{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T19:19:03Z","timestamp":1790882343861,"version":"4.1.0"},"reference-count":50,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,8,14]],"date-time":"2025-08-14T00:00:00Z","timestamp":1755129600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100008097","name":"Edward N and Della L Thome Memorial Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008097","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000053","name":"National Eye Institute","doi-asserted-by":"publisher","award":["K08 EY022948"],"award-info":[{"award-number":["K08 EY022948"]}],"id":[{"id":"10.13039\/100000053","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007311","name":"Cleveland Clinic Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007311","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100002028","name":"Collins Medical Trust","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100002028","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","award":["P30 EY010572"],"award-info":[{"award-number":["P30 EY010572"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100018313","name":"Cleveland Eye Bank Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100018313","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100001818","name":"Research to Prevent Blindness","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001818","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006668","name":"Oregon Health and Science University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006668","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","ophthalmologyscience.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Ophthalmology Science"],"published-print":{"date-parts":[[2026,1]]},"DOI":"10.1016\/j.xops.2025.100920","type":"journal-article","created":{"date-parts":[[2025,8,29]],"date-time":"2025-08-29T02:57:19Z","timestamp":1756436239000},"page":"100920","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"title":["Age-related Eye Disease Studies Supplements and Genetic Risk Score Are Crucial Determinants of Intestinal Microbial Alterations in Advanced Age-Related Macular Degeneration"],"prefix":"10.1016","volume":"6","author":[{"given":"Neda","family":"Dadgar","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin","family":"Fung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scott","family":"McClintic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christina","family":"Metea","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victor","family":"Lloren\u00e7","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamed","family":"Saleh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yukiko K.","family":"Nakamura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cody","family":"Jahrig","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lee","family":"Kiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cathleen","family":"Janowitz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sean","family":"Davin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ariel","family":"Balter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kim-Anh","family":"Le Cao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa","family":"Karstens","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tammy M.","family":"Martin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael L.","family":"Klein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2918-5470","authenticated-orcid":false,"given":"Phoebe","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.xops.2025.100920_bib1","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1111\/cge.12206","article-title":"Age-related macular degeneration-clinical review and genetics update","volume":"84","author":"Ratnapriya","year":"2013","journal-title":"Clin Genet"},{"key":"10.1016\/j.xops.2025.100920_bib2","doi-asserted-by":"crossref","first-page":"1677","DOI":"10.3390\/nu10111677","article-title":"The role of diet, micronutrients and the gut microbiota in age-related macular degeneration: new perspectives from the gut-retina axis","volume":"10","author":"Rinninella","year":"2018","journal-title":"Nutrients"},{"key":"10.1016\/j.xops.2025.100920_bib3","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1038\/ng.3448","article-title":"A large genome-wide association study of age-related macular degeneration highlights contributions of rare and common variants","volume":"48","author":"Fritsche","year":"2016","journal-title":"Nat Genet"},{"key":"10.1016\/j.xops.2025.100920_bib4","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1001\/jama.2015.9677","article-title":"Effect of omega-3 fatty acids, lutein\/zeaxanthin, or other nutrient supplementation on cognitive function: the AREDS2 randomized clinical trial","volume":"314","author":"Chew","year":"2015","journal-title":"JAMA"},{"key":"10.1016\/j.xops.2025.100920_bib5","doi-asserted-by":"crossref","first-page":"1604","DOI":"10.1016\/j.ophtha.2013.01.021","article-title":"Long-term effects of vitamins C and E, beta-carotene, and zinc on age-related macular degeneration: AREDS report no. 35","volume":"120","author":"Chew","year":"2013","journal-title":"Ophthalmology"},{"key":"10.1016\/j.xops.2025.100920_bib6","doi-asserted-by":"crossref","first-page":"1781","DOI":"10.3390\/ijms17111781","article-title":"Carotenoid cleavage oxygenases from microbes and photosynthetic organisms: features and functions","volume":"17","author":"Ahrazem","year":"2016","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.xops.2025.100920_bib7","doi-asserted-by":"crossref","DOI":"10.1002\/mnfr.201600685","article-title":"Host-related factors explaining interindividual variability of carotenoid bioavailability and tissue concentrations in humans","volume":"61","author":"Bohn","year":"2017","journal-title":"Mol Nutr Food Res"},{"key":"10.1016\/j.xops.2025.100920_bib8","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1111\/ceo.13343","article-title":"Role of diet and food intake in age-related macular degeneration: a systematic review","volume":"47","author":"Chapman","year":"2019","journal-title":"Clin Exp Ophthalmol"},{"key":"10.1016\/j.xops.2025.100920_bib9","doi-asserted-by":"crossref","first-page":"2645","DOI":"10.3390\/ijms18122645","article-title":"Impact of omega-3 fatty acids on the gut microbiota","volume":"18","author":"Costantini","year":"2017","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.xops.2025.100920_bib10","doi-asserted-by":"crossref","first-page":"2314","DOI":"10.1080\/10408398.2017.1322552","article-title":"Carotenoids biosynthesis and cleavage related genes from bacteria to plants","volume":"58","author":"Liang","year":"2018","journal-title":"Crit Rev Food Sci Nutr"},{"key":"10.1016\/j.xops.2025.100920_bib11","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1007\/s00203-018-1506-2","article-title":"Smoking and the intestinal microbiome","volume":"200","author":"Savin","year":"2018","journal-title":"Arch Microbiol"},{"key":"10.1016\/j.xops.2025.100920_bib12","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1038\/nm.3145","article-title":"Intestinal microbiota metabolism of L-carnitine, a nutrient in red meat, promotes atherosclerosis","volume":"19","author":"Koeth","year":"2013","journal-title":"Nat Med"},{"key":"10.1016\/j.xops.2025.100920_bib13","doi-asserted-by":"crossref","first-page":"1366","DOI":"10.15252\/emmm.201606531","article-title":"Gut microbiota influences pathological angiogenesis in obesity-driven choroidal neovascularization","volume":"8","author":"Andriessen","year":"2016","journal-title":"EMBO Mol Med"},{"key":"10.1016\/j.xops.2025.100920_bib14","doi-asserted-by":"crossref","first-page":"E4472","DOI":"10.1073\/pnas.1702302114","article-title":"Involvement of a gut-retina axis in protection against dietary glycemia-induced age-related macular degeneration","volume":"114","author":"Rowan","year":"2017","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.xops.2025.100920_bib15","doi-asserted-by":"crossref","DOI":"10.1038\/srep40826","article-title":"Association of the intestinal microbiome with the development of neovascular age-related macular degeneration","volume":"7","author":"Zinkernagel","year":"2017","journal-title":"Sci Rep"},{"key":"10.1016\/j.xops.2025.100920_bib16","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1038\/s41525-020-00141-0","article-title":"Associations of the intestinal microbiome with the complement system in neovascular age-related macular degeneration","volume":"5","author":"Zysset-Burri","year":"2020","journal-title":"NPJ Genom Med"},{"key":"10.1016\/j.xops.2025.100920_bib17","doi-asserted-by":"crossref","DOI":"10.1016\/j.preteyeres.2022.101117","article-title":"The role of the gut microbiome in eye diseases","volume":"92","author":"Zysset-Burri","year":"2023","journal-title":"Prog Retin Eye Res"},{"key":"10.1016\/j.xops.2025.100920_bib18","doi-asserted-by":"crossref","first-page":"249","DOI":"10.4056\/aigs.1443528","article-title":"The earth microbiome project: meeting report of the \"1 EMP meeting on sample selection and acquisition\" at Argonne National Laboratory October 6 2010","volume":"3","author":"Gilbert","year":"2010","journal-title":"Stand Genomic Sci"},{"key":"10.1016\/j.xops.2025.100920_bib19","doi-asserted-by":"crossref","first-page":"3747","DOI":"10.1167\/iovs.16-19733","article-title":"Gut microbial alterations associated with protection from autoimmune uveitis","volume":"57","author":"Nakamura","year":"2016","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.xops.2025.100920_bib22","doi-asserted-by":"crossref","first-page":"2639","DOI":"10.1038\/ismej.2017.119","article-title":"Exact sequence variants should replace operational taxonomic units in marker-gene data analysis","volume":"11","author":"Callahan","year":"2017","journal-title":"ISME J"},{"key":"10.1016\/j.xops.2025.100920_bib20","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1186\/1471-2105-12-253","article-title":"Sparse PLS discriminant analysis: biologically relevant feature selection and graphical displays for multiclass problems","volume":"12","author":"Le Cao","year":"2011","journal-title":"BMC Bioinform"},{"key":"10.1016\/j.xops.2025.100920_bib21","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0160169","article-title":"MixMC: a multivariate statistical framework to gain insight into microbial communities","volume":"11","author":"Le Cao","year":"2016","journal-title":"PLOS One"},{"key":"10.1016\/j.xops.2025.100920_bib23","doi-asserted-by":"crossref","first-page":"8228","DOI":"10.1128\/AEM.71.12.8228-8235.2005","article-title":"UniFrac: a new phylogenetic method for comparing microbial communities","volume":"71","author":"Lozupone","year":"2005","journal-title":"Appl Environ Microbiol"},{"key":"10.1016\/j.xops.2025.100920_bib24","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0061217","article-title":"phyloseq: an R package for reproducible interactive analysis and graphics of microbiome census data","volume":"8","author":"McMurdie","year":"2013","journal-title":"PLOS One"},{"key":"10.1016\/j.xops.2025.100920_bib25","doi-asserted-by":"crossref","DOI":"10.1186\/gb-2010-11-10-r106","article-title":"Differential expression analysis for sequence count data","volume":"11","author":"Anders","year":"2010","journal-title":"Genome Biol"},{"key":"10.1016\/j.xops.2025.100920_bib26","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0166104","article-title":"Piphillin: improved prediction of metagenomic content by direct inference from human microbiomes","volume":"11","author":"Iwai","year":"2016","journal-title":"PLOS One"},{"key":"10.1016\/j.xops.2025.100920_bib27","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1186\/s12864-019-6427-1","article-title":"Piphillin predicts metagenomic composition and dynamics from DADA2-corrected 16S rDNA sequences","volume":"21","author":"Narayan","year":"2020","journal-title":"BMC Genomics"},{"key":"10.1016\/j.xops.2025.100920_bib28","doi-asserted-by":"crossref","first-page":"1000","DOI":"10.1016\/j.cell.2014.08.006","article-title":"Immunoglobulin A coating identifies colitogenic bacteria in inflammatory bowel disease","volume":"158","author":"Palm","year":"2014","journal-title":"Cell"},{"key":"10.1016\/j.xops.2025.100920_bib29","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1159\/000094141","article-title":"CFH gene variant, Y402H, and smoking, body mass index, environmental associations with advanced age-related macular degeneration","volume":"61","author":"Seddon","year":"2006","journal-title":"Hum Hered"},{"key":"10.1016\/j.xops.2025.100920_bib30","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1534\/genetics.116.196998","article-title":"Bivariate analysis of age-related macular degeneration progression using genetic risk scores","volume":"206","author":"Ding","year":"2017","journal-title":"Genetics"},{"key":"10.1016\/j.xops.2025.100920_bib32","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1167\/iovs.64.5.11","article-title":"Metagenomic sequencing analysis identifies cross-cohort gut microbial signatures associated with age-related macular degeneration","volume":"64","author":"Xue","year":"2023","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.xops.2025.100920_bib33","doi-asserted-by":"crossref","first-page":"3209","DOI":"10.1038\/s41467-018-05681-9","article-title":"Commensal microflora-induced T cell responses mediate progressive neurodegeneration in glaucoma","volume":"9","author":"Chen","year":"2018","journal-title":"Nat Commun"},{"key":"10.1016\/j.xops.2025.100920_bib34","doi-asserted-by":"crossref","DOI":"10.1155\/2017\/9351507","article-title":"Proteobacteria: a common factor in human diseases","volume":"2017","author":"Rizzatti","year":"2017","journal-title":"Biomed Res Int"},{"key":"10.1016\/j.xops.2025.100920_bib35","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1038\/s41575-021-00512-7","article-title":"Leveraging diet to engineer the gut microbiome","volume":"18","author":"Wolter","year":"2021","journal-title":"Nat Rev Gastroenterol Hepatol"},{"key":"10.1016\/j.xops.2025.100920_bib36","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/j.anaerobe.2013.03.011","article-title":"Diet, the human gut microbiota, and IBD","volume":"24","author":"Wu","year":"2013","journal-title":"Anaerobe"},{"key":"10.1016\/j.xops.2025.100920_bib37","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1080\/19490976.2017.1349041","article-title":"Gut microbiome in multiple sclerosis: the players involved and the roles they play","volume":"8","author":"Shahi","year":"2017","journal-title":"Gut Microbes"},{"key":"10.1016\/j.xops.2025.100920_bib38","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1093\/femsec\/fiu002","article-title":"Altered gut microbial energy and metabolism in children with non-alcoholic fatty liver disease","volume":"91","author":"Michail","year":"2015","journal-title":"FEMS Microbiol Ecol"},{"key":"10.1016\/j.xops.2025.100920_bib39","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.01202","article-title":"Expansion of intestinal Prevotella copri correlates with enhanced susceptibility to arthritis","volume":"2","author":"Scher","year":"2013","journal-title":"Elife"},{"key":"10.1016\/j.xops.2025.100920_bib40","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.bpg.2013.03.005","article-title":"Intestinal microbiota: a source of novel biomarkers in inflammatory bowel diseases?","volume":"27","author":"Berry","year":"2013","journal-title":"Best Pract Res Clin Gastroenterol"},{"key":"10.1016\/j.xops.2025.100920_bib41","doi-asserted-by":"crossref","first-page":"1464","DOI":"10.3748\/wjg.v24.i13.1464","article-title":"Fecal microbial dysbiosis in Chinese patients with inflammatory bowel disease","volume":"24","author":"Ma","year":"2018","journal-title":"World J Gastroenterol"},{"key":"10.1016\/j.xops.2025.100920_bib42","doi-asserted-by":"crossref","first-page":"1308","DOI":"10.1111\/ene.13026","article-title":"Gut microbiota in early pediatric multiple sclerosis: a case-control study","volume":"23","author":"Tremlett","year":"2016","journal-title":"Eur J Neurol"},{"key":"10.1016\/j.xops.2025.100920_bib43","doi-asserted-by":"crossref","first-page":"1373","DOI":"10.1016\/j.bbmt.2015.04.016","article-title":"Intestinal blautia is associated with reduced death from graft-versus-host disease","volume":"21","author":"Jenq","year":"2015","journal-title":"Biol Blood Marrow Transplant"},{"key":"10.1016\/j.xops.2025.100920_bib44","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1093\/ecco-jcc\/jjx153","article-title":"Characteristics of faecal microbiota in paediatric Crohn's disease and their dynamic changes during infliximab therapy","volume":"12","author":"Wang","year":"2018","journal-title":"J Crohns Colitis"},{"key":"10.1016\/j.xops.2025.100920_bib45","doi-asserted-by":"crossref","first-page":"4668","DOI":"10.4049\/jimmunol.1501664","article-title":"TNFR2 deficiency acts in concert with gut microbiota to precipitate spontaneous sex-biased central nervous system demyelinating autoimmune disease","volume":"195","author":"Miller","year":"2015","journal-title":"J Immunol"},{"key":"10.1016\/j.xops.2025.100920_bib46","doi-asserted-by":"crossref","first-page":"1137","DOI":"10.1097\/MIB.0000000000000750","article-title":"Current understanding of dysbiosis in disease in human and animal models","volume":"22","author":"DeGruttola","year":"2016","journal-title":"Inflamm Bowel Dis"},{"key":"10.1016\/j.xops.2025.100920_bib47","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1053\/j.gastro.2020.09.060","article-title":"Aging, frailty, and the microbiome-how dysbiosis influences human aging and disease","volume":"160","author":"Haran","year":"2021","journal-title":"Gastroenterology"},{"key":"10.1016\/j.xops.2025.100920_bib50","doi-asserted-by":"crossref","first-page":"1483","DOI":"10.3945\/ajcn.116.143453","article-title":"Dietary intake of alpha-linolenic acid and risk of age-related macular degeneration","volume":"105","author":"Wu","year":"2017","journal-title":"Am J Clin Nutr"},{"key":"10.1016\/j.xops.2025.100920_bib51","doi-asserted-by":"crossref","first-page":"634","DOI":"10.1016\/j.ophtha.2016.12.033","article-title":"Dietary intakes of eicosapentaenoic acid and docosahexaenoic acid and risk of age-related macular degeneration","volume":"124","author":"Wu","year":"2017","journal-title":"Ophthalmology"},{"key":"10.1016\/j.xops.2025.100920_bib55","doi-asserted-by":"crossref","DOI":"10.1136\/bmjophth-2023-001573","article-title":"Analysis of biofluid metabolomic profiles to the discovery of biomarkers in age-related macular degeneration","volume":"9","author":"Wu","year":"2024","journal-title":"BMJ Open Ophthalmol"},{"key":"10.1016\/j.xops.2025.100920_bib53","doi-asserted-by":"crossref","first-page":"9603","DOI":"10.1073\/pnas.1401191111","article-title":"Cytochrome P450-generated metabolites derived from omega-3 fatty acids attenuate neovascularization","volume":"111","author":"Yanai","year":"2014","journal-title":"Proc Natl Acad Sci USA"}],"container-title":["Ophthalmology Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2666914525002180?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2666914525002180?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T09:38:26Z","timestamp":1778924306000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2666914525002180"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":50,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2026,1]]}},"alternative-id":["S2666914525002180"],"URL":"https:\/\/doi.org\/10.1016\/j.xops.2025.100920","relation":{},"ISSN":["2666-9145"],"issn-type":[{"value":"2666-9145","type":"print"}],"subject":[],"published":{"date-parts":[[2026,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Age-related Eye Disease Studies Supplements and Genetic Risk Score Are Crucial Determinants of Intestinal Microbial Alterations in Advanced Age-Related Macular Degeneration","name":"articletitle","label":"Article Title"},{"value":"Ophthalmology Science","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.xops.2025.100920","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 by the American Academy of Ophthalmology.","name":"copyright","label":"Copyright"}],"article-number":"100920"}}