{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T16:44:46Z","timestamp":1780505086141,"version":"3.54.1"},"reference-count":66,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T00:00:00Z","timestamp":1661990400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T00:00:00Z","timestamp":1661990400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,8,29]],"date-time":"2022-08-29T00:00:00Z","timestamp":1661731200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100001818","name":"Research to Prevent Blindness","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001818","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004100","name":"Labex","doi-asserted-by":"publisher","award":["ANR-10-LABX-0065"],"award-info":[{"award-number":["ANR-10-LABX-0065"]}],"id":[{"id":"10.13039\/501100004100","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100002924","name":"Glaucoma Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100002924","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006312","name":"BrightFocus Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006312","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008097","name":"Edward N. and Della L. Thome Memorial Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008097","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000005","name":"U.S. Department of Defense","doi-asserted-by":"publisher","award":["2019-447-005"],"award-info":[{"award-number":["2019-447-005"]}],"id":[{"id":"10.13039\/100000005","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000005","name":"U.S. Department of Defense","doi-asserted-by":"publisher","award":["W81XWH-22-9-0011"],"award-info":[{"award-number":["W81XWH-22-9-0011"]}],"id":[{"id":"10.13039\/100000005","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000053","name":"National Eye Institute","doi-asserted-by":"publisher","award":["K08EY031801"],"award-info":[{"award-number":["K08EY031801"]}],"id":[{"id":"10.13039\/100000053","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000053","name":"National Eye Institute","doi-asserted-by":"publisher","award":["P30EY001765"],"award-info":[{"award-number":["P30EY001765"]}],"id":[{"id":"10.13039\/100000053","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000781","name":"European Research Council","doi-asserted-by":"publisher","award":["610110"],"award-info":[{"award-number":["610110"]}],"id":[{"id":"10.13039\/501100000781","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000781","name":"European Research Council","doi-asserted-by":"publisher","award":["R01-EY013178"],"award-info":[{"award-number":["R01-EY013178"]}],"id":[{"id":"10.13039\/501100000781","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000781","name":"European Research Council","doi-asserted-by":"publisher","award":["U01-EY033001"],"award-info":[{"award-number":["U01-EY033001"]}],"id":[{"id":"10.13039\/501100000781","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["ophthalmologyscience.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Ophthalmology Science"],"published-print":{"date-parts":[[2022,9]]},"DOI":"10.1016\/j.xops.2022.100216","type":"journal-article","created":{"date-parts":[[2022,9,5]],"date-time":"2022-09-05T03:32:09Z","timestamp":1662348729000},"page":"100216","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":9,"title":["Neuroprotection, Neuroenhancement, and Neuroregeneration of the Retina and Optic Nerve"],"prefix":"10.1016","volume":"2","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5372-5457","authenticated-orcid":false,"given":"Thomas V.","family":"Johnson","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adriana","family":"Di Polo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9-Alain","family":"Sahel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joel S.","family":"Schuman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.xops.2022.100216_bib1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.preteyeres.2017.01.002","article-title":"BAX to basics: how the BCL2 gene family controls the death of retinal ganglion cells","volume":"57","author":"Maes","year":"2017","journal-title":"Prog Retin Eye Res"},{"key":"10.1016\/j.xops.2022.100216_bib2","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/j.exer.2013.04.021","article-title":"JUN regulates early transcriptional responses to axonal injury in retinal ganglion cells","volume":"112","author":"Fernandes","year":"2013","journal-title":"Exp Eye Res"},{"key":"10.1016\/j.xops.2022.100216_bib3","doi-asserted-by":"crossref","first-page":"1372","DOI":"10.3390\/cells10061372","article-title":"Multifactorial pathogenic processes of retinal ganglion cell degeneration in glaucoma towards multi-target strategies for broader treatment effects","volume":"10","author":"Tezel","year":"2021","journal-title":"Cells"},{"key":"10.1016\/j.xops.2022.100216_bib4","doi-asserted-by":"crossref","first-page":"e2945","DOI":"10.1038\/cddis.2017.338","article-title":"JUN is important for ocular hypertension-induced retinal ganglion cell degeneration","volume":"8","author":"Syc-Mazurek","year":"2017","journal-title":"Cell Death Dis"},{"key":"10.1016\/j.xops.2022.100216_bib5","doi-asserted-by":"crossref","first-page":"e4","DOI":"10.1371\/journal.pgen.0010004","article-title":"Susceptibility to neurodegeneration in a glaucoma is modified by Bax gene dosage","volume":"1","author":"Libby","year":"2005","journal-title":"PloS Genet"},{"key":"10.1016\/j.xops.2022.100216_bib6","doi-asserted-by":"crossref","first-page":"1142","DOI":"10.1016\/j.neuron.2017.06.008","article-title":"Enhanced functional genomic screening identifies novel mediators of dual leucine zipper kinase-dependent injury signaling in neurons","volume":"94","author":"Welsbie","year":"2017","journal-title":"Neuron"},{"key":"10.1016\/j.xops.2022.100216_bib7","first-page":"549","article-title":"Functional genomic screening identifies dual leucine zipper kinase as a key mediator of retinal ganglion cell death","volume":"10","author":"Welsbie","year":"2013","journal-title":"Neurotherapeutics"},{"key":"10.1016\/j.xops.2022.100216_bib8","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2020.108271","article-title":"GLP-1 receptor agonist NLY01 reduces retinal inflammation and neuron death secondary to ocular hypertension","volume":"33","author":"Sterling","year":"2020","journal-title":"Cell Rep"},{"key":"10.1016\/j.xops.2022.100216_bib9","doi-asserted-by":"crossref","first-page":"1433","DOI":"10.1172\/JCI79735","article-title":"NRF2 promotes neuronal survival in neurodegeneration and acute nerve damage","volume":"125","author":"Xiong","year":"2015","journal-title":"J\u00a0Clin Invest"},{"key":"10.1016\/j.xops.2022.100216_bib10","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.abd2590","article-title":"Receptor-ligand supplementation via a self-cleaving 2A peptide-based gene therapy promotes CNS axonal transport with functional recovery","volume":"7","author":"Khatib","year":"2021","journal-title":"Sci Adv"},{"key":"10.1016\/j.xops.2022.100216_bib11","doi-asserted-by":"crossref","first-page":"1039","DOI":"10.1016\/j.neuron.2019.11.006","article-title":"Single-cell profiles of retinal ganglion cells differing in resilience to injury reveal neuroprotective genes","volume":"104","author":"Tran","year":"2019","journal-title":"Neuron"},{"key":"10.1016\/j.xops.2022.100216_bib12","doi-asserted-by":"crossref","first-page":"2607","DOI":"10.1016\/j.neuron.2022.06.003","article-title":"Core transcription programs controlling injury-induced neurodegeneration of retinal ganglion cells","volume":"110","author":"Tian","year":"2022","journal-title":"Neuron"},{"key":"10.1016\/j.xops.2022.100216_bib13","doi-asserted-by":"crossref","first-page":"2625","DOI":"10.1016\/j.neuron.2022.06.002","article-title":"Overlapping transcriptional programs promote survival and axonal regeneration of injured retinal ganglion cells","volume":"110","author":"Jacobi","year":"2022","journal-title":"Neuron"},{"key":"10.1016\/j.xops.2022.100216_bib14","doi-asserted-by":"crossref","first-page":"2646","DOI":"10.1016\/j.neuron.2022.06.022","article-title":"Single-cell transcriptome analysis of regenerating RGCs reveals potent glaucoma neural repair genes","volume":"110","author":"Li","year":"2022","journal-title":"Neuron"},{"key":"10.1016\/j.xops.2022.100216_bib15","doi-asserted-by":"crossref","first-page":"1874","DOI":"10.1016\/j.ophtha.2018.06.017","article-title":"Oral memantine for the treatment of glaucoma: design and results of 2 randomized, placebo-controlled, phase 3 studies","volume":"125","author":"Weinreb","year":"2018","journal-title":"Ophthalmology"},{"key":"10.1016\/j.xops.2022.100216_bib16","doi-asserted-by":"crossref","first-page":"2770","DOI":"10.1167\/iovs.12-9476","article-title":"Intervals between visual field tests when monitoring the glaucomatous patient: wait-and-see approach","volume":"53","author":"Crabb","year":"2012","journal-title":"Invest Ophth Vis Sci"},{"key":"10.1016\/j.xops.2022.100216_bib17","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1167\/iovs.17-21562","article-title":"Detection of functional change using cluster trend analysis in glaucoma","volume":"58","author":"Gardiner","year":"2017","journal-title":"Invest Ophth Vis Sci"},{"key":"10.1016\/j.xops.2022.100216_bib18","doi-asserted-by":"crossref","first-page":"7681","DOI":"10.1167\/iovs.14-15040","article-title":"Clustering visual field test points based on rates of progression to improve the prediction of future damage","volume":"55","author":"Hirasawa","year":"2014","journal-title":"Invest Ophth Vis Sci"},{"key":"10.1016\/j.xops.2022.100216_bib19","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1080\/14737159.2020.1758067","article-title":"A\u00a0CNN-aided method to predict glaucoma progression using DARC (detection of apoptosing retinal cells)","volume":"20","author":"Normando","year":"2020","journal-title":"Expert Rev Mol Diagn"},{"key":"10.1016\/j.xops.2022.100216_bib20","doi-asserted-by":"crossref","first-page":"756","DOI":"10.1126\/science.aal0092","article-title":"Vitamin B3 modulates mitochondrial vulnerability and prevents glaucoma in aged mice","volume":"355","author":"Williams","year":"2017","journal-title":"Science"},{"key":"10.1016\/j.xops.2022.100216_bib21","doi-asserted-by":"crossref","first-page":"2509","DOI":"10.1167\/iovs.19-27099","article-title":"Nicotinamide deficiency in primary open-angle glaucoma","volume":"60","author":"Kouassi","year":"2019","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.xops.2022.100216_bib22","doi-asserted-by":"crossref","first-page":"4263","DOI":"10.3390\/nu13124263","article-title":"Association between daily niacin intake and glaucoma: National Health and Nutrition Examination Survey","volume":"13","author":"Taechameekietichai","year":"2021","journal-title":"Nutrients"},{"key":"10.1016\/j.xops.2022.100216_bib23","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2021.101988","article-title":"Nicotinamide provides neuroprotection in glaucoma by protecting against mitochondrial and metabolic dysfunction","volume":"43","author":"Tribble","year":"2021","journal-title":"Redox Biol"},{"key":"10.1016\/j.xops.2022.100216_bib24","doi-asserted-by":"crossref","first-page":"893","DOI":"10.3390\/pharmaceutics13060893","article-title":"Systemic treatment with nicotinamide riboside is protective in two mouse models of retinal ganglion cell damage","volume":"13","author":"Zhang","year":"2021","journal-title":"Pharmaceutics"},{"key":"10.1016\/j.xops.2022.100216_bib25","doi-asserted-by":"crossref","first-page":"1910","DOI":"10.3390\/nu12071910","article-title":"Nicotinamide-rich diet in DBA\/2J mice preserves retinal ganglion cell metabolic function as assessed by PERG adaptation to Flicker","volume":"12","author":"Chou","year":"2020","journal-title":"Nutrients"},{"key":"10.1016\/j.xops.2022.100216_bib26","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1001\/jamaophthalmol.2021.4576","article-title":"Nicotinamide and pyruvate for neuroenhancement in open-angle glaucoma: a phase 2 randomized clinical trial","volume":"140","author":"De Moraes","year":"2022","journal-title":"JAMA Ophthalmol"},{"key":"10.1016\/j.xops.2022.100216_bib27","doi-asserted-by":"crossref","first-page":"903","DOI":"10.1111\/ceo.13818","article-title":"Improvement in inner retinal function in glaucoma with nicotinamide (vitamin B3) supplementation: a crossover randomized clinical trial","volume":"48","author":"Hui","year":"2020","journal-title":"Clin Exp Ophthalmol"},{"key":"10.1016\/j.xops.2022.100216_bib28","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0144341","article-title":"Synapse loss and dendrite remodeling in a mouse model of glaucoma","volume":"10","author":"Berry","year":"2015","journal-title":"Plos One"},{"key":"10.1016\/j.xops.2022.100216_bib29","doi-asserted-by":"crossref","first-page":"fcz035","DOI":"10.1093\/braincomms\/fcz035","article-title":"Midget retinal ganglion cell dendritic and mitochondrial degeneration is an early feature of human glaucoma","volume":"1","author":"Tribble","year":"2019","journal-title":"Brain Commun"},{"key":"10.1016\/j.xops.2022.100216_bib30","doi-asserted-by":"crossref","first-page":"1164","DOI":"10.1016\/j.cell.2007.10.036","article-title":"The classical complement cascade mediates CNS synapse elimination","volume":"131","author":"Stevens","year":"2007","journal-title":"Cell"},{"key":"10.1016\/j.xops.2022.100216_bib31","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s13024-016-0091-6","article-title":"Inhibition of the classical pathway of the complement cascade prevents early dendritic and synaptic degeneration in glaucoma","volume":"11","author":"Williams","year":"2016","journal-title":"Mol Neurodegener"},{"key":"10.1016\/j.xops.2022.100216_bib32","doi-asserted-by":"crossref","first-page":"2379","DOI":"10.1016\/j.ymthe.2018.08.017","article-title":"Complement C3-targeted gene therapy restricts onset and progression of neurodegeneration in chronic mouse glaucoma","volume":"26","author":"Bosco","year":"2018","journal-title":"Mol Ther"},{"key":"10.1016\/j.xops.2022.100216_bib33","doi-asserted-by":"crossref","first-page":"1963","DOI":"10.1093\/brain\/awy142","article-title":"Insulin signalling promotes dendrite and synapse regeneration and restores circuit function after axonal injury","volume":"141","author":"Agostinone","year":"2018","journal-title":"Brain"},{"key":"10.1016\/j.xops.2022.100216_bib34","doi-asserted-by":"crossref","first-page":"3649","DOI":"10.1007\/s00018-016-2318-7","article-title":"Metabolic and redox signaling in the retina","volume":"74","author":"Leveillard","year":"2017","journal-title":"Cell Mol Life Sci"},{"key":"10.1016\/j.xops.2022.100216_bib35","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1016\/j.neuron.2019.05.044","article-title":"Thrombospondin-1 mediates axon regeneration in retinal ganglion cells","volume":"103","author":"Bray","year":"2019","journal-title":"Neuron"},{"key":"10.1016\/j.xops.2022.100216_bib36","doi-asserted-by":"crossref","first-page":"2540","DOI":"10.1016\/j.celrep.2018.07.105","article-title":"Lin28 signaling supports mammalian PNS and CNS axon regeneration","volume":"24","author":"Wang","year":"2018","journal-title":"Cell Rep"},{"key":"10.1016\/j.xops.2022.100216_bib37","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.neuron.2019.04.033","article-title":"Elevating growth factor responsiveness and axon regeneration by modulating presynaptic inputs","volume":"103","author":"Zhang","year":"2019","journal-title":"Neuron"},{"key":"10.1016\/j.xops.2022.100216_bib38","first-page":"E209","article-title":"Mobile zinc increases rapidly in the retina after optic nerve injury and regulates ganglion cell survival and optic nerve regeneration","volume":"114","author":"Li","year":"2017","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.xops.2022.100216_bib39","doi-asserted-by":"crossref","first-page":"963","DOI":"10.1126\/science.1161566","article-title":"Promoting axon regeneration in the adult CNS by modulation of the PTEN\/mTOR pathway","volume":"322","author":"Park","year":"2008","journal-title":"Science"},{"key":"10.1016\/j.xops.2022.100216_bib40","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1016\/j.neuron.2009.11.021","article-title":"SOCS3 deletion promotes optic nerve regeneration in\u00a0vivo","volume":"64","author":"Smith","year":"2009","journal-title":"Neuron"},{"key":"10.1016\/j.xops.2022.100216_bib41","doi-asserted-by":"crossref","first-page":"9149","DOI":"10.1073\/pnas.1119449109","article-title":"Full-length axon regeneration in the adult mouse optic nerve and partial recovery of simple visual behaviors","volume":"109","author":"de Lima","year":"2012","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.xops.2022.100216_bib42","doi-asserted-by":"crossref","first-page":"1073","DOI":"10.1038\/nn.4340","article-title":"Neural activity promotes long-distance, target-specific regeneration of adult retinal axons","volume":"19","author":"Lim","year":"2016","journal-title":"Nat Neurosci"},{"key":"10.1016\/j.xops.2022.100216_bib43","doi-asserted-by":"crossref","first-page":"1038","DOI":"10.1056\/NEJMoa1608368","article-title":"Autologous induced stem-cell-derived retinal cells for macular degeneration","volume":"376","author":"Mandai","year":"2017","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.xops.2022.100216_bib44","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1136\/bjophthalmol-2020-316225","article-title":"Long-term safety and tolerability of subretinal transplantation of embryonic stem cell-derived retinal pigment epithelium in Asian Stargardt disease patients","volume":"105","author":"Sung","year":"2021","journal-title":"Br J Ophthalmol"},{"key":"10.1016\/j.xops.2022.100216_bib45","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1038\/nature05161","article-title":"Retinal repair by transplantation of photoreceptor precursors","volume":"444","author":"MacLaren","year":"2006","journal-title":"Nature"},{"key":"10.1016\/j.xops.2022.100216_bib46","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.preteyeres.2018.11.001","article-title":"Transplantation of photoreceptors into the degenerative retina: current state and future perspectives","volume":"69","author":"Gasparini","year":"2019","journal-title":"Prog Retin Eye Res"},{"key":"10.1016\/j.xops.2022.100216_bib47","doi-asserted-by":"crossref","first-page":"1426","DOI":"10.3390\/cells10061426","article-title":"Retinal ganglion cell transplantation: approaches for overcoming challenges to functional integration","volume":"10","author":"Zhang","year":"2021","journal-title":"Cells"},{"key":"10.1016\/j.xops.2022.100216_bib48","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/ncomms10472","article-title":"Transplanted neurons integrate into adult retinas and respond to light","volume":"7","author":"Venugopalan","year":"2016","journal-title":"Nat Commun"},{"key":"10.1016\/j.xops.2022.100216_bib49","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1016\/j.omtm.2021.03.004","article-title":"Transplantation of miPSC\/mESC-derived retinal ganglion cells into healthy and glaucomatous retinas","volume":"21","author":"Oswald","year":"2021","journal-title":"Mol Ther-Meth Clin D"},{"key":"10.1016\/j.xops.2022.100216_bib50","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/j.stemcr.2020.12.001","article-title":"Role of the internal limiting membrane in structural engraftment and topographic spacing of transplanted human stem cell-derived retinal ganglion cells","volume":"16","author":"Zhang","year":"2021","journal-title":"Stem Cell Rep"},{"key":"10.1016\/j.xops.2022.100216_bib51","doi-asserted-by":"crossref","first-page":"13717","DOI":"10.1073\/pnas.1510595112","article-title":"Transgenic expression of the proneural transcription factor Ascl1 in M\u00fcller glia stimulates retinal regeneration in young mice","volume":"112","author":"Ueki","year":"2015","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.xops.2022.100216_bib52","doi-asserted-by":"crossref","DOI":"10.1126\/science.abb8598","article-title":"Gene regulatory networks controlling vertebrate retinal regeneration","volume":"370","author":"Hoang","year":"2020","journal-title":"Science"},{"key":"10.1016\/j.xops.2022.100216_bib53","doi-asserted-by":"crossref","first-page":"2195","DOI":"10.1016\/j.celrep.2020.01.075","article-title":"STAT signaling modifies Ascl1 chromatin binding and limits neural regeneration from muller glia in adult mouse retina","volume":"30","author":"Jorstad","year":"2020","journal-title":"Cell Rep"},{"key":"10.1016\/j.xops.2022.100216_bib54","doi-asserted-by":"crossref","first-page":"1380","DOI":"10.1002\/glia.24181","article-title":"NFkB-signaling promotes glial reactivity and suppresses Muller glia-mediated neuron regeneration in the mammalian retina","volume":"70","author":"Palazzo","year":"2022","journal-title":"Glia"},{"key":"10.1016\/j.xops.2022.100216_bib55","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2021.109857","article-title":"Efficient stimulation of retinal regeneration from Muller glia in adult mice using combinations of proneural bHLH transcription factors","volume":"37","author":"Todd","year":"2021","journal-title":"Cell Rep"},{"key":"10.1016\/j.xops.2022.100216_bib56","doi-asserted-by":"crossref","DOI":"10.15252\/embr.202153732","article-title":"Nanotube-like processes facilitate material transfer between photoreceptors","volume":"22","author":"Kalargyrou","year":"2021","journal-title":"Embo Rep"},{"key":"10.1016\/j.xops.2022.100216_bib57","doi-asserted-by":"crossref","DOI":"10.15252\/embj.2020107264","article-title":"Photoreceptor nanotubes mediate the in\u00a0vivo exchange of intracellular material","volume":"40","author":"Ortin-Martinez","year":"2021","journal-title":"Embo J"},{"key":"10.1016\/j.xops.2022.100216_bib58","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/ncomms13029","article-title":"Donor and host photoreceptors engage in material transfer following transplantation of post-mitotic photoreceptor precursors","volume":"7","author":"Pearson","year":"2016","journal-title":"Nat Commun"},{"key":"10.1016\/j.xops.2022.100216_bib59","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1002\/dvdy.24535","article-title":"Cell lineage tracing in the retina: could material transfer distort conclusions?","volume":"247","author":"Boudreau-Pinsonneault","year":"2018","journal-title":"Dev Dynam"},{"key":"10.1016\/j.xops.2022.100216_bib60","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/ncomms13537","article-title":"Transplanted photoreceptor precursors transfer proteins to host photoreceptors by a mechanism of cytoplasmic fusion","volume":"7","author":"Singh","year":"2016","journal-title":"Nat Commun"},{"key":"10.1016\/j.xops.2022.100216_bib61","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/ncomms13028","article-title":"Retinal transplantation of photoreceptors results in donor-host cytoplasmic exchange","volume":"7","author":"Santos-Ferreira","year":"2016","journal-title":"Nat Commun"},{"key":"10.1016\/j.xops.2022.100216_bib62","doi-asserted-by":"crossref","first-page":"1223","DOI":"10.1038\/s41591-021-01351-4","article-title":"Partial recovery of visual function in a blind patient after optogenetic therapy","volume":"27","author":"Sahel","year":"2021","journal-title":"Nat Med"},{"key":"10.1016\/j.xops.2022.100216_bib63","doi-asserted-by":"crossref","first-page":"774","DOI":"10.1016\/j.cell.2020.04.033","article-title":"Dynamic stimulation of visual cortex produces form vision in sighted and blind humans","volume":"181","author":"Beauchamp","year":"2020","journal-title":"Cell"},{"key":"10.1016\/j.xops.2022.100216_bib64","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1111\/ceo.12812","article-title":"Performance of real-world functional vision tasks by blind subjects improves after implantation with the Argus\u00ae II retinal prosthesis system","volume":"45","author":"Dagnelie","year":"2017","journal-title":"Clin Exp Ophthalmol"},{"key":"10.1016\/j.xops.2022.100216_bib65","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s43246-021-00133-2","article-title":"Photovoltaic retinal prosthesis restores high-resolution responses to single-pixel stimulation in blind retinas","volume":"2","author":"Chenais","year":"2021","journal-title":"Commun Mater"},{"key":"10.1016\/j.xops.2022.100216_bib66","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41467-022-28125-x","article-title":"Simultaneous perception of prosthetic and natural vision in AMD patients","volume":"13","author":"Palanker","year":"2022","journal-title":"Nat Commun"}],"container-title":["Ophthalmology Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2666914522001051?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2666914522001051?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,13]],"date-time":"2025-11-13T06:21:21Z","timestamp":1763014881000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2666914522001051"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,9]]},"references-count":66,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2022,9]]}},"alternative-id":["S2666914522001051"],"URL":"https:\/\/doi.org\/10.1016\/j.xops.2022.100216","relation":{},"ISSN":["2666-9145"],"issn-type":[{"value":"2666-9145","type":"print"}],"subject":[],"published":{"date-parts":[[2022,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Neuroprotection, Neuroenhancement, and Neuroregeneration of the Retina and Optic Nerve","name":"articletitle","label":"Article Title"},{"value":"Ophthalmology Science","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.xops.2022.100216","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"simple-article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 by the American Academy of Ophthalmology.","name":"copyright","label":"Copyright"}],"article-number":"100216"}}