{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T22:00:52Z","timestamp":1792101652426,"version":"4.4.0"},"reference-count":19,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2023,6,1]],"date-time":"2023-06-01T00:00:00Z","timestamp":1685577600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,6,1]],"date-time":"2023-06-01T00:00:00Z","timestamp":1685577600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,2,21]],"date-time":"2023-02-21T00:00:00Z","timestamp":1676937600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000053","name":"National Eye Institute","doi-asserted-by":"publisher","award":["P30-EY026877"],"award-info":[{"award-number":["P30-EY026877"]}],"id":[{"id":"10.13039\/100000053","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100001818","name":"Research to Prevent Blindness","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001818","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["ophthalmologyscience.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Ophthalmology Science"],"published-print":{"date-parts":[[2023,6]]},"DOI":"10.1016\/j.xops.2023.100290","type":"journal-article","created":{"date-parts":[[2023,2,24]],"date-time":"2023-02-24T20:15:15Z","timestamp":1677269715000},"page":"100290","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":34,"title":["Safety and Target Engagement of Complement C1q Inhibitor ANX007 in Neurodegenerative Eye\u00a0Disease"],"prefix":"10.1016","volume":"3","author":[{"given":"Yang","family":"Sun","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Wirta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wendy","family":"Murahashi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vidhu","family":"Mathur","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sethu","family":"Sankaranarayanan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lori K.","family":"Taylor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ted","family":"Yednock","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9628-0825","authenticated-orcid":false,"given":"Donald S.","family":"Fong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1390-7360","authenticated-orcid":false,"given":"Jeffrey L.","family":"Goldberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.xops.2023.100290_bib1","author":"Biggerstaff"},{"key":"10.1016\/j.xops.2023.100290_bib2","doi-asserted-by":"crossref","first-page":"620","DOI":"10.1016\/j.exer.2006.03.002","article-title":"Retinal synthesis and deposition of complement components induced by ocular hypertension","volume":"83","author":"Kuehn","year":"2006","journal-title":"Exp Eye Res"},{"key":"10.1016\/j.xops.2023.100290_bib3","doi-asserted-by":"crossref","first-page":"1901","DOI":"10.1001\/jama.2014.3192","article-title":"The pathophysiology and treatment of glaucoma. A review","volume":"311","author":"Weinreb","year":"2014","journal-title":"JAMA"},{"key":"10.1016\/j.xops.2023.100290_bib4","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1111\/cxo.13114","article-title":"Management of open-angle glaucoma by primary eye-care practitioners towards a personalized medicine approach","volume":"104","author":"Phu","year":"2020","journal-title":"Clin Exp Optom"},{"key":"10.1016\/j.xops.2023.100290_bib5","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1038\/s41433-019-0633-6","article-title":"Treatment choices for newly diagnosed primary open angle glaucoma and ocular hypertension patients","volume":"34","author":"Garg","year":"2020","journal-title":"Eye (Lond)"},{"key":"10.1016\/j.xops.2023.100290_bib6","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1038\/s41433-019-0687-5","article-title":"Systematic reviews and randomised controlled trials on open-angle glaucoma","volume":"34","author":"Wormald","year":"2020","journal-title":"Eye (Lond)"},{"key":"10.1016\/j.xops.2023.100290_bib7","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1186\/s12974-020-02024-8","article-title":"The good, the bad, and the opportunities of the complement system in neurodegenerative disease","volume":"17","author":"Schartz","year":"2020","journal-title":"J\u00a0Neuroinflammation"},{"key":"10.1016\/j.xops.2023.100290_bib8","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/bs.ai.2017.06.004","article-title":"Complement system in neural elimination in development and disease","volume":"135","author":"Presumey","year":"2017","journal-title":"Adv Immunol"},{"key":"10.1016\/j.xops.2023.100290_bib9","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1146\/annurev-neuro-061010-113810","article-title":"The complement system: an unexpected role in synaptic pruning during development and disease","volume":"35","author":"Stephan","year":"2012","journal-title":"Annu Rev Neurosci"},{"key":"10.1016\/j.xops.2023.100290_bib10","doi-asserted-by":"crossref","first-page":"5071","DOI":"10.1167\/iovs.10-5289","article-title":"Oxidative stress and the regulation of complement activation in human glaucoma","volume":"51","author":"Tezel","year":"2010","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"1","key":"10.1016\/j.xops.2023.100290_bib11","doi-asserted-by":"crossref","first-page":"11572","DOI":"10.1038\/s41598-019-48054-y","article-title":"Towards a microbead occlusion model of glaucoma for a non-human primate","volume":"9","author":"Lambert","year":"2019","journal-title":"Sci Rep"},{"key":"10.1016\/j.xops.2023.100290_bib12","doi-asserted-by":"crossref","first-page":"1024","DOI":"10.1167\/iovs.05-0830","article-title":"Complement component 1Q (C1Q) upregulation in retina of murine, primate, and human glaucomatous eyes","volume":"47","author":"Stasi","year":"2006","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.xops.2023.100290_bib13","doi-asserted-by":"crossref","first-page":"1164","DOI":"10.1016\/j.cell.2007.10.036","article-title":"The classical complement cascade mediates CNS synapse elimination","volume":"131","author":"Stevens","year":"2007","journal-title":"Cell"},{"key":"10.1016\/j.xops.2023.100290_bib14","doi-asserted-by":"crossref","first-page":"1429","DOI":"10.1172\/JCI44646","article-title":"Molecular clustering identifies complement and endothelin induction as early events in a mouse model of glaucoma","volume":"121","author":"Howell","year":"2011","journal-title":"J\u00a0Clin Invest"},{"key":"10.1016\/j.xops.2023.100290_bib15","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1186\/s13024-018-0278-0","article-title":"Subretinal macrophages produce classical complement activator C1q leading to the progression of focal retinal degeneration","volume":"13","author":"Jiao","year":"2018","journal-title":"Mol Neurodegen"},{"key":"10.1016\/j.xops.2023.100290_bib16","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1177\/1091581817740873","article-title":"Nonclinical development of ANX005: a humanized anti-C1q antibody for treatment of autoimmune and neurodegenerative diseases","volume":"36","author":"Lansita","year":"2017","journal-title":"Int J Toxicol"},{"key":"10.1016\/j.xops.2023.100290_bib17","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1186\/1742-2094-10-76","article-title":"Deficiency of complement component 5 ameliorates glaucoma in DBA\/2J mice","volume":"10","author":"Howell","year":"2013","journal-title":"J\u00a0Neuroinflammation"},{"key":"10.1016\/j.xops.2023.100290_bib18","doi-asserted-by":"crossref","first-page":"108077","DOI":"10.1016\/j.exer.2020.108077","article-title":"The aqueous humor proteome of primary open-angle glaucoma: an extensive review","volume":"197","author":"Hubens","year":"2020","journal-title":"Exp Eye Res"},{"key":"10.1016\/j.xops.2023.100290_bib19","doi-asserted-by":"crossref","first-page":"7348","DOI":"10.1038\/s41598-018-25557-8","article-title":"Classical and alternative complement activation on photoreceptor outer segments drives monocyte-dependent retinal atrophy","volume":"8","author":"Katscjke","year":"2018","journal-title":"Sci Rep"}],"container-title":["Ophthalmology Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2666914523000222?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2666914523000222?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,13]],"date-time":"2025-11-13T06:22:00Z","timestamp":1763014920000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2666914523000222"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,6]]},"references-count":19,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2023,6]]}},"alternative-id":["S2666914523000222"],"URL":"https:\/\/doi.org\/10.1016\/j.xops.2023.100290","relation":{},"ISSN":["2666-9145"],"issn-type":[{"value":"2666-9145","type":"print"}],"subject":[],"published":{"date-parts":[[2023,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Safety and Target Engagement of Complement C1q Inhibitor ANX007 in Neurodegenerative Eye\u00a0Disease","name":"articletitle","label":"Article Title"},{"value":"Ophthalmology Science","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.xops.2023.100290","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 by the American Academy of Ophthalmology.","name":"copyright","label":"Copyright"}],"article-number":"100290"}}