{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,25]],"date-time":"2026-02-25T20:13:49Z","timestamp":1772050429653,"version":"3.50.1"},"reference-count":15,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,12,11]],"date-time":"2024-12-11T00:00:00Z","timestamp":1733875200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003977","name":"Israel Science Foundation","doi-asserted-by":"publisher","award":["3485\/19"],"award-info":[{"award-number":["3485\/19"]}],"id":[{"id":"10.13039\/501100003977","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["ophthalmologyscience.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Ophthalmology Science"],"published-print":{"date-parts":[[2025,3]]},"DOI":"10.1016\/j.xops.2024.100677","type":"journal-article","created":{"date-parts":[[2024,12,16]],"date-time":"2024-12-16T15:10:48Z","timestamp":1734361848000},"page":"100677","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Patients with Age-related Macular Degeneration Have Increased Susceptibility to Valvular Heart Disease"],"prefix":"10.1016","volume":"5","author":[{"given":"Natan","family":"Lishinsky-Fischer","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Itay","family":"Chowers","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yahel","family":"Shwartz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0043-4354","authenticated-orcid":false,"given":"Jaime","family":"Levy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.xops.2024.100677_bib1","doi-asserted-by":"crossref","first-page":"483","DOI":"10.4065\/mcp.2009.0706","article-title":"Valvular heart disease: diagnosis and management","volume":"85","author":"Maganti","year":"2010","journal-title":"Mayo Clin Proc"},{"key":"10.1016\/j.xops.2024.100677_bib2","doi-asserted-by":"crossref","DOI":"10.1136\/bmjophth-2022-001154","article-title":"Subretinal drusenoid deposits are strongly associated with coexistent high-risk vascular diseases","volume":"7","author":"Ledesma-Gil","year":"2022","journal-title":"BMJ Open Ophthalmol"},{"key":"10.1016\/j.xops.2024.100677_bib3","doi-asserted-by":"crossref","first-page":"2038","DOI":"10.1177\/11206721241244413","article-title":"Quantifying cardiac dysfunction and valvular heart disease associated with subretinal drusenoid deposits in age-related macular degeneration","volume":"34","author":"Fei","year":"2024","journal-title":"Eur J Ophthalmol"},{"key":"10.1016\/j.xops.2024.100677_bib4","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1186\/1471-2415-10-31","article-title":"Clinical risk factors for age-related macular degeneration: a systematic review and meta-analysis","volume":"10","author":"Chakravarthy","year":"2010","journal-title":"BMC Ophthalmol"},{"key":"10.1016\/j.xops.2024.100677_bib5","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1038\/s41569-021-00570-z","article-title":"Global epidemiology of valvular heart disease","volume":"18","author":"Coffey","year":"2021","journal-title":"Nat Rev Cardiol"},{"key":"10.1016\/j.xops.2024.100677_bib6","article-title":"Diabetes mellitus and risk of age-related macular degeneration: a systematic review and meta-analysis","volume":"9","author":"Chen","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.xops.2024.100677_bib7","doi-asserted-by":"crossref","first-page":"913","DOI":"10.3390\/ijms22020913","article-title":"Extracellular matrix in calcific aortic valve Disease: architecture, dynamic and Perspectives","volume":"22","author":"Di Vito","year":"2021","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.xops.2024.100677_bib8","first-page":"32","article-title":"Valvular heart disease epidemiology","volume":"10","author":"Aluru","year":"2022","journal-title":"Med Sci (Basel)"},{"key":"10.1016\/j.xops.2024.100677_bib9","first-page":"962","article-title":"Epidemiology of acquired valvular heart disease","volume":"30","author":"Iung","year":"2014","journal-title":"Can J Cardiol"},{"key":"10.1016\/j.xops.2024.100677_bib10","doi-asserted-by":"crossref","first-page":"1184","DOI":"10.3892\/etm.2016.3048","article-title":"Pathophysiology of valvular heart disease","volume":"11","author":"Zeng","year":"2016","journal-title":"Exp Ther Med"},{"key":"10.1016\/j.xops.2024.100677_bib11","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1016\/j.atherosclerosis.2007.03.040","article-title":"Complement system is activated in stenotic aortic valves","volume":"196","author":"Helske","year":"2008","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.xops.2024.100677_bib12","doi-asserted-by":"crossref","first-page":"2782","DOI":"10.1161\/01.CIR.96.9.2782","article-title":"Continuous infusion of prostacyclin normalizes plasma markers of endothelial cell injury and platelet aggregation in primary pulmonary hypertension","volume":"96","author":"Friedman","year":"1997","journal-title":"Circulation"},{"key":"10.1016\/j.xops.2024.100677_bib13","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1016\/1047-2797(94)00092-8","article-title":"Methods of assessing prevalent cardiovascular disease in the Cardiovascular Health Study","volume":"5","author":"Psaty","year":"1995","journal-title":"Ann Epidemiol"},{"key":"10.1016\/j.xops.2024.100677_bib14","first-page":"459","article-title":"Classification techniques in machine learning: applications and issues","volume":"13","author":"Soofi","year":"2017","journal-title":"J\u00a0Basic Appl Sci"},{"key":"10.1016\/j.xops.2024.100677_bib15","article-title":"Random forest vs logistic regression: binary classification for heterogeneous datasets","volume":"1","author":"Kirasich","year":"2018","journal-title":"SMU Data Sci Rev"}],"container-title":["Ophthalmology Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2666914524002136?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2666914524002136?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,2,25]],"date-time":"2026-02-25T19:45:05Z","timestamp":1772048705000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2666914524002136"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3]]},"references-count":15,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2025,3]]}},"alternative-id":["S2666914524002136"],"URL":"https:\/\/doi.org\/10.1016\/j.xops.2024.100677","relation":{},"ISSN":["2666-9145"],"issn-type":[{"value":"2666-9145","type":"print"}],"subject":[],"published":{"date-parts":[[2025,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Patients with Age-related Macular Degeneration Have Increased Susceptibility to Valvular Heart Disease","name":"articletitle","label":"Article Title"},{"value":"Ophthalmology Science","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.xops.2024.100677","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 by the American Academy of Ophthalmology.","name":"copyright","label":"Copyright"}],"article-number":"100677"}}