{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T02:50:00Z","timestamp":1791427800252,"version":"4.3.3"},"reference-count":34,"publisher":"Elsevier BV","issue":"11","license":[{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T00:00:00Z","timestamp":1787875200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100031478","name":"NextGenerationEU","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100031478","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100019771","name":"European Union's Research and Innovation","doi-asserted-by":"publisher","award":["PNRR-MR1-2023-12378435"],"award-info":[{"award-number":["PNRR-MR1-2023-12378435"]}],"id":[{"id":"10.13039\/100019771","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","ophthalmologyscience.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Ophthalmology Science"],"published-print":{"date-parts":[[2026,11]]},"DOI":"10.1016\/j.xops.2026.101396","type":"journal-article","created":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T16:04:33Z","timestamp":1788365073000},"page":"101396","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Peripheral Vascular Alterations in USH2A-Retinitis Pigmentosa and Relationship with Macular Involvement: A Cross-Sectional Study"],"prefix":"10.1016","volume":"6","author":[{"given":"Alessandro","family":"Arrigo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2891-2012","authenticated-orcid":false,"given":"Giovanni","family":"Forte","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emanuela","family":"Aragona","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Virginia","family":"Pini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Camilla","family":"Petruzziello","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9462-1040","authenticated-orcid":false,"given":"Ottavio","family":"Cremona","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Filippo","family":"Casoni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9630-0830","authenticated-orcid":false,"given":"Alessio","family":"Antropoli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4023-5387","authenticated-orcid":false,"given":"Lorenzo","family":"Bianco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0385-7961","authenticated-orcid":false,"given":"Maurizio","family":"Battaglia Parodi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3238-9682","authenticated-orcid":false,"given":"Francesco","family":"Bandello","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"10","key":"10.1016\/j.xops.2026.101396_bib1","article-title":"Retinitis pigmentosa: pathogenesis, diagnostic findings, and treatment","volume":"15","author":"Kamde","year":"2023","journal-title":"Cureus"},{"issue":"4","key":"10.1016\/j.xops.2026.101396_bib2","article-title":"USH2A variants causing retinitis pigmentosa or Usher syndrome provoke differential retinal phenotypes in disease-specific organoids","volume":"4","author":"Sanjurjo-Soriano","year":"2023","journal-title":"HGG Adv"},{"issue":"2","key":"10.1016\/j.xops.2026.101396_bib3","doi-asserted-by":"crossref","first-page":"213","DOI":"10.3390\/diagnostics11020213","article-title":"USH2A-Related retinitis pigmentosa: staging of disease severity and morpho-functional studies","volume":"11","author":"Falsini","year":"2021","journal-title":"Diagnostics (Basel)"},{"issue":"6","key":"10.1016\/j.xops.2026.101396_bib4","doi-asserted-by":"crossref","first-page":"1975","DOI":"10.1086\/302926","article-title":"Missense mutation in the USH2A gene: association with recessive retinitis pigmentosa without hearing loss","volume":"66","author":"Rivolta","year":"2000","journal-title":"Am J Hum Genet"},{"issue":"1","key":"10.1016\/j.xops.2026.101396_bib5","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1177\/11206721241247421","article-title":"Optical coherence tomography (OCT) and OCT-angiography in syndromic versus non-syndromic USH2A-associated retinopathy","volume":"35","author":"Antropoli","year":"2025","journal-title":"Eur J Ophthalmol"},{"issue":"1","key":"10.1016\/j.xops.2026.101396_bib6","doi-asserted-by":"crossref","first-page":"800","DOI":"10.1038\/s41598-023-27994-6","article-title":"Characterizing macular edema in retinitis pigmentosa through a combined structural and microvascular optical coherence tomography investigation","volume":"13","author":"Arrigo","year":"2023","journal-title":"Sci Rep"},{"issue":"10","key":"10.1016\/j.xops.2026.101396_bib7","doi-asserted-by":"crossref","first-page":"1959","DOI":"10.1097\/IAE.0000000000004560","article-title":"The impact of cystoid maculopathy in USH2A retinitis pigmentosa: a retrospective 5-year analysis","volume":"45","author":"Arrigo","year":"2025","journal-title":"Retina"},{"issue":"8","key":"10.1016\/j.xops.2026.101396_bib8","doi-asserted-by":"crossref","first-page":"1348","DOI":"10.1097\/IAE.0000000000003801","article-title":"Hyperreflective band in the ganglion cell layer in retinitis pigmentosa","volume":"43","author":"Antropoli","year":"2023","journal-title":"Retina"},{"key":"10.1016\/j.xops.2026.101396_bib9","doi-asserted-by":"crossref","DOI":"10.1097\/IAE.0000000000004437","article-title":"The superficial capillary plexus perivascular gliosis occurring in retinitis pigmentosa revealed by multimodal retinal imaging","author":"Arrigo","year":"2025","journal-title":"Retina"},{"issue":"7","key":"10.1016\/j.xops.2026.101396_bib10","doi-asserted-by":"crossref","first-page":"1424","DOI":"10.1038\/s41433-022-02139-7","article-title":"Morphological and functional involvement of the inner retina in retinitis pigmentosa","volume":"37","author":"Arrigo","year":"2023","journal-title":"Eye (Lond)"},{"issue":"12","key":"10.1016\/j.xops.2026.101396_bib11","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1167\/iovs.64.12.8","article-title":"Hyperautofluorescent ring pattern in Retinitis pigmentosa: clinical implications and modifications over time","volume":"64","author":"Antropoli","year":"2023","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"1","key":"10.1016\/j.xops.2026.101396_bib12","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1007\/s10384-023-01031-5","article-title":"Measuring macular pigment optical density using reflective images of confocal scanning laser system","volume":"68","author":"Morita","year":"2024","journal-title":"Jpn J Ophthalmol"},{"key":"10.1016\/j.xops.2026.101396_bib13","doi-asserted-by":"crossref","DOI":"10.1016\/j.preteyeres.2024.101326","article-title":"Exploring retinal conditions through blue light reflectance imaging","volume":"105","author":"Leit\u00e3o Guerra","year":"2025","journal-title":"Prog Retin Eye Res"},{"issue":"8","key":"10.1016\/j.xops.2026.101396_bib14","doi-asserted-by":"crossref","first-page":"4852","DOI":"10.1167\/iovs.12-9713","article-title":"Profiles of macular pigment optical density and their changes following supplemental lutein and zeaxanthin: new results from the LUNA study","volume":"53","author":"Zeimer","year":"2012","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"10.1016\/j.xops.2026.101396_bib15","doi-asserted-by":"crossref","DOI":"10.1016\/j.exer.2024.110043","article-title":"Imaging macular carotenoids and their related proteins in the human retina with confocal resonance Raman and fluorescence microscopy","volume":"247","author":"Li","year":"2024","journal-title":"Exp Eye Res"},{"key":"10.1016\/j.xops.2026.101396_bib16","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/j.exer.2017.12.015","article-title":"Reliability of a two-wavelength autofluorescence technique by Heidelberg Spectralis to measure macular pigment optical density in Asian subjects","volume":"168","author":"Obana","year":"2018","journal-title":"Exp Eye Res"},{"issue":"5","key":"10.1016\/j.xops.2026.101396_bib17","doi-asserted-by":"crossref","first-page":"2941","DOI":"10.1167\/iovs.13-13568","article-title":"Comparison of two methods to measure macular pigment optical density in healthy subjects","volume":"55","author":"Creuzot-Garcher","year":"2014","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"11","key":"10.1016\/j.xops.2026.101396_bib18","doi-asserted-by":"crossref","first-page":"1595","DOI":"10.1136\/bjophthalmol-2018-313669","article-title":"Classification of disease severity in retinitis pigmentosa","volume":"103","author":"Iftikhar","year":"2019","journal-title":"Br J Ophthalmol"},{"key":"10.1016\/j.xops.2026.101396_bib19","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.ajo.2016.12.006","article-title":"Insights into epiretinal membranes: presence of ectopic inner foveal layers and a new optical coherence tomography staging scheme","volume":"175","author":"Govetto","year":"2017","journal-title":"Am J Ophthalmol"},{"issue":"7","key":"10.1016\/j.xops.2026.101396_bib20","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1038\/nmeth.2019","article-title":"Fiji: an open-source platform for biological-image analysis","volume":"9","author":"Schindelin","year":"2012","journal-title":"Nat Methods"},{"issue":"34","key":"10.1016\/j.xops.2026.101396_bib21","doi-asserted-by":"crossref","DOI":"10.1097\/MD.0000000000030068","article-title":"Optical coherence tomography angiography in retinitis pigmentosa: a narrative review","volume":"101","author":"Lu","year":"2022","journal-title":"Medicine (Baltimore)"},{"issue":"7","key":"10.1016\/j.xops.2026.101396_bib22","doi-asserted-by":"crossref","first-page":"1287","DOI":"10.1007\/s00417-017-3633-x","article-title":"Retinal and choroidal vascular features in patients with retinitis pigmentosa imaged by OCT based microangiography","volume":"255","author":"Rezaei","year":"2017","journal-title":"Graefes Arch Clin Exp Ophthalmol"},{"issue":"4","key":"10.1016\/j.xops.2026.101396_bib23","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1136\/bjophthalmol-2019-314243","article-title":"Characterisation of microvascular abnormalities using OCT angiography in patients with biallelic variants in USH2A and MYO7A","volume":"104","author":"Hagag","year":"2020","journal-title":"Br J Ophthalmol"},{"issue":"1","key":"10.1016\/j.xops.2026.101396_bib24","doi-asserted-by":"crossref","first-page":"50","DOI":"10.3390\/diagnostics10010050","article-title":"Widefield swept source OCTA in retinitis pigmentosa","volume":"10","author":"Mastropasqua","year":"2020","journal-title":"Diagnostics (Basel)"},{"key":"10.1016\/j.xops.2026.101396_bib25","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1007\/s10792-025-03873-z","article-title":"Structural and vascular features of the retina and choroid with retinitis pigmentosa imaged using ultra-widefield swept-source optical coherence tomography angiography","volume":"46","author":"Zhao","year":"2026","journal-title":"Int Ophthalmol"},{"key":"10.1016\/j.xops.2026.101396_bib26","doi-asserted-by":"crossref","DOI":"10.1038\/srep42201","article-title":"Detailed vascular anatomy of the human retina by projection-resolved optical coherence tomography angiography","volume":"7","author":"Campbell","year":"2017","journal-title":"Sci Rep"},{"issue":"1","key":"10.1016\/j.xops.2026.101396_bib27","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-018-31488-1","article-title":"Quantitative progression of retinitis pigmentosa by optical coherence tomography angiography","volume":"8","author":"Jauregui","year":"2018","journal-title":"Sci Rep"},{"issue":"1","key":"10.1016\/j.xops.2026.101396_bib28","doi-asserted-by":"crossref","first-page":"e59","DOI":"10.1111\/aos.13475","article-title":"Optical coherence tomography angiography of the macular microvasculature changes in retinitis pigmentosa","volume":"96","author":"Koyanagi","year":"2018","journal-title":"Acta Ophthalmol"},{"key":"10.1016\/j.xops.2026.101396_bib29","first-page":"1487","article-title":"Association of retinal vessel attenuation with visual function in eyes with retinitis pigmentosa","volume":"8","author":"Nakagawa","year":"2014","journal-title":"Clin Ophthalmol"},{"issue":"4","key":"10.1016\/j.xops.2026.101396_bib30","doi-asserted-by":"crossref","DOI":"10.1016\/j.xops.2025.100767","article-title":"Loss of peripheral retinal vessels in Retinitis pigmentosa","volume":"5","author":"Ameri","year":"2025","journal-title":"Ophthalmol Sci"},{"issue":"5","key":"10.1016\/j.xops.2026.101396_bib31","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1016\/S0161-6420(95)30953-0","article-title":"Histopathology of bone spicule pigmentation in retinitis pigmentosa","volume":"102","author":"Li","year":"1995","journal-title":"Ophthalmology"},{"key":"10.1016\/j.xops.2026.101396_bib32","doi-asserted-by":"crossref","DOI":"10.1016\/j.preteyeres.2025.101357","article-title":"M\u00fcller cells trophism and pathology as the next therapeutic targets for retinal diseases","volume":"106","author":"Arrigo","year":"2025","journal-title":"Prog Retin Eye Res"},{"key":"10.1016\/j.xops.2026.101396_bib33","doi-asserted-by":"crossref","DOI":"10.1016\/j.preteyeres.2022.101111","article-title":"Quantitative approaches in multimodal fundus imaging: state of the art and future perspectives","volume":"92","author":"Arrigo","year":"2023","journal-title":"Prog Retin Eye Res"},{"issue":"13","key":"10.1016\/j.xops.2026.101396_bib34","doi-asserted-by":"crossref","DOI":"10.3390\/ijms241310702","article-title":"Physiological significance of the heterogeneous distribution of Zeaxanthin and lutein in the retina of the human eye","volume":"24","author":"Grudzinski","year":"2023","journal-title":"Int J Mol Sci"}],"container-title":["Ophthalmology Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2666914526003349?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2666914526003349?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T01:59:01Z","timestamp":1791424741000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2666914526003349"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,11]]},"references-count":34,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2026,11]]}},"alternative-id":["S2666914526003349"],"URL":"https:\/\/doi.org\/10.1016\/j.xops.2026.101396","relation":{},"ISSN":["2666-9145"],"issn-type":[{"value":"2666-9145","type":"print"}],"subject":[],"published":{"date-parts":[[2026,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Peripheral Vascular Alterations in USH2A-Retinitis Pigmentosa and Relationship with Macular Involvement: A Cross-Sectional Study","name":"articletitle","label":"Article Title"},{"value":"Ophthalmology Science","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.xops.2026.101396","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 American Academy of Ophthalmology, Inc. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"101396"}}