{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T09:05:03Z","timestamp":1784106303075,"version":"3.55.0"},"reference-count":38,"publisher":"Elsevier BV","issue":"7","license":[{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T00:00:00Z","timestamp":1778198400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100017950","name":"Shanghai Municipal Health Commission","doi-asserted-by":"publisher","award":["2025ZZ2068"],"award-info":[{"award-number":["2025ZZ2068"]}],"id":[{"id":"10.13039\/100017950","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100017950","name":"Shanghai Municipal Health Commission","doi-asserted-by":"publisher","award":["BCFKH-YK-20221123-05"],"award-info":[{"award-number":["BCFKH-YK-20221123-05"]}],"id":[{"id":"10.13039\/100017950","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","ophthalmologyscience.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Ophthalmology Science"],"published-print":{"date-parts":[[2026,7]]},"DOI":"10.1016\/j.xops.2026.101236","type":"journal-article","created":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T09:16:47Z","timestamp":1778836607000},"page":"101236","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Quantitative Analysis of Choroidal Thickness and Blood Flow in Thyroid-Associated Ophthalmopathy Using Ultra-Widefield Swept-Source OCT Angiography"],"prefix":"10.1016","volume":"6","author":[{"given":"Guodong","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kunhua","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingyang","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tianyu","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.xops.2026.101236_bib1","doi-asserted-by":"crossref","DOI":"10.1016\/j.beem.2022.101620","article-title":"Pathophysiology of thyroid-associated orbitopathy","volume":"37","author":"Lee","year":"2023","journal-title":"Best Pract Res Clin Endocrinol Metab"},{"key":"10.1016\/j.xops.2026.101236_bib2","doi-asserted-by":"crossref","first-page":"726","DOI":"10.1056\/NEJMra0905750","article-title":"Graves' ophthalmopathy","volume":"362","author":"Bahn","year":"2010","journal-title":"N Engl J Med"},{"key":"10.1016\/j.xops.2026.101236_bib3","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1016\/j.survophthal.2023.01.003","article-title":"Orbital and ocular perfusion in thyroid eye disease","volume":"68","author":"Goel","year":"2023","journal-title":"Surv Ophthalmol"},{"key":"10.1016\/j.xops.2026.101236_bib4","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1186\/s12886-024-03569-5","article-title":"Optical coherence tomography angiography in thyroid associated ophthalmopathy: a systematic review","volume":"24","author":"Rajabi","year":"2024","journal-title":"BMC Ophthalmol"},{"key":"10.1016\/j.xops.2026.101236_bib5","doi-asserted-by":"crossref","first-page":"1555","DOI":"10.1007\/s00417-009-1144-0","article-title":"Intraocular pressure and superior ophthalmic vein blood flow velocity in Graves' orbitopathy: relation with the clinical features","volume":"247","author":"Konuk","year":"2009","journal-title":"Graefes Arch Clin Exp Ophthalmol"},{"key":"10.1016\/j.xops.2026.101236_bib6","doi-asserted-by":"crossref","first-page":"5612","DOI":"10.1167\/iovs.10-6907","article-title":"Retrobulbar ocular blood flow changes after orbital decompression in Graves' ophthalmopathy measured by color Doppler imaging","volume":"52","author":"Perez-Lopez","year":"2011","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.xops.2026.101236_bib7","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1186\/s40662-020-00180-9","article-title":"Reduced macular inner retinal thickness and microvascular density in the early stage of patients with dysthyroid optic neuropathy","volume":"7","author":"Wu","year":"2020","journal-title":"Eye Vis (Lond)"},{"key":"10.1016\/j.xops.2026.101236_bib8","doi-asserted-by":"crossref","first-page":"1159","DOI":"10.1007\/s40123-024-00912-3","article-title":"Effect of intraorbital mechanical compression on retinal microvascular perfusion in quiescent thyroid-associated ophthalmopathy based on ocular biomechanics measured by Corvis ST","volume":"13","author":"Fang","year":"2024","journal-title":"Ophthalmol Ther"},{"key":"10.1016\/j.xops.2026.101236_bib9","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.1109\/TMI.2022.3222638","article-title":"Ultra-widefield OCT angiography","volume":"42","author":"Niederleithner","year":"2023","journal-title":"IEEE Trans Med Imaging"},{"key":"10.1016\/j.xops.2026.101236_bib10","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1038\/s41598-024-82745-5","article-title":"Quantitative analysis of choroidal vascular structures and anatomical changes in pachychoroid spectrum diseases using ultra-widefield SS-OCTA","volume":"15","author":"Xiao","year":"2025","journal-title":"Sci Rep"},{"key":"10.1016\/j.xops.2026.101236_bib11","article-title":"Ultra-widefield color fundus photography combined with high-speed ultra-widefield swept-source optical coherence tomography angiography for noninvasive detection of lesions in diabetic retinopathy","volume":"10","author":"Li","year":"2022","journal-title":"Front Public Health"},{"key":"10.1016\/j.xops.2026.101236_bib12","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1167\/iovs.65.2.6","article-title":"Central and peripheral changes in retinal vein occlusion and fellow eyes in ultra-widefield optical coherence tomography angiography","volume":"65","author":"Zhao","year":"2024","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.xops.2026.101236_bib13","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-022-23389-1","article-title":"Quantitative analysis of choroidal vasculature in central serous chorioretinopathy using ultra-widefield swept-source optical coherence tomography angiography","volume":"12","author":"Zeng","year":"2022","journal-title":"Sci Rep"},{"key":"10.1016\/j.xops.2026.101236_bib14","doi-asserted-by":"crossref","first-page":"G43","DOI":"10.1530\/EJE-21-0479","article-title":"The 2021 European Group on Graves' orbitopathy (EUGOGO) clinical practice guidelines for the medical management of Graves' orbitopathy","volume":"185","author":"Bartalena","year":"2021","journal-title":"Eur J Endocrinol"},{"key":"10.1016\/j.xops.2026.101236_bib15","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1016\/j.preteyeres.2009.12.002","article-title":"The multifunctional choroid","volume":"29","author":"Nickla","year":"2010","journal-title":"Prog Retin Eye Res"},{"key":"10.1016\/j.xops.2026.101236_bib16","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1016\/j.clinimag.2022.06.019","article-title":"Imaging of superior ophthalmic vein: a pictorial overview","volume":"89","author":"Romano","year":"2022","journal-title":"Clin Imaging"},{"key":"10.1016\/j.xops.2026.101236_bib17","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1111\/cxo.12472","article-title":"Thyroid eye disease: a review","volume":"100","author":"Weiler","year":"2017","journal-title":"Clin Exp Optom"},{"key":"10.1016\/j.xops.2026.101236_bib18","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1002\/jcu.20154","article-title":"Graves' ophthalmopathy: comparison of the Doppler sonography parameters with the clinical activity score","volume":"33","author":"Yanik","year":"2005","journal-title":"J Clin Ultrasound"},{"key":"10.1016\/j.xops.2026.101236_bib19","doi-asserted-by":"crossref","first-page":"658","DOI":"10.4158\/EP-2017-0229","article-title":"Retinal microvasculature alteration in active thyroid-associated ophthalmopathy","volume":"24","author":"Ye","year":"2018","journal-title":"Endocr Pract"},{"key":"10.1016\/j.xops.2026.101236_bib20","doi-asserted-by":"crossref","first-page":"2533","DOI":"10.1007\/s00417-019-04442-8","article-title":"Early macular and peripapillary vasculature dropout in active thyroid eye disease","volume":"257","author":"Jamshidian Tehrani","year":"2019","journal-title":"Graefes Arch Clin Exp Ophthalmol"},{"key":"10.1016\/j.xops.2026.101236_bib21","first-page":"609","article-title":"Relationship of thyroid states and serum thrombomodulin (TM) levels in patients with Graves' disease: TM, a possible new marker of the peripheral activity of thyroid hormones","volume":"76","author":"Morikawa","year":"1993","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.xops.2026.101236_bib22","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1016\/S0022-3565(24)38899-8","article-title":"Vascular contraction and relaxation to thrombin and trypsin: thrombomodulin preferentially attenuates thrombin-induced contraction","volume":"295","author":"Bhattacharya","year":"2000","journal-title":"J Pharmacol Exp Ther"},{"key":"10.1016\/j.xops.2026.101236_bib23","doi-asserted-by":"crossref","first-page":"1042","DOI":"10.1136\/bjo.80.12.1042","article-title":"Retrobulbar pressures measured during surgical decompression of the orbit","volume":"80","author":"Otto","year":"1996","journal-title":"Br J Ophthalmol"},{"key":"10.1016\/j.xops.2026.101236_bib24","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1080\/02713683.2019.1675177","article-title":"Reduced retinal microvascular density related to activity status and serum antibodies in patients with Graves' ophthalmopathy","volume":"45","author":"Wu","year":"2020","journal-title":"Curr Eye Res"},{"key":"10.1016\/j.xops.2026.101236_bib25","doi-asserted-by":"crossref","first-page":"1135","DOI":"10.18240\/ijo.2022.07.14","article-title":"Reduced choroidal peripapillary capillaries in thyroid-associated ophthalmopathy with early stage of dysthyroid optic neuropathy","volume":"15","author":"Wu","year":"2022","journal-title":"Int J Ophthalmol"},{"key":"10.1016\/j.xops.2026.101236_bib26","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1016\/S0021-5155(02)00485-9","article-title":"Colour Doppler imaging of superior ophthalmic vein in thyroid-associated eye disease","volume":"46","author":"Somer","year":"2002","journal-title":"Jpn J Ophthalmol"},{"key":"10.1016\/j.xops.2026.101236_bib27","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.1136\/bjo.84.9.1027","article-title":"Colour Doppler imaging of the orbital vasculature in Graves' disease with computed tomographic correlation","volume":"84","author":"Alp","year":"2000","journal-title":"Br J Ophthalmol"},{"key":"10.1016\/j.xops.2026.101236_bib28","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1097\/IOP.0b013e3182831bd8","article-title":"Superior ophthalmic vein enlargement and increased muscle index in dysthyroid optic neuropathy","volume":"29","author":"Lima Bda","year":"2013","journal-title":"Ophthal Plast Reconstr Surg"},{"key":"10.1016\/j.xops.2026.101236_bib29","first-page":"80","article-title":"Color Doppler imaging of orbital venous flow in dysthyroid optic neuropathy","volume":"38","author":"Nakase","year":"1994","journal-title":"Jpn J Ophthalmol"},{"key":"10.1016\/j.xops.2026.101236_bib30","doi-asserted-by":"crossref","first-page":"666","DOI":"10.3109\/02713683.2013.867355","article-title":"Intraocular pressure lowering effect of orbital decompression is related to increased venous outflow in Graves orbitopathy","volume":"39","author":"Onaran","year":"2014","journal-title":"Curr Eye Res"},{"key":"10.1016\/j.xops.2026.101236_bib31","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1038\/eye.2016.93","article-title":"Choroidal changes observed with enhanced depth imaging optical coherence tomography in patients with mild Graves orbitopathy","volume":"30","author":"Ozkan","year":"2016","journal-title":"Eye (Lond)"},{"key":"10.1016\/j.xops.2026.101236_bib32","doi-asserted-by":"crossref","DOI":"10.1155\/2018\/3529395","article-title":"Analysis in choroidal thickness in patients with Graves' ophthalmopathy using spectral-domain optical coherence tomography","volume":"2018","author":"Yu","year":"2018","journal-title":"J Ophthalmol"},{"key":"10.1016\/j.xops.2026.101236_bib33","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1080\/02713683.2016.1198488","article-title":"Choroidal thickness in patients with Graves' ophthalmopathy","volume":"42","author":"Caliskan","year":"2017","journal-title":"Curr Eye Res"},{"key":"10.1016\/j.xops.2026.101236_bib34","doi-asserted-by":"crossref","first-page":"1081","DOI":"10.1136\/bjo-2023-323694","article-title":"Choroidal thickness in patients with thyroid-associated ophthalmopathy, as determined by swept-source optical coherence tomography","volume":"108","author":"Zhong","year":"2024","journal-title":"Br J Ophthalmol"},{"key":"10.1016\/j.xops.2026.101236_bib35","doi-asserted-by":"crossref","first-page":"3419","DOI":"10.1007\/s00417-022-05727-1","article-title":"Extraocular muscle enlargement","volume":"260","author":"Rana","year":"2022","journal-title":"Graefes Arch Clin Exp Ophthalmol"},{"key":"10.1016\/j.xops.2026.101236_bib36","doi-asserted-by":"crossref","first-page":"1103","DOI":"10.1007\/s00417-020-04616-9","article-title":"Evaluation of choroidal thickness and choroidal vascular blood flow in patients with thyroid-associated orbitopathy (TAO) using SD-OCT and Angio-OCT","volume":"258","author":"Del Noce","year":"2020","journal-title":"Graefes Arch Clin Exp Ophthalmol"},{"key":"10.1016\/j.xops.2026.101236_bib37","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1186\/s40662-021-00242-6","article-title":"Choroidal vascularity index in thyroid-associated ophthalmopathy: a cross-sectional study","volume":"8","author":"Loiudice","year":"2021","journal-title":"Eye Vis (Lond)"},{"key":"10.1016\/j.xops.2026.101236_bib38","doi-asserted-by":"crossref","first-page":"124","DOI":"10.5935\/0004-2749.20190019","article-title":"Comparison of choroidal thickness in patients with active and stable thyroid eye disease","volume":"82","author":"Gul","year":"2019","journal-title":"Arq Bras Oftalmol"}],"container-title":["Ophthalmology Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2666914526001740?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2666914526001740?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T08:14:43Z","timestamp":1784103283000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2666914526001740"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7]]},"references-count":38,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2026,7]]}},"alternative-id":["S2666914526001740"],"URL":"https:\/\/doi.org\/10.1016\/j.xops.2026.101236","relation":{},"ISSN":["2666-9145"],"issn-type":[{"value":"2666-9145","type":"print"}],"subject":[],"published":{"date-parts":[[2026,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Quantitative Analysis of Choroidal Thickness and Blood Flow in Thyroid-Associated Ophthalmopathy Using Ultra-Widefield Swept-Source OCT Angiography","name":"articletitle","label":"Article Title"},{"value":"Ophthalmology Science","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.xops.2026.101236","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 American Academy of Ophthalmology, Inc. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"101236"}}