{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T01:16:35Z","timestamp":1793754995586,"version":"4.6.1"},"reference-count":37,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T00:00:00Z","timestamp":1780963200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100017712","name":"Ganzhou City Bureau of Science and Technology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100017712","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004479","name":"Jiangxi Provincial Natural Science Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004479","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","jtcvsstructural.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["JTCVS Structural and Endovascular"],"published-print":{"date-parts":[[2026,9]]},"DOI":"10.1016\/j.xjse.2026.100132","type":"journal-article","created":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T00:14:00Z","timestamp":1781828040000},"page":"100132","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Prognostic value of endothelial activation and stress index (EASIX) on short-term and long-term outcomes in type B aortic dissection after thoracic endovascular repair: An observational study"],"prefix":"10.1016","volume":"11","author":[{"given":"Xiaosi","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dongqin","family":"Cai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nianjin","family":"Xie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Songyuan","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3220-1280","authenticated-orcid":false,"given":"Jianfang","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"36","key":"10.1016\/j.xjse.2026.100132_bib1","doi-asserted-by":"crossref","first-page":"3538","DOI":"10.1093\/eurheartj\/ehae179","article-title":"2024 ESC guidelines for the management of peripheral arterial and aortic diseases","volume":"45","author":"Mazzolai","year":"2024","journal-title":"Eur Heart J"},{"issue":"8","key":"10.1016\/j.xjse.2026.100132_bib2","doi-asserted-by":"crossref","first-page":"748","DOI":"10.1161\/CIRCULATIONAHA.115.015302","article-title":"Outcomes of patients with acute type B (DeBakey III) aortic dissection: a 13-year, single-center experience","volume":"132","author":"Afifi","year":"2015","journal-title":"Circulation"},{"issue":"6","key":"10.1016\/j.xjse.2026.100132_bib3","doi-asserted-by":"crossref","first-page":"816","DOI":"10.1161\/01.CIR.0000154569.08857.7A","article-title":"Thoracic and abdominal aortic aneurysms","volume":"111","author":"Isselbacher","year":"2005","journal-title":"Circulation"},{"issue":"3","key":"10.1016\/j.xjse.2026.100132_bib4","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/j.carpath.2016.03.002","article-title":"Consensus statement on surgical pathology of the aorta from the Society for Cardiovascular Pathology and the Association for European Cardiovascular Pathology: II. Noninflammatory degenerative diseases\u2014nomenclature and diagnostic criteria","volume":"25","author":"Halushka","year":"2016","journal-title":"Cardiovasc Pathol"},{"issue":"3","key":"10.1016\/j.xjse.2026.100132_bib5","first-page":"219","article-title":"The inflammatory response to stent grafting of the thoracic aorta","volume":"26","author":"\u00d8deg\u00e5rd","year":"2007","journal-title":"Int Angiol"},{"key":"10.1016\/j.xjse.2026.100132_bib6","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijcard.2024.132494","article-title":"Exploring hemodynamic mechanisms and re-intervention strategies for partial false lumen thrombosis in Stanford type B aortic dissection after thoracic aortic endovascular repair","volume":"417","author":"Wang","year":"2024","journal-title":"Int J Cardiol"},{"issue":"11","key":"10.1016\/j.xjse.2026.100132_bib7","doi-asserted-by":"crossref","first-page":"5635","DOI":"10.3390\/ijms22115635","article-title":"Investigation of wall shear stress in cardiovascular research and in clinical practice-from bench to bedside","volume":"22","author":"Urschel","year":"2021","journal-title":"Int J Mol Sci"},{"issue":"3","key":"10.1016\/j.xjse.2026.100132_bib8","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1038\/s41409-019-0703-1","article-title":"EASIX and mortality after allogeneic stem cell transplantation","volume":"55","author":"Luft","year":"2020","journal-title":"Bone Marrow Transplant"},{"issue":"18","key":"10.1016\/j.xjse.2026.100132_bib9","doi-asserted-by":"crossref","first-page":"5374","DOI":"10.1182\/bloodadvances.2022008617","article-title":"EASIX-1 year and late mortality after allogeneic stem cell transplantation","volume":"7","author":"Kordelas","year":"2023","journal-title":"Blood Adv"},{"issue":"9","key":"10.1016\/j.xjse.2026.100132_bib10","doi-asserted-by":"crossref","first-page":"1165","DOI":"10.7150\/ijms.85870","article-title":"Association between endothelial activation and stress index and 28-day mortality in septic ICU patients: a retrospective cohort study","volume":"20","author":"Xu","year":"2023","journal-title":"Int J Med Sci"},{"issue":"1","key":"10.1016\/j.xjse.2026.100132_bib11","article-title":"Endothelial activation and stress index is a reliable predictor for the prevalence and mortality outcomes of stroke","volume":"15","author":"Huang","year":"2025","journal-title":"Sci Rep"},{"issue":"8","key":"10.1016\/j.xjse.2026.100132_bib12","doi-asserted-by":"crossref","first-page":"1008","DOI":"10.1007\/s00392-024-02534-y","article-title":"EASIX (endothelial activation and stress index) predicts mortality in patients with coronary artery disease","volume":"114","author":"Finke","year":"2025","journal-title":"Clin Res Cardiol"},{"issue":"1","key":"10.1016\/j.xjse.2026.100132_bib13","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1186\/s12872-024-04353-5","article-title":"Association between endothelial activation and stress index and 30-day mortality risk in acute myocardial infarction patients: a study based on the medical information mart for intensive care-IV database","volume":"24","author":"Sang","year":"2024","journal-title":"BMC Cardiovasc Disord"},{"issue":"4","key":"10.1016\/j.xjse.2026.100132_bib14","doi-asserted-by":"crossref","DOI":"10.1111\/jch.70057","article-title":"Endothelial activation and stress index predicts all-cause and cardiovascular mortality in hypertensive individuals: a nationwide study","volume":"27","author":"Dong","year":"2025","journal-title":"J Clin Hypertens (Greenwich)"},{"issue":"11","key":"10.1016\/j.xjse.2026.100132_bib15","doi-asserted-by":"crossref","first-page":"1585","DOI":"10.1007\/s00392-025-02715-3","article-title":"EASIX as a predictor of 3-year mortality in aortic stenosis patients undergoing TAVR","volume":"114","author":"Mousa Basha","year":"2025","journal-title":"Clin Res Cardiol"},{"issue":"2","key":"10.1016\/j.xjse.2026.100132_bib16","doi-asserted-by":"crossref","DOI":"10.1093\/ejcts\/ezad426","article-title":"EACTS\/STS guidelines for diagnosing and treating acute and chronic syndromes of the aortic organ","volume":"65","author":"Czerny","year":"2024","journal-title":"Eur J Cardiothorac Surg"},{"issue":"4","key":"10.1016\/j.xjse.2026.100132_bib17","doi-asserted-by":"crossref","first-page":"620","DOI":"10.1161\/CIRCRESAHA.115.306301","article-title":"Endothelial cell dysfunction and the pathobiology of atherosclerosis","volume":"118","author":"Gimbrone","year":"2016","journal-title":"Circ Res"},{"issue":"1","key":"10.1016\/j.xjse.2026.100132_bib18","doi-asserted-by":"crossref","first-page":"42","DOI":"10.2174\/157016112798829823","article-title":"Hypertension and endothelial dysfunction: therapeutic approach","volume":"10","author":"Ghiadoni","year":"2012","journal-title":"Curr Vasc Pharmacol"},{"issue":"2","key":"10.1016\/j.xjse.2026.100132_bib19","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1042\/CS20200573","article-title":"Sepsis plasma-derived exosomal miR-1-3p induces endothelial cell dysfunction by targeting SERP1","volume":"135","author":"Gao","year":"2021","journal-title":"Clin Sci (Lond)"},{"key":"10.1016\/j.xjse.2026.100132_bib20","doi-asserted-by":"crossref","DOI":"10.1155\/2022\/1131235","article-title":"Serum lactate dehydrogenase is a sensitive predictor of systemic complications of acute pancreatitis","volume":"2022","author":"Huang","year":"2022","journal-title":"Gastroenterol Res Pract"},{"issue":"5","key":"10.1016\/j.xjse.2026.100132_bib21","doi-asserted-by":"crossref","first-page":"682","DOI":"10.3390\/antiox10050682","article-title":"Hydrogen sulfide attenuates aortic remodeling in aortic dissection associating with moderated inflammation and oxidative stress through a NO-dependent pathway","volume":"10","author":"Lu","year":"2021","journal-title":"Antioxidants (Basel)"},{"key":"10.1016\/j.xjse.2026.100132_bib22","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2019.108704","article-title":"Shikonin attenuates acetaminophen-induced acute liver injury via inhibition of oxidative stress and inflammation","volume":"112","author":"Guo","year":"2019","journal-title":"Biomed Pharmacother"},{"key":"10.1016\/j.xjse.2026.100132_bib23","doi-asserted-by":"crossref","DOI":"10.1155\/2020\/1347165","article-title":"Association of lactate dehydrogenase with in-hospital mortality in patients with acute aortic dissection: a retrospective observational study","volume":"2020","author":"He","year":"2020","journal-title":"Int J Hypertens"},{"issue":"2","key":"10.1016\/j.xjse.2026.100132_bib24","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1111\/j.1523-1755.2004.761_5.x","article-title":"Endothelial injury and dysfunction: role in the extension phase of acute renal failure","volume":"66","author":"Molitoris","year":"2004","journal-title":"Kidney Int"},{"issue":"4","key":"10.1016\/j.xjse.2026.100132_bib25","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1038\/ajh.2009.5","article-title":"Determinants of long-term mortality in patients with type B acute aortic dissection","volume":"22","author":"Sakakura","year":"2009","journal-title":"Am J Hypertens"},{"issue":"10","key":"10.1016\/j.xjse.2026.100132_bib26","doi-asserted-by":"crossref","first-page":"2968","DOI":"10.3390\/ijms19102968","article-title":"The main determinants of diabetes mellitus vascular complications: endothelial dysfunction and platelet hyperaggregation","volume":"19","author":"Carrizzo","year":"2018","journal-title":"Int J Mol Sci"},{"issue":"21","key":"10.1016\/j.xjse.2026.100132_bib27","doi-asserted-by":"crossref","first-page":"3253","DOI":"10.1182\/blood-2014-09-600411","article-title":"Eculizumab reduces complement activation, inflammation, endothelial damage, thrombosis, and renal injury markers in aHUS","volume":"125","author":"Cofiell","year":"2015","journal-title":"Blood"},{"issue":"1","key":"10.1016\/j.xjse.2026.100132_bib28","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1080\/09537104.2020.1847266","article-title":"Association between platelet counts and morbidity and mortality after endovascular repair for type B aortic dissection","volume":"33","author":"Xie","year":"2022","journal-title":"Platelets"},{"issue":"2","key":"10.1016\/j.xjse.2026.100132_bib29","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1016\/j.jvs.2021.08.086","article-title":"Age-related differences in acute aortic dissection","volume":"75","author":"Wu","year":"2022","journal-title":"J Vasc Surg"},{"issue":"24","key":"10.1016\/j.xjse.2026.100132_bib30","doi-asserted-by":"crossref","first-page":"2415","DOI":"10.1016\/j.jacc.2022.04.017","article-title":"False lumen flow assessment by magnetic resonance imaging and long-term outcomes in uncomplicated aortic dissection","volume":"79","author":"Evangelista","year":"2022","journal-title":"J Am Coll Cardiol"},{"issue":"2","key":"10.1016\/j.xjse.2026.100132_bib31","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1016\/j.jvs.2022.08.037","article-title":"Anemia is associated with higher mortality and morbidity after thoracic endovascular aortic repair","volume":"77","author":"Yin","year":"2023","journal-title":"J Vasc Surg"},{"issue":"1","key":"10.1016\/j.xjse.2026.100132_bib32","article-title":"Association of biomarkers related to preoperative inflammatory and coagulation with postoperative in-hospital deaths in patients with type A acute aortic dissection","volume":"11","author":"Li","year":"2021","journal-title":"Sci Rep"},{"issue":"5","key":"10.1016\/j.xjse.2026.100132_bib33","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1161\/01.ATV.0000063385.12476.A7","article-title":"Endothelium-dependent effects of statins","volume":"23","author":"Wolfrum","year":"2003","journal-title":"Arterioscler Thromb Vasc Biol"},{"issue":"3","key":"10.1016\/j.xjse.2026.100132_bib34","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1161\/01.CIR.94.3.258","article-title":"Angiotensin-converting enzyme inhibition with quinapril improves endothelial vasomotor dysfunction in patients with coronary artery disease. The TREND (Trial on Reversing ENdothelial Dysfunction) study","volume":"94","author":"Mancini","year":"1996","journal-title":"Circulation"},{"issue":"5","key":"10.1016\/j.xjse.2026.100132_bib35","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1093\/cvr\/cvae047","article-title":"SGLT2 inhibitors: from glucose-lowering to cardiovascular benefits","volume":"120","author":"Preda","year":"2024","journal-title":"Cardiovasc Res"},{"issue":"5","key":"10.1016\/j.xjse.2026.100132_bib36","doi-asserted-by":"crossref","first-page":"788","DOI":"10.1016\/j.ejvs.2021.02.026","article-title":"Timing and outcome of endovascular repair for uncomplicated type B aortic dissection","volume":"61","author":"Xie","year":"2021","journal-title":"Eur J Vasc Endovasc Surg"},{"issue":"2","key":"10.1016\/j.xjse.2026.100132_bib37","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1093\/eurheartj\/ehr352","article-title":"The win ratio: a new approach to the analysis of composite endpoints in clinical trials based on clinical priorities","volume":"33","author":"Pocock","year":"2012","journal-title":"Eur Heart J"}],"container-title":["JTCVS Structural and Endovascular"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2950605026000379?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2950605026000379?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T02:12:12Z","timestamp":1791252732000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2950605026000379"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9]]},"references-count":37,"alternative-id":["S2950605026000379"],"URL":"https:\/\/doi.org\/10.1016\/j.xjse.2026.100132","relation":{},"ISSN":["2950-6050"],"issn-type":[{"value":"2950-6050","type":"print"}],"subject":[],"published":{"date-parts":[[2026,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Prognostic value of endothelial activation and stress index (EASIX) on short-term and long-term outcomes in type B aortic dissection after thoracic endovascular repair: An observational study","name":"articletitle","label":"Article Title"},{"value":"JTCVS Structural and Endovascular","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.xjse.2026.100132","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Author(s). Published by Elsevier Inc. on behalf of The American Association for Thoracic Surgery.","name":"copyright","label":"Copyright"}],"article-number":"100132"}}