{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T14:58:42Z","timestamp":1789570722111,"version":"build-2803163510"},"reference-count":27,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:00:00Z","timestamp":1693526400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T00:00:00Z","timestamp":1693526400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,4,7]],"date-time":"2023-04-07T00:00:00Z","timestamp":1680825600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["ophthalmologyscience.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Ophthalmology Science"],"published-print":{"date-parts":[[2023,9]]},"DOI":"10.1016\/j.xops.2023.100308","type":"journal-article","created":{"date-parts":[[2023,4,13]],"date-time":"2023-04-13T05:51:56Z","timestamp":1681365116000},"page":"100308","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":13,"title":["Reduced Cone Density Is Associated with Multiple Sclerosis"],"prefix":"10.1016","volume":"3","author":[{"given":"Gemma","family":"McIlwaine","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5243-7536","authenticated-orcid":false,"given":"Lajos","family":"Csincsik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachel","family":"Coey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luping","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8608-430X","authenticated-orcid":false,"given":"Denise","family":"Fitzgerald","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1222-0524","authenticated-orcid":false,"given":"Jill","family":"Moffat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adam M.","family":"Dubis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gavin","family":"McDonnell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stella","family":"Hughes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tunde","family":"Peto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7467-2174","authenticated-orcid":false,"given":"Imre","family":"Lengyel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.xops.2023.100308_bib1","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1002\/ana.24487","article-title":"Optical coherence tomography reflects brain atrophy in multiple sclerosis: a four-year study","volume":"78","author":"Saidha","year":"2015","journal-title":"Ann Neurol"},{"key":"10.1016\/j.xops.2023.100308_bib2","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1093\/brain\/awu335","article-title":"Vision and vision-related outcome measures in multiple sclerosis","volume":"138","author":"Balcer","year":"2015","journal-title":"Brain"},{"key":"10.1016\/j.xops.2023.100308_bib3","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1167\/iovs.17-22821","article-title":"Outer retinal dysfunction in the absence of structural abnormalities in multiple sclerosis","volume":"59","author":"Hanson","year":"2018","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.xops.2023.100308_bib4","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1007\/s10633-021-09855-7","article-title":"A\u00a0three-year longitudinal study of retinal function and structure in patients with multiple sclerosis","volume":"144","author":"Hanson","year":"2022","journal-title":"Doc Ophthalmol"},{"key":"10.1016\/j.xops.2023.100308_bib5","doi-asserted-by":"crossref","first-page":"2235","DOI":"10.1002\/acn3.51473","article-title":"Optical coherence tomography in multiple sclerosis: a 3-year prospective multicenter study","volume":"8","author":"Paul","year":"2021","journal-title":"Ann Clin Transl Neurol"},{"key":"10.1016\/j.xops.2023.100308_bib6","doi-asserted-by":"crossref","first-page":"1449","DOI":"10.1177\/1352458511418630","article-title":"Visual dysfunction in multiple sclerosis correlates better with optical coherence tomography derived estimates of macular ganglion cell layer thickness than peripapillary retinal nerve fiber layer thickness","volume":"17","author":"Saidha","year":"2011","journal-title":"Mult Scler"},{"key":"10.1016\/j.xops.2023.100308_bib7","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1016\/j.ophtha.2005.10.040","article-title":"Relation of visual function to retinal nerve fiber layer thickness in multiple sclerosis","volume":"113","author":"Fisher","year":"2006","journal-title":"Ophthalmology"},{"key":"10.1016\/j.xops.2023.100308_bib8","doi-asserted-by":"crossref","first-page":"200","DOI":"10.4103\/1110-1083.202376","article-title":"Visual dysfunction and neurological disability in multiple sclerosis patients in correlation with the retinal nerve fiber layer and the ganglion cell layer using optical coherence tomography. Original Article","volume":"53","author":"Gomaa","year":"2016","journal-title":"Egypt J Neurol Psychiatry Neurosurg"},{"key":"10.1016\/j.xops.2023.100308_bib9","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1002\/ana.22366","article-title":"Diagnostic criteria for multiple sclerosis: 2010 revisions to the McDonald criteria","volume":"69","author":"Polman","year":"2011","journal-title":"Ann Neurol"},{"key":"10.1016\/j.xops.2023.100308_bib10","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1212\/WNL.0000000000012125","article-title":"APOSTEL 2.0 recommendations for reporting quantitative optical coherence tomography studies","volume":"97","author":"Aytulun","year":"2021","journal-title":"Neurology"},{"key":"10.1016\/j.xops.2023.100308_bib11","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1038\/nmeth.2089","article-title":"NIH Image to ImageJ: 25 years of image analysis","volume":"9","author":"Schneider","year":"2012","journal-title":"Nat Methods"},{"key":"10.1016\/j.xops.2023.100308_bib12","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1002\/jemt.20393","article-title":"User-friendly semiautomated assembly of accurate image mosaics in microscopy","volume":"70","author":"Thevenaz","year":"2007","journal-title":"Microsc Res Tech"},{"key":"10.1016\/j.xops.2023.100308_bib13","series-title":"GNU Image Manipulation Program (GIMP). Version 2.10.32","year":"1996"},{"key":"10.1016\/j.xops.2023.100308_bib14","doi-asserted-by":"crossref","first-page":"5751","DOI":"10.1167\/iovs.15-16954","article-title":"Assessment of different sampling methods for measuring and representing macular cone density using flood-illuminated adaptive optics","volume":"56","author":"Feng","year":"2015","journal-title":"Invest Opthalmol Vis Sci"},{"key":"10.1016\/j.xops.2023.100308_bib15","first-page":"S16","article-title":"Evaluating loss of visual function in multiple sclerosis as measured by low-contrast letter acuity","volume":"74 Suppl 3","author":"Balcer","year":"2010","journal-title":"Neurology"},{"key":"10.1016\/j.xops.2023.100308_bib16","doi-asserted-by":"crossref","DOI":"10.3389\/fneur.2020.618879","article-title":"Optical coherence tomography and optical coherence tomography angiography findings after optic neuritis in multiple sclerosis","volume":"11","author":"Murphy","year":"2020","journal-title":"Front Neurol"},{"key":"10.1016\/j.xops.2023.100308_bib17","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/j.jns.2009.04.010","article-title":"Relationship of optic nerve and brain conventional and non-conventional MRI measures and retinal nerve fiber layer thickness, as assessed by OCT and GDx: a pilot study","volume":"282","author":"Frohman","year":"2009","journal-title":"J\u00a0Neurol Sci"},{"key":"10.1016\/j.xops.2023.100308_bib18","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1212\/WNL.0b013e3182a3525e","article-title":"Retinal periphlebitis is associated with multiple sclerosis severity","volume":"81","author":"Ortiz-Perez","year":"2013","journal-title":"Neurology"},{"key":"10.1016\/j.xops.2023.100308_bib19","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1212\/WNL.52.1.179","article-title":"Multiple sclerosis associated with uveitis in two large clinic-based series","volume":"52","author":"Biousse","year":"1999","journal-title":"Neurology"},{"key":"10.1016\/j.xops.2023.100308_bib20","doi-asserted-by":"crossref","first-page":"1250","DOI":"10.1016\/j.ophtha.2011.11.032","article-title":"Ganglion cell loss in relation to visual disability in multiple sclerosis","volume":"119","author":"Walter","year":"2012","journal-title":"Ophthalmology"},{"issue":"Pt 2","key":"10.1016\/j.xops.2023.100308_bib21","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1093\/brain\/awr264","article-title":"Optical coherence tomography segmentation reveals ganglion cell layer pathology after optic neuritis","volume":"135","author":"Syc","year":"2012","journal-title":"Brain"},{"key":"10.1016\/j.xops.2023.100308_bib22","doi-asserted-by":"crossref","first-page":"675","DOI":"10.3389\/fneur.2017.00675","article-title":"The temporal retinal nerve fiber layer thickness is the most important optical coherence tomography estimate in multiple sclerosis","volume":"8","author":"Birkeldh","year":"2017","journal-title":"Front Neurol"},{"key":"10.1016\/j.xops.2023.100308_bib23","first-page":"93","article-title":"Inner retinal layer disease: multiple sclerosis","volume":"5","author":"Sabaner","year":"2020","journal-title":"Beyoglu Eye J"},{"key":"10.1016\/j.xops.2023.100308_bib24","article-title":"Photoreceptor outer nuclear layer thickness changes in optic neuritis follow up","volume":"39","author":"Fard","year":"2019","journal-title":"Mult Scler Relat Disord"},{"key":"10.1016\/j.xops.2023.100308_bib25","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1167\/tvst.10.14.11","article-title":"Short-term parafoveal cone loss despite preserved ellipsoid zone in rod cone dystrophy","volume":"10","author":"Roshandel","year":"2021","journal-title":"Transl Vis Sci Technol"},{"key":"10.1016\/j.xops.2023.100308_bib26","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1038\/75614","article-title":"Protection of Rpe65-deficient mice identifies rhodopsin as a mediator of light-induced retinal degeneration","volume":"25","author":"Grimm","year":"2000","journal-title":"Nat Genet"},{"key":"10.1016\/j.xops.2023.100308_bib27","doi-asserted-by":"crossref","first-page":"6858","DOI":"10.1167\/iovs.10-5499","article-title":"Intersubject variability of foveal cone photoreceptor density in relation to eye length","volume":"51","author":"Li","year":"2010","journal-title":"Invest Opthalmol Vis Sci"}],"container-title":["Ophthalmology Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2666914523000404?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2666914523000404?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,13]],"date-time":"2025-11-13T06:24:57Z","timestamp":1763015097000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2666914523000404"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,9]]},"references-count":27,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2023,9]]}},"alternative-id":["S2666914523000404"],"URL":"https:\/\/doi.org\/10.1016\/j.xops.2023.100308","relation":{},"ISSN":["2666-9145"],"issn-type":[{"value":"2666-9145","type":"print"}],"subject":[],"published":{"date-parts":[[2023,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Reduced Cone Density Is Associated with Multiple Sclerosis","name":"articletitle","label":"Article Title"},{"value":"Ophthalmology Science","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.xops.2023.100308","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Published by Elsevier Inc. on behalf of the American Academy of Ophthalmology.","name":"copyright","label":"Copyright"}],"article-number":"100308"}}