{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T09:49:03Z","timestamp":1792057743513,"version":"4.4.0"},"reference-count":33,"publisher":"Elsevier BV","issue":"10","license":[{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T00:00:00Z","timestamp":1786579200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["Priority Programme SPP 2416"],"award-info":[{"award-number":["Priority Programme SPP 2416"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["525934737"],"award-info":[{"award-number":["525934737"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["CodeChi"],"award-info":[{"award-number":["CodeChi"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","ophthalmologyscience.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Ophthalmology Science"],"published-print":{"date-parts":[[2026,10]]},"DOI":"10.1016\/j.xops.2026.101374","type":"journal-article","created":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T23:30:25Z","timestamp":1787182225000},"page":"101374","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Sex-Specific Differences in Corneal Remodeling after Descemet Membrane Endothelial Keratoplasty in Fuchs Endothelial Corneal Dystrophy"],"prefix":"10.1016","volume":"6","author":[{"given":"Niloofar","family":"Kalantari","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregor","family":"Lang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sigrid","family":"Roters","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martine J.","family":"Jager","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Berthold","family":"Seitz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2034-3687","authenticated-orcid":false,"given":"Gerd","family":"Geerling","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9133-1099","authenticated-orcid":false,"given":"Sarah Barbara","family":"Zwingelberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.xops.2026.101374_bib1","doi-asserted-by":"crossref","DOI":"10.1016\/j.preteyeres.2019.07.001","article-title":"Immune reactions after modern lamellar (DALK, DSAEK, DMEK) versus conventional penetrating corneal transplantation","volume":"73","author":"Hos","year":"2019","journal-title":"Prog Retin Eye Res"},{"issue":"3","key":"10.1016\/j.xops.2026.101374_bib2","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1007\/s00347-018-0800-3","article-title":"Ten years of Descemet membrane endothelial keratoplasty in Fuchs endothelial corneal dystrophy: what have we learned?","volume":"116","author":"Matthaei","year":"2019","journal-title":"Ophthalmologe"},{"key":"10.1016\/j.xops.2026.101374_bib3","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/S1350-9462(02)00059-9","article-title":"Identity and regulation of ion transport mechanisms in the corneal endothelium","volume":"22","author":"Bonanno","year":"2003","journal-title":"Prog Retin Eye Res"},{"key":"10.1016\/j.xops.2026.101374_bib4","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1167\/iovs.13-12689","article-title":"Endothelial cell microRNA expression in human late-onset Fuchs endothelial corneal dystrophy","volume":"55","author":"Matthaei","year":"2014","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.xops.2026.101374_bib5","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/0039-6257(93)90099-S","article-title":"Fuchs' endothelial dystrophy of the cornea","volume":"38","author":"Adamis","year":"1993","journal-title":"Surv Ophthalmol"},{"key":"10.1016\/j.xops.2026.101374_bib6","doi-asserted-by":"crossref","DOI":"10.1016\/j.preteyeres.2020.100863","article-title":"Fuchs endothelial corneal dystrophy: the vicious cycle of fuchs pathogenesis","volume":"80","author":"Ong Tone","year":"2021","journal-title":"Prog Retin Eye Res"},{"issue":"1","key":"10.1016\/j.xops.2026.101374_bib15","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1001\/archophthalmol.2010.334","article-title":"Standardized \u201cno-touch\u201d technique for Descemet membrane endothelial keratoplasty","volume":"129","author":"Dapena","year":"2011","journal-title":"Arch Ophthalmol"},{"issue":"4","key":"10.1016\/j.xops.2026.101374_bib16","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1097\/ICU.0000000000000072","article-title":"Optimizing outcomes with Descemet membrane endothelial keratoplasty","volume":"25","author":"Kruse","year":"2014","journal-title":"Curr Opin Ophthalmol"},{"key":"10.1016\/j.xops.2026.101374_bib17","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1016\/j.ajo.2019.12.001","article-title":"Outcome of Descemet membrane endothelial keratoplasty using corneas from donors \u226580 years of age","volume":"211","author":"Schaub","year":"2020","journal-title":"Am J Ophthalmol"},{"key":"10.1016\/j.xops.2026.101374_bib18","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/j.ajo.2018.03.036","article-title":"Evolution of consecutive Descemet membrane endothelial keratoplasty outcomes","volume":"190","author":"Schrittenlocher","year":"2018","journal-title":"Am J Ophthalmol"},{"key":"10.1016\/j.xops.2026.101374_bib19","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1097\/00003226-200104000-00001","article-title":"Deep lamellar endothelial keratoplasty in the first United States patients","volume":"20","author":"Terry","year":"2001","journal-title":"Cornea"},{"key":"10.1016\/j.xops.2026.101374_bib20","first-page":"1354","article-title":"Complications of DMEK keratoplasty","volume":"234","author":"Bachmann","year":"2017","journal-title":"Klin Monbl Augenheilkd"},{"issue":"8","key":"10.1016\/j.xops.2026.101374_bib21","doi-asserted-by":"crossref","first-page":"912","DOI":"10.1016\/j.ophtha.2022.04.005","article-title":"Disparities in visual acuity outcomes after endothelial keratoplasty: an IRIS Registry analysis","volume":"129","author":"Srikumaran","year":"2022","journal-title":"Ophthalmology"},{"key":"10.1016\/j.xops.2026.101374_bib7","doi-asserted-by":"crossref","first-page":"6718","DOI":"10.1167\/iovs.12-9669","article-title":"Endothelial Cdkn1a (p21) overexpression and accelerated senescence in a mouse model of Fuchs endothelial corneal dystrophy","volume":"53","author":"Matthaei","year":"2012","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"4","key":"10.1016\/j.xops.2026.101374_bib8","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0175112","article-title":"Comprehensive characterization of DNA methylation changes in Fuchs endothelial corneal dystrophy","volume":"12","author":"Khuc","year":"2017","journal-title":"PLoS One"},{"key":"10.1016\/j.xops.2026.101374_bib9","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-019-52727-z","article-title":"Aberrant DNA methylation of miRNAs in Fuchs endothelial corneal dystrophy","volume":"9","author":"Pan","year":"2019","journal-title":"Sci Rep"},{"issue":"2","key":"10.1016\/j.xops.2026.101374_bib10","doi-asserted-by":"crossref","first-page":"305","DOI":"10.3390\/jpm12020305","article-title":"Sociodemographic and risk factors for Fuchs endothelial corneal dystrophy: a nationwide matched case-control study in Taiwan","volume":"12","author":"Chang","year":"2022","journal-title":"J Pers Med"},{"issue":"3","key":"10.1016\/j.xops.2026.101374_bib11","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1097\/ICO.0000000000002737","article-title":"Long-term outcome of Descemet membrane endothelial keratoplasty in eyes with Fuchs endothelial corneal dystrophy versus pseudophakic bullous keratopathy","volume":"41","author":"Zwingelberg","year":"2022","journal-title":"Cornea"},{"key":"10.1016\/j.xops.2026.101374_bib12","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1001\/archopht.124.6.777","article-title":"Clinical study of Fuchs corneal endothelial dystrophy leading to penetrating keratoplasty: a 30-year experience","volume":"124","author":"Afshari","year":"2006","journal-title":"Arch Ophthalmol"},{"key":"10.1016\/j.xops.2026.101374_bib13","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1097\/ICO.0b013e31821c9b8f","article-title":"A multicenter study to map genes for Fuchs endothelial corneal dystrophy","volume":"31","author":"Louttit","year":"2012","journal-title":"Cornea"},{"key":"10.1016\/j.xops.2026.101374_bib14","first-page":"2508","article-title":"Genetic screen of African Americans with Fuchs endothelial corneal dystrophy","volume":"19","author":"Minear","year":"2013","journal-title":"Mol Vis"},{"key":"10.1016\/j.xops.2026.101374_bib22","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1097\/00003226-199309000-00001","article-title":"In vivo confocal microscopic studies of endothelial wound healing","volume":"12","author":"Ichijima","year":"1993","journal-title":"Cornea"},{"key":"10.1016\/j.xops.2026.101374_bib23","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.exer.2011.08.014","article-title":"Proliferative capacity of corneal endothelial cells","volume":"95","author":"Joyce","year":"2012","journal-title":"Exp Eye Res"},{"key":"10.1016\/j.xops.2026.101374_bib24","first-page":"443","article-title":"Cellular migration in corneal endothelial wound repair","volume":"26","author":"Matsuda","year":"1985","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.xops.2026.101374_bib25","doi-asserted-by":"crossref","DOI":"10.1016\/j.xops.2021.100006","article-title":"Increased corneal endothelial cell migration in Fuchs endothelial corneal dystrophy","volume":"1","author":"Ong Tone","year":"2021","journal-title":"Ophthalmol Sci"},{"key":"10.1016\/j.xops.2026.101374_bib26","doi-asserted-by":"crossref","first-page":"828","DOI":"10.1111\/aos.13841","article-title":"Asymmetrical endothelial cell migration","volume":"96","author":"Miron","year":"2018","journal-title":"Acta Ophthalmol"},{"key":"10.1016\/j.xops.2026.101374_bib27","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1097\/ICO.0000000000000054","article-title":"Donor endothelial cell migration after Descemet membrane endothelial keratoplasty","volume":"33","author":"Hos","year":"2014","journal-title":"Cornea"},{"key":"10.1016\/j.xops.2026.101374_bib28","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1002\/jhbp.40","article-title":"Gender discordance and graft survival","volume":"21","author":"Croome","year":"2014","journal-title":"J Hepatobiliary Pancreat Sci"},{"issue":"8","key":"10.1016\/j.xops.2026.101374_bib29","first-page":"2417","article-title":"The cologne-mecklenburg-vorpommern DMEK Donor Study (COMEDOS): design and review of the influence of donor characteristics on DMEK outcome","volume":"260","author":"Schrittenlocher","year":"2022","journal-title":"Graefes Arch Clin Exp Ophthalmol"},{"issue":"10","key":"10.1016\/j.xops.2026.101374_bib30","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0276043","article-title":"Impact of gender mismatch on corneal graft rejection and rejection-related graft failure in repeat penetrating keratoplasty","volume":"17","author":"Chuckpaiwong","year":"2022","journal-title":"PLoS One"},{"key":"10.1016\/j.xops.2026.101374_bib31","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-024-61948-w","article-title":"Influence of obesity, diabetes mellitus and smoking on Fuchs endothelial corneal dystrophy","volume":"14","author":"Zwingelberg","year":"2024","journal-title":"Sci Rep"},{"key":"10.1016\/j.xops.2026.101374_bib32","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1073\/pnas.1912546116","article-title":"Ultraviolet A\u2013induced DNA damage in Fuchs endothelial corneal dystrophy","volume":"117","author":"Liu","year":"2020","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.xops.2026.101374_bib33","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1097\/ICO.0000000000000385","article-title":"Comparison of specular microscopes","volume":"34","author":"Luft","year":"2015","journal-title":"Cornea"}],"container-title":["Ophthalmology Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S266691452600312X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S266691452600312X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T09:24:27Z","timestamp":1792056267000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S266691452600312X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10]]},"references-count":33,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2026,10]]}},"alternative-id":["S266691452600312X"],"URL":"https:\/\/doi.org\/10.1016\/j.xops.2026.101374","relation":{},"ISSN":["2666-9145"],"issn-type":[{"value":"2666-9145","type":"print"}],"subject":[],"published":{"date-parts":[[2026,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Sex-Specific Differences in Corneal Remodeling after Descemet Membrane Endothelial Keratoplasty in Fuchs Endothelial Corneal Dystrophy","name":"articletitle","label":"Article Title"},{"value":"Ophthalmology Science","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.xops.2026.101374","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 American Academy of Ophthalmology, Inc. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"101374"}}