{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T18:06:16Z","timestamp":1790445976498,"version":"4.1.0"},"reference-count":25,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,10,23]],"date-time":"2023-10-23T00:00:00Z","timestamp":1698019200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100006312","name":"BrightFocus Foundation","doi-asserted-by":"publisher","award":["2019073"],"award-info":[{"award-number":["2019073"]}],"id":[{"id":"10.13039\/100006312","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004752","name":"State Government of Victoria","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004752","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["2008382"],"award-info":[{"award-number":["2008382"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["1194667"],"award-info":[{"award-number":["1194667"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","ophthalmologyscience.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Ophthalmology Science"],"published-print":{"date-parts":[[2024,3]]},"DOI":"10.1016\/j.xops.2023.100419","type":"journal-article","created":{"date-parts":[[2023,10,30]],"date-time":"2023-10-30T15:17:00Z","timestamp":1698679020000},"page":"100419","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":25,"title":["Targeted High-Density Microperimetry Testing of Nascent Geographic Atrophy in Age-Related Macular Degeneration"],"prefix":"10.1016","volume":"4","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8623-6684","authenticated-orcid":false,"given":"Zhichao","family":"Wu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9492-3927","authenticated-orcid":false,"given":"Lauren A.B.","family":"Hodgson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9441-4356","authenticated-orcid":false,"given":"Robyn H.","family":"Guymer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.xops.2023.100419_bib1","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1016\/j.oret.2017.08.018","article-title":"Design characteristics of geographic atrophy treatment trials: systematic review of registered trials in ClinicalTrials.gov","volume":"2","author":"Cheng","year":"2018","journal-title":"Ophthalmol Retina"},{"key":"10.1016\/j.xops.2023.100419_bib2","doi-asserted-by":"crossref","first-page":"666","DOI":"10.1001\/jamaophthalmol.2018.1544","article-title":"Efficacy and safety of Lampalizumab for geographic atrophy due to age-related macular degeneration: chroma and spectri Phase 3 randomized clinical trials","volume":"136","author":"Holz","year":"2018","journal-title":"JAMA Ophthalmol"},{"key":"10.1016\/j.xops.2023.100419_bib3","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1016\/j.ophtha.2020.08.027","article-title":"C5 inhibitor Avacincaptad pegol for geographic atrophy due to age-related macular degeneration: A randomized pivotal Phase 2\/3 trial","volume":"128","author":"Jaffe","year":"2021","journal-title":"Ophthalmology"},{"key":"10.1016\/j.xops.2023.100419_bib4","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1016\/j.ophtha.2019.07.011","article-title":"Complement C3 inhibitor pegcetacoplan for geographic atrophy secondary to age-related macular degeneration: A randomized phase 2 trial","volume":"127","author":"Liao","year":"2020","journal-title":"Ophthalmology"},{"key":"10.1016\/j.xops.2023.100419_bib5","doi-asserted-by":"crossref","first-page":"1556","DOI":"10.1016\/j.ophtha.2018.03.059","article-title":"Emixustat hydrochloride for geographic atrophy secondary to age-related macular degeneration: a randomized clinical trial","volume":"125","author":"Rosenfeld","year":"2018","journal-title":"Ophthalmology"},{"key":"10.1016\/j.xops.2023.100419_bib6","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1016\/j.oret.2020.03.019","article-title":"Orally administered alpha lipoic acid as a treatment for geographic atrophy: A randomized clinical trial","volume":"4","author":"Kim","year":"2020","journal-title":"Ophthalmol Retina"},{"key":"10.1016\/j.xops.2023.100419_bib7","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1016\/j.oret.2017.08.015","article-title":"Treatment of geographic atrophy with intravitreal sirolimus: the Age-Related Eye Disease Study 2 Ancillary Study","volume":"2","author":"Gensler","year":"2018","journal-title":"Ophthalmol Retina"},{"key":"10.1016\/j.xops.2023.100419_bib8","doi-asserted-by":"crossref","first-page":"1028","DOI":"10.1016\/j.oret.2018.03.001","article-title":"A\u00a0randomized Phase 2 study of an anti\u2013amyloid \u03b2 monoclonal antibody in geographic atrophy secondary to age-related macular degeneration","volume":"2","author":"Rosenfeld","year":"2018","journal-title":"Ophthalmol Retina"},{"key":"10.1016\/j.xops.2023.100419_bib9","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1016\/j.oret.2018.03.004","article-title":"Geographic atrophy trials: turning the ship around may not be that easy","volume":"2","author":"Guymer","year":"2018","journal-title":"Ophthalmol Retina"},{"key":"10.1016\/j.xops.2023.100419_bib10","doi-asserted-by":"crossref","first-page":"2415","DOI":"10.1016\/j.ophtha.2014.06.034","article-title":"Optical coherence tomography-defined changes preceding the development of drusen-associated atrophy in age-related macular degeneration","volume":"121","author":"Wu","year":"2014","journal-title":"Ophthalmology"},{"key":"10.1016\/j.xops.2023.100419_bib11","doi-asserted-by":"crossref","first-page":"1546","DOI":"10.1167\/iovs.14-16211","article-title":"Fundus autofluorescence characteristics of nascent geographic atrophy in age-related macular degeneration","volume":"56","author":"Wu","year":"2015","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.xops.2023.100419_bib12","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1167\/iovs.14-15614","article-title":"Microperimetry of nascent geographic atrophy in age-related macular degeneration","volume":"56","author":"Wu","year":"2014","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.xops.2023.100419_bib13","doi-asserted-by":"crossref","first-page":"3519","DOI":"10.1167\/iovs.17-21696","article-title":"Optical coherence tomography features preceding the onset of advanced age-related macular degeneration","volume":"58","author":"Ferrara","year":"2017","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.xops.2023.100419_bib14","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1016\/j.oret.2019.12.011","article-title":"Prospective longitudinal evaluation of nascent geographic atrophy in age-related macular degeneration","volume":"4","author":"Wu","year":"2020","journal-title":"Ophthalmol Retina"},{"key":"10.1016\/j.xops.2023.100419_bib15","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/j.ophtha.2022.09.004","article-title":"Incomplete retinal pigment epithelial and outer retinal atrophy: longitudinal evaluation in age-related macular degeneration","volume":"130","author":"Wu","year":"2023","journal-title":"Ophthalmology"},{"key":"10.1016\/j.xops.2023.100419_bib16","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1016\/j.ophtha.2019.09.035","article-title":"Incomplete retinal pigment epithelial and outer retinal atrophy in age-related macular degeneration: classification of atrophy\u00a0meeting Report 4","volume":"127","author":"Guymer","year":"2020","journal-title":"Ophthalmology"},{"key":"10.1016\/j.xops.2023.100419_bib17","doi-asserted-by":"crossref","first-page":"1764","DOI":"10.1016\/j.ophtha.2017.06.032","article-title":"Optical coherence tomography predictors of risk for progression to non-neovascular atrophic age-related macular degeneration","volume":"124","author":"Sleiman","year":"2017","journal-title":"Ophthalmology"},{"key":"10.1016\/j.xops.2023.100419_bib18","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1159\/000515148","article-title":"Clinical Perspectives and Trends: microperimetry as a trial endpoint in retinal disease","volume":"244","author":"Yang","year":"2021","journal-title":"Ophthalmologica"},{"key":"10.1016\/j.xops.2023.100419_bib19","doi-asserted-by":"crossref","DOI":"10.1016\/j.preteyeres.2020.100907","article-title":"Fundus-controlled perimetry (microperimetry): application as outcome measure in clinical trials","volume":"82","author":"Pfau","year":"2021","journal-title":"Prog Retin Eye Res"},{"key":"10.1016\/j.xops.2023.100419_bib20","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1016\/j.ophtha.2018.09.015","article-title":"Subthreshold nanosecond laser intervention in age-related macular degeneration: the LEAD randomized controlled clinical trial","volume":"126","author":"Guymer","year":"2019","journal-title":"Ophthalmology"},{"key":"10.1016\/j.xops.2023.100419_bib21","doi-asserted-by":"crossref","first-page":"1026","DOI":"10.1016\/j.oret.2019.07.008","article-title":"Secondary and exploratory outcomes of the subthreshold nanosecond laser intervention randomized trial in age-related macular degeneration: a LEAD study report","volume":"3","author":"Wu","year":"2019","journal-title":"Ophthalmol Retina"},{"key":"10.1016\/j.xops.2023.100419_bib22","doi-asserted-by":"crossref","first-page":"7378","DOI":"10.1167\/iovs.13-12617","article-title":"Intrasession test-retest variability of microperimetry in age-related macular\u00a0degeneration","volume":"54","author":"Wu","year":"2013","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.xops.2023.100419_bib23","doi-asserted-by":"crossref","first-page":"1094","DOI":"10.1097\/IAE.0000000000002982","article-title":"Using microperimetry and low-luminance visual acuity to detect the onset of late age-related macular degeneration: a LEAD study report","volume":"41","author":"Wu","year":"2021","journal-title":"Retina"},{"key":"10.1016\/j.xops.2023.100419_bib24","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1167\/tvst.12.7.11","article-title":"Systematic underestimation of visual sensitivity loss on microperimetry: implications for testing protocols in clinical trials","volume":"12","author":"Wu","year":"2023","journal-title":"Transl Vis Sci Technol"},{"key":"10.1016\/j.xops.2023.100419_bib25","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1159\/000510887","article-title":"Can the onset of atrophic age-related macular degeneration be an acceptable endpoint for preventative trials?","volume":"243","author":"Wu","year":"2020","journal-title":"Ophthalmologica"}],"container-title":["Ophthalmology Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2666914523001513?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2666914523001513?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T09:37:29Z","timestamp":1778924249000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2666914523001513"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,3]]},"references-count":25,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2024,3]]}},"alternative-id":["S2666914523001513"],"URL":"https:\/\/doi.org\/10.1016\/j.xops.2023.100419","relation":{},"ISSN":["2666-9145"],"issn-type":[{"value":"2666-9145","type":"print"}],"subject":[],"published":{"date-parts":[[2024,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Targeted High-Density Microperimetry Testing of Nascent Geographic Atrophy in Age-Related Macular Degeneration","name":"articletitle","label":"Article Title"},{"value":"Ophthalmology Science","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.xops.2023.100419","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 by the American Academy of Ophthalmology.","name":"copyright","label":"Copyright"}],"article-number":"100419"}}