{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T02:19:52Z","timestamp":1793413192509,"version":"4.5.0"},"reference-count":29,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,11,26]],"date-time":"2025-11-26T00:00:00Z","timestamp":1764115200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000272","name":"National Institute for Health Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000272","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001349","name":"National Medical Research Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001349","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","ophthalmologyscience.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Ophthalmology Science"],"published-print":{"date-parts":[[2026,2]]},"DOI":"10.1016\/j.xops.2025.101027","type":"journal-article","created":{"date-parts":[[2025,12,4]],"date-time":"2025-12-04T00:46:40Z","timestamp":1764809200000},"page":"101027","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"title":["Standardization of Imaging Criteria for Detecting Macular Fibrosis in Neovascular Age-Related Macular Degeneration"],"prefix":"10.1016","volume":"6","author":[{"given":"Usha","family":"Chakravarthy","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lajos","family":"Csincsik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kelvin Y.C.","family":"Teo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marion R.","family":"Munk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dilraj S.","family":"Grewal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robyn H.","family":"Guymer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Glenn J.","family":"Jaffe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tunde","family":"Peto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"SriniVas R.","family":"Sadda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanni","family":"Staurenghi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3358-3516","authenticated-orcid":false,"given":"Chui M.G.","family":"Cheung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph","family":"Carroll","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emil Anthony T.","family":"Say","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Talisa E.","family":"de Carlo Forest","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ramtohul","family":"Prithvi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fung","family":"Adrian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Borrelli","family":"Enrico","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bhende","family":"Muna","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Querques","family":"Giuseppe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Theelen","family":"Thomas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rao","family":"Chetan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Agarwal","family":"Aniruddha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cicinelli","family":"Maria","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jesse J.","family":"Jung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan Carlos","family":"Guti\u00e9rrez Hern\u00e1ndez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen","family":"Fred","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iovino","family":"Claudio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arevalo J.","family":"Fernando","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gaudric","family":"Alain","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hartnett M.","family":"Elizabeth","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valckenberg","family":"Steffen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosenfeld","family":"Philip","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Boyer","family":"David","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheung","family":"Gemmy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Domalpally","family":"Amitha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mano","family":"Fukutaro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Khalid","family":"Hagar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Moussa","family":"Magdy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bacci","family":"Tommaso","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francisco J.","family":"Rodriguez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huemer","family":"Josef","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Souied","family":"Eric","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tsui","family":"Edmund","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank G.","family":"Holz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Byon","family":"Iksoo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ach","family":"Thomas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dysli","family":"Chantal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bousquet","family":"Elodie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Falavarjani","family":"Khalil","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Krivosic","family":"Val\u00e9rie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Colin S.","family":"Tan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sivaprasad","family":"Sobha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabiani","family":"Claudia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Crincoli","family":"Emanuele","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiosi","family":"Flavia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.xops.2025.101027_bib1","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1136\/bjo.87.5.609","article-title":"Identification of lesion components that influence visual function in age related macular degeneration","volume":"87","author":"Hogg","year":"2003","journal-title":"Br J Ophthalmol"},{"key":"10.1016\/j.xops.2025.101027_bib2","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1167\/tvst.10.13.5","article-title":"Three-year outcomes of neovascular age-related macular degeneration in eyes that do not develop macular atrophy or subretinal fibrosis","volume":"10","author":"Gabrielle","year":"2021","journal-title":"Transl Vis Sci Technol"},{"key":"10.1016\/j.xops.2025.101027_bib3","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.1016\/j.oret.2019.06.002","article-title":"The evolution of fibrosis and atrophy and their relationship with visual outcomes in Asian persons with neovascular age-related macular degeneration","volume":"3","author":"Cheung","year":"2019","journal-title":"Ophthalmol Retina"},{"key":"10.1016\/j.xops.2025.101027_bib4","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1016\/j.survophthal.2023.03.004","article-title":"Fibrosis in neovascular age-related macular degeneration: a review of definitions based on clinical imaging","volume":"68","author":"Bachmeier","year":"2023","journal-title":"Surv Ophthalmol"},{"key":"10.1016\/j.xops.2025.101027_bib5","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1016\/j.ajo.2022.09.008","article-title":"Review of fibrosis in neovascular age-related macular degeneration","volume":"246","author":"Cheong","year":"2023","journal-title":"Am J Ophthalmol"},{"key":"10.1016\/j.xops.2025.101027_bib6","doi-asserted-by":"crossref","first-page":"3243","DOI":"10.1038\/s41433-024-03308-6","article-title":"Fibrosis in age-related neovascular macular degeneration in the anti-VEGF era","volume":"38","author":"Armendariz","year":"2024","journal-title":"Eye (Lond)"},{"key":"10.1016\/j.xops.2025.101027_bib7","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1016\/j.ophtha.2018.08.035","article-title":"Macular morphology and visual acuity in year five of the comparison of age-related macular degeneration treatments trials","volume":"126","author":"Jaffe","year":"2019","journal-title":"Ophthalmology"},{"key":"10.1016\/j.xops.2025.101027_bib8","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.1016\/j.ophtha.2018.01.004","article-title":"Development and course of scars in the comparison of age-related macular degeneration treatments trials","volume":"125","author":"Daniel","year":"2018","journal-title":"Ophthalmology"},{"key":"10.1016\/j.xops.2025.101027_bib9","doi-asserted-by":"crossref","first-page":"664","DOI":"10.1016\/j.oret.2022.03.010","article-title":"Long-term retinal morphology and functional associations in treated neovascular age-related macular degeneration: findings from the inhibition of VEGF in age-related choroidal neovascularisation trial","volume":"6","author":"Peto","year":"2022","journal-title":"Ophthalmol Retina"},{"key":"10.1016\/j.xops.2025.101027_bib10","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.ajo.2023.12.011","article-title":"Features associated with vision in eyes with subfoveal fibrosis from neovascular age-related macular degeneration","volume":"261","author":"Teo","year":"2024","journal-title":"Am J Ophthalmol"},{"key":"10.1016\/j.xops.2025.101027_bib11","doi-asserted-by":"crossref","first-page":"2285","DOI":"10.1097\/IAE.0000000000002779","article-title":"Prevalence and risk factors for the development of physician-graded subretinal fibrosis in eyes treated for neovascular age-related macular degeneration","volume":"40","author":"Teo","year":"2020","journal-title":"Retina"},{"key":"10.1016\/j.xops.2025.101027_bib12","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1097\/IAE.0000000000003267","article-title":"The impact of disease activity on 5-year outcomes in patients undergoing treatment for neovascular age-related macular degeneration","volume":"42","author":"Chong Teo","year":"2022","journal-title":"Retina"},{"key":"10.1016\/j.xops.2025.101027_bib13","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1016\/j.ophtha.2013.10.019","article-title":"Risk of scar in the comparison of age-related macular degeneration treatments trials","volume":"121","author":"Daniel","year":"2014","journal-title":"Ophthalmology"},{"key":"10.1016\/j.xops.2025.101027_bib14","doi-asserted-by":"crossref","first-page":"752","DOI":"10.1016\/j.oret.2020.02.012","article-title":"Subretinal fibrosis in HARBOR varies by choroidal neovascularization subtype","volume":"4","author":"Adrean","year":"2020","journal-title":"Ophthalmol Retina"},{"key":"10.1016\/j.xops.2025.101027_bib15","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/j.ajo.2013.02.012","article-title":"Subfoveal fibrosis in eyes with neovascular age-related macular degeneration treated with intravitreal ranibizumab","volume":"156","author":"Bloch","year":"2013","journal-title":"Am J Ophthalmol"},{"key":"10.1016\/j.xops.2025.101027_bib16","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1016\/j.ajo.2023.03.033","article-title":"Ten-year incidence of fibrosis and risk factors for its development in neovascular age-related macular degeneration","volume":"252","author":"Romano","year":"2023","journal-title":"Am J Ophthalmol"},{"key":"10.1016\/j.xops.2025.101027_bib17","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1001\/jamaophthalmol.2020.3001","article-title":"Associations of variation in retinal thickness with visual acuity and anatomic outcomes in eyes with neovascular age-related macular degeneration lesions treated with anti-vascular endothelial growth factor agents","volume":"138","author":"Evans","year":"2020","journal-title":"JAMA Ophthalmol"},{"key":"10.1016\/j.xops.2025.101027_bib18","doi-asserted-by":"crossref","first-page":"852","DOI":"10.1136\/bjo-2023-323577","article-title":"Comparative assessment of subretinal hyper-reflective material in patients treated with brolucizumab versus aflibercept in HAWK and HARRIER","volume":"108","author":"Sadda","year":"2024","journal-title":"Br J Ophthalmol"},{"key":"10.1016\/j.xops.2025.101027_bib19","doi-asserted-by":"crossref","first-page":"1751","DOI":"10.1016\/j.ophtha.2016.03.045","article-title":"Five-year outcomes with anti-vascular endothelial growth factor treatment of neovascular age-related macular degeneration: the comparison of age-related macular degeneration treatments trials","volume":"123","author":"Maguire","year":"2016","journal-title":"Ophthalmology"},{"key":"10.1016\/j.xops.2025.101027_bib20","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1016\/j.oret.2017.08.019","article-title":"Tomographic biomarkers predicting progression to fibrosis in treated neovascular age-related macular degeneration: a multimodal imaging study","volume":"2","author":"Casalino","year":"2018","journal-title":"Ophthalmol Retina"},{"key":"10.1016\/j.xops.2025.101027_bib21","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1016\/j.ajo.2025.01.011","article-title":"Agreement between color, fluorescein angiography, and spectral domain optical coherence tomography in the detection of macular fibrosis in neovascular age-related macular degeneration","volume":"272","author":"Csincsik","year":"2025","journal-title":"Am J Ophthalmol"},{"key":"10.1016\/j.xops.2025.101027_bib22","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1016\/j.oret.2025.01.015","article-title":"Standardization of OCT angiography nomenclature in retinal vascular diseases: consensus-based recommendations","volume":"9","author":"Munk","year":"2025","journal-title":"Ophthalmol Retina"},{"key":"10.1016\/j.xops.2025.101027_bib23","doi-asserted-by":"crossref","DOI":"10.1097\/IAE.0000000000004502","article-title":"Large retinal capillary aneurysm: a delphi consensus study and updated nomenclature for a signature optical coherence tomography lesion","author":"Popovic","year":"2025","journal-title":"Retina"},{"key":"10.1016\/j.xops.2025.101027_bib24","doi-asserted-by":"crossref","first-page":"1736","DOI":"10.1016\/j.ophtha.2021.07.025","article-title":"Diagnostic accuracy of monitoring tests of fellow eyes in patients with unilateral neovascular age-related macular degeneration: early detection of neovascular age-related macular degeneration study","volume":"128","author":"Sivaprasad","year":"2021","journal-title":"Ophthalmology"},{"key":"10.1016\/j.xops.2025.101027_bib25","doi-asserted-by":"crossref","first-page":"1526","DOI":"10.1016\/S0161-6420(89)32707-2","article-title":"The use of fundus photographs and fluorescein angiograms in the identification and treatment of choroidal neovascularization in the Macular Photocoagulation Study. The Macular Photocoagulation Study Group","volume":"96","author":"Chamberlin","year":"1989","journal-title":"Ophthalmology"},{"key":"10.1016\/j.xops.2025.101027_bib26","doi-asserted-by":"crossref","first-page":"1324","DOI":"10.1097\/IAE.0000000000000877","article-title":"Correlation of visual acuity with fibrotic scar location in treated neovascular age-related macular degeneration eyes","volume":"36","author":"Ryu","year":"2016","journal-title":"Retina"},{"key":"10.1016\/j.xops.2025.101027_bib27","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/j.ajo.2020.02.016","article-title":"Spectral-domain optical coherence tomography analysis of fibrotic lesions in neovascular age-related macular degeneration","volume":"214","author":"Souied","year":"2020","journal-title":"Am J Ophthalmol"},{"key":"10.1016\/j.xops.2025.101027_bib28","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1159\/000446857","article-title":"Clinical application of multicolor imaging technology","volume":"236","author":"Tan","year":"2016","journal-title":"Ophthalmologica"},{"key":"10.1016\/j.xops.2025.101027_bib29","doi-asserted-by":"crossref","first-page":"1512","DOI":"10.1097\/IAE.0000000000002638","article-title":"Comparison of multicolor imaging and color fundus photography in the detection of pathological findings in eyes with polypoidal choroidal vasculopathy","volume":"40","author":"Tan","year":"2020","journal-title":"Retina"}],"container-title":["Ophthalmology Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2666914525003252?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2666914525003252?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,3,20]],"date-time":"2026-03-20T06:57:34Z","timestamp":1773989854000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2666914525003252"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2]]},"references-count":29,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026,2]]}},"alternative-id":["S2666914525003252"],"URL":"https:\/\/doi.org\/10.1016\/j.xops.2025.101027","relation":{},"ISSN":["2666-9145"],"issn-type":[{"value":"2666-9145","type":"print"}],"subject":[],"published":{"date-parts":[[2026,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Standardization of Imaging Criteria for Detecting Macular Fibrosis in Neovascular Age-Related Macular Degeneration","name":"articletitle","label":"Article Title"},{"value":"Ophthalmology Science","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.xops.2025.101027","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 by the American Academy of Ophthalmology.","name":"copyright","label":"Copyright"}],"article-number":"101027"}}