{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T10:43:27Z","timestamp":1789469007869,"version":"build-2803163510"},"reference-count":58,"publisher":"Elsevier BV","issue":"9","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T00:00:00Z","timestamp":1782345600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","ophthalmologyscience.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Ophthalmology Science"],"published-print":{"date-parts":[[2026,9]]},"DOI":"10.1016\/j.xops.2026.101308","type":"journal-article","created":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T20:52:28Z","timestamp":1782852748000},"page":"101308","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Vision-Related Patient-Reported Outcomes in Randomized Controlled Trials of Age-Related Macular Degeneration: A Systematic Review"],"prefix":"10.1016","volume":"6","author":[{"given":"Nicolas S.","family":"Bodmer","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melisa","family":"Guezelguen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leyla","family":"Huber","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeremy","family":"Howell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4159-3960","authenticated-orcid":false,"given":"Livia","family":"Faes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9868-154X","authenticated-orcid":false,"given":"Lucas M.","family":"Bachmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dun Jack","family":"Fu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kimberly","family":"Spooner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sobha","family":"Sivaprasad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin K.","family":"Schmid","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.xops.2026.101308_bib1","doi-asserted-by":"crossref","first-page":"e1175","DOI":"10.1016\/S2214-109X(25)00143-3","article-title":"Global burden of vision impairment due to age-related macular degeneration, 1990-2021, with forecasts to 2050: a systematic analysis for the Global Burden of Disease Study 2021","volume":"13","year":"2025","journal-title":"Lancet Glob Health"},{"key":"10.1016\/j.xops.2026.101308_bib2","first-page":"101","article-title":"The spectrum of functional, structural, and patient-reported outcomes in intermediate age-related macular degeneration: a MACUSTAR study report","volume":"248","author":"Terheyden","year":"2025","journal-title":"Ophthalmologica"},{"key":"10.1016\/j.xops.2026.101308_bib3","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1016\/j.oret.2022.12.007","article-title":"Characteristics and spatial distribution of structural features in age-related macular degeneration: a MACUSTAR study report","volume":"7","author":"Sa\u00dfmannshausen","year":"2023","journal-title":"Ophthalmol Retina"},{"key":"10.1016\/j.xops.2026.101308_bib4","doi-asserted-by":"crossref","first-page":"8724","DOI":"10.1038\/s41598-024-54619-3","article-title":"Defining the structure-function relationship of specific lesions in early and advanced age-related macular degeneration","volume":"14","author":"Tan","year":"2024","journal-title":"Sci Rep"},{"key":"10.1016\/j.xops.2026.101308_bib5","first-page":"1063","article-title":"Impact of incident age-related macular degeneration and associated vision loss on vision-related quality of life","volume":"106","author":"Man","year":"2022","journal-title":"Br J Ophthalmol"},{"key":"10.1016\/j.xops.2026.101308_bib6","doi-asserted-by":"crossref","first-page":"750","DOI":"10.1111\/aos.14731","article-title":"The impact of advanced age-related macular degeneration on the National Eye Institute's Visual Function Questionnaire-25","volume":"99","author":"Patnaik","year":"2021","journal-title":"Acta Ophthalmol"},{"key":"10.1016\/j.xops.2026.101308_bib7","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1038\/eye.2014.41","article-title":"An introduction to patient-reported outcome measures in ophthalmic research","volume":"28","author":"Denniston","year":"2014","journal-title":"Eye"},{"issue":"1","key":"10.1016\/j.xops.2026.101308_bib10","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1177\/2168479014549858","article-title":"The Patient-Reported Outcome (PRO) consortium: lessons learned along the path to PRO instrument qualification: lessons learned along the path to PRO instrument qualification","volume":"49","author":"Hayes","year":"2015","journal-title":"Ther Innov Regul Sci"},{"key":"10.1016\/j.xops.2026.101308_bib11","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ajo.2016.04.012","article-title":"Defining a minimum set of standardized patient-centered outcome measures for macular degeneration","volume":"168","author":"Rodrigues","year":"2016","journal-title":"Am J Ophthalmol"},{"issue":"2","key":"10.1016\/j.xops.2026.101308_bib12","doi-asserted-by":"crossref","first-page":"712","DOI":"10.1167\/iovs.09-3766","article-title":"Reliability and validity of the National Eye Institute Visual Function Questionnaire-25 in patients with age-related macular degeneration","volume":"51","author":"Revicki","year":"2010","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.xops.2026.101308_bib13","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1016\/j.ophtha.2009.09.002","article-title":"Vision-related function after ranibizumab treatment by better- or worse-seeing eye: clinical trial results from MARINA and ANCHOR","volume":"117","author":"Bressler","year":"2010","journal-title":"Ophthalmology"},{"key":"10.1016\/j.xops.2026.101308_bib14","doi-asserted-by":"crossref","first-page":"1560","DOI":"10.1136\/bjophthalmol-2014-306544","article-title":"Patient-reported outcomes in randomised controlled trials on age-related macular degeneration","volume":"99","author":"Krezel","year":"2015","journal-title":"Br J Ophthalmol"},{"key":"10.1016\/j.xops.2026.101308_bib15","article-title":"The PRISMA 2020 statement: an updated guideline for reporting systematic reviews","volume":"372","author":"Page","year":"2021","journal-title":"BMJ"},{"key":"10.1016\/j.xops.2026.101308_bib17","article-title":"RoB 2: a revised tool for assessing risk of bias in randomised trials","volume":"366","author":"Sterne","year":"2019","journal-title":"BMJ"},{"issue":"12","key":"10.1016\/j.xops.2026.101308_bib18","doi-asserted-by":"crossref","first-page":"5347","DOI":"10.1167\/iovs.16-21192","article-title":"The impact of supplemental antioxidants on visual function in nonadvanced age-related macular degeneration: a head-to-head randomized clinical trial","volume":"58","author":"Akuffo","year":"2017","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.xops.2026.101308_bib19","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1097\/IAE.0000000000003980","volume":"44","author":"Boyer","year":"2024","journal-title":"Retina"},{"key":"10.1016\/j.xops.2026.101308_bib20","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1001\/archophthalmol.2008.562","volume":"127","author":"Bressler","year":"2009","journal-title":"Arch Ophthalmol"},{"issue":"10","key":"10.1016\/j.xops.2026.101308_bib21","doi-asserted-by":"crossref","first-page":"1893","DOI":"10.1016\/S0161-6420(01)00754-0","article-title":"Depression, visual acuity, comorbidity, and disability associated with age-related macular degeneration","volume":"108","author":"Brody","year":"2001","journal-title":"Ophthalmology"},{"key":"10.1016\/j.xops.2026.101308_bib22","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1001\/archopht.123.1.46","article-title":"Self-management of age-related macular degeneration at the 6-month follow-up: a randomized controlled trial: a randomized controlled trial","volume":"123","author":"Brody","year":"2005","journal-title":"Arch Ophthalmol"},{"key":"10.1016\/j.xops.2026.101308_bib23","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1159\/000345492","article-title":"Monitoring of drusen and geographic atrophy area size after cataract surgery using the MD3RI tool for computer-aided contour drawing","volume":"229","author":"Brunner","year":"2013","journal-title":"Ophthalmologica"},{"key":"10.1016\/j.xops.2026.101308_bib24","doi-asserted-by":"crossref","first-page":"1460","DOI":"10.1001\/archopht.125.11.1460","article-title":"Improved vision-related function after ranibizumab treatment of neovascular age-related macular degeneration: results of a randomized clinical trial: results of a randomized clinical trial","volume":"125","author":"Chang","year":"2007","journal-title":"Arch Ophthalmol"},{"key":"10.1016\/j.xops.2026.101308_bib25","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.ajo.2004.02.011","article-title":"Health- and vision-related quality of life among patients with choroidal neovascularization secondary to age-related macular degeneration at enrollment in randomized trials of submacular surgery: SST report no. 4","volume":"138","author":"Dong","year":"2004","journal-title":"Am J Ophthalmol"},{"key":"10.1016\/j.xops.2026.101308_bib26","doi-asserted-by":"crossref","first-page":"947","DOI":"10.1016\/j.ophtha.2023.04.014","article-title":"Surgery, tissue plasminogen activator, antiangiogenic agents, and age-related macular degeneration study: a randomized controlled trial for submacular hemorrhage secondary to age-related macular degeneration","volume":"130","author":"Gabrielle","year":"2023","journal-title":"Ophthalmology"},{"key":"10.1016\/j.xops.2026.101308_bib27","doi-asserted-by":"crossref","first-page":"2537","DOI":"10.1016\/j.ophtha.2012.09.006","article-title":"Intravitreal aflibercept (VEGF trap-eye) in wet age-related macular degeneration","volume":"119","author":"Heier","year":"2012","journal-title":"Ophthalmology"},{"key":"10.1016\/j.xops.2026.101308_bib28","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1016\/j.oret.2020.01.019","article-title":"Visual function decline resulting from geographic atrophy: results from the chroma and Spectri phase 3 trials","volume":"4","author":"Heier","year":"2020","journal-title":"Ophthalmol Retina"},{"key":"10.1016\/j.xops.2026.101308_bib29","article-title":"Effect of supplemental lutein and zeaxanthin on serum, macular pigmentation, and visual performance in patients with early age-related macular degeneration","volume":"2015","author":"Huang","year":"2015","journal-title":"Biomed Res Int"},{"key":"10.1016\/j.xops.2026.101308_bib30","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/S0140-6736(24)00687-1","article-title":"Stereotactic radiotherapy for neovascular age-related macular degeneration (STAR): a pivotal, randomised, double-masked, sham-controlled device trial","volume":"404","author":"Jackson","year":"2024","journal-title":"Lancet"},{"key":"10.1016\/j.xops.2026.101308_bib31","doi-asserted-by":"crossref","first-page":"1499","DOI":"10.1007\/s00417-019-04328-9","article-title":"Effects of home reading training on reading and quality of life in AMD-a randomized and controlled study","volume":"257","author":"Kaltenegger","year":"2019","journal-title":"Graefes Arch Clin Exp Ophthalmol"},{"key":"10.1016\/j.xops.2026.101308_bib32","doi-asserted-by":"crossref","first-page":"1331","DOI":"10.1016\/j.ophtha.2020.03.035","article-title":"Efficacy and safety of abicipar in neovascular age-related macular degeneration: 52-week results of phase 3 randomized controlled study","volume":"127","author":"Kunimoto","year":"2020","journal-title":"Ophthalmology"},{"key":"10.1016\/j.xops.2026.101308_bib33","doi-asserted-by":"crossref","DOI":"10.1097\/OPX.0b013e31812f755f","article-title":"Impact of cataract surgery on quality of life in patients with early age-related macular degeneration","volume":"84","author":"Lamoureux","year":"2007","journal-title":"Optom Vis Sci"},{"key":"10.1016\/j.xops.2026.101308_bib34","doi-asserted-by":"crossref","first-page":"1141","DOI":"10.1016\/S0140-6736(24)00063-1","article-title":"Intravitreal aflibercept 8 mg in neovascular age-related macular degeneration (PULSAR): 48-week results from a randomised, double-masked, non-inferiority, phase 3 trial","volume":"403","author":"Lanzetta","year":"2024","journal-title":"Lancet"},{"key":"10.1016\/j.xops.2026.101308_bib35","doi-asserted-by":"crossref","first-page":"786","DOI":"10.1001\/jamaophthalmol.2018.1804","article-title":"Efficacy and safety of intravitreal aflibercept for polypoidal choroidal vasculopathy in the PLANET study: a randomized clinical trial","volume":"136","author":"Lee","year":"2018","journal-title":"JAMA Ophthalmol"},{"key":"10.1016\/j.xops.2026.101308_bib36","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/j.oret.2016.12.001","article-title":"Subthreshold nanosecond Laser Intervention in intermediate age-related Macular degeneration: study design and baseline characteristics of the laser in early stages of age-related Macular degeneration study (report number 1)","volume":"1","author":"Lek","year":"2017","journal-title":"Ophthalmol Retina"},{"key":"10.1016\/j.xops.2026.101308_bib37","doi-asserted-by":"crossref","first-page":"792","DOI":"10.1038\/sj.eye.6702900","article-title":"Quality of life in patients with age-related macular degeneration: results from the VISION study","volume":"22","author":"Leys","year":"2008","journal-title":"Eye (Lond)"},{"key":"10.1016\/j.xops.2026.101308_bib38","doi-asserted-by":"crossref","first-page":"1831","DOI":"10.1007\/s00417-007-0558-9","article-title":"Quality of life in a prospective, randomised pilot-trial of photodynamic therapy versus full macular translocation in treatment of neovascular age-related macular degeneration--a report of 1 year results","volume":"245","author":"L\u00fcke","year":"2007","journal-title":"Graefes Arch Clin Exp Ophthalmol"},{"key":"10.1016\/j.xops.2026.101308_bib39","doi-asserted-by":"crossref","first-page":"1307","DOI":"10.1016\/j.ophtha.2003.10.031","article-title":"Baseline characteristics, the 25-item National Eye Institute visual functioning questionnaire, and their associations in the complications of age-related macular degeneration prevention trial (CAPT)","volume":"111","author":"Maguire","year":"2004","journal-title":"Ophthalmology"},{"key":"10.1016\/j.xops.2026.101308_bib40","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0143085","article-title":"The chronic care for wet age related macular degeneration (CHARMED) study: a randomized controlled trial","volume":"10","author":"Markun","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.xops.2026.101308_bib41","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1007\/s00347-012-2715-8","article-title":"Einfluss visueller Rehabilitation auf sekund\u00e4re depressive St\u00f6rungen bei altersabh\u00e4ngiger Makuladegeneration: eine randomisierte kontrollierte Pilotstudie","volume":"110","author":"Mielke","year":"2013","journal-title":"Ophthalmologe"},{"key":"10.1016\/j.xops.2026.101308_bib42","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1111\/j.1755-3768.2009.01567.x","article-title":"Vision-related function after low-dose transpupillary thermotherapy versus photodynamic therapy for neovascular age-related macular degeneration","volume":"88","author":"Odergren","year":"2010","journal-title":"Acta Ophthalmol"},{"key":"10.1016\/j.xops.2026.101308_bib43","doi-asserted-by":"crossref","first-page":"216","DOI":"10.5301\/ejo.5000069","article-title":"Carotenoids in Age-related Maculopathy Italian Study (CARMIS): two-year results of a randomized study","volume":"22","author":"Piermarocchi","year":"2012","journal-title":"Eur J Ophthalmol"},{"key":"10.1016\/j.xops.2026.101308_bib44","doi-asserted-by":"crossref","first-page":"1443","DOI":"10.1136\/bjo.2003.037457","article-title":"Enhanced low vision rehabilitation for people with age related macular degeneration: a randomised controlled trial","volume":"88","author":"Reeves","year":"2004","journal-title":"Br J Ophthalmol"},{"key":"10.1016\/j.xops.2026.101308_bib45","first-page":"196","article-title":"The impact of saffron (Crocus sativus) supplementation on visual function in patients with dry age-related macular degeneration","volume":"11","author":"Riazi","year":"2017","journal-title":"Ital J Med"},{"key":"10.1016\/j.xops.2026.101308_bib46","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1016\/j.optm.2011.08.008","article-title":"Randomized, double-blind, placebo-controlled study of zeaxanthin and visual function in patients with atrophic age-related macular degeneration: the Zeaxanthin and Visual Function Study (ZVF) FDA IND #78, 973","volume":"82","author":"Richer","year":"2011","journal-title":"Optometry"},{"key":"10.1016\/j.xops.2026.101308_bib47","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1177\/0145482X1410800303","article-title":"Personality and functional vision in older adults with age-related macular degeneration","volume":"108","author":"Rovner","year":"2014","journal-title":"J Vis Impair Blind"},{"key":"10.1016\/j.xops.2026.101308_bib48","doi-asserted-by":"crossref","first-page":"1649","DOI":"10.1016\/j.ophtha.2013.01.022","article-title":"Improving function in age-related macular degeneration: a randomized clinical trial","volume":"120","author":"Rovner","year":"2013","journal-title":"Ophthalmology"},{"key":"10.1016\/j.xops.2026.101308_bib49","doi-asserted-by":"crossref","first-page":"886","DOI":"10.1001\/archpsyc.64.8.886","article-title":"Preventing depression in age-related macular degeneration","volume":"64","author":"Rovner","year":"2007","journal-title":"Arch Gen Psychiatry"},{"key":"10.1016\/j.xops.2026.101308_bib50","doi-asserted-by":"crossref","first-page":"1042","DOI":"10.1001\/archopht.123.8.1042","article-title":"A randomized controlled trial to determine the effectiveness of prism spectacles for patients with age-related macular degeneration","volume":"123","author":"Smith","year":"2005","journal-title":"Arch Ophthalmol"},{"key":"10.1016\/j.xops.2026.101308_bib51","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.1136\/bjo.2003.030445","article-title":"Visual functioning and quality of life in the SubFoveal Radiotherapy Study (SFRADS): SFRADS report 2","volume":"89","author":"Stevenson","year":"2005","journal-title":"Br J Ophthalmol"},{"key":"10.1016\/j.xops.2026.101308_bib52","doi-asserted-by":"crossref","first-page":"1","DOI":"10.36351\/pjo.v39i1.1471","article-title":"Effectiveness of prism spectacles in patients with age related macular degeneration: a randomized control trial study","volume":"39","author":"Tanveer","year":"2022","journal-title":"Pak J Ophthalmol"},{"key":"10.1016\/j.xops.2026.101308_bib53","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1620\/tjem.240.209","article-title":"\u0391-lipoic acid treatment improves vision-related quality of life in patients with dry age-related macular degeneration","volume":"240","author":"Tao","year":"2016","journal-title":"Tohoku J Exp Med"},{"key":"10.1016\/j.xops.2026.101308_bib54","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1097\/OPX.0000000000001588","article-title":"Randomized controlled trial of a spectacle lens for macular degeneration","volume":"97","author":"Visser","year":"2020","journal-title":"Optom Vis Sci"},{"key":"10.1016\/j.xops.2026.101308_bib55","doi-asserted-by":"crossref","first-page":"3305","DOI":"10.1007\/s11136-020-02580-9","article-title":"Six and eight weeks injection frequencies of bevacizumab are non-inferior to the current four weeks injection frequency for quality of life in neovascular age-related macular degeneration: a randomized controlled trial","volume":"29","author":"Visser","year":"2020","journal-title":"Qual Life Res"},{"key":"10.1016\/j.xops.2026.101308_bib56","doi-asserted-by":"crossref","first-page":"1876","DOI":"10.1016\/j.ophtha.2008.05.023","article-title":"Complications of Age-related Macular Degeneration Prevention Trial Research Group. Night vision symptoms and progression of age-related macular degeneration in the complications of Age-related Macular Degeneration Prevention Trial","volume":"115","author":"Ying","year":"2008","journal-title":"Ophthalmology"},{"key":"10.1016\/j.xops.2026.101308_bib57","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1001\/archopht.121.2.211","article-title":"National Eye Institute Visual Function Questionnaire in the age-related Eye Disease Study (AREDS): AREDS report no. 10: AREDS report no. 10","volume":"121","author":"Clemons","year":"2003","journal-title":"Arch Ophthalmol"},{"key":"10.1016\/j.xops.2026.101308_bib58","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1186\/s12886-022-02520-w","article-title":"Severity of age-related macular degeneration at first presentation in Bhutan: a 3-year national study","volume":"22","author":"Rai","year":"2022","journal-title":"BMC Ophthalmol"},{"key":"10.1016\/j.xops.2026.101308_bib59","doi-asserted-by":"crossref","first-page":"1703","DOI":"10.2147\/OPTH.S64200","article-title":"The impact of a better-seeing eye and a worse-seeing eye on vision-related quality of life","volume":"8","author":"Hirneiss","year":"2014","journal-title":"Clin Ophthalmol"},{"key":"10.1016\/j.xops.2026.101308_bib60","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/j.ajo.2004.09.028","article-title":"Vision-related quality of life in patients suffering from age-related macular degeneration","volume":"139","author":"Berdeaux","year":"2005","journal-title":"Am J Ophthalmol"},{"key":"10.1016\/j.xops.2026.101308_bib61","doi-asserted-by":"crossref","first-page":"814","DOI":"10.1001\/jama.2013.879","article-title":"Reporting of patient-reported outcomes in randomized trials: the CONSORT PRO extension","volume":"309","author":"Calvert","year":"2013","journal-title":"JAMA"}],"container-title":["Ophthalmology Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2666914526002460?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2666914526002460?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T09:22:33Z","timestamp":1789464153000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2666914526002460"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9]]},"references-count":58,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2026,9]]}},"alternative-id":["S2666914526002460"],"URL":"https:\/\/doi.org\/10.1016\/j.xops.2026.101308","relation":{},"ISSN":["2666-9145"],"issn-type":[{"value":"2666-9145","type":"print"}],"subject":[],"published":{"date-parts":[[2026,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Vision-Related Patient-Reported Outcomes in Randomized Controlled Trials of Age-Related Macular Degeneration: A Systematic Review","name":"articletitle","label":"Article Title"},{"value":"Ophthalmology Science","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.xops.2026.101308","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 American Academy of Ophthalmology, Inc. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"101308"}}