{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T16:22:20Z","timestamp":1792167740888,"version":"4.4.0"},"reference-count":14,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,7,25]],"date-time":"2024-07-25T00:00:00Z","timestamp":1721865600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["ophthalmologyscience.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Ophthalmology Science"],"published-print":{"date-parts":[[2025,1]]},"DOI":"10.1016\/j.xops.2024.100589","type":"journal-article","created":{"date-parts":[[2024,7,30]],"date-time":"2024-07-30T22:39:37Z","timestamp":1722379177000},"page":"100589","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":11,"title":["Phase I Study of Intravitreal Injection of Autologous CD34+ Stem Cells from Bone Marrow in Eyes with Vision Loss from Retinitis Pigmentosa"],"prefix":"10.1016","volume":"5","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5911-6671","authenticated-orcid":false,"given":"Susanna S.","family":"Park","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerhard","family":"Bauer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian","family":"Fury","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mehrdad","family":"Abedi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas","family":"Perotti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dane","family":"Colead-Bergum","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan A.","family":"Nolta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.xops.2024.100589_bib1","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/j.preteyeres.2018.03.005","article-title":"Non-syndromic retinitis pigmentosa","volume":"66","author":"Verbakel","year":"2018","journal-title":"Prog Retin Eye Res"},{"key":"10.1016\/j.xops.2024.100589_bib2","article-title":"Vitamin A and fish oils for preventing the progression of retinitis pigmentosa","volume":"6","author":"Schwartz","year":"2020","journal-title":"Cochrane Database Syst Rev"},{"key":"10.1016\/j.xops.2024.100589_bib3","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.167546","article-title":"Natural history of retinitis pigmentosa based on genotype, vitamin A\/E supplementation, and an electroretinogram biomarker","volume":"8","author":"Comander","year":"2023","journal-title":"JCI Insight"},{"key":"10.1016\/j.xops.2024.100589_bib6","doi-asserted-by":"crossref","first-page":"1460","DOI":"10.1016\/j.ophtha.2021.03.031","article-title":"Durability of Voretigene Neparvovec for biallelic RPE65-mediated inherited retinal disease: phase 3 results at 3 and 4 years","volume":"128","author":"Maguire","year":"2021","journal-title":"Ophthalmology"},{"key":"10.1016\/j.xops.2024.100589_bib7","doi-asserted-by":"crossref","first-page":"260","DOI":"10.2174\/138920211795860071","article-title":"Good epidemiologic practice in retinitis pigmentosa: from phenotyping to biobanking","volume":"12","author":"Chizzolini","year":"2011","journal-title":"Curr Genomics"},{"key":"10.1016\/j.xops.2024.100589_bib8","doi-asserted-by":"crossref","DOI":"10.1016\/j.preteyeres.2019.100779","article-title":"Retinal stem cell transplantation: balancing safety and potential","volume":"75","author":"Singh","year":"2020","journal-title":"Prog Retin Eye Res"},{"key":"10.1016\/j.xops.2024.100589_bib10","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/j.preteyeres.2016.10.002","article-title":"Advances in bone marrow stem cell therapy for retinal dysfunction","volume":"56","author":"Park","year":"2017","journal-title":"Prog Retin Eye Res"},{"key":"10.1016\/j.xops.2024.100589_bib11","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1161\/CIRCRESAHA.115.308165","article-title":"PreSERVE-AMI: a randomized, double-blind, placebo-controlled clinical trial of intracoronary administration of autologous CD34+ cells in patients with left ventricular dysfunction post STEMI","volume":"120","author":"Quyyumi","year":"2017","journal-title":"Circ Res"},{"key":"10.1016\/j.xops.2024.100589_bib12","doi-asserted-by":"crossref","first-page":"4125","DOI":"10.1167\/iovs.16-19252","article-title":"Intravitreal administration of human bone marrow CD34+ stem cells in a murine model of retinal degeneration","volume":"57","author":"Moisseiev","year":"2016","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.xops.2024.100589_bib13","doi-asserted-by":"crossref","DOI":"10.1016\/j.exer.2019.107865","article-title":"Effects of intravitreal injection of human CD34+ bone marrow stem cells in a murine model of diabetic retinopathy","volume":"190","author":"Yazdanyar","year":"2020","journal-title":"Exp Eye Res"},{"key":"10.1016\/j.xops.2024.100589_bib14","doi-asserted-by":"crossref","first-page":"1275","DOI":"10.21037\/atm-20-4662","article-title":"Subretinal versus intravitreal administration of human CD34+ bone marrow-derived stem cells in a rat model of inherited retinal degeneration","volume":"9","author":"Park","year":"2021","journal-title":"Ann Transl Med"},{"key":"10.1016\/j.xops.2024.100589_bib15","doi-asserted-by":"crossref","first-page":"986","DOI":"10.1167\/iovs.11-8833","article-title":"Long-term effects of intravitreal injection of GMP-grade bone-marrow-derived CD34+ cells in NOD-SCID mice with acute ischemia-reperfusion injury","volume":"53","author":"Park","year":"2012","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.xops.2024.100589_bib16","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1167\/iovs.14-15415","article-title":"Intravitreal autologous bone marrow CD34+ cell therapy for ischemic and degenerative retinal disorders: preliminary phase 1 clinical trial findings","volume":"56","author":"Park","year":"2014","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.xops.2024.100589_bib17","doi-asserted-by":"crossref","first-page":"2163","DOI":"10.1161\/CIRCULATIONAHA.106.644518","article-title":"CD34-positive cells exhibit increased potency and safety for therapeutic neovascularization after myocardial infarction compared with total mononuclear cells","volume":"114","author":"Kawamoto","year":"2006","journal-title":"Circulation"}],"container-title":["Ophthalmology Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2666914524001258?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2666914524001258?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,2,25]],"date-time":"2026-02-25T19:43:25Z","timestamp":1772048605000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2666914524001258"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1]]},"references-count":14,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,1]]}},"alternative-id":["S2666914524001258"],"URL":"https:\/\/doi.org\/10.1016\/j.xops.2024.100589","relation":{},"ISSN":["2666-9145"],"issn-type":[{"value":"2666-9145","type":"print"}],"subject":[],"published":{"date-parts":[[2025,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Phase I Study of Intravitreal Injection of Autologous CD34+ Stem Cells from Bone Marrow in Eyes with Vision Loss from Retinitis Pigmentosa","name":"articletitle","label":"Article Title"},{"value":"Ophthalmology Science","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.xops.2024.100589","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 by the American Academy of Ophthalmology.","name":"copyright","label":"Copyright"}],"article-number":"100589"}}