{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T21:08:32Z","timestamp":1790111312879,"version":"4.0.1"},"reference-count":18,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T00:00:00Z","timestamp":1719792000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T00:00:00Z","timestamp":1719792000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,2,16]],"date-time":"2024-02-16T00:00:00Z","timestamp":1708041600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100012618","name":"National Institute for Health Research Biomedical Research Centre at Moorfields Eye Hospital NHS Foundation Trust and UCL Instit","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012618","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["ophthalmologyscience.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Ophthalmology Science"],"published-print":{"date-parts":[[2024,7]]},"DOI":"10.1016\/j.xops.2024.100496","type":"journal-article","created":{"date-parts":[[2024,2,20]],"date-time":"2024-02-20T16:07:26Z","timestamp":1708445246000},"page":"100496","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":27,"title":["Artificial Intelligence to Differentiate Pediatric Pseudopapilledema and True Papilledema on Fundus Photographs"],"prefix":"10.1016","volume":"4","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6169-1373","authenticated-orcid":false,"given":"Melinda Y.","family":"Chang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gena","family":"Heidary","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shannon","family":"Beres","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stacy L.","family":"Pineles","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric D.","family":"Gaier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0677-7414","authenticated-orcid":false,"given":"Ryan","family":"Gise","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1942-225X","authenticated-orcid":false,"given":"Mark","family":"Reid","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kleanthis","family":"Avramidis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad","family":"Rostami","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shrikanth","family":"Narayanan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.xops.2024.100496_bib1","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1016\/j.survophthal.2016.03.007","article-title":"Optic disk drusen in children","volume":"61","author":"Chang","year":"2016","journal-title":"Surv Ophthalmol"},{"key":"10.1016\/j.xops.2024.100496_bib2","doi-asserted-by":"crossref","first-page":"1839","DOI":"10.1016\/j.ophtha.2017.06.016","article-title":"Accuracy of diagnostic imaging modalities for classifying pediatric eyes as papilledema versus pseudopapilledema","volume":"124","author":"Chang","year":"2017","journal-title":"Ophthalmology"},{"key":"10.1016\/j.xops.2024.100496_bib3","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1136\/bjophthalmol-2017-310196","article-title":"Detecting optic nerve head swelling on ultrasound and optical coherence tomography in children and young people: an observational study","volume":"102","author":"Dahlmann-Noor","year":"2018","journal-title":"Br J Ophthalmol"},{"key":"10.1016\/j.xops.2024.100496_bib4","first-page":"532","article-title":"Use of MultiColor imaging in the assessment of suspected papilledema in 20 consecutive children","volume":"20","author":"Malem","year":"2016","journal-title":"J\u00a0AAPOS"},{"key":"10.1016\/j.xops.2024.100496_bib5","doi-asserted-by":"crossref","first-page":"174","DOI":"10.3928\/01913913-20100719-05","article-title":"Optical coherence tomography as an adjunctive tool for diagnosing papilledema in young patients","volume":"48","author":"Martinez","year":"2011","journal-title":"J\u00a0Pediatr Ophthalmol Strabismus"},{"key":"10.1016\/j.xops.2024.100496_bib6","first-page":"38","article-title":"Bruch's membrane opening on optical coherence tomography in pediatric papilledema and pseudopapilledema","volume":"22","author":"Thompson","year":"2018","journal-title":"J\u00a0AAPOS"},{"key":"10.1016\/j.xops.2024.100496_bib7","doi-asserted-by":"crossref","first-page":"1501","DOI":"10.1007\/s00381-017-3454-6","article-title":"The efficacy of orbital ultrasonography and magnetic resonance imaging findings with direct measurement of intracranial pressure in distinguishing papilledema from pseudopapilledema","volume":"33","author":"Ozturk","year":"2017","journal-title":"Childs Nerv Syst"},{"key":"10.1016\/j.xops.2024.100496_bib8","doi-asserted-by":"crossref","first-page":"1416","DOI":"10.1016\/j.ophtha.2020.03.027","article-title":"Imaging methods for differentiating pediatric papilledema from pseudopapilledema: a report by the American Academy of Ophthalmology","volume":"127","author":"Chang","year":"2020","journal-title":"Ophthalmology"},{"key":"10.1016\/j.xops.2024.100496_bib9","doi-asserted-by":"crossref","first-page":"1687","DOI":"10.1056\/NEJMoa1917130","article-title":"Artificial intelligence to detect papilledema from ocular fundus photographs","volume":"382","author":"Milea","year":"2020","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.xops.2024.100496_bib10","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1016\/j.jbi.2008.08.010","article-title":"Research electronic data capture (REDCap)--a metadata-driven methodology and workflow process for providing translational research informatics support","volume":"42","author":"Harris","year":"2009","journal-title":"J\u00a0Biomed Inform"},{"key":"10.1016\/j.xops.2024.100496_bib11","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1136\/jnnp.45.1.13","article-title":"Swelling of the optic nerve head: a staging scheme","volume":"45","author":"Frisen","year":"1982","journal-title":"J\u00a0Neurol Neurosurg Psychiatry"},{"key":"10.1016\/j.xops.2024.100496_bib12","series-title":"Automating Detection of Papilledema in Pediatric Fundus Images with Explainable Machine Learning","author":"Avramidis","year":"2022"},{"key":"10.1016\/j.xops.2024.100496_bib13","doi-asserted-by":"crossref","first-page":"964","DOI":"10.1002\/sim.5587","article-title":"A\u00a0weighted generalized score statistic for comparison of predictive values of diagnostic tests","volume":"32","author":"Kosinski","year":"2013","journal-title":"Stat Med"},{"key":"10.1016\/j.xops.2024.100496_bib14","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1002\/ana.25839","article-title":"Optic disc classification by deep learning versus expert neuro-ophthalmologists","volume":"88","author":"Biousse","year":"2020","journal-title":"Ann Neurol"},{"key":"10.1016\/j.xops.2024.100496_bib15","first-page":"66","article-title":"Decision support system for detection of papilledema through fundus retinal images","volume":"41","author":"Akbar","year":"2017","journal-title":"J\u00a0Med Syst"},{"key":"10.1016\/j.xops.2024.100496_bib16","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1364\/BOE.8.001005","article-title":"Fully automated diagnosis of papilledema through robust extraction of vascular patterns and ocular pathology from fundus photographs","volume":"8","author":"Fatima","year":"2017","journal-title":"Biomed Opt Express"},{"key":"10.1016\/j.xops.2024.100496_bib17","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1186\/s12886-019-1184-0","article-title":"Accuracy of machine learning for differentiation between optic neuropathies and pseudopapilledema","volume":"19","author":"Ahn","year":"2019","journal-title":"BMC Ophthalmol"},{"key":"10.1016\/j.xops.2024.100496_bib18","first-page":"344","article-title":"Outcome of pediatric patients referred for papilledema","volume":"19","author":"Kovarik","year":"2015","journal-title":"J\u00a0AAPOS"}],"container-title":["Ophthalmology Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2666914524000320?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2666914524000320?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,7,15]],"date-time":"2024-07-15T11:37:03Z","timestamp":1721043423000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2666914524000320"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,7]]},"references-count":18,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2024,7]]}},"alternative-id":["S2666914524000320"],"URL":"https:\/\/doi.org\/10.1016\/j.xops.2024.100496","relation":{},"ISSN":["2666-9145"],"issn-type":[{"value":"2666-9145","type":"print"}],"subject":[],"published":{"date-parts":[[2024,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Artificial Intelligence to Differentiate Pediatric Pseudopapilledema and True Papilledema on Fundus Photographs","name":"articletitle","label":"Article Title"},{"value":"Ophthalmology Science","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.xops.2024.100496","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 by the American Academy of Ophthalmology.","name":"copyright","label":"Copyright"}],"article-number":"100496"}}