{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T09:04:53Z","timestamp":1784106293516,"version":"3.55.0"},"reference-count":23,"publisher":"Elsevier BV","issue":"7","license":[{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,4,21]],"date-time":"2026-04-21T00:00:00Z","timestamp":1776729600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000053","name":"National Eye Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000053","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100001818","name":"Research to Prevent Blindness","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001818","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007015","name":"University of Wisconsin-Madison","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007015","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","ophthalmologyscience.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Ophthalmology Science"],"published-print":{"date-parts":[[2026,7]]},"DOI":"10.1016\/j.xops.2026.101207","type":"journal-article","created":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T03:44:19Z","timestamp":1777607059000},"page":"101207","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Comparison of Clarus, Optos, and Heidelberg Systems for Geographic Atrophy Area Measurements"],"prefix":"10.1016","volume":"6","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-2223-6426","authenticated-orcid":false,"given":"Jacob","family":"Bogost","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-6773-1189","authenticated-orcid":false,"given":"Thomas","family":"Saunders","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer","family":"Heathcote","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8564-6537","authenticated-orcid":false,"given":"Jeong W.","family":"Pak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-8563-0104","authenticated-orcid":false,"given":"David","family":"Lopez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7601-6090","authenticated-orcid":false,"given":"Colin","family":"Froines","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara","family":"Blodi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roomasa","family":"Channa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0504-3053","authenticated-orcid":false,"given":"Kathleen","family":"Schildroth","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin","family":"Kurt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mihai","family":"Mititelu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4498-6495","authenticated-orcid":false,"given":"Kimberly","family":"Stepien","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5693-5065","authenticated-orcid":false,"given":"Jonathan S.","family":"Chang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1554-3211","authenticated-orcid":false,"given":"Michael","family":"Altaweel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5619-0446","authenticated-orcid":false,"given":"Justin","family":"Gottlieb","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karina","family":"Conlin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricia","family":"Sabb","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nayan","family":"Patel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8145-9619","authenticated-orcid":false,"given":"Amitha","family":"Domalpally","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.xops.2026.101207_bib1","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1001\/jama.2023.26074","article-title":"Age-Related macular degeneration: a review","volume":"331","author":"Fleckenstein","year":"2024","journal-title":"JAMA"},{"key":"10.1016\/j.xops.2026.101207_bib2","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/j.ophtha.2006.09.016","article-title":"The long-term natural history of geographic atrophy from age-related macular degeneration: enlargement of atrophy and implications for interventional clinical trials","volume":"114","author":"Sunness","year":"2007","journal-title":"Ophthalmology"},{"key":"10.1016\/j.xops.2026.101207_bib3","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1016\/j.ophtha.2017.08.038","article-title":"The progression of geographic atrophy secondary to age-related macular degeneration","volume":"125","author":"Fleckenstein","year":"2018","journal-title":"Ophthalmology"},{"key":"10.1016\/j.xops.2026.101207_bib4","doi-asserted-by":"crossref","first-page":"1806","DOI":"10.1097\/IAE.0000000000001283","article-title":"Clinical endpoints for the Study of geographic atrophy secondary to age-related macular degeneration","volume":"36","author":"Sadda","year":"2016","journal-title":"Retina"},{"key":"10.1016\/j.xops.2026.101207_bib5","doi-asserted-by":"crossref","first-page":"1434","DOI":"10.1016\/S0140-6736(23)01520-9","article-title":"Pegcetacoplan for the treatment of geographic atrophy secondary to age-related macular degeneration (OAKS and DERBY): two multicentre, randomised, double-masked, sham-controlled, phase 3 trials","volume":"402","author":"Heier","year":"2023","journal-title":"Lancet"},{"key":"10.1016\/j.xops.2026.101207_bib6","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1016\/j.ophtha.2020.08.027","article-title":"C5 inhibitor avacincaptad pegol for geographic atrophy due to age-related macular degeneration: a randomized pivotal phase 2\/3 trial","volume":"128","author":"Jaffe","year":"2021","journal-title":"Ophthalmology"},{"key":"10.1016\/j.xops.2026.101207_bib7","first-page":"1051","article-title":"Fundus autofluorescence and development of geographic atrophy in age-related macular degeneration","volume":"42","author":"Holz","year":"2001","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.xops.2026.101207_bib8","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1016\/j.ajo.2006.11.041","article-title":"Progression of geographic atrophy and impact of fundus autofluorescence patterns in age-related macular degeneration","volume":"143","author":"Holz","year":"2007","journal-title":"Am J Ophthalmol"},{"key":"10.1016\/j.xops.2026.101207_bib9","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1186\/s40942-016-0035-x","article-title":"Clinical applications of fundus autofluorescence in retinal disease","volume":"2","author":"Yung","year":"2016","journal-title":"Int J Retina Vitreous"},{"key":"10.1016\/j.xops.2026.101207_bib10","doi-asserted-by":"crossref","first-page":"9497","DOI":"10.1167\/iovs.11-8346","article-title":"Blue-light versus green-light autofluorescence: lesion size of areas of geographic atrophy","volume":"52","author":"Wolf-Schnurrbusch","year":"2011","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.xops.2026.101207_bib11","doi-asserted-by":"crossref","DOI":"10.1016\/j.xops.2023.100383","article-title":"Gradeability and reproducibility of geographic atrophy measurement in GATHER-1, a phase II\/III randomized interventional trial","volume":"4","author":"Li","year":"2024","journal-title":"Ophthalmol Sci"},{"key":"10.1016\/j.xops.2026.101207_bib12","doi-asserted-by":"crossref","first-page":"BIO121","DOI":"10.1167\/iovs.17-21764","article-title":"Green-Light autofluorescence versus combined blue-light autofluorescence and near-infrared reflectance imaging in geographic atrophy secondary to age-related macular degeneration","volume":"58","author":"Pfau","year":"2017","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.xops.2026.101207_bib13","doi-asserted-by":"crossref","first-page":"1688","DOI":"10.3390\/diagnostics15131688","article-title":"Blue light and green light fundus autofluorescence, complementary to optical coherence tomography, in age-related macular degeneration evaluation","volume":"15","author":"Ranetti","year":"2025","journal-title":"Diagnostics (Basel)"},{"key":"10.1016\/j.xops.2026.101207_bib14","doi-asserted-by":"crossref","first-page":"987","DOI":"10.1016\/j.oret.2024.04.017","article-title":"Comparison of blue-light autofluorescence and ultrawidefield green-light autofluorescence for assessing geographic atrophy","volume":"8","author":"Abbasgholizadeh","year":"2024","journal-title":"Ophthalmol Retina"},{"key":"10.1016\/j.xops.2026.101207_bib15","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1167\/tvst.13.11.1","article-title":"Comparison of geographic atrophy measurements between blue-light heidelberg standard field and green-light optos ultrawide field autofluorescence","volume":"13","author":"Froines","year":"2024","journal-title":"Transl Vis Sci Technol"},{"key":"10.1016\/j.xops.2026.101207_bib16","doi-asserted-by":"crossref","first-page":"590","DOI":"10.3928\/23258160-20190905-09","article-title":"Photopigment bleaching phenomenon with scanning laser ophthalmoscopy and fluorescein angiography","volume":"50","author":"Breazzano","year":"2019","journal-title":"Ophthalmic Surg Lasers Imaging Retina"},{"key":"10.1016\/j.xops.2026.101207_bib17","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1016\/j.ophtha.2016.12.002","article-title":"Imaging protocols in clinical studies in advanced age-related macular degeneration: recommendations from classification of atrophy consensus meetings","volume":"124","author":"Holz","year":"2017","journal-title":"Ophthalmology"},{"key":"10.1016\/j.xops.2026.101207_bib18","doi-asserted-by":"crossref","first-page":"7640","DOI":"10.1167\/iovs.11-7457","article-title":"Semiautomated image processing method for identification and quantification of geographic atrophy in age-related macular degeneration","volume":"52","author":"Schmitz-Valckenberg","year":"2011","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.xops.2026.101207_bib19","doi-asserted-by":"crossref","first-page":"1621","DOI":"10.1001\/archopht.121.11.1621","article-title":"Potential public health impact of Age-Related Eye Disease Study results: AREDS report no. 11","volume":"121","author":"Bressler","year":"2003","journal-title":"Arch Ophthalmol"},{"key":"10.1016\/j.xops.2026.101207_bib20","doi-asserted-by":"crossref","DOI":"10.1016\/j.xops.2025.100787","article-title":"Longitudinal comparison of geographic atrophy enlargement using manual, semiautomated, and deep learning approaches","volume":"5","author":"Bogost","year":"2025","journal-title":"Ophthalmol Sci"},{"key":"10.1016\/j.xops.2026.101207_bib21","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1167\/tvst.10.9.33","article-title":"Manual versus semi-automated measurement of geographic atrophy area in eyes with age-related macular degeneration","volume":"10","author":"Mahmoudzadeh","year":"2021","journal-title":"Transl Vis Sci Technol"},{"key":"10.1016\/j.xops.2026.101207_bib22","doi-asserted-by":"crossref","first-page":"389","DOI":"10.2147\/OPTH.S41731","article-title":"Comparison of ultra-widefield fluorescein angiography with the Heidelberg Spectralis((R)) noncontact ultra-widefield module versus the Optos((R)) Optomap((R))","volume":"7","author":"Witmer","year":"2013","journal-title":"Clin Ophthalmol"},{"key":"10.1016\/j.xops.2026.101207_bib23","doi-asserted-by":"crossref","first-page":"4076","DOI":"10.1167\/iovs.12-9471","article-title":"Spectral transmission of the human crystalline lens in adult and elderly persons: color and total transmission of visible light","volume":"53","author":"Artigas","year":"2012","journal-title":"Invest Ophthalmol Vis Sci"}],"container-title":["Ophthalmology Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2666914526001454?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2666914526001454?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T08:16:31Z","timestamp":1784103391000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2666914526001454"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7]]},"references-count":23,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2026,7]]}},"alternative-id":["S2666914526001454"],"URL":"https:\/\/doi.org\/10.1016\/j.xops.2026.101207","relation":{},"ISSN":["2666-9145"],"issn-type":[{"value":"2666-9145","type":"print"}],"subject":[],"published":{"date-parts":[[2026,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Comparison of Clarus, Optos, and Heidelberg Systems for Geographic Atrophy Area Measurements","name":"articletitle","label":"Article Title"},{"value":"Ophthalmology Science","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.xops.2026.101207","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 American Academy of Ophthalmology, Inc. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"101207"}}