{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T17:57:51Z","timestamp":1792691871777,"version":"4.5.0"},"reference-count":29,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,9,26]],"date-time":"2024-09-26T00:00:00Z","timestamp":1727308800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000053","name":"National Eye Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000053","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100031022","name":"Center for Cancer Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100031022","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000072","name":"National Institute of Dental and Craniofacial Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000072","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["ZIADE000747"],"award-info":[{"award-number":["ZIADE000747"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000124","name":"Office of Research on Women&apos;s Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000124","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","ophthalmologyscience.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Ophthalmology Science"],"published-print":{"date-parts":[[2025,1]]},"DOI":"10.1016\/j.xops.2024.100627","type":"journal-article","created":{"date-parts":[[2024,9,30]],"date-time":"2024-09-30T19:11:02Z","timestamp":1727723462000},"page":"100627","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":8,"title":["Systemic Treatment with the Janus Kinase Inhibitor Baricitinib in Ocular Chronic Graft-versus-Host Disease"],"prefix":"10.1016","volume":"5","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1724-6109","authenticated-orcid":false,"given":"Taylor","family":"McManus","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noa G.","family":"Holtzman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aaron","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chantal","family":"Cousineau-Krieger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan","family":"Vitale","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edmond J.","family":"FitzGibbon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Debbie","family":"Payne","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janine","family":"Newgen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Celestina","family":"Igbinosun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annie P.","family":"Im","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cody","family":"Peer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Sr.","given":"William Douglas","family":"Figg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edward W.","family":"Cowen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacqueline W.","family":"Mays","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven","family":"Pavletic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6370-6295","authenticated-orcid":false,"given":"M.Teresa","family":"Magone","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.xops.2024.100627_bib1","doi-asserted-by":"crossref","first-page":"1190","DOI":"10.1080\/09273948.2021.1939390","article-title":"A\u00a0review of ocular graft-versus-host disease: pathophysiology, clinical presentation and management","volume":"29","author":"Carreno-Galeano","year":"2021","journal-title":"Ocul Immunol Inflamm"},{"key":"10.1016\/j.xops.2024.100627_bib2","doi-asserted-by":"crossref","first-page":"1038","DOI":"10.4103\/ijo.IJO_2016_20","article-title":"Update on ocular graft-versus-host disease","volume":"69","author":"Nair","year":"2021","journal-title":"Indian J Ophthalmol"},{"key":"10.1016\/j.xops.2024.100627_bib3","doi-asserted-by":"crossref","first-page":"1669","DOI":"10.1016\/j.ophtha.2015.04.011","article-title":"Vision-related quality of life in patients with ocular graft-versus-host disease","volume":"122","author":"Saboo","year":"2015","journal-title":"Ophthalmology"},{"key":"10.1016\/j.xops.2024.100627_bib4","doi-asserted-by":"crossref","first-page":"1125","DOI":"10.1016\/j.bbmt.2017.12.797","article-title":"The role of Janus kinase signaling in graft-versus-host disease and graft versus leukemia","volume":"24","author":"Schroeder","year":"2018","journal-title":"Biol Blood Marrow Transplant"},{"key":"10.1016\/j.xops.2024.100627_bib5","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1016\/j.jtos.2018.04.007","article-title":"Tear inflammatory mediators and protein in eyes of post allogenic hematopoeitic stem cell transplant patients","volume":"16","author":"Nair","year":"2018","journal-title":"Ocul Surf"},{"key":"10.1016\/j.xops.2024.100627_bib6","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1016\/j.jtos.2019.12.005","article-title":"Tear cytokine levels in the diagnosis and severity assessment of ocular chronic graft-versus-host disease(GVHD)","volume":"18","author":"Hu","year":"2020","journal-title":"Ocul Surf"},{"key":"10.1016\/j.xops.2024.100627_bib7","doi-asserted-by":"crossref","first-page":"1984","DOI":"10.1002\/pro.3519","article-title":"The molecular details of cytokine signaling via the JAK\/STAT pathway","volume":"27","author":"Morris","year":"2018","journal-title":"Protein Sci"},{"key":"10.1016\/j.xops.2024.100627_bib8","doi-asserted-by":"crossref","DOI":"10.1016\/j.autrev.2019.102390","article-title":"JAK inhibitors for the treatment of autoimmune and inflammatory diseases","volume":"18","author":"Jamilloux","year":"2019","journal-title":"Autoimmun Rev"},{"key":"10.1016\/j.xops.2024.100627_bib9","doi-asserted-by":"crossref","first-page":"1642","DOI":"10.1182\/blood.2021014448","article-title":"Three US food and drug administration-approved therapies for chronic GVHD","volume":"139","author":"Zeiser","year":"2022","journal-title":"Blood"},{"key":"10.1016\/j.xops.2024.100627_bib10","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1056\/NEJMoa2033122","article-title":"Ruxolitinib for glucocorticoid-refractory chronic graft-versus-host disease","volume":"385","author":"Zeiser","year":"2021","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.xops.2024.100627_bib11","doi-asserted-by":"crossref","DOI":"10.1016\/j.leukres.2021.106642","article-title":"Ruxolitinib for chronic steroid-refractory graft versus host disease: a single center experience","volume":"109","author":"Xue","year":"2021","journal-title":"Leuk Res"},{"key":"10.1016\/j.xops.2024.100627_bib12","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.jtos.2023.01.001","article-title":"Can Janus kinase inhibition improve ocular graft versus host disease?","volume":"28","author":"Sajjan","year":"2023","journal-title":"Ocul Surf"},{"key":"10.1016\/j.xops.2024.100627_bib13","doi-asserted-by":"crossref","first-page":"2483","DOI":"10.1038\/s41375-018-0123-z","article-title":"Baricitinib-induced blockade of interferon gamma receptor and interleukin-6 receptor for the prevention and treatment of graft-versus-host disease","volume":"32","author":"Choi","year":"2018","journal-title":"Leukemia"},{"key":"10.1016\/j.xops.2024.100627_bib14","doi-asserted-by":"crossref","first-page":"35721","DOI":"10.18632\/oncotarget.26291","article-title":"Targeting IFNGR\/IL6R or downstream JAK1\/JAK2 to control GvHD","volume":"9","author":"Ashami","year":"2018","journal-title":"Oncotarget"},{"key":"10.1016\/j.xops.2024.100627_bib15","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1016\/j.bbmt.2014.12.001","article-title":"National Institutes of Health consensus development project on criteria for clinical trials in chronic graft-versus-host disease: I. The 2014 diagnosis and staging working group report","volume":"21","author":"Jagasia","year":"2015","journal-title":"Biol Blood Marrow Transplant"},{"key":"10.1016\/j.xops.2024.100627_bib16","doi-asserted-by":"crossref","first-page":"S251","DOI":"10.1016\/S2666-6367(23)00398-6","article-title":"Baricitinib for refractory chronic graft-versus-host disease (cGVHD): results of a phase 1\/2 study","volume":"29","author":"Holtzman","year":"2023","journal-title":"Transplant Cell Ther"},{"key":"10.1016\/j.xops.2024.100627_bib17","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1097\/ICO.0000000000003430","article-title":"Evaluating moisture migration in schirmer test strips: exploring brand-specific variations and introducing calibration and conversionMethods","volume":"43","author":"Magone","year":"2023","journal-title":"Cornea"},{"key":"10.1016\/j.xops.2024.100627_bib18","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1097\/ICO.0000000000001206","article-title":"A\u00a0pilot randomized trial on safety and efficacy of a novel topical combined inhibitor of Janus kinase 1\/3 and spleen tyrosine kinase for GVHD-associated ocular surface disease","volume":"36","author":"Kheirkhah","year":"2017","journal-title":"Cornea"},{"key":"10.1016\/j.xops.2024.100627_bib19","doi-asserted-by":"crossref","first-page":"1031","DOI":"10.1038\/sj.bmt.1704453","article-title":"Topical corticosteroid therapy for cicatricial conjunctivitis associated with chronic graft-versus-host disease","volume":"33","author":"Robinson","year":"2004","journal-title":"Bone Marrow Transplant"},{"key":"10.1016\/j.xops.2024.100627_bib20","doi-asserted-by":"crossref","first-page":"2372","DOI":"10.2353\/ajpath.2009.090318","article-title":"Epithelial mesenchymal transition in human ocular chronic graft-versus-host disease","volume":"175","author":"Ogawa","year":"2009","journal-title":"Am J Pathol"},{"key":"10.1016\/j.xops.2024.100627_bib21","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1016\/j.ajo.2018.02.020","article-title":"Subtarsal fibrosis is associated with ocular surface epitheliopathy in graft-versus-host disease","volume":"189","author":"Kheirkhah","year":"2018","journal-title":"Am J Ophthalmol"},{"key":"10.1016\/j.xops.2024.100627_bib22","first-page":"111","article-title":"A\u00a0significant role of stromal fibroblasts in rapidly progressive dry eye in patients with chronic GVHD","volume":"42","author":"Ogawa","year":"2001","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.xops.2024.100627_bib23","doi-asserted-by":"crossref","first-page":"904","DOI":"10.1016\/j.ophtha.2004.11.035","article-title":"Correlation of corneal complications with eyelid cicatricial pathologies in patients with Stevens-Johnson syndrome and toxic epidermal necrolysis syndrome","volume":"112","author":"Di Pascuale","year":"2005","journal-title":"Ophthalmology"},{"key":"10.1016\/j.xops.2024.100627_bib24","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1159\/000325034","article-title":"Conjunctival scrape cytology findings in patients with chronic graft-versus-host disease following allogeneic bone marrow transplantation","volume":"54","author":"Hosseini","year":"2010","journal-title":"Acta Cytol"},{"key":"10.1016\/j.xops.2024.100627_bib25","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1038\/bmt.2015.72","article-title":"Meibography and meibomian gland measurements in ocular graft-versus-host disease","volume":"50","author":"Engel","year":"2015","journal-title":"Bone Marrow Transplant"},{"key":"10.1016\/j.xops.2024.100627_bib26","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1016\/j.jtos.2018.05.002","article-title":"Corneal fluorescein staining and ocular symptoms but not Schirmer test are useful as indicators of response to treatment in chronic ocular GVHD","volume":"16","author":"Amparo","year":"2018","journal-title":"Ocul Surf"},{"key":"10.1016\/j.xops.2024.100627_bib27","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1038\/sj.bmt.1705900","article-title":"Ocular surface and tear functions after topical cyclosporine treatment in dry eye patients with chronic graft-versus-host disease","volume":"41","author":"Wang","year":"2008","journal-title":"Bone Marrow Transplant"},{"key":"10.1016\/j.xops.2024.100627_bib28","doi-asserted-by":"crossref","first-page":"e43","DOI":"10.1016\/j.ophtha.2012.03.017","article-title":"Immunomodulatory effect of the topical ophthalmic Janus kinase inhibitor tofacitinib (CP-690,550) in patients with dry eye disease","volume":"119","author":"Huang","year":"2012","journal-title":"Ophthalmology"},{"key":"10.1016\/j.xops.2024.100627_bib29","doi-asserted-by":"crossref","first-page":"1328","DOI":"10.1016\/j.ophtha.2012.01.028","article-title":"Tofacitinib (CP-690,550), a Janus kinase inhibitor for dry eye disease: results from a phase 1\/2 trial","volume":"119","author":"Liew","year":"2012","journal-title":"Ophthalmology"}],"container-title":["Ophthalmology Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2666914524001635?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2666914524001635?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T09:37:45Z","timestamp":1778924265000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2666914524001635"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1]]},"references-count":29,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,1]]}},"alternative-id":["S2666914524001635"],"URL":"https:\/\/doi.org\/10.1016\/j.xops.2024.100627","relation":{},"ISSN":["2666-9145"],"issn-type":[{"value":"2666-9145","type":"print"}],"subject":[],"published":{"date-parts":[[2025,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Systemic Treatment with the Janus Kinase Inhibitor Baricitinib in Ocular Chronic Graft-versus-Host Disease","name":"articletitle","label":"Article Title"},{"value":"Ophthalmology Science","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.xops.2024.100627","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 by the American Academy of Ophthalmology.","name":"copyright","label":"Copyright"}],"article-number":"100627"}}