{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T12:01:08Z","timestamp":1782475268722,"version":"3.54.5"},"reference-count":33,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T00:00:00Z","timestamp":1625097600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T00:00:00Z","timestamp":1625097600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,4,23]],"date-time":"2021-04-23T00:00:00Z","timestamp":1619136000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000062","name":"NIDDK","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000062","name":"NIDDK","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000062","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["kidneymedicinejournal.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Kidney Medicine"],"published-print":{"date-parts":[[2021,7]]},"DOI":"10.1016\/j.xkme.2021.02.012","type":"journal-article","created":{"date-parts":[[2021,4,28]],"date-time":"2021-04-28T14:32:18Z","timestamp":1619620338000},"page":"653-658","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":29,"title":["Molecular Analysis of the Kidney From a Patient With COVID-19\u2013Associated Collapsing Glomerulopathy"],"prefix":"10.1016","volume":"3","author":[{"given":"Kristin","family":"Meliambro","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuezhu","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fadi","family":"Salem","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhengzi","family":"Yi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zeguo","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lili","family":"Chan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miriam","family":"Chung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jorge","family":"Chancay","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ha My T.","family":"Vy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Girish","family":"Nadkarni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jenny S.","family":"Wong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia","family":"Fu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyung","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weijia","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John C.","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kirk N.","family":"Campbell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.xkme.2021.02.012_bib1","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1681\/ASN.2020050615","article-title":"AKI in hospitalized patients with COVID-19","volume":"32","author":"Chan","year":"2021","journal-title":"J Am Soc Nephrol"},{"issue":"1","key":"10.1016\/j.xkme.2021.02.012_bib2","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/j.kint.2020.04.003","article-title":"Renal histopathological analysis of 26 postmortem findings of patients with COVID-19 in China","volume":"98","author":"Su","year":"2020","journal-title":"Kidney Int"},{"issue":"8","key":"10.1016\/j.xkme.2021.02.012_bib3","doi-asserted-by":"crossref","first-page":"1683","DOI":"10.1681\/ASN.2020040432","article-title":"Ultrastructural evidence for direct renal infection with SARS-CoV-2","volume":"31","author":"Farkash","year":"2020","journal-title":"J\u00a0Am Soc Nephrol"},{"issue":"6","key":"10.1016\/j.xkme.2021.02.012_bib4","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1056\/NEJMc2011400","article-title":"Multiorgan and renal tropism of SARS-CoV-2","volume":"383","author":"Puelles","year":"2020","journal-title":"N\u00a0Engl J Med"},{"issue":"9","key":"10.1016\/j.xkme.2021.02.012_bib5","doi-asserted-by":"crossref","first-page":"1948","DOI":"10.1681\/ASN.2020050699","article-title":"COVID-19-associated kidney injury: a case series of kidney biopsy findings","volume":"31","author":"Sharma","year":"2020","journal-title":"J\u00a0Am Soc Nephrol"},{"issue":"9","key":"10.1016\/j.xkme.2021.02.012_bib6","doi-asserted-by":"crossref","first-page":"1959","DOI":"10.1681\/ASN.2020060802","article-title":"Kidney biopsy findings in patients with COVID-19","volume":"31","author":"Kudose","year":"2020","journal-title":"J\u00a0Am Soc Nephrol"},{"issue":"8","key":"10.1016\/j.xkme.2021.02.012_bib7","doi-asserted-by":"crossref","first-page":"1688","DOI":"10.1681\/ASN.2020050558","article-title":"AKI and collapsing glomerulopathy associated with COVID-19 and APOL 1 high-risk genotype","volume":"31","author":"Wu","year":"2020","journal-title":"J\u00a0Am Soc Nephrol"},{"issue":"9","key":"10.1016\/j.xkme.2021.02.012_bib8","doi-asserted-by":"crossref","first-page":"1944","DOI":"10.1681\/ASN.2020050683","article-title":"Histopathologic and ultrastructural findings in postmortem kidney biopsy material in 12 patients with AKI and COVID-19","volume":"31","author":"Golmai","year":"2020","journal-title":"J\u00a0Am Soc Nephrol"},{"issue":"9","key":"10.1016\/j.xkme.2021.02.012_bib9","doi-asserted-by":"crossref","first-page":"2158","DOI":"10.1681\/ASN.2020050744","article-title":"Postmortem kidney pathology findings in patients with COVID-19","volume":"31","author":"Santoriello","year":"2020","journal-title":"J\u00a0Am Soc Nephrol"},{"key":"10.1016\/j.xkme.2021.02.012_bib10","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1016\/j.kint.2020.05.025","article-title":"Thrombotic microangiopathy in a patient with COVID-19","volume":"98","author":"Jhaveri","year":"2020","journal-title":"Kidney Int"},{"issue":"1","key":"10.1016\/j.xkme.2021.02.012_bib11","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1016\/j.kint.2020.04.006","article-title":"Collapsing glomerulopathy in a COVID-19 patient","volume":"98","author":"Kissling","year":"2020","journal-title":"Kidney Int"},{"issue":"6","key":"10.1016\/j.xkme.2021.02.012_bib12","doi-asserted-by":"crossref","first-page":"940","DOI":"10.1016\/j.ekir.2020.04.017","article-title":"Acute kidney injury due to collapsing glomerulopathy following COVID-19 infection","volume":"5","author":"Peleg","year":"2020","journal-title":"Kidney Int Rep"},{"issue":"6","key":"10.1016\/j.xkme.2021.02.012_bib13","doi-asserted-by":"crossref","first-page":"935","DOI":"10.1016\/j.ekir.2020.04.002","article-title":"Collapsing glomerulopathy in a patient with coronavirus disease 2019 (COVID-19)","volume":"5","author":"Larsen","year":"2020","journal-title":"Kidney Int Rep"},{"key":"10.1016\/j.xkme.2021.02.012_bib14","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1093\/ckj\/sft002","article-title":"Viruses and collapsing glomerulopathy: a brief critical review","volume":"6","author":"Chandra","year":"2013","journal-title":"Clin Kidney J"},{"key":"10.1016\/j.xkme.2021.02.012_bib15","first-page":"125","article-title":"Demonstration of human immunodeficiency virus in renal epithelium in HIV-associated nephropathy","volume":"2","author":"Cohen","year":"1989","journal-title":"Mod Pathol"},{"key":"10.1016\/j.xkme.2021.02.012_bib16","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1186\/s12882-016-0330-7","article-title":"Collapsing glomerulopathy in a young woman with APOL1 risk alleles following acute parvovirus B19 infection: a case report investigation","volume":"17","author":"Besse","year":"2016","journal-title":"BMC Nephrol"},{"key":"10.1016\/j.xkme.2021.02.012_bib17","doi-asserted-by":"crossref","first-page":"607","DOI":"10.2215\/CJN.07311009","article-title":"Treatment with IFN-{alpha}, -{beta}, or -{gamma} is associated with collapsing focal segmental glomerulosclerosis","volume":"5","author":"Markowitz","year":"2010","journal-title":"Clin J Am Soc Nephrol"},{"key":"10.1016\/j.xkme.2021.02.012_bib18","doi-asserted-by":"crossref","first-page":"2129","DOI":"10.1681\/ASN.2011040388","article-title":"APOL1 genetic variants in focal segmental glomerulosclerosis and HIV-associated nephropathy","volume":"22","author":"Kopp","year":"2011","journal-title":"J\u00a0Am Soc Nephrol"},{"key":"10.1016\/j.xkme.2021.02.012_bib19","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1038\/ki.2014.270","article-title":"Innate immunity pathways regulate the nephropathy gene apolipoprotein L1","volume":"87","author":"Nichols","year":"2015","journal-title":"Kidney Int"},{"key":"10.1016\/j.xkme.2021.02.012_bib20","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1038\/nm.4287","article-title":"Transgenic expression of human APOL1 risk variants in podocytes induces kidney disease in mice","volume":"23","author":"Beckerman","year":"2017","journal-title":"Nat Med"},{"key":"10.1016\/j.xkme.2021.02.012_bib21","doi-asserted-by":"crossref","first-page":"830","DOI":"10.1073\/pnas.1522913113","article-title":"APOL1 kidney disease risk variants cause cytotoxicity by depleting cellular potassium and inducing stress-activated protein kinases","volume":"113","author":"Olabisi","year":"2016","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.xkme.2021.02.012_bib22","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.1681\/ASN.2016050567","article-title":"APOL1 renal-risk variants induce mitochondrial dysfunction","volume":"28","author":"Ma","year":"2017","journal-title":"J\u00a0Am Soc Nephrol"},{"key":"10.1016\/j.xkme.2021.02.012_bib23","doi-asserted-by":"crossref","first-page":"1918","DOI":"10.1056\/NEJMoa1803731","article-title":"Genomic mismatch at LIMS1 locus and kidney allograft rejection","volume":"380","author":"Steers","year":"2019","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.xkme.2021.02.012_bib24","doi-asserted-by":"crossref","first-page":"5501","DOI":"10.1172\/JCI125519","article-title":"FOXM1 drives proximal tubule proliferation during repair from acute ischemic kidney injury","volume":"129","author":"Chang-Panesso","year":"2019","journal-title":"J\u00a0Clin Invest"},{"key":"10.1016\/j.xkme.2021.02.012_bib25","doi-asserted-by":"crossref","first-page":"102560","DOI":"10.1016\/j.autrev.2020.102560","article-title":"Re: Patiently waiting for the results of anti-IL 6 therapy in severe COVID-19 infection [letter]","volume":"19","author":"McGonagle","year":"2020","journal-title":"Autoimmun Rev"},{"key":"10.1016\/j.xkme.2021.02.012_bib26","doi-asserted-by":"crossref","first-page":"8173","DOI":"10.1074\/jbc.M708920200","article-title":"HIV-1 Nef disrupts the podocyte actin cytoskeleton by interacting with diaphanous interacting protein","volume":"283","author":"Lu","year":"2008","journal-title":"J\u00a0Biol Chem"},{"key":"10.1016\/j.xkme.2021.02.012_bib27","doi-asserted-by":"crossref","first-page":"1979","DOI":"10.1056\/NEJM200106283442604","article-title":"Nephropathy and establishment of a renal reservoir of HIV type 1 during primary infection","volume":"344","author":"Winston","year":"2001","journal-title":"N\u00a0Engl J Med"},{"issue":"2","key":"10.1016\/j.xkme.2021.02.012_bib28","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1016\/j.kint.2020.05.021","article-title":"Am I a coronavirus?","volume":"98","author":"Smith","year":"2020","journal-title":"Kidney Int"},{"key":"10.1016\/j.xkme.2021.02.012_bib29","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1172\/JCI200421004","article-title":"Nef stimulates proliferation of glomerular podocytes through activation of Src-dependent Stat3 and MAPK1,2 pathways","volume":"114","author":"He","year":"2004","journal-title":"J\u00a0Clin Invest"},{"key":"10.1016\/j.xkme.2021.02.012_bib30","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1038\/ki.2009.98","article-title":"Knockdown of Stat3 activity in\u00a0vivo prevents diabetic glomerulopathy","volume":"76","author":"Lu","year":"2009","journal-title":"Kidney Int"},{"key":"10.1016\/j.xkme.2021.02.012_bib31","doi-asserted-by":"crossref","first-page":"1624","DOI":"10.1007\/s00125-016-4021-5","article-title":"JAK inhibition in the treatment of diabetic kidney disease","volume":"59","author":"Brosius","year":"2016","journal-title":"Diabetologia"},{"key":"10.1016\/j.xkme.2021.02.012_bib32","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/j.yexcr.2017.02.016","article-title":"Foxc1 and Foxc2 are necessary to maintain glomerular podocytes","volume":"352","author":"Motojima","year":"2017","journal-title":"Exp Cell Res"},{"key":"10.1016\/j.xkme.2021.02.012_bib33","doi-asserted-by":"crossref","first-page":"1306","DOI":"10.1038\/labinvest.2017.69","article-title":"Re-expression of Sall1 in podocytes protects against adriamycin-induced nephrosis","volume":"97","author":"Hosoe-Nagai","year":"2017","journal-title":"Lab Invest"}],"container-title":["Kidney Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2590059521000819?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2590059521000819?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,12]],"date-time":"2025-11-12T01:22:20Z","timestamp":1762910540000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2590059521000819"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,7]]},"references-count":33,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2021,7]]}},"alternative-id":["S2590059521000819"],"URL":"https:\/\/doi.org\/10.1016\/j.xkme.2021.02.012","relation":{},"ISSN":["2590-0595"],"issn-type":[{"value":"2590-0595","type":"print"}],"subject":[],"published":{"date-parts":[[2021,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Molecular Analysis of the Kidney From a Patient With COVID-19\u2013Associated Collapsing Glomerulopathy","name":"articletitle","label":"Article Title"},{"value":"Kidney Medicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.xkme.2021.02.012","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 The Authors. Published by Elsevier Inc. on behalf of the National Kidney Foundation, Inc.","name":"copyright","label":"Copyright"}]}}