{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,6]],"date-time":"2026-05-06T01:40:23Z","timestamp":1778031623401,"version":"3.51.4"},"reference-count":47,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,6,15]],"date-time":"2023-06-15T00:00:00Z","timestamp":1686787200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["ophthalmologyscience.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Ophthalmology Science"],"published-print":{"date-parts":[[2024,1]]},"DOI":"10.1016\/j.xops.2023.100354","type":"journal-article","created":{"date-parts":[[2023,6,20]],"date-time":"2023-06-20T13:03:03Z","timestamp":1687266183000},"page":"100354","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"title":["Retinal Vascular Occlusion after Severe Acute Respiratory Syndrome Coronavirus Vaccination"],"prefix":"10.1016","volume":"4","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2426-3900","authenticated-orcid":false,"given":"Rohan Bir","family":"Singh","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-6746-5127","authenticated-orcid":false,"given":"Uday Pratap Singh","family":"Parmar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rudraksh","family":"Gupta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonio Jacobo Vega","family":"Garcia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0290-8667","authenticated-orcid":false,"given":"Wonkyung","family":"Cho","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4669-906X","authenticated-orcid":false,"given":"Kanwar Partap","family":"Singh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aniruddha","family":"Agarwal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.xops.2023.100354_bib1","doi-asserted-by":"crossref","first-page":"947","DOI":"10.1038\/s41562-021-01122-8","article-title":"A\u00a0global database of COVID-19 vaccinations","volume":"5","author":"Mathieu","year":"2021","journal-title":"Nat Hum Behav"},{"key":"10.1016\/j.xops.2023.100354_bib2","doi-asserted-by":"crossref","first-page":"e590","DOI":"10.1016\/S2214-109X(21)00043-7","article-title":"An interactive website tracking COVID-19 vaccine development","volume":"9","author":"Shrotri","year":"2021","journal-title":"Lancet Glob Health"},{"key":"10.1016\/j.xops.2023.100354_bib6","doi-asserted-by":"crossref","first-page":"3398","DOI":"10.4103\/ijo.IJO_2824_21","article-title":"After the storm: opthalmic manifestations of COVID-19 vaccines","volume":"69","author":"Sen","year":"2021","journal-title":"Ind J Ophthalmol"},{"key":"10.1016\/j.xops.2023.100354_bib7","series-title":"Ocular adverse events after inactivated COVID-19 vaccination in Xiamen","volume":"10","author":"Chen","year":"2022"},{"key":"10.1016\/j.xops.2023.100354_bib8","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.ajo.2022.02.011","article-title":"COVID-19 vaccination and the eye","volume":"240","author":"Wang","year":"2022","journal-title":"Am J Ophthalmol"},{"key":"10.1016\/j.xops.2023.100354_bib9","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1007\/s40123-021-00415-5","article-title":"The eye of the storm: COVID-19 vaccination and the eye","volume":"11","author":"Ng","year":"2022","journal-title":"Ophthalmol Ther"},{"key":"10.1016\/j.xops.2023.100354_bib10","doi-asserted-by":"crossref","first-page":"1630","DOI":"10.3390\/vaccines10101630","article-title":"Glaucoma cases following SARS-CoV-2 vaccination: a VAERS database analysis","volume":"10","author":"Singh","year":"2022","journal-title":"Vaccines (Basel)"},{"key":"10.1016\/j.xops.2023.100354_bib11","article-title":"Vaccine-associated corneal graft rejection following SARS-CoV-2 vaccination: a CDC-VAERS database analysis","author":"Singh","year":"2022","journal-title":"Br J Ophthalmol"},{"key":"10.1016\/j.xops.2023.100354_bib12","article-title":"Vaccine-associated corneal graft rejection following SARS-CoV-2 vaccination: a CDC-VAERS database analysis","author":"Singh","year":"2022","journal-title":"Br J Ophthalmol"},{"key":"10.1016\/j.xops.2023.100354_bib13","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1097\/ICO.0000000000003246","article-title":"Herpetic eye disease after SARS-CoV-2 vaccination: a CDC-VAERS database analysis","volume":"42","author":"Singh","year":"2023","journal-title":"Cornea"},{"key":"10.1016\/j.xops.2023.100354_bib15","doi-asserted-by":"crossref","first-page":"884","DOI":"10.1093\/qjmed\/hcab287","article-title":"Combined central retinal artery and vein occlusion shortly after mRNA-SARS-CoV-2 vaccination","volume":"114","author":"Ikegami","year":"2022","journal-title":"QJM"},{"key":"10.1016\/j.xops.2023.100354_bib16","first-page":"7","article-title":"Combined central retinal artery and vein occlusion with ischemic optic neuropathy after COVID-19 vaccination","volume":"15","author":"Lee","year":"2022","journal-title":"Int Med Case Rep J"},{"key":"10.1016\/j.xops.2023.100354_bib17","series-title":"Susac syndrome following COVID-19 vaccination: a case report","volume":"10","author":"Chen","year":"2022"},{"key":"10.1016\/j.xops.2023.100354_bib18","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2022.845615","article-title":"Case report: recanalization of branch retinal artery occlusion due to microthrombi following the first dose of SARS-CoV-2 mRNA vaccination","volume":"13","author":"Kang","year":"2022","journal-title":"Front Pharmacol"},{"key":"10.1016\/j.xops.2023.100354_bib19","doi-asserted-by":"crossref","first-page":"987","DOI":"10.2147\/OPTH.S357359","article-title":"Branch retinal artery occlusions, paracentral acute middle maculopathy and acute macular neuroretinopathy after COVID-19 vaccinations","volume":"16","author":"Ishibashi","year":"2022","journal-title":"Clin Ophthalmol"},{"key":"10.1016\/j.xops.2023.100354_bib20","doi-asserted-by":"crossref","DOI":"10.1136\/bcr-2021-247159","article-title":"Paracentral acute middle maculopathy in Susac syndrome after dual exposure to SARS-CoV-2 antigen","volume":"15","author":"Malerbi","year":"2022","journal-title":"BMJ Case Rep"},{"key":"10.1016\/j.xops.2023.100354_bib21","doi-asserted-by":"crossref","first-page":"3716","DOI":"10.4103\/ijo.IJO_1148_22","article-title":"Central retinal artery occlusion after vaccination with whole virion inactivated SARSCoV- 2 vaccine Covaxin","volume":"70","author":"Thakar","year":"2022","journal-title":"Indian J Ophthalmol"},{"key":"10.1016\/j.xops.2023.100354_bib22","article-title":"Central retinal artery occlusion following COVID-19 vaccine administration","volume":"26","author":"Abdin","year":"2022","journal-title":"Am J Ophthalmol Case Rep"},{"key":"10.1016\/j.xops.2023.100354_bib23","article-title":"COVID-19 Vaccine-associated ocular adverse effects: an overview","volume":"10","author":"Ichhpujani","year":"2022","journal-title":"Vaccines (Basel)"},{"key":"10.1016\/j.xops.2023.100354_bib24","first-page":"11","article-title":"Vision-threatening ocular adverse events after vaccination against coronavirus disease 2019","author":"Choi","year":"2022","journal-title":"J\u00a0Clin Med"},{"key":"10.1016\/j.xops.2023.100354_bib25","article-title":"Ocular vascular events following COVID-19 vaccines: a systematic review","volume":"10","author":"Abu Serhan","year":"2022","journal-title":"Vaccines (Basel)"},{"key":"10.1016\/j.xops.2023.100354_bib26","doi-asserted-by":"crossref","DOI":"10.1016\/j.jstrokecerebrovasdis.2022.106552","article-title":"Isolated and combined unilateral central retinal artery and vein occlusions after vaccination. A review of the literature","volume":"31","author":"Su","year":"2022","journal-title":"J\u00a0Stroke Cerebrovasc Dis"},{"key":"10.1016\/j.xops.2023.100354_bib27","doi-asserted-by":"crossref","DOI":"10.1016\/j.jstrokecerebrovasdis.2022.106617","article-title":"Retinal artery\/vein occlusion complicating SARS-CoV-2 vaccinations","volume":"31","author":"Finsterer","year":"2022","journal-title":"J\u00a0Stroke Cerebrovasc Dis"},{"key":"10.1016\/j.xops.2023.100354_bib28","article-title":"Retinal vascular occlusion after COVID-19 vaccination: more coincidence than causal relationship? Data from a retrospective multicentre study","volume":"11","author":"Feltgen","year":"2022","journal-title":"J\u00a0Clin Med"},{"key":"10.1016\/j.xops.2023.100354_bib29","article-title":"Paracentral acute middle maculopathy associated with cilioretinal artery insufficiency following COVID-19 vaccination in a young patient","volume":"14","author":"Katerini","year":"2022","journal-title":"Cureus"},{"key":"10.1016\/j.xops.2023.100354_bib30","doi-asserted-by":"crossref","first-page":"1020","DOI":"10.1002\/kjm2.12591","article-title":"Combined central retinal artery occlusion and vein occlusion with exudative retinal detachment following COVID-19 vaccination","volume":"38","author":"Chen","year":"2022","journal-title":"Kaohsiung J Med Sci"},{"key":"10.1016\/j.xops.2023.100354_bib31","doi-asserted-by":"crossref","first-page":"465","DOI":"10.4103\/2211-5056.353129","article-title":"Ocular inflammatory manifestations following COVID-19 vaccinations in Taiwan: a case series","volume":"12","author":"Wang","year":"2022","journal-title":"Taiwan J Ophthalmol"},{"key":"10.1016\/j.xops.2023.100354_bib32","article-title":"Simultaneous unilateral central retinal vein occlusion and branch retinal artery occlusion after coronavirus disease 2019 (COVID-19) mRNA vaccine","author":"Ruiz","year":"2022","journal-title":"Arq Bras Oftalmol"},{"key":"10.1016\/j.xops.2023.100354_bib33","doi-asserted-by":"crossref","first-page":"880","DOI":"10.1093\/qjmed\/hcac011","article-title":"The diagnosis of central retinal artery occlusion after mRNA-SARS-CoV-2 vaccination","volume":"115","author":"Au","year":"2022","journal-title":"QJM"},{"key":"10.1016\/j.xops.2023.100354_bib34","doi-asserted-by":"crossref","first-page":"1793","DOI":"10.1007\/s00417-022-05953-7","article-title":"Retinal vascular occlusions in\u00a0COVID-19 infection and vaccination: a literature review","volume":"261","author":"Yeo","year":"2023","journal-title":"Graefe\u2019s Arch Clin Exp Ophthalmol"},{"key":"10.1016\/j.xops.2023.100354_bib35","first-page":"614","article-title":"New onset of Susac syndrome after mRNA COVID-19 vaccine: a case report","volume":"270","author":"Bianco","year":"2023","journal-title":"J\u00a0Neurol"},{"key":"10.1016\/j.xops.2023.100354_bib36","doi-asserted-by":"crossref","first-page":"2448","DOI":"10.1001\/jama.2021.7517","article-title":"US case reports of cerebral venous sinus thrombosis with thrombocytopenia after Ad26.COV2.S vaccination, March 2 to April 21, 2021","volume":"325","author":"See","year":"2021","journal-title":"JAMA"},{"key":"10.1016\/j.xops.2023.100354_bib37","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1182\/blood.2021012217","article-title":"Frequency of positive anti-PF4\/polyanion antibody tests after COVID-19 vaccination with ChAdOx1 nCoV-19 and BNT162b2","volume":"138","author":"Thiele","year":"2021","journal-title":"Blood"},{"key":"10.1016\/j.xops.2023.100354_bib38","article-title":"Acute-onset central serous retinopathy after immunization with COVID-19 mRNA vaccine","volume":"23","author":"Fowler","year":"2021","journal-title":"Am J Ophthalmol Case Rep"},{"key":"10.1016\/j.xops.2023.100354_bib42","doi-asserted-by":"crossref","first-page":"2187","DOI":"10.1056\/NEJMoa2101544","article-title":"Safety and efficacy of single-dose Ad26.COV2.S vaccine against Covid-19","volume":"384","author":"Sadoff","year":"2021","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.xops.2023.100354_bib43","doi-asserted-by":"crossref","first-page":"2603","DOI":"10.1056\/NEJMoa2034577","article-title":"Safety and efficacy of the BNT162b2 mRNA Covid-19 vaccine","volume":"383","author":"Polack","year":"2020","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.xops.2023.100354_bib44","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1038\/s41586-021-03324-6","article-title":"mRNA vaccine-elicited antibodies to SARS-CoV-2 and circulating variants","volume":"592","author":"Wang","year":"2021","journal-title":"Nature"},{"key":"10.1016\/j.xops.2023.100354_bib45","doi-asserted-by":"crossref","first-page":"1920","DOI":"10.1056\/NEJMoa2022483","article-title":"An mRNA vaccine against SARS-CoV-2 \u2014 preliminary report","volume":"383","author":"Jackson","year":"2020","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.xops.2023.100354_bib47","doi-asserted-by":"crossref","first-page":"2094","DOI":"10.1111\/jth.15402","article-title":"The SSC platelet immunology register of VITT and VIITP: toward standardization of laboratory and clinical parameters","volume":"19","author":"Choi","year":"2021","journal-title":"J\u00a0Thromb Haemost"},{"key":"10.1016\/j.xops.2023.100354_bib49","doi-asserted-by":"crossref","first-page":"2092","DOI":"10.1056\/NEJMoa2104840","article-title":"Thrombotic thrombocytopenia after ChAdOx1 nCov-19 vaccination","volume":"384","author":"Greinacher","year":"2021","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.xops.2023.100354_bib50","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1182\/blood-2013-01-478966","article-title":"Complex formation with nucleic acids and aptamers alters the antigenic properties of platelet factor 4","volume":"122","author":"Jaax","year":"2013","journal-title":"Blood"},{"key":"10.1016\/j.xops.2023.100354_bib51","author":"Aleem"},{"key":"10.1016\/j.xops.2023.100354_bib52","article-title":"Inflammation in retinal vein occlusion","volume":"2013","author":"Deobhakta","year":"2013","journal-title":"Int J Inflam"},{"key":"10.1016\/j.xops.2023.100354_bib53","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1038\/s41577-021-00526-x","article-title":"COVID-19 vaccines: modes of immune activation and future challenges","volume":"21","author":"Teijaro","year":"2021","journal-title":"Nat Rev Immunol"},{"key":"10.1016\/j.xops.2023.100354_bib54","doi-asserted-by":"crossref","first-page":"S53","DOI":"10.1016\/j.jaci.2009.07.008","article-title":"Immunologic messenger molecules: cytokines, interferons, and chemokines","volume":"125","author":"Commins","year":"2010","journal-title":"J\u00a0Allergy Clin Immunol"},{"key":"10.1016\/j.xops.2023.100354_bib55","doi-asserted-by":"crossref","first-page":"3399","DOI":"10.1161\/01.ATV.17.12.3399","article-title":"Effect of human recombinant interleukin-6 and interleukin-8 on monocyte procoagulant activity","volume":"17","author":"Neumann","year":"1997","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1016\/j.xops.2023.100354_bib56","doi-asserted-by":"crossref","first-page":"1626","DOI":"10.1016\/S0140-6736(96)91112-5","article-title":"Occlusion of central retinal vein after hepatitis B vaccination","volume":"347","author":"Devin","year":"1996","journal-title":"Lancet"}],"container-title":["Ophthalmology Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2666914523000866?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2666914523000866?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,13]],"date-time":"2025-11-13T06:25:17Z","timestamp":1763015117000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2666914523000866"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,1]]},"references-count":47,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2024,1]]}},"alternative-id":["S2666914523000866"],"URL":"https:\/\/doi.org\/10.1016\/j.xops.2023.100354","relation":{},"ISSN":["2666-9145"],"issn-type":[{"value":"2666-9145","type":"print"}],"subject":[],"published":{"date-parts":[[2024,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Retinal Vascular Occlusion after Severe Acute Respiratory Syndrome Coronavirus Vaccination","name":"articletitle","label":"Article Title"},{"value":"Ophthalmology Science","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.xops.2023.100354","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 by the American Academy of Ophthalmology.","name":"copyright","label":"Copyright"}],"article-number":"100354"}}