{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T16:22:18Z","timestamp":1787934138678,"version":"build-2784847793"},"reference-count":36,"publisher":"Elsevier BV","issue":"9","license":[{"start":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:00:00Z","timestamp":1693526400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:00:00Z","timestamp":1693526400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,6,26]],"date-time":"2023-06-26T00:00:00Z","timestamp":1687737600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100010643","name":"Cidara Therapeutics","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010643","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100014425","name":"Acorda Therapeutics","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100014425","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["kidneymedicinejournal.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Kidney Medicine"],"published-print":{"date-parts":[[2023,9]]},"DOI":"10.1016\/j.xkme.2023.100696","type":"journal-article","created":{"date-parts":[[2023,7,1]],"date-time":"2023-07-01T11:50:07Z","timestamp":1688212207000},"page":"100696","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":17,"title":["The Burden of Pruritus Associated With CKD: A Mixed Methods Analysis Among Patients Undergoing Dialysis"],"prefix":"10.1016","volume":"5","author":[{"given":"Fr\u00e9d\u00e9rique","family":"Menzaghi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margaret K.","family":"Vernon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Mattera","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joshua","family":"Cirulli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Warren","family":"Wen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert H.","family":"Spencer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine","family":"Munera","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.xkme.2023.100696_bib1","doi-asserted-by":"crossref","first-page":"11","DOI":"10.2147\/IJNRD.S108045","article-title":"Chronic kidney disease-associated pruritus: impact on quality of life and current management challenges","volume":"10","author":"Shirazian","year":"2017","journal-title":"Int J Nephrol Renovasc Dis"},{"issue":"suppl 3","key":"10.1016\/j.xkme.2023.100696_bib2","doi-asserted-by":"crossref","first-page":"i16","DOI":"10.1093\/ckj\/sfab167","article-title":"Clinical management of chronic kidney disease-associated pruritus: current treatment options and future approaches","volume":"14","author":"Lipman","year":"2021","journal-title":"Clin Kidney J"},{"issue":"4","key":"10.1016\/j.xkme.2023.100696_bib3","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1038\/ki.2013.454","article-title":"Uremic pruritus","volume":"87","author":"Mettang","year":"2015","journal-title":"Kidney Int"},{"issue":"1","key":"10.1016\/j.xkme.2023.100696_bib4","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1053\/j.ajkd.2020.01.002","article-title":"Pruritus as a patient-reported primary trial end point in hemodialysis: evaluation and implications","volume":"76","author":"Nair","year":"2020","journal-title":"Am J Kidney Dis"},{"issue":"9","key":"10.1016\/j.xkme.2023.100696_bib5","doi-asserted-by":"crossref","first-page":"1387","DOI":"10.1016\/j.ekir.2020.04.027","article-title":"CKD-associated pruritus: new insights into diagnosis, pathogenesis, and management","volume":"5","author":"Verduzco","year":"2020","journal-title":"Kidney Int Rep"},{"issue":"9","key":"10.1016\/j.xkme.2023.100696_bib6","doi-asserted-by":"crossref","first-page":"1626","DOI":"10.1038\/sj.ki.5000251","article-title":"Etiology and prognostic significance of severe uremic pruritus in chronic hemodialysis patients","volume":"69","author":"Narita","year":"2006","journal-title":"Kidney Int"},{"issue":"12","key":"10.1016\/j.xkme.2023.100696_bib7","doi-asserted-by":"crossref","first-page":"3495","DOI":"10.1093\/ndt\/gfl461","article-title":"Pruritus in haemodialysis patients: international results from the dialysis outcomes and practice patterns study (DOPPS)","volume":"21","author":"Pisoni","year":"2006","journal-title":"Nephrol Dial Transplant"},{"issue":"8","key":"10.1016\/j.xkme.2023.100696_bib8","doi-asserted-by":"crossref","first-page":"1410","DOI":"10.2215\/CJN.00100110","article-title":"A\u00a0longitudinal study of uremic pruritus in hemodialysis patients","volume":"5","author":"Mathur","year":"2010","journal-title":"Clin J Am Soc Nephrol"},{"issue":"3","key":"10.1016\/j.xkme.2023.100696_bib9","doi-asserted-by":"crossref","first-page":"361","DOI":"10.2340\/00015555-2280","article-title":"Clinical findings and provision of care in haemodialysis patients with chronic itch: new results from the German epidemiological haemodialysis itch study","volume":"96","author":"Hayani","year":"2016","journal-title":"Acta Derm Venereol"},{"issue":"4","key":"10.1016\/j.xkme.2023.100696_bib10","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1111\/hdi.12521","article-title":"Symptoms among patients receiving in-center hemodialysis: A qualitative study","volume":"21","author":"Cox","year":"2017","journal-title":"Hemodial Int"},{"key":"10.1016\/j.xkme.2023.100696_bib11","doi-asserted-by":"crossref","first-page":"249","DOI":"10.2147\/CCID.S55942","article-title":"Nalfurafine hydrochloride to treat pruritus: a review","volume":"8","author":"Inui","year":"2015","journal-title":"Clin Cosmet Investig Dermatol"},{"issue":"3","key":"10.1016\/j.xkme.2023.100696_bib12","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1001\/archderm.1982.01650150016012","article-title":"Clinical features of pruritus among patients undergoing maintenance hemodialysis","volume":"118","author":"Gilchrest","year":"1982","journal-title":"Arch Dermatol"},{"issue":"12","key":"10.1016\/j.xkme.2023.100696_bib13","first-page":"CD011393","article-title":"Interventions for itch in people with advanced chronic kidney disease","volume":"12","author":"Hercz","year":"2020","journal-title":"Cochrane Database Syst Rev"},{"issue":"3","key":"10.1016\/j.xkme.2023.100696_bib14","doi-asserted-by":"crossref","first-page":"e38","DOI":"10.1097\/itx.0000000000000038","article-title":"A\u00a0review of the management of uremic pruritus: current perspectives and future directions","volume":"5","author":"Westby","year":"2020","journal-title":"Itch"},{"issue":"4","key":"10.1016\/j.xkme.2023.100696_bib17","doi-asserted-by":"crossref","first-page":"1328","DOI":"10.1093\/ndt\/gfn769","article-title":"How do nephrologists in haemodialysis units consider the symptom of itch? Results of a survey in Germany","volume":"24","author":"Weisshaar","year":"2009","journal-title":"Nephrol Dial Transplant"},{"issue":"4","key":"10.1016\/j.xkme.2023.100696_bib18","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1016\/j.jpainsymman.2019.06.010","article-title":"Reasons for underreporting of uremic pruritus in people with chronic kidney disease: a qualitative study","volume":"58","author":"Aresi","year":"2019","journal-title":"J\u00a0Pain Symptom Manage"},{"issue":"2","key":"10.1016\/j.xkme.2023.100696_bib19","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1080\/00015550152384236","article-title":"A\u00a0questionnaire for the assessment of pruritus: validation in uremic patients","volume":"81","author":"Yosipovitch","year":"2001","journal-title":"Acta Derm Venereol"},{"issue":"5","key":"10.1016\/j.xkme.2023.100696_bib20","doi-asserted-by":"crossref","first-page":"842","DOI":"10.1016\/S0190-9622(03)02478-2","article-title":"Prevalence and characterization of uremic pruritus in patients undergoing hemodialysis: uremic pruritus is still a major problem for patients with end-stage renal disease","volume":"49","author":"Zucker","year":"2003","journal-title":"J\u00a0Am Acad Dermatol"},{"issue":"7","key":"10.1016\/j.xkme.2023.100696_bib21","doi-asserted-by":"crossref","first-page":"1429","DOI":"10.1111\/jdv.15483","article-title":"The course of chronic itch in hemodialysis patients: results of a 4-year follow-up study of GEHIS (German epidemiological hemodialysis itch study)","volume":"33","author":"Plewig","year":"2019","journal-title":"J\u00a0Eur Acad Dermatol Venereol"},{"issue":"1","key":"10.1016\/j.xkme.2023.100696_bib22","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.xkme.2020.08.011","article-title":"Self-reported pruritus and clinical, dialysis-related, and patient-reported outcomes in hemodialysis patients","volume":"3","author":"Sukul","year":"2021","journal-title":"Kidney Med"},{"issue":"3","key":"10.1016\/j.xkme.2023.100696_bib23","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1093\/ckj\/sfab218","article-title":"The relationship between chronic kidney disease-associated pruritus and health-related quality of life: a systematic review","volume":"15","author":"Poku","year":"2022","journal-title":"Clin Kidney J"},{"issue":"10","key":"10.1016\/j.xkme.2023.100696_bib24","doi-asserted-by":"crossref","first-page":"1813","DOI":"10.2215\/CJN.01610214","article-title":"Setting research priorities for patients on or nearing dialysis","volume":"9","author":"Manns","year":"2014","journal-title":"Clin J Am Soc Nephrol"},{"issue":"3","key":"10.1016\/j.xkme.2023.100696_bib25","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1038\/ki.2015.110","article-title":"Executive summary of the KDIGO Controversies Conference on Supportive Care in Chronic Kidney Disease: developing a roadmap to improving quality care","volume":"88","author":"Davison","year":"2015","journal-title":"Kidney Int"},{"issue":"5","key":"10.1016\/j.xkme.2023.100696_bib26","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1016\/j.jaad.2013.12.018","article-title":"Patient perspectives in the management of psoriasis: results from the population-based multinational assessment of psoriasis and psoriatic arthritis survey","volume":"70","author":"Lebwohl","year":"2014","journal-title":"J\u00a0Am Acad Dermatol"},{"issue":"1","key":"10.1016\/j.xkme.2023.100696_bib27","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1186\/s12882-019-1234-0","article-title":"Multidimensional pruritus assessment in hemodialysis patients","volume":"20","author":"Alt\u0131nok Ersoy","year":"2019","journal-title":"BMC Nephrol"},{"issue":"7","key":"10.1016\/j.xkme.2023.100696_bib28","article-title":"Uremic pruritus: prevalence and impact on quality of life and depressive symptoms in hemodialysis patients","volume":"11","author":"Satti","year":"2019","journal-title":"Cureus"},{"issue":"3","key":"10.1016\/j.xkme.2023.100696_bib29","doi-asserted-by":"crossref","first-page":"276","DOI":"10.2340\/00015555-1749","article-title":"Uraemic pruritus markedly affects the quality of life and depressive symptoms in haemodialysis patients with end-stage renal disease","volume":"94","author":"Suse\u0142","year":"2014","journal-title":"Acta Derm Venereol"},{"issue":"4","key":"10.1016\/j.xkme.2023.100696_bib30","doi-asserted-by":"crossref","first-page":"1132","DOI":"10.1016\/j.jaad.2020.06.991","article-title":"Clinically meaningful change in itch intensity scores: an evaluation in patients with chronic kidney disease-associated pruritus","volume":"84","author":"Vernon","year":"2021","journal-title":"J\u00a0Am Acad Dermatol"},{"issue":"1","key":"10.1016\/j.xkme.2023.100696_bib31","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1186\/s41687-021-00404-z","article-title":"Psychometric validation and meaningful change thresholds of the Worst Itching Intensity Numerical Rating Scale for assessing itch in patients with chronic kidney disease-associated pruritus","volume":"5","author":"Vernon","year":"2021","journal-title":"J\u00a0Patient Rep Outcomes"},{"issue":"3","key":"10.1016\/j.xkme.2023.100696_bib32","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1056\/NEJMoa1912770","article-title":"A\u00a0phase 3 trial of difelikefalin in hemodialysis patients with pruritus","volume":"382","author":"Fishbane","year":"2020","journal-title":"N\u00a0Engl J Med"},{"issue":"6","key":"10.1016\/j.xkme.2023.100696_bib34","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1177\/2168479015580384","article-title":"Partnering with patients in the development and lifecycle of medicines: a call for action","volume":"49","author":"Hoos","year":"2015","journal-title":"Ther Innov Regul Sci"},{"issue":"5","key":"10.1016\/j.xkme.2023.100696_bib35","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1177\/2168479016662902","article-title":"Patient engagement at a tipping point-the need for cultural change across patient, sponsor, and regulator stakeholders: insights from the DIA conference, \u201cPatient Engagement in Benefit Risk Assessment Throughout the Life Cycle of Medical Products.\u201d","volume":"50","author":"Smith","year":"2016","journal-title":"Ther Innov Regul Sci"},{"issue":"4","key":"10.1016\/j.xkme.2023.100696_bib36","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1053\/j.ajkd.2020.12.011","article-title":"Qualitative research in CKD: how to appraise and interpret the evidence","volume":"77","author":"Baumgart","year":"2021","journal-title":"Am J Kidney Dis"},{"issue":"6","key":"10.1016\/j.xkme.2023.100696_bib37","doi-asserted-by":"crossref","first-page":"713","DOI":"10.2340\/00015555-1823","article-title":"Qualitative interviews on chronic pruritus in haemodialysis patients","volume":"94","author":"Weiss","year":"2014","journal-title":"Acta Derm Venereol"},{"issue":"12","key":"10.1016\/j.xkme.2023.100696_bib38","doi-asserted-by":"crossref","first-page":"2000","DOI":"10.2215\/CJN.03280317","article-title":"International comparisons of prevalence, awareness, and treatment of pruritus in people on hemodialysis","volume":"12","author":"Rayner","year":"2017","journal-title":"Clin J Am Soc Nephrol"},{"issue":"5","key":"10.1016\/j.xkme.2023.100696_bib39","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1053\/j.ajkd.2017.05.018","article-title":"Treatment of uremic pruritus: a systematic review","volume":"70","author":"Simonsen","year":"2017","journal-title":"Am J Kidney Dis"}],"container-title":["Kidney Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2590059523001140?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2590059523001140?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,12]],"date-time":"2025-11-12T01:25:44Z","timestamp":1762910744000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2590059523001140"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,9]]},"references-count":36,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2023,9]]}},"alternative-id":["S2590059523001140"],"URL":"https:\/\/doi.org\/10.1016\/j.xkme.2023.100696","relation":{},"ISSN":["2590-0595"],"issn-type":[{"value":"2590-0595","type":"print"}],"subject":[],"published":{"date-parts":[[2023,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The Burden of Pruritus Associated With CKD: A Mixed Methods Analysis Among Patients Undergoing Dialysis","name":"articletitle","label":"Article Title"},{"value":"Kidney Medicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.xkme.2023.100696","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 The Authors. Published by Elsevier Inc. on behalf of the National Kidney Foundation, Inc.","name":"copyright","label":"Copyright"}],"article-number":"100696"}}