{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T09:04:30Z","timestamp":1784106270119,"version":"3.55.0"},"reference-count":34,"publisher":"Elsevier BV","issue":"7","license":[{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T00:00:00Z","timestamp":1777939200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","ophthalmologyscience.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Ophthalmology Science"],"published-print":{"date-parts":[[2026,7]]},"DOI":"10.1016\/j.xops.2026.101228","type":"journal-article","created":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T14:01:18Z","timestamp":1778767278000},"page":"101228","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Epiretinal Membrane Is Associated with Acquired Vitelliform Lesion Morphometrics in Intermediate Age-Related Macular Degeneration"],"prefix":"10.1016","volume":"6","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0818-6124","authenticated-orcid":false,"given":"Alberto","family":"Quarta","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7394-000X","authenticated-orcid":false,"given":"Rouzbeh","family":"Abbasgholizadeh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianfeng","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shinichiro","family":"Chujo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6334-8387","authenticated-orcid":false,"given":"Ceren","family":"Soylu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sweetha Bindu","family":"Velaga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alireza","family":"Mahmoudi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sophiana","family":"Lindeberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0574-1660","authenticated-orcid":false,"given":"Mai","family":"Alhelaly","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muneeswar G.","family":"Nittala","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9213-5575","authenticated-orcid":false,"given":"Giulia","family":"Corradetti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1541-4735","authenticated-orcid":false,"given":"Rodolfo","family":"Mastropasqua","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7756-5091","authenticated-orcid":false,"given":"Charles","family":"Wykoff","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4939-3306","authenticated-orcid":false,"given":"Srinivas R.","family":"Sadda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.xops.2026.101228_bib1","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1167\/iovs.66.9.19","article-title":"In vivo characterization of Bruch's membrane breaks in neovascular age-related macular degeneration using high-resolution optical coherence tomography","volume":"66","author":"Alhelaly","year":"2025","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.xops.2026.101228_bib2","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1097\/IAE.0000000000004664","article-title":"Type 4 macular neovascularization (NV): a new member of the Optical Coherence Tomography (OCT) classification of NV Age-Related Macular Degeneration (AMD)","volume":"46","author":"Chan","year":"2025","journal-title":"Retina"},{"key":"10.1016\/j.xops.2026.101228_bib3","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.ajo.2022.02.006","article-title":"Histology and clinical lifecycle of acquired vitelliform lesion, a pathway to advanced age-related macular degeneration","volume":"240","author":"Brinkmann","year":"2022","journal-title":"Am J Ophthalmol"},{"key":"10.1016\/j.xops.2026.101228_bib4","doi-asserted-by":"crossref","first-page":"854","DOI":"10.1016\/j.oret.2024.04.009","article-title":"Acquired vitelliform lesions in intermediate age-related macular degeneration","volume":"8","author":"Lindenberg","year":"2024","journal-title":"Ophthalmol Retina"},{"key":"10.1016\/j.xops.2026.101228_bib5","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1016\/j.oret.2024.04.003","article-title":"Predictive factors influencing the evolution of acquired vitelliform lesions in intermediate age-related macular degeneration eyes","volume":"8","author":"Mahmoudi","year":"2024","journal-title":"Ophthalmol Retina"},{"key":"10.1016\/j.xops.2026.101228_bib6","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1016\/j.oret.2023.10.011","article-title":"Atrophic lesions associated with age-related macular degeneration","volume":"8","author":"Mahmoudi","year":"2024","journal-title":"Ophthalmol Retina"},{"key":"10.1016\/j.xops.2026.101228_bib7","doi-asserted-by":"crossref","first-page":"690","DOI":"10.1007\/s00417-004-0980-1","article-title":"Anomalous posterior vitreous detachment: a unifying concept in vitreo-retinal disease","volume":"242","author":"Sebag","year":"2004","journal-title":"Graefes Arch Clin Exp Ophthalmol"},{"key":"10.1016\/j.xops.2026.101228_bib8","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.ajo.2016.12.006","article-title":"Insights into epiretinal membranes: presence of ectopic inner foveal layers and a new optical coherence tomography staging scheme","volume":"175","author":"Govetto","year":"2017","journal-title":"Am J Ophthalmol"},{"key":"10.1016\/j.xops.2026.101228_bib9","doi-asserted-by":"crossref","first-page":"1117","DOI":"10.1097\/IAE.0000000000004429","article-title":"The role of gliosis in idiopathic epiretinal membranes: new insights","volume":"45","author":"Quarta","year":"2025","journal-title":"Retina"},{"key":"10.1016\/j.xops.2026.101228_bib10","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.ajo.2017.10.011","article-title":"Tractional abnormalities of the central foveal bouquet in epiretinal membranes: clinical spectrum and pathophysiological perspectives","volume":"184","author":"Govetto","year":"2017","journal-title":"Am J Ophthalmol"},{"key":"10.1016\/j.xops.2026.101228_bib11","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1007\/s10384-024-01127-6","article-title":"Epiretinal membrane: an overview and update","volume":"68","author":"Matoba","year":"2024","journal-title":"Jpn J Ophthalmol"},{"key":"10.1016\/j.xops.2026.101228_bib12","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1038\/s41433-025-04103-7","article-title":"Vitelliform lesions and choroidal changes in chorioretinal disorders: pathophysiological insights and clinical implications","volume":"40","author":"Feo","year":"2024","journal-title":"Eye"},{"key":"10.1016\/j.xops.2026.101228_bib13","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1186\/s12886-021-01944-0","article-title":"Epiretinal membrane appearance or progression after intravitreal injection in age-related macular degeneration","volume":"21","author":"Taniguchi","year":"2021","journal-title":"BMC Ophthalmol"},{"key":"10.1016\/j.xops.2026.101228_bib14","doi-asserted-by":"crossref","first-page":"1540","DOI":"10.1097\/IAE.0000000000000531","article-title":"Epiretinal membranes in neovascular age-related macular degeneration: effect on outcomes of anti-vascular endothelial growth factor therapy","volume":"35","author":"Karaca","year":"2015","journal-title":"Retina"},{"key":"10.1016\/j.xops.2026.101228_bib15","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1080\/08820538.2017.1395892","article-title":"The impact of epiretinal membrane in neovascular age-related macular degeneration treatment: a spectral-domain optical coherence tomography study","volume":"33","author":"Chatziralli","year":"2018","journal-title":"Semin Ophthalmol"},{"key":"10.1016\/j.xops.2026.101228_bib16","doi-asserted-by":"crossref","first-page":"844","DOI":"10.1016\/j.ophtha.2012.10.036","article-title":"Clinical classification of age-related macular degeneration","volume":"120","author":"Ferris","year":"2013","journal-title":"Ophthalmology"},{"key":"10.1016\/j.xops.2026.101228_bib17","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1016\/j.ophtha.2019.11.004","article-title":"Consensus nomenclature for reporting neovascular age-related macular degeneration data","volume":"127","author":"Spaide","year":"2020","journal-title":"Ophthalmology"},{"key":"10.1016\/j.xops.2026.101228_bib18","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1016\/j.ophtha.2017.09.028","article-title":"Consensus definition for atrophy associated with age-related macular degeneration on OCT","volume":"125","author":"Sadda","year":"2018","journal-title":"Ophthalmology"},{"key":"10.1016\/j.xops.2026.101228_bib19","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1016\/j.oret.2020.12.009","article-title":"Imaging features associated with progression to geographic atrophy in age-related macular degeneration","volume":"5","author":"Jaffe","year":"2021","journal-title":"Ophthalmol Retina"},{"key":"10.1016\/j.xops.2026.101228_bib20","doi-asserted-by":"crossref","DOI":"10.1016\/j.exer.2025.110415","article-title":"Quantitative comparison of inner and outer retinal intraretinal hyperreflective foci in age-related macular degeneration","volume":"256","author":"Ashrafkhorasani","year":"2025","journal-title":"Exp Eye Res"},{"key":"10.1016\/j.xops.2026.101228_bib21","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1097\/IAE.0000000000002657","article-title":"Subretinal drusenoid deposit in age-related macular degeneration: histologic insights into initiation, progression to atrophy, and imaging","volume":"40","author":"Chen","year":"2020","journal-title":"Retina"},{"key":"10.1016\/j.xops.2026.101228_bib22","doi-asserted-by":"crossref","first-page":"1382","DOI":"10.3390\/biomedicines11051382","article-title":"Advanced ImageJ analysis in degenerative acquired vitelliform lesions using techniques based on optical coherence tomography","volume":"11","author":"Damian","year":"2023","journal-title":"Biomedicines"},{"key":"10.1016\/j.xops.2026.101228_bib23","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1177\/11206721241282429","article-title":"Impact of vitreomacular interface on intravitreal Brolucizumab efficacy in age-related macular neovascularization","volume":"35","author":"Ruggeri","year":"2025","journal-title":"Eur J Ophthalmol"},{"key":"10.1016\/j.xops.2026.101228_bib24","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1016\/j.ajo.2007.07.024","article-title":"Posterior vitreomacular adhesion: a potential risk factor for exudative age-related macular degeneration?","volume":"144","author":"Krebs","year":"2007","journal-title":"Am J Ophthalmol"},{"key":"10.1016\/j.xops.2026.101228_bib25","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.ajo.2009.01.014","article-title":"Vitreomacular adhesion in active and end-stage age-related macular degeneration","volume":"148","author":"Robison","year":"2009","journal-title":"Am J Ophthalmol"},{"key":"10.1016\/j.xops.2026.101228_bib26","doi-asserted-by":"crossref","first-page":"1734","DOI":"10.1016\/j.ophtha.2014.03.036","article-title":"Vitreoretinal interface changes in geographic atrophy","volume":"121","author":"Abdillahi","year":"2014","journal-title":"Ophthalmology"},{"key":"10.1016\/j.xops.2026.101228_bib27","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1097\/IAE.0000000000004672","article-title":"Hyperreflective retinal spots in epiretinal membranes: evolving significance across disease stages","volume":"46","author":"Quarta","year":"2025","journal-title":"Retina"},{"key":"10.1016\/j.xops.2026.101228_bib28","doi-asserted-by":"crossref","first-page":"2327","DOI":"10.1097\/IAE.0000000000001875","article-title":"Correlation between inner-retinal changes and outer-retinal damage in patients with idiopathic epiretinal membrane","volume":"38","author":"Cho","year":"2017","journal-title":"Retina"},{"key":"10.1016\/j.xops.2026.101228_bib29","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/j.ajo.2015.03.027","article-title":"Preoperative prognostic factors and predictive score in patients operated on for combined cataract and idiopathic epiretinal membrane","volume":"160","author":"Kauffmann","year":"2015","journal-title":"Am J Ophthalmol"},{"key":"10.1016\/j.xops.2026.101228_bib30","doi-asserted-by":"crossref","first-page":"2139","DOI":"10.1007\/s00417-021-05110-6","article-title":"Prognostic factors of idiopathic epiretinal membrane surgery and evolution of alterations of the central cone bouquet","volume":"259","author":"Ortoli","year":"2021","journal-title":"Graefes Arch Clin Exp Ophthalmol"},{"key":"10.1016\/j.xops.2026.101228_bib31","doi-asserted-by":"crossref","first-page":"2353","DOI":"10.2147\/OPTH.S254544","article-title":"The central subfoveal bouquet in idiopathic epiretinal membranes","volume":"14","author":"Damasceno","year":"2020","journal-title":"Clin Ophthalmol"},{"key":"10.1016\/j.xops.2026.101228_bib32","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1136\/bjo-2024-327109","article-title":"Stage-specific dynamics of macular pigment optical density as a prognostic biomarker in epiretinal membrane surgery","volume":"109","author":"Quarta","year":"2025","journal-title":"Br J Ophthalmol"},{"key":"10.1016\/j.xops.2026.101228_bib33","doi-asserted-by":"crossref","first-page":"1218","DOI":"10.1016\/j.oret.2018.06.009","article-title":"Epiretinal membrane surgery outcomes in eyes with subretinal drusenoid deposits","volume":"2","author":"Wilde","year":"2018","journal-title":"Ophthalmol Retina"},{"key":"10.1016\/j.xops.2026.101228_bib34","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1016\/j.oret.2018.01.004","article-title":"Outcomes of Pars Plana vitrectomy for epiretinal membrane in eyes with coexisting dry age-related macular degeneration","volume":"2","author":"Obeid","year":"2018","journal-title":"Ophthalmol Retina"}],"container-title":["Ophthalmology Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2666914526001661?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2666914526001661?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T08:14:31Z","timestamp":1784103271000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2666914526001661"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7]]},"references-count":34,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2026,7]]}},"alternative-id":["S2666914526001661"],"URL":"https:\/\/doi.org\/10.1016\/j.xops.2026.101228","relation":{},"ISSN":["2666-9145"],"issn-type":[{"value":"2666-9145","type":"print"}],"subject":[],"published":{"date-parts":[[2026,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Epiretinal Membrane Is Associated with Acquired Vitelliform Lesion Morphometrics in Intermediate Age-Related Macular Degeneration","name":"articletitle","label":"Article Title"},{"value":"Ophthalmology Science","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.xops.2026.101228","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 American Academy of Ophthalmology, Inc. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"101228"}}