{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T20:12:52Z","timestamp":1792872772472,"version":"4.5.0"},"reference-count":27,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,11,21]],"date-time":"2023-11-21T00:00:00Z","timestamp":1700524800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["OT2HL161847"],"award-info":[{"award-number":["OT2HL161847"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01MD014712"],"award-info":[{"award-number":["R01MD014712"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["U01DK100846"],"award-info":[{"award-number":["U01DK100846"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["U2CDK114886"],"award-info":[{"award-number":["U2CDK114886"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["U54DK083912"],"award-info":[{"award-number":["U54DK083912"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["UL1TR002319"],"award-info":[{"award-number":["UL1TR002319"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["UM1AI109568"],"award-info":[{"award-number":["UM1AI109568"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000030","name":"Centers for Disease Control and Prevention","doi-asserted-by":"publisher","award":["75D301-21-P-12254"],"award-info":[{"award-number":["75D301-21-P-12254"]}],"id":[{"id":"10.13039\/100000030","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["kidneymedicinejournal.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Kidney Medicine"],"published-print":{"date-parts":[[2024,2]]},"DOI":"10.1016\/j.xkme.2023.100748","type":"journal-article","created":{"date-parts":[[2023,11,27]],"date-time":"2023-11-27T13:16:54Z","timestamp":1701091014000},"page":"100748","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":7,"title":["Clinical Characteristics and Histopathology in Adults With Focal Segmental Glomerulosclerosis"],"prefix":"10.1016","volume":"6","author":[{"given":"Katherine R.","family":"Tuttle","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clint W.","family":"Abner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick D.","family":"Walker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaijun","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"Rava","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jihaeng","family":"Heo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Bunke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"3","key":"10.1016\/j.xkme.2023.100748_bib1","first-page":"350","article-title":"Pathophysiology of focal segmental glomerulosclerosis","volume":"22","author":"Reidy","year":"2007","journal-title":"Pediatr\u00a0Nephrol"},{"issue":"18","key":"10.1016\/j.xkme.2023.100748_bib2","doi-asserted-by":"crossref","DOI":"10.1097\/MD.0000000000003633","article-title":"Epidemiology of glomerular disease in Southern Arizona: review of 10-year renal biopsy data","volume":"95","author":"Murugapandian","year":"2016","journal-title":"Med (Baltim)"},{"issue":"4","key":"10.1016\/j.xkme.2023.100748_bib3","doi-asserted-by":"crossref","first-page":"614","DOI":"10.2215\/CJN.10871016","article-title":"Temporal and demographic trends in glomerular disease epidemiology in the Southeastern United States, 1986-2015","volume":"12","author":"O\u2019Shaughnessy","year":"2017","journal-title":"Clin J Am Soc Nephrol"},{"issue":"7","key":"10.1016\/j.xkme.2023.100748_bib4","doi-asserted-by":"crossref","first-page":"1170","DOI":"10.2215\/CJN.11261114","article-title":"Patient characteristics and outcomes by GN subtype in ESRD","volume":"10","author":"O\u2019Shaughnessy","year":"2015","journal-title":"Clin J Am Soc Nephrol"},{"issue":"2","key":"10.1016\/j.xkme.2023.100748_bib5","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1093\/ndt\/gfv386","article-title":"Differences in initial treatment modality for end-stage renal disease among glomerulonephritis subtypes in the USA","volume":"31","author":"O\u2019Shaughnessy","year":"2016","journal-title":"Nephrol Dial Transplant"},{"issue":"5","key":"10.1016\/j.xkme.2023.100748_bib6","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1016\/S0272-6386(97)90485-6","article-title":"Changing etiologies of unexplained adult nephrotic syndrome: a comparison of renal biopsy findings from 1976-1979 and 1995-1997","volume":"30","author":"Haas","year":"1997","journal-title":"Am J Kidney Dis"},{"issue":"5","key":"10.1016\/j.xkme.2023.100748_bib7","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1016\/S0272-6386(96)90098-0","article-title":"The racial prevalence of glomerular lesions in nephrotic adults","volume":"27","author":"Korbet","year":"1996","journal-title":"Am J Kidney Dis"},{"issue":"2","key":"10.1016\/j.xkme.2023.100748_bib8","first-page":"79","article-title":"Racial differences in the prevalence and presentation of glomerular disease in adults","volume":"42","author":"Pontier","year":"1994","journal-title":"Clin Nephrol"},{"issue":"1","key":"10.1016\/j.xkme.2023.100748_bib9","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1053\/j.arrt.2003.10.015","article-title":"Racial and ethnic differences in the incidence and progression of focal segmental glomerulosclerosis in children","volume":"11","author":"Andreoli","year":"2004","journal-title":"Adv Ren Replace Ther"},{"issue":"3","key":"10.1016\/j.xkme.2023.100748_bib10","doi-asserted-by":"crossref","first-page":"399","DOI":"10.2215\/CJN.06100612","article-title":"Association of histologic variants in FSGS clinical trial with presenting features and outcomes","volume":"8","author":"D\u2019Agati","year":"2013","journal-title":"Clin J Am Soc Nephrol"},{"issue":"5993","key":"10.1016\/j.xkme.2023.100748_bib11","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1126\/science.1193032","article-title":"Association of trypanolytic ApoL1 variants with kidney disease in African Americans","volume":"329","author":"Genovese","year":"2010","journal-title":"Science"},{"issue":"3","key":"10.1016\/j.xkme.2023.100748_bib12","doi-asserted-by":"crossref","first-page":"344","DOI":"10.2215\/CJN.00660113","article-title":"Histologic classification of FSGS: does form delineate function?","volume":"8","author":"Choi","year":"2013","journal-title":"Clin J Am Soc Nephrol"},{"key":"10.1016\/j.xkme.2023.100748_bib13","doi-asserted-by":"crossref","DOI":"10.1155\/2016\/4632768","article-title":"FSGS: diagnosis and diagnostic work-up","volume":"2016","author":"Sprangers","year":"2016","journal-title":"BioMed Res Int"},{"issue":"5","key":"10.1016\/j.xkme.2023.100748_bib14","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1053\/j.ackd.2014.02.010","article-title":"Morphologic variants of focal segmental glomerulosclerosis and their significance","volume":"21","author":"Stokes","year":"2014","journal-title":"Adv Chronic Kidney Dis"},{"issue":"4s","key":"10.1016\/j.xkme.2023.100748_bib15","first-page":"S1","article-title":"KDIGO 2021 Clinical Practice Guideline for the Management of Glomerular Diseases","volume":"100","year":"2021","journal-title":"Kidney Int"},{"issue":"19","key":"10.1016\/j.xkme.2023.100748_bib16","doi-asserted-by":"crossref","first-page":"1737","DOI":"10.1056\/NEJMoa2102953","article-title":"New creatinine- and cystatin C\u2013based equations to estimate GFR without race","volume":"385","author":"Inker","year":"2021","journal-title":"N\u00a0Engl J Med"},{"issue":"2","key":"10.1016\/j.xkme.2023.100748_bib17","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1053\/j.ajkd.2003.10.024","article-title":"Pathologic classification of focal segmental glomerulosclerosis: a working proposal","volume":"43","author":"D\u2019Agati","year":"2004","journal-title":"Am J Kidney Dis"},{"issue":"2","key":"10.1016\/j.xkme.2023.100748_bib18","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1093\/ndt\/gfw443","article-title":"Interstitial fibrosis scored on whole-slide digital imaging of kidney biopsies is a predictor of outcome in proteinuric glomerulopathies","volume":"33","author":"Mariani","year":"2018","journal-title":"Nephrol Dial Transplant"},{"issue":"7","key":"10.1016\/j.xkme.2023.100748_bib19","doi-asserted-by":"crossref","first-page":"2168","DOI":"10.1093\/ndt\/gfp528","article-title":"Scoring system for renal pathology in Fabry disease: report of the International Study Group of Fabry Nephropathy (ISGFN)","volume":"25","author":"Fogo","year":"2010","journal-title":"Nephrol Dial Transplant"},{"issue":"2","key":"10.1016\/j.xkme.2023.100748_bib20","doi-asserted-by":"crossref","first-page":"181","DOI":"10.5858\/133.2.181","article-title":"The renal biopsy","volume":"133","author":"Walker","year":"2009","journal-title":"Arch Pathol Lab Med"},{"issue":"2","key":"10.1016\/j.xkme.2023.100748_bib21","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1053\/snep.2003.50012","article-title":"Pathologic classification of focal segmental glomerulosclerosis","volume":"23","author":"D\u2019Agati","year":"2003","journal-title":"Semin Nephrol"},{"issue":"1","key":"10.1016\/j.xkme.2023.100748_bib22","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1093\/ndt\/gfm523","article-title":"Pathological variants of focal segmental glomerulosclerosis in an adult Dutch population--epidemiology and outcome","volume":"23","author":"Deegens","year":"2008","journal-title":"Nephrol Dial Transplant"},{"issue":"1","key":"10.1016\/j.xkme.2023.100748_bib23","doi-asserted-by":"crossref","first-page":"28","DOI":"10.5812\/nephropathol.8959","article-title":"Frequency and clinicopathological characteristics of variants of primary focal segmental glomerulosclerosis in adults presenting with nephrotic syndrome","volume":"2","author":"Shakeel","year":"2013","journal-title":"J\u00a0Nephropathol"},{"issue":"3","key":"10.1016\/j.xkme.2023.100748_bib24","doi-asserted-by":"crossref","first-page":"148","DOI":"10.4103\/0971-4065.132003","article-title":"Frequency and clinicopathological correlations of histopathological variants of pediatric idiopathic focal segmental glomerulosclerosis","volume":"24","author":"Shakeel","year":"2014","journal-title":"Indian J Nephrol"},{"issue":"3","key":"10.1016\/j.xkme.2023.100748_bib25","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1681\/ASN.2016030357","article-title":"African ancestry\u2013specific alleles and kidney disease risk in Hispanics\/Latinos","volume":"28","author":"Kramer","year":"2017","journal-title":"J\u00a0Am Soc Nephrol"},{"issue":"23","key":"10.1016\/j.xkme.2023.100748_bib26","doi-asserted-by":"crossref","first-page":"2183","DOI":"10.1056\/NEJMoa1310345","article-title":"APOL1 risk variants, race, and progression of chronic kidney disease","volume":"369","author":"Parsa","year":"2013","journal-title":"N\u00a0Engl J Med"},{"issue":"4","key":"10.1016\/j.xkme.2023.100748_bib27","doi-asserted-by":"crossref","first-page":"1498","DOI":"10.1093\/ndt\/gfr796","article-title":"APOL1 allelic variants are associated with lower age of dialysis initiation and thereby increased dialysis vintage in African and Hispanic Americans with non-diabetic end-stage kidney disease","volume":"27","author":"Tzur","year":"2012","journal-title":"Nephrol Dial Transplant"}],"container-title":["Kidney Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2590059523001668?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2590059523001668?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,12]],"date-time":"2025-11-12T01:26:15Z","timestamp":1762910775000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2590059523001668"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,2]]},"references-count":27,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2024,2]]}},"alternative-id":["S2590059523001668"],"URL":"https:\/\/doi.org\/10.1016\/j.xkme.2023.100748","relation":{},"ISSN":["2590-0595"],"issn-type":[{"value":"2590-0595","type":"print"}],"subject":[],"published":{"date-parts":[[2024,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Clinical Characteristics and Histopathology in Adults With Focal Segmental Glomerulosclerosis","name":"articletitle","label":"Article Title"},{"value":"Kidney Medicine","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.xkme.2023.100748","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 The Authors. Published by Elsevier Inc. on behalf of the National Kidney Foundation, Inc.","name":"copyright","label":"Copyright"}],"article-number":"100748"}}