{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T12:37:34Z","timestamp":1788352654657,"version":"build-2803163510"},"reference-count":28,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T00:00:00Z","timestamp":1719792000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T00:00:00Z","timestamp":1719792000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,1,16]],"date-time":"2024-01-16T00:00:00Z","timestamp":1705363200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006312","name":"BrightFocus Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006312","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["ophthalmologyscience.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Ophthalmology Science"],"published-print":{"date-parts":[[2024,7]]},"DOI":"10.1016\/j.xops.2024.100473","type":"journal-article","created":{"date-parts":[[2024,1,20]],"date-time":"2024-01-20T02:02:40Z","timestamp":1705716160000},"page":"100473","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":10,"title":["A Noninvasive Clinical Method to Measure in\u00a0Vivo Mechanical Strains of the Lamina Cribrosa by OCT"],"prefix":"10.1016","volume":"4","author":[{"given":"Vanessa","family":"Hannay","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1806-5593","authenticated-orcid":false,"given":"Cameron","family":"Czerpak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0095-8756","authenticated-orcid":false,"given":"Harry A.","family":"Quigley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thao D.","family":"Nguyen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.xops.2024.100473_bib1","doi-asserted-by":"crossref","first-page":"2081","DOI":"10.1016\/j.ophtha.2014.05.013","article-title":"Global prevalence of glaucoma and projections of glaucoma burden through 2040: a systematic review and meta-analysis","volume":"121","author":"Tham","year":"2014","journal-title":"Ophthalmology"},{"key":"10.1016\/j.xops.2024.100473_bib2","doi-asserted-by":"crossref","first-page":"1268","DOI":"10.1001\/archopht.120.10.1268","article-title":"Reduction of intraocular pressure and glaucoma progression: results from the Early Manifest Glaucoma Trial","volume":"120","author":"Heijl","year":"2002","journal-title":"Arch Ophthalmol"},{"key":"10.1016\/j.xops.2024.100473_bib3","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1097\/IJG.0b013e31806540a1","article-title":"Risk factors and open-angle glaucoma: classification and application","volume":"16","author":"Boland","year":"2007","journal-title":"J\u00a0Glaucoma"},{"key":"10.1016\/j.xops.2024.100473_bib4","doi-asserted-by":"crossref","first-page":"4135","DOI":"10.1167\/iovs.14-14643","article-title":"Rates of glaucomatous visual field change in a large clinical population","volume":"55","author":"Chauhan","year":"2014","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.xops.2024.100473_bib5","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1001\/archopht.1981.03930010635009","article-title":"Optic nerve damage in human glaucoma. II. The site of injury and susceptibility to damage","volume":"99","author":"Quigley","year":"1981","journal-title":"Arch Ophthalmol"},{"key":"10.1016\/j.xops.2024.100473_bib6","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1001\/archopht.1981.03930010139020","article-title":"Regional differences in the structure of the lamina cribrosa and their relation to glaucomatous optic nerve damage","volume":"99","author":"Quigley","year":"1981","journal-title":"Arch Ophthalmol"},{"key":"10.1016\/j.xops.2024.100473_bib7","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.preteyeres.2004.06.001","article-title":"The optic nerve head as a biomechanical structure: a new paradigm for understanding the role of IOP-related stress and strain in the pathophysiology of glaucomatous optic nerve head damage","volume":"24","author":"Burgoyne","year":"2005","journal-title":"Prog Retin Eye Res"},{"key":"10.1016\/j.xops.2024.100473_bib8","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/bs.pbr.2015.04.003","article-title":"The contribution of the sclera and lamina cribrosa to the pathogenesis of glaucoma: diagnostic and treatment implications","volume":"220","author":"Quigley","year":"2015","journal-title":"Prog Brain Res"},{"key":"10.1016\/j.xops.2024.100473_bib9","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1167\/iovs.17-21982","article-title":"In\u00a0vivo three-dimensional lamina cribrosa strains in healthy, ocular hypertensive, and glaucoma eyes following acute intraocular pressure elevation","volume":"59","author":"Beotra","year":"2018","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.xops.2024.100473_bib10","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1167\/iovs.61.3.27","article-title":"In\u00a0vivo measurements of prelamina and lamina cribrosa biomechanical properties in humans","volume":"61","author":"Zhang","year":"2020","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.xops.2024.100473_bib11","doi-asserted-by":"crossref","first-page":"1190","DOI":"10.1016\/j.ophtha.2016.02.008","article-title":"In\u00a0vivo 3-dimensional strain mapping of the optic nerve head following introcular pressure lowering by trabeculectomy","volume":"123","author":"Girard","year":"2016","journal-title":"Ophthalmology"},{"key":"10.1016\/j.xops.2024.100473_bib12","doi-asserted-by":"crossref","first-page":"5825","DOI":"10.1167\/iovs.16-20560","article-title":"In\u00a0vivo 3-dimensional strain mapping confirms large optic nerve head deformations following horizontal eye movements","volume":"57","author":"Wang","year":"2016","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.xops.2024.100473_bib13","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1016\/j.actbio.2019.06.050","article-title":"In\u00a0vivo characterization of the deformation of the human optic nerve head using optical coherence tomography and digital volume correlation","volume":"96","author":"Midgett","year":"2019","journal-title":"Acta Biomater"},{"key":"10.1016\/j.xops.2024.100473_bib14","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.ogla.2022.07.005","article-title":"The strain response to intraocular pressure decrease in the lamina cribrosa of patients with glaucoma","volume":"6","author":"Czerpak","year":"2022","journal-title":"Ophthalmol Glaucoma"},{"key":"10.1016\/j.xops.2024.100473_bib15","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.ophtha.2022.08.007","article-title":"Differing associations between optic nerve head strains and visual field loss in patients with normal- and high-tension glaucoma","volume":"130","author":"Chuangsuwanich","year":"2023","journal-title":"Ophthalmology"},{"key":"10.1016\/j.xops.2024.100473_bib16","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1016\/0002-9394(83)90389-6","article-title":"Morphologic changes in the lamina cribrosa correlated with neural loss in open-angle glaucoma","volume":"95","author":"Quigley","year":"1983","journal-title":"Am J Ophthalmol"},{"key":"10.1016\/j.xops.2024.100473_bib17","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1007\/s11340-014-9874-2","article-title":"A\u00a0fast iterative digital volume correlation algorithm for large deformations","volume":"55","author":"Bar-Kochba","year":"2015","journal-title":"Exp Mech"},{"key":"10.1016\/j.xops.2024.100473_bib18","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/j.actbio.2016.12.054","article-title":"The pressure-induced deformation response of the human lamina cribrosa: analysis of regional variations","volume":"53","author":"Midgett","year":"2017","journal-title":"Acta Biomater"},{"key":"10.1016\/j.xops.2024.100473_bib19","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/j.actbio.2020.01.049","article-title":"The inflation response of the human lamina cribrosa and sclera: analysis of deformation and interaction","volume":"106","author":"Midgett","year":"2020","journal-title":"Acta Biomater"},{"key":"10.1016\/j.xops.2024.100473_bib20","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1167\/iovs.61.4.41","article-title":"The effects of glaucoma on the pressure-induced strain response of the human lamina cribrosa","volume":"61","author":"Midgett","year":"2020","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.xops.2024.100473_bib21","doi-asserted-by":"crossref","first-page":"1714","DOI":"10.1167\/iovs.11-8009","article-title":"Biomechanics of the human posterior sclera: age- and glaucoma-related changes measured using inflation testing","volume":"53","author":"Coudrillier","year":"2012","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.xops.2024.100473_bib22","doi-asserted-by":"crossref","first-page":"602","DOI":"10.1016\/j.jmbbm.2013.03.027","article-title":"Material properties of the posterior human sclera","volume":"29","author":"Grytz","year":"2014","journal-title":"J\u00a0Mech Behav Biomed Mater"},{"key":"10.1016\/j.xops.2024.100473_bib23","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1167\/iovs.63.11.18","article-title":"Quantitative microstructural analysis of cellular and tissue remodeling in human glaucoma optic nerve head","volume":"63","author":"Guan","year":"2022","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.xops.2024.100473_bib24","doi-asserted-by":"crossref","first-page":"7661","DOI":"10.1167\/iovs.15-17624","article-title":"The connective tissue components of optic nerve head cupping in monkey experimental glaucoma part 1: global change","volume":"56","author":"Yang","year":"2015","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.xops.2024.100473_bib25","doi-asserted-by":"crossref","first-page":"5189","DOI":"10.1167\/iovs.03-0174","article-title":"Anatomic relationship between lamina cribrosa, intraocular space, and cerebrospinal fluid space","volume":"44","author":"Jonas","year":"2003","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.xops.2024.100473_bib26","doi-asserted-by":"crossref","first-page":"5258","DOI":"10.1167\/iovs.12-9705","article-title":"Quantitative mapping of collagen fiber orientation in non-glaucoma and glaucoma posterior human sclerae","volume":"53","author":"Pijanka","year":"2012","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.xops.2024.100473_bib27","doi-asserted-by":"crossref","DOI":"10.1016\/j.preteyeres.2019.100773","article-title":"Scleral structure and biomechanics","volume":"74","author":"Boote","year":"2020","journal-title":"Prog Retin Eye Res"},{"key":"10.1016\/j.xops.2024.100473_bib28","doi-asserted-by":"crossref","unstructured":"Yuan Z, Czerpak CA, Kashaf MS, et\u00a0al. Biomechanical strain responses in the optic nerve head region in glaucoma patients after intraocular pressure lowering. medRxiv. Posted online June 1, 2023. https:\/\/doi.org\/10.1101\/2023.05.30.23290662.","DOI":"10.1101\/2023.05.30.23290662"}],"container-title":["Ophthalmology Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2666914524000095?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2666914524000095?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,7,15]],"date-time":"2024-07-15T15:36:47Z","timestamp":1721057807000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2666914524000095"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,7]]},"references-count":28,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2024,7]]}},"alternative-id":["S2666914524000095"],"URL":"https:\/\/doi.org\/10.1016\/j.xops.2024.100473","relation":{},"ISSN":["2666-9145"],"issn-type":[{"value":"2666-9145","type":"print"}],"subject":[],"published":{"date-parts":[[2024,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A Noninvasive Clinical Method to Measure in\u00a0Vivo Mechanical Strains of the Lamina Cribrosa by OCT","name":"articletitle","label":"Article Title"},{"value":"Ophthalmology Science","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.xops.2024.100473","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 by the American Academy of Ophthalmology.","name":"copyright","label":"Copyright"}],"article-number":"100473"}}