: a narrative review","volume":"16","author":"Miles","year":"2024","journal-title":"J Thorac Dis"},{"issue":"5","key":"10.1016\/j.xjon.2026.101826_bib37","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0217911","article-title":"Patterns of diuretic use in the intensive care unit","volume":"14","author":"McCoy","year":"2019","journal-title":"PLoS One"},{"key":"10.1016\/j.xjon.2026.101826_bib38","doi-asserted-by":"crossref","first-page":"17","DOI":"10.21037\/asj-23-29","article-title":"Optimal diuretic dosing strategies following cardiac surgery: a retrospective cohort study","volume":"4","author":"O\u2019Connell","year":"2024","journal-title":"AME Surg J"}],"container-title":["JTCVS Open"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2666273626002494?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2666273626002494?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T22:15:38Z","timestamp":1793225738000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2666273626002494"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8]]},"references-count":38,"alternative-id":["S2666273626002494"],"URL":"https:\/\/doi.org\/10.1016\/j.xjon.2026.101826","relation":{},"ISSN":["2666-2736"],"issn-type":[{"value":"2666-2736","type":"print"}],"subject":[],"published":{"date-parts":[[2026,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Predicting acute kidney injury in adults after cardiac surgery with a novel clinical metric: The cardiac diuretic-responsiveness index","name":"articletitle","label":"Article Title"},{"value":"JTCVS Open","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.xjon.2026.101826","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Author(s). Published by Elsevier Inc. on behalf of The American Association for Thoracic Surgery.","name":"copyright","label":"Copyright"}],"article-number":"101826"}}