{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T23:51:30Z","timestamp":1790812290323,"version":"4.1.0"},"reference-count":26,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T00:00:00Z","timestamp":1654041600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T00:00:00Z","timestamp":1654041600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,1,18]],"date-time":"2022-01-18T00:00:00Z","timestamp":1642464000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100017024","name":"Salah Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100017024","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002806","name":"Carl Zeiss Meditec AG","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002806","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000053","name":"National Eye Institute","doi-asserted-by":"publisher","award":["P30EY014801"],"award-info":[{"award-number":["P30EY014801"]}],"id":[{"id":"10.13039\/100000053","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100001818","name":"Research to Prevent Blindness","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001818","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["ophthalmologyscience.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Ophthalmology Science"],"published-print":{"date-parts":[[2022,6]]},"DOI":"10.1016\/j.xops.2022.100116","type":"journal-article","created":{"date-parts":[[2022,1,24]],"date-time":"2022-01-24T12:54:59Z","timestamp":1643028899000},"page":"100116","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":48,"title":["Multimodal Imaging, OCT B-Scan Localization, and En Face OCT Detection of Macular Hyperpigmentation in Eyes with Intermediate Age-Related Macular Degeneration"],"prefix":"10.1016","volume":"2","author":[{"given":"Rita","family":"Laiginhas","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeremy","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengxi","family":"Shen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingying","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Omer","family":"Trivizki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nadia K.","family":"Waheed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanni","family":"Gregori","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip J.","family":"Rosenfeld","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.xops.2022.100116_bib1","doi-asserted-by":"crossref","first-page":"1484","DOI":"10.1001\/archopht.123.11.1484","article-title":"The age-related eye disease study severity scale for age-related macular degeneration: AREDS report no. 17","volume":"123","author":"Davis","year":"2005","journal-title":"Arch Ophthalmol"},{"key":"10.1016\/j.xops.2022.100116_bib2","doi-asserted-by":"crossref","first-page":"1570","DOI":"10.1001\/archopht.123.11.1570","article-title":"A\u00a0simplified severity scale for age-related macular degeneration: AREDS report no. 18","volume":"123","author":"Ferris","year":"2005","journal-title":"Arch Ophthalmol"},{"key":"10.1016\/j.xops.2022.100116_bib3","doi-asserted-by":"crossref","first-page":"1767","DOI":"10.1016\/S0161-6420(02)01146-6","article-title":"Ten-year incidence and progression of age-related maculopathy: the Beaver Dam Eye Study","volume":"109","author":"Klein","year":"2002","journal-title":"Ophthalmology"},{"key":"10.1016\/j.xops.2022.100116_bib4","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.ophtha.2006.07.017","article-title":"Ten-year incidence and progression of age-related maculopathy. The Blue Mountains Eye Study","volume":"114","author":"Wang","year":"2007","journal-title":"Ophthalmology"},{"key":"10.1016\/j.xops.2022.100116_bib5","doi-asserted-by":"crossref","first-page":"844","DOI":"10.1016\/j.ophtha.2012.10.036","article-title":"Clinical classification of age-related macular degeneration","volume":"120","author":"Ferris","year":"2013","journal-title":"Ophthalmology"},{"key":"10.1016\/j.xops.2022.100116_bib6","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1016\/S0002-9394(01)01218-1","article-title":"The age-related eye disease study system for classifying age-related macular degeneration from stereoscopic color fundus photographs: the Age-Related Eye Disease Study report number 6","volume":"132","year":"2001","journal-title":"Am J Ophthalmol"},{"issue":"4","key":"10.1016\/j.xops.2022.100116_bib7","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1016\/j.ophtha.2016.12.002","article-title":"Imaging protocols in clinical studies in advanced age-related macular degeneration recommendations from Classification of Atrophy Consensus Meetings","volume":"124","author":"Holz","year":"2017","journal-title":"Ophthalmology"},{"key":"10.1016\/j.xops.2022.100116_bib8","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1016\/j.ophtha.2017.09.028","article-title":"Consensus definition for atrophy associated with age-related macular degeneration on OCT: Classification of Atrophy report 3","volume":"125","author":"Sadda","year":"2018","journal-title":"Ophthalmology"},{"key":"10.1016\/j.xops.2022.100116_bib9","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1016\/j.ophtha.2010.08.010","article-title":"Documentation of intraretinal retinal pigment epithelium migration via high-speed ultrahigh-resolution optical coherence tomography","volume":"118","author":"Ho","year":"2011","journal-title":"Ophthalmology"},{"key":"10.1016\/j.xops.2022.100116_bib10","doi-asserted-by":"crossref","first-page":"1883","DOI":"10.1016\/j.ophtha.2008.04.041","article-title":"Drusen ultrastructure imaging with spectral domain optical coherence tomography in age-related macular degeneration","volume":"115","author":"Khanifar","year":"2008","journal-title":"Ophthalmology"},{"key":"10.1016\/j.xops.2022.100116_bib11","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1136\/bjo.2005.076612","article-title":"Ultrahigh resolution optical coherence tomography in non-exudative age related macular degeneration","volume":"90","author":"Pieroni","year":"2006","journal-title":"Br J Ophthalmol"},{"key":"10.1016\/j.xops.2022.100116_bib12","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1016\/j.ophtha.2008.10.006","article-title":"Photoreceptor layer thinning over drusen in eyes with age-related macular degeneration imaged in\u00a0vivo with spectral-domain optical coherence tomography","volume":"116","author":"Schuman","year":"2009","journal-title":"Ophthalmology"},{"key":"10.1016\/j.xops.2022.100116_bib13","doi-asserted-by":"crossref","first-page":"5479","DOI":"10.1167\/iovs.16-19816","article-title":"Associations between retinal pigment epithelium and drusen volume changes during the lifecycle of large drusenoid pigment epithelial detachments","volume":"57","author":"Balaratnasingam","year":"2016","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"10","key":"10.1016\/j.xops.2022.100116_bib14","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1167\/iovs.62.10.34","article-title":"Hyperreflective foci, optical coherence tomography progression indicators in age-related macular degeneration, include transdifferentiated retinal pigment epithelium","volume":"62","author":"Cao","year":"2021","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"12","key":"10.1016\/j.xops.2022.100116_bib15","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1167\/iovs.62.12.2","article-title":"Progressive dysmorphia of retinal pigment epithelium in age-related macular degeneration investigated by fluorescence lifetime imaging","volume":"62","author":"Hammer","year":"2021","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.xops.2022.100116_bib16","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/j.ajo.2016.11.002","article-title":"En face optical coherence tomography imaging for the detection of nascent geographic atrophy","volume":"174","author":"Schaal","year":"2017","journal-title":"Am J Ophthalmol"},{"issue":"12","key":"10.1016\/j.xops.2022.100116_bib17","doi-asserted-by":"crossref","first-page":"1214","DOI":"10.1016\/j.oret.2021.02.004","article-title":"Persistent hypertransmission defects on en face OCT imaging as a stand-alone precursor for the future formation of geographic atrophy","volume":"5","author":"Shi","year":"2021","journal-title":"Ophthalmol Retina"},{"key":"10.1016\/j.xops.2022.100116_bib18","doi-asserted-by":"crossref","first-page":"127","DOI":"10.3928\/23258160-20130313-05","article-title":"Comparison of geographic atrophy measurements from the OCT fundus image and the sub-RPE slab image","volume":"44","author":"Yehoshua","year":"2013","journal-title":"Ophthalmic Surg Lasers Imaging Retina"},{"key":"10.1016\/j.xops.2022.100116_bib19","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1016\/j.ophtha.2010.08.018","article-title":"Progression of geographic atrophy in age-related macular degeneration imaged with spectral domain optical coherence tomography","volume":"118","author":"Yehoshua","year":"2011","journal-title":"Ophthalmology"},{"key":"10.1016\/j.xops.2022.100116_bib20","doi-asserted-by":"crossref","first-page":"3431","DOI":"10.1167\/iovs.18-24143","article-title":"Quantity of intraretinal hyperreflective foci in patients with intermediate age-related macular degeneration correlates with 1-year progression","volume":"59","author":"Nassisi","year":"2018","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.xops.2022.100116_bib21","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1111\/opo.12283","article-title":"Infrared reflectance imaging in age-related macular degeneration","volume":"36","author":"Ly","year":"2016","journal-title":"Ophthalmic Physiol Opt"},{"key":"10.1016\/j.xops.2022.100116_bib22","doi-asserted-by":"crossref","first-page":"3098","DOI":"10.1167\/iovs.05-1104","article-title":"Fundus near infrared fluorescence correlates with fundus near infrared reflectance","volume":"47","author":"Weinberger","year":"2006","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.xops.2022.100116_bib23","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/j.ajo.2020.01.005","article-title":"Near-infrared reflectance imaging for quantification of atrophy associated with age-related macular degeneration","volume":"212","author":"Abdelfattah","year":"2020","journal-title":"Am J Ophthalmol"},{"key":"10.1016\/j.xops.2022.100116_bib24","doi-asserted-by":"crossref","first-page":"1551","DOI":"10.1007\/s00417-017-3693-y","article-title":"Proposal of a simple optical coherence tomography-based scoring system for progression of age-related macular degeneration","volume":"255","author":"Lei","year":"2017","journal-title":"Graefes Arch Clin Exp Ophthalmol"},{"key":"10.1016\/j.xops.2022.100116_bib25","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1016\/j.oret.2020.06.026","article-title":"Predicting progression of age-related macular degeneration using OCT and fundus photography","volume":"5","author":"Wu","year":"2021","journal-title":"Ophthalmol Retina"},{"key":"10.1016\/j.xops.2022.100116_bib26","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1167\/tvst.10.4.11","article-title":"Validation of a novel automated algorithm to measure drusen volume and area using swept source optical coherence tomography angiography","volume":"10","author":"Jiang","year":"2021","journal-title":"Transl Vis Sci Technol"}],"container-title":["Ophthalmology Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2666914522000057?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2666914522000057?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,13]],"date-time":"2025-11-13T06:22:24Z","timestamp":1763014944000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2666914522000057"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,6]]},"references-count":26,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2022,6]]}},"alternative-id":["S2666914522000057"],"URL":"https:\/\/doi.org\/10.1016\/j.xops.2022.100116","relation":{},"ISSN":["2666-9145"],"issn-type":[{"value":"2666-9145","type":"print"}],"subject":[],"published":{"date-parts":[[2022,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Multimodal Imaging, OCT B-Scan Localization, and En Face OCT Detection of Macular Hyperpigmentation in Eyes with Intermediate Age-Related Macular Degeneration","name":"articletitle","label":"Article Title"},{"value":"Ophthalmology Science","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.xops.2022.100116","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 by the American Academy of Ophthalmology.","name":"copyright","label":"Copyright"}],"article-number":"100116"}}