{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T16:29:19Z","timestamp":1780676959651,"version":"3.54.1"},"reference-count":65,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,8,12]],"date-time":"2025-08-12T00:00:00Z","timestamp":1754956800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100001818","name":"Research to Prevent Blindness","doi-asserted-by":"publisher","award":["GR004596-1"],"award-info":[{"award-number":["GR004596-1"]}],"id":[{"id":"10.13039\/100001818","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100031478","name":"NextGenerationEU","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100031478","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003407","name":"Ministero dell\u2019Istruzione, dell\u2019Universit\u00e0 e della Ricerca","doi-asserted-by":"publisher","award":["PE00000006"],"award-info":[{"award-number":["PE00000006"]}],"id":[{"id":"10.13039\/501100003407","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000009","name":"Foundation for the National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000009","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["ophthalmologyscience.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Ophthalmology Science"],"published-print":{"date-parts":[[2026,1]]},"DOI":"10.1016\/j.xops.2025.100918","type":"journal-article","created":{"date-parts":[[2025,8,20]],"date-time":"2025-08-20T01:32:28Z","timestamp":1755653548000},"page":"100918","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"title":["Topical WIN 55 212-2 Confers Long-Term Intraocular Pressure\u2013Independent Neuroprotection in the DBA\/2J Mouse Model of Glaucoma"],"prefix":"10.1016","volume":"6","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0013-6189","authenticated-orcid":false,"given":"Gabriele","family":"Gallo Afflitto","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tsung-Han","family":"Chou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mascha Louisa","family":"Korsch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Aiello","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annagrazia","family":"Adornetto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rossella","family":"Russo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giacinto","family":"Bagetta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlo","family":"Nucci","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vittorio","family":"Porciatti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.xops.2025.100918_bib1","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1097\/IJG.0000000000002083","article-title":"Primary open angle glaucoma prevalence in Europe: a systematic review and meta-analysis","volume":"31","author":"Gallo Afflitto","year":"2022","journal-title":"J Glaucoma"},{"key":"10.1016\/j.xops.2025.100918_bib2","doi-asserted-by":"crossref","first-page":"2711","DOI":"10.1038\/s41433-024-03103-3","article-title":"Racial-ethnic disparities in concurrent rates of peripapillary & macular OCT parameters among a large glaucomatous clinical population","volume":"38","author":"Gallo Afflitto","year":"2024","journal-title":"Eye (Lond)"},{"key":"10.1016\/j.xops.2025.100918_bib3","doi-asserted-by":"crossref","DOI":"10.1097\/IJG.0000000000002613","article-title":"Glaucoma and risk of fractures: a systematic review, meta-analysis and network meta-analysis","author":"Gallo Afflitto","year":"2025","journal-title":"J Glaucoma"},{"key":"10.1016\/j.xops.2025.100918_bib4","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1001\/jama.2020.21899","article-title":"Glaucoma in adults-screening, diagnosis, and management: a review","volume":"325","author":"Stein","year":"2021","journal-title":"JAMA"},{"key":"10.1016\/j.xops.2025.100918_bib5","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1097\/IIO.0000000000000479","article-title":"Minimally invasive glaucoma surgery","volume":"63","author":"Gallo Afflitto","year":"2023","journal-title":"Int Ophthalmol Clin"},{"key":"10.1016\/j.xops.2025.100918_bib6","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1016\/S0002-9394(00)00538-9","article-title":"The relationship between control of intraocular pressure and visual field Deterioration.The AGIS investigators","volume":"130","year":"2000","journal-title":"Am J Ophthalmol"},{"key":"10.1016\/j.xops.2025.100918_bib7","doi-asserted-by":"crossref","first-page":"2271","DOI":"10.1016\/j.ophtha.2009.06.042","article-title":"Natural history of open-angle glaucoma","volume":"116","author":"Heijl","year":"2009","journal-title":"Ophthalmology"},{"key":"10.1016\/j.xops.2025.100918_bib8","doi-asserted-by":"crossref","DOI":"10.1016\/j.xops.2022.100216","article-title":"Neuroprotection, neuroenhancement, and neuroregeneration of the retina and optic nerve","volume":"2","author":"Johnson","year":"2022","journal-title":"Ophthalmol Sci"},{"key":"10.1016\/j.xops.2025.100918_bib9","doi-asserted-by":"crossref","DOI":"10.1016\/j.xops.2023.100322","article-title":"Pattern electroretinogram in ocular hypertension, glaucoma suspect and early manifest glaucoma eyes: a systematic review and meta-analysis","volume":"3","author":"Gallo Afflitto","year":"2023","journal-title":"Ophthalmol Sci"},{"key":"10.1016\/j.xops.2025.100918_bib10","doi-asserted-by":"crossref","first-page":"634","DOI":"10.1038\/s43587-021-00098-4","article-title":"Autophagy in healthy aging and disease","volume":"1","author":"Aman","year":"2021","journal-title":"Reviewpaper Nat Aging"},{"key":"10.1016\/j.xops.2025.100918_bib11","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1038\/nrn3961","article-title":"Compromised autophagy and neurodegenerative diseases. ReviewPaper","volume":"16","author":"Menzies","year":"2015","journal-title":"Nat Rev Neurosci"},{"key":"10.1016\/j.xops.2025.100918_bib12","doi-asserted-by":"crossref","DOI":"10.1038\/cddis.2011.29","article-title":"Calpain-mediated cleavage of Beclin-1 and autophagy deregulation following retinal ischemic injury in vivo","volume":"2","author":"Russo","year":"2011","journal-title":"Cell Death Dis"},{"key":"10.1016\/j.xops.2025.100918_bib13","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1038\/s41420-025-02490-0","article-title":"Sex and region-specific disruption of autophagy and mitophagy in Alzheimer's disease: linking cellular dysfunction to cognitive decline","volume":"11","author":"Adlimoghaddam","year":"2025","journal-title":"Cell Death Discov"},{"key":"10.1016\/j.xops.2025.100918_bib14","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1038\/s41420-018-0077-y","article-title":"Contribution of autophagy to ocular hypertension and neurodegeneration in the DBA\/2J spontaneous glaucoma mouse model","volume":"4","author":"Hirt","year":"2018","journal-title":"Cell Death Discov"},{"key":"10.1016\/j.xops.2025.100918_bib15","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1038\/s41419-018-1044-5","article-title":"Rapamycin and fasting sustain autophagy response activated by ischemia\/reperfusion injury and promote retinal ganglion cell survival","volume":"9","author":"Russo","year":"2018","journal-title":"Cell Death Dis"},{"key":"10.1016\/j.xops.2025.100918_bib16","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1016\/j.ophtha.2011.11.003","article-title":"Glaucoma 2.0: neuroprotection, neuroregeneration, neuroenhancement","volume":"119","author":"Chang","year":"2012","journal-title":"Ophthalmology"},{"key":"10.1016\/j.xops.2025.100918_bib17","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2022.112981","article-title":"CB(1)R, CB(2)R and TRPV1 expression and modulation in in vivo, animal glaucoma models: a systematic review","volume":"150","author":"Gallo Afflitto","year":"2022","journal-title":"Biomed Pharmacother"},{"key":"10.1016\/j.xops.2025.100918_bib18","doi-asserted-by":"crossref","first-page":"2997","DOI":"10.1167\/iovs.06-1355","article-title":"Involvement of the endocannabinoid system in retinal damage after high intraocular pressure-induced ischemia in rats","volume":"48","author":"Nucci","year":"2007","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.xops.2025.100918_bib19","doi-asserted-by":"crossref","DOI":"10.3390\/jcm9124036","article-title":"CannabinEYEds: the endocannabinoid system as a regulator of the ocular surface nociception, inflammatory response, neovascularization and wound healing","volume":"9","author":"Aiello","year":"2020","journal-title":"J Clin Med"},{"key":"10.1016\/j.xops.2025.100918_bib20","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2021.112505","article-title":"Is there a rational basis for cannabinoids research and development in ocular pain therapy? A systematic review of preclinical evidence","volume":"146","author":"Scuteri","year":"2022","journal-title":"Biomed Pharmacother"},{"key":"10.1016\/j.xops.2025.100918_bib21","series-title":"Cannabinoids in autoimmune and rheumatic diseases, Mosaic of Autoimmunity: The Novel Factors of Autoimmune Diseases","first-page":"417","author":"Navarini","year":"2019"},{"key":"10.1016\/j.xops.2025.100918_bib22","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1016\/S0079-6123(08)01131-X","article-title":"Potential roles of (endo)cannabinoids in the treatment of glaucoma: from intraocular pressure control to neuroprotection","volume":"173","author":"Nucci","year":"2008","journal-title":"Prog Brain Res"},{"key":"10.1016\/j.xops.2025.100918_bib23","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.brainresbull.2020.03.014","article-title":"Age-dependent alteration in mitochondrial dynamics and autophagy in hippocampal neuron of cannabinoid CB1 receptor-deficient mice","volume":"160","author":"Kataoka","year":"2020","journal-title":"Brain Res Bull"},{"key":"10.1016\/j.xops.2025.100918_bib24","doi-asserted-by":"crossref","DOI":"10.1016\/j.brainres.2024.149414","article-title":"Cannabidiol induces autophagy via CB(1) receptor and reduces alpha-synuclein cytosolic levels","volume":"1850","author":"Erustes","year":"2025","journal-title":"Brain Res"},{"key":"10.1016\/j.xops.2025.100918_bib25","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1001\/archopht.121.1.87","article-title":"Effect of WIN 55212-2, a cannabinoid receptor agonist, on aqueous humor dynamics in monkeys","volume":"121","author":"Chien","year":"2003","journal-title":"Arch Ophthalmol"},{"key":"10.1016\/j.xops.2025.100918_bib26","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1089\/jop.2007.0074","article-title":"Topical WIN55212-2 alleviates intraocular hypertension in rats through a CB1 receptor mediated mechanism of action","volume":"24","author":"Oltmanns","year":"2008","journal-title":"J Ocul Pharmacol Ther"},{"key":"10.1016\/j.xops.2025.100918_bib27","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1016\/j.exer.2005.09.017","article-title":"Chronic topical administration of WIN-55-212-2 maintains a reduction in IOP in a rat glaucoma model without adverse effects","volume":"82","author":"Hosseini","year":"2006","journal-title":"Exp Eye Res"},{"key":"10.1016\/j.xops.2025.100918_bib28","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1080\/02713680802419724","article-title":"Comparison of topical and intravenous administration of WIN 55-212-2 in normotensive rabbits","volume":"33","author":"Samudre","year":"2008","journal-title":"Curr Eye Res"},{"key":"10.1016\/j.xops.2025.100918_bib29","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1046\/j.0953-816X.2000.01401.x","article-title":"The synthetic cannabinoid WIN55212-2 decreases the intraocular pressure in human glaucoma resistant to conventional therapies","volume":"13","author":"Porcella","year":"2001","journal-title":"Eur J Neurosci"},{"key":"10.1016\/j.xops.2025.100918_bib30","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.exer.2013.02.009","article-title":"Neuroprotective effects of topical CB1 agonist WIN 55212-2 on retinal ganglion cells after acute rise in intraocular pressure induced ischemia in rat","volume":"110","author":"Pinar-Sueiro","year":"2013","journal-title":"Exp Eye Res"},{"key":"10.1016\/j.xops.2025.100918_bib31","doi-asserted-by":"crossref","DOI":"10.1042\/NS20210038","article-title":"Neuroprotection of retinal ganglion cells in vivo using the activation of the endogenous cannabinoid signaling system in mammalian eyes","volume":"6","author":"Maguire","year":"2022","journal-title":"Neuronal Signal"},{"key":"10.1016\/j.xops.2025.100918_bib32","first-page":"951","article-title":"Essential iris atrophy, pigment dispersion, and glaucoma in DBA\/2J mice","volume":"39","author":"John","year":"1998","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.xops.2025.100918_bib33","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/j.ejphar.2017.03.018","article-title":"Rimonabant, a selective cannabinoid(1) receptor antagonist, protects against light-induced retinal degeneration in vitro and in vivo","volume":"803","author":"Imamura","year":"2017","journal-title":"Eur J Pharmacol"},{"key":"10.1016\/j.xops.2025.100918_bib34","doi-asserted-by":"crossref","first-page":"1398","DOI":"10.3390\/cells10061398","article-title":"Modeling retinal ganglion cell dysfunction in optic neuropathies","volume":"10","author":"Porciatti","year":"2021","journal-title":"Cells"},{"key":"10.1016\/j.xops.2025.100918_bib35","doi-asserted-by":"crossref","first-page":"3057","DOI":"10.2147\/OPTH.S266453","article-title":"Physiochemical properties and cytotoxicity of a benzalkonium Chloride-free, micellar emulsion ophthalmic formulation of latanoprost","volume":"14","author":"Halder","year":"2020","journal-title":"Clin Ophthalmol"},{"key":"10.1016\/j.xops.2025.100918_bib37","doi-asserted-by":"crossref","first-page":"1411","DOI":"10.1002\/cne.23521","article-title":"The RNA binding protein RBPMS is a selective marker of ganglion cells in the mammalian retina","volume":"522","author":"Rodriguez","year":"2014","journal-title":"J Comp Neurol"},{"key":"10.1016\/j.xops.2025.100918_bib38","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1167\/iovs.65.4.19","article-title":"Comparison of Brn3a and RBPMS labeling to assess retinal ganglion cell loss during aging and in a model of optic neuropathy","volume":"65","author":"Meng","year":"2024","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.xops.2025.100918_bib39","doi-asserted-by":"crossref","first-page":"3049","DOI":"10.1167\/iovs.09-4364","article-title":"Calpain activation in experimental glaucoma","volume":"51","author":"Huang","year":"2010","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.xops.2025.100918_bib40","doi-asserted-by":"crossref","first-page":"12242","DOI":"10.1073\/pnas.0505138102","article-title":"Calcineurin cleavage is triggered by elevated intraocular pressure, and calcineurin inhibition blocks retinal ganglion cell death in experimental glaucoma","volume":"102","author":"Huang","year":"2005","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.xops.2025.100918_bib41","doi-asserted-by":"crossref","first-page":"1094","DOI":"10.4161\/auto.24469","article-title":"Autophagy master regulator TFEB induces clearance of toxic SERPINA1\/alpha-1-antitrypsin polymers","volume":"9","author":"Pastore","year":"2013","journal-title":"Autophagy"},{"key":"10.1016\/j.xops.2025.100918_bib42","doi-asserted-by":"crossref","DOI":"10.1016\/j.mcpro.2021.100117","article-title":"Proteome characterization of glaucoma aqueous humor","volume":"20","author":"Liu","year":"2021","journal-title":"Mol Cell Proteomics"},{"key":"10.1016\/j.xops.2025.100918_bib43","first-page":"763","article-title":"Candidate glaucoma biomarkers: from proteins to metabolites, and the pitfalls to clinical applications","volume":"10","author":"Fernandez-Vega Cueto","year":"2021","journal-title":"Biology (Basel)"},{"key":"10.1016\/j.xops.2025.100918_bib44","doi-asserted-by":"crossref","first-page":"1133","DOI":"10.1006\/jmcc.2001.1373","article-title":"Intracellular calcium level required for calpain activation in a single myocardial cell","volume":"33","author":"Matsumura","year":"2001","journal-title":"J Mol Cell Cardiol"},{"key":"10.1016\/j.xops.2025.100918_bib45","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1038\/s41419-022-04608-z","article-title":"Targeting autophagy peptidase ATG4B with a novel natural product inhibitor Azalomycin F4a for advanced gastric cancer","volume":"13","author":"Zhong","year":"2022","journal-title":"Cell Death Dis"},{"key":"10.1016\/j.xops.2025.100918_bib46","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1167\/iovs.66.1.63","article-title":"CAMK2D and complement factor I-Involved Calcium\/Calmodulin signaling modulates sodium iodate-induced mouse retinal degeneration","volume":"66","author":"Xu","year":"2025","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.xops.2025.100918_bib47","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1186\/s12967-023-04432-9","article-title":"Glutathione Peroxidase 3 induced mitochondria-mediated apoptosis via AMPK\/ERK1\/2 pathway and resisted autophagy-related ferroptosis via AMPK\/mTOR pathway in hyperplastic prostate","volume":"21","author":"Li","year":"2023","journal-title":"J Transl Med"},{"key":"10.1016\/j.xops.2025.100918_bib48","doi-asserted-by":"crossref","first-page":"2635","DOI":"10.1167\/iovs.17-23434","article-title":"Proteomic alterations in aqueous humor from patients with primary open angle glaucoma","volume":"59","author":"Sharma","year":"2018","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.xops.2025.100918_bib49","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1016\/S0962-8924(00)01800-6","article-title":"Calmodulin: a prototypical calcium sensor","volume":"10","author":"Chin","year":"2000","journal-title":"Trends Cell Biol"},{"key":"10.1016\/j.xops.2025.100918_bib50","doi-asserted-by":"crossref","first-page":"756","DOI":"10.1126\/science.aal0092","article-title":"Vitamin B3 modulates mitochondrial vulnerability and prevents glaucoma in aged mice","volume":"355","author":"Williams","year":"2017","journal-title":"Science"},{"key":"10.1016\/j.xops.2025.100918_bib51","doi-asserted-by":"crossref","first-page":"2362","DOI":"10.1038\/s41591-024-03068-6","article-title":"Peripheral blood mononuclear cell respiratory function is associated with progressive glaucomatous vision loss","volume":"30","author":"Petriti","year":"2024","journal-title":"Nat Med"},{"key":"10.1016\/j.xops.2025.100918_bib52","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.adl5722","article-title":"Insulin restores retinal ganglion cell functional connectivity and promotes visual recovery in glaucoma","volume":"10","author":"El Hajji","year":"2024","journal-title":"Sci Adv"},{"key":"10.1016\/j.xops.2025.100918_bib53","doi-asserted-by":"crossref","first-page":"3778","DOI":"10.1007\/s12035-022-02817-3","article-title":"Serpin signatures in prion and alzheimer's diseases","volume":"59","author":"Zattoni","year":"2022","journal-title":"Mol Neurobiol"},{"key":"10.1016\/j.xops.2025.100918_bib54","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1002\/ana.10414","article-title":"Plasma and cerebrospinal fluid alpha1-antichymotrypsin levels in Alzheimer's disease: correlation with cognitive impairment","volume":"53","author":"DeKosky","year":"2003","journal-title":"Ann Neurol"},{"key":"10.1016\/j.xops.2025.100918_bib55","doi-asserted-by":"crossref","first-page":"8412","DOI":"10.1038\/s41598-017-08688-2","article-title":"Glaucoma is associated with plasmin proteolytic activation mediated through oxidative inactivation of neuroserpin","volume":"7","author":"Gupta","year":"2017","journal-title":"Sci Rep"},{"key":"10.1016\/j.xops.2025.100918_bib56","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.jprot.2013.12.006","article-title":"Comparative proteomic study in serum of patients with primary open-angle glaucoma and pseudoexfoliation glaucoma","volume":"98","author":"Gonzalez-Iglesias","year":"2014","journal-title":"J Proteomics"},{"key":"10.1016\/j.xops.2025.100918_bib57","doi-asserted-by":"crossref","first-page":"971","DOI":"10.2174\/1570159X16666171206144045","article-title":"Glaucoma and alzheimer disease: one age-related neurodegenerative disease of the brain","volume":"16","author":"Mancino","year":"2018","journal-title":"Curr Neuropharmacol"},{"key":"10.1016\/j.xops.2025.100918_bib58","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1023\/A:1022949121078","article-title":"Alzheimer's peptide and serine proteinase inhibitors in glaucoma and exfoliation syndrome","volume":"106","author":"Janciauskiene","year":"2003","journal-title":"Doc Ophthalmol"},{"key":"10.1016\/j.xops.2025.100918_bib59","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1080\/17520363.2024.2347190","article-title":"alpha-1 antitrypsin is promising for the identification of glaucoma severity and is associated with glaucomatous neural damage","volume":"18","author":"Yuan","year":"2024","journal-title":"Biomark Med"},{"key":"10.1016\/j.xops.2025.100918_bib60","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1016\/j.ophtha.2023.10.014","article-title":"Risk of Alzheimer's disease and related dementias in persons with glaucoma: a national cohort study","volume":"131","author":"Crump","year":"2024","journal-title":"Ophthalmology"},{"key":"10.1016\/j.xops.2025.100918_bib61","doi-asserted-by":"crossref","first-page":"6059","DOI":"10.1167\/iovs.10-7108","article-title":"Application of advanced statistics in ophthalmology","volume":"52","author":"Fan","year":"2011","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.xops.2025.100918_bib62","article-title":"ChatGPT-Assisted classification of postoperative bleeding following micro-invasive glaucoma surgery using electronic health record data","volume":"5","author":"Shaheen","year":"2024","journal-title":"Ophthalmol Sci"},{"key":"10.1016\/j.xops.2025.100918_bib63","doi-asserted-by":"crossref","first-page":"608","DOI":"10.1016\/j.ogla.2024.07.003","article-title":"Refractive outcomes following combined cataract and microinvasive glaucoma surgery","volume":"7","author":"Shaheen","year":"2024","journal-title":"Ophthalmol Glaucoma"},{"key":"10.1016\/j.xops.2025.100918_bib64","doi-asserted-by":"crossref","first-page":"4564","DOI":"10.1167\/iovs.07-0483","article-title":"Longitudinal evaluation of retinal ganglion cell function and IOP in the DBA\/2J mouse model of glaucoma","volume":"48","author":"Saleh","year":"2007","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.xops.2025.100918_bib65","author":"Spitze"},{"key":"10.1016\/j.xops.2025.100918_bib66","doi-asserted-by":"crossref","first-page":"2503","DOI":"10.1002\/glia.24056","article-title":"Cannabinoid signaling promotes the de-differentiation and proliferation of muller glia-derived progenitor cells","volume":"69","author":"Campbell","year":"2021","journal-title":"Glia"}],"container-title":["Ophthalmology Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2666914525002167?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2666914525002167?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,3,7]],"date-time":"2026-03-07T21:45:16Z","timestamp":1772919916000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2666914525002167"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":65,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1]]}},"alternative-id":["S2666914525002167"],"URL":"https:\/\/doi.org\/10.1016\/j.xops.2025.100918","relation":{},"ISSN":["2666-9145"],"issn-type":[{"value":"2666-9145","type":"print"}],"subject":[],"published":{"date-parts":[[2026,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Topical WIN 55 212-2 Confers Long-Term Intraocular Pressure\u2013Independent Neuroprotection in the DBA\/2J Mouse Model of Glaucoma","name":"articletitle","label":"Article Title"},{"value":"Ophthalmology Science","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.xops.2025.100918","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 by the American Academy of Ophthalmology.","name":"copyright","label":"Copyright"}],"article-number":"100918"}}