{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T02:47:08Z","timestamp":1790736428997,"version":"4.1.0"},"reference-count":48,"publisher":"Elsevier BV","issue":"9","license":[{"start":{"date-parts":[[2017,9,1]],"date-time":"2017-09-01T00:00:00Z","timestamp":1504224000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100001691","name":"JSPS","doi-asserted-by":"publisher","award":["JP15K08078"],"award-info":[{"award-number":["JP15K08078"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["jpharmsci.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Pharmaceutical Sciences"],"published-print":{"date-parts":[[2017,9]]},"DOI":"10.1016\/j.xphs.2017.03.011","type":"journal-article","created":{"date-parts":[[2017,3,18]],"date-time":"2017-03-18T16:15:43Z","timestamp":1489853743000},"page":"2642-2649","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":35,"title":["Snail-Induced Epithelial-to-Mesenchymal Transition Enhances P-gp-Mediated Multidrug Resistance in HCC827 Cells"],"prefix":"10.1016","volume":"106","author":[{"given":"Takumi","family":"Tomono","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kentaro","family":"Yano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takuo","family":"Ogihara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"5","key":"10.1016\/j.xphs.2017.03.011_bib1","doi-asserted-by":"crossref","first-page":"a001883","DOI":"10.1101\/cshperspect.a001883","article-title":"Tumor suppressive functions of p53","volume":"1","author":"Zilfou","year":"2009","journal-title":"Cold Spring Harb Perspect Biol"},{"issue":"6","key":"10.1016\/j.xphs.2017.03.011_bib2","doi-asserted-by":"crossref","first-page":"904","DOI":"10.1016\/S0022-5223(19)33941-8","article-title":"Tumor necrosis factor-alpha alters response of lung cancer cells to oxidative stress","volume":"102","author":"Pogrebniak","year":"1991","journal-title":"J\u00a0Thorac Cardiovasc Surg"},{"issue":"7","key":"10.1016\/j.xphs.2017.03.011_bib3","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1038\/nrc1926","article-title":"Tumour microenvironment: TGFbeta: the molecular Jekyll and Hyde of cancer","volume":"6","author":"Bierie","year":"2006","journal-title":"Nat Rev Cancer"},{"issue":"Pt 1","key":"10.1016\/j.xphs.2017.03.011_bib4","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1042\/BST0330241","article-title":"ABC transporters in the balance: is there a role in multidrug resistance?","volume":"33","author":"Polgar","year":"2005","journal-title":"Biochem Soc Trans"},{"issue":"8","key":"10.1016\/j.xphs.2017.03.011_bib5","doi-asserted-by":"crossref","first-page":"1502","DOI":"10.1080\/10428190701402895","article-title":"Evaluation of the MDR1, ABCG2, Topoisomerases II alpha and GSTpi gene expression in patients affected by aggressive mantle cell lymphoma treated by the R-Hyper-CVAD regimen","volume":"48","author":"Galimberti","year":"2007","journal-title":"Leuk Lymphoma"},{"issue":"5","key":"10.1016\/j.xphs.2017.03.011_bib6","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1007\/s00277-007-0269-7","article-title":"CD34-related coexpression of MDR1 and BCRP indicates a clinically resistant phenotype in patients with acute myeloid leukemia (AML) of older age","volume":"86","author":"van den Heuvel-Eibrink","year":"2007","journal-title":"Ann Hematol"},{"issue":"12","key":"10.1016\/j.xphs.2017.03.011_bib7","doi-asserted-by":"crossref","first-page":"3881","DOI":"10.1182\/blood-2005-10-009084","article-title":"ABCG2 expression, function, and promoter methylation in human multiple myeloma","volume":"108","author":"Turner","year":"2006","journal-title":"Blood"},{"issue":"15","key":"10.1016\/j.xphs.2017.03.011_bib8","first-page":"63","article-title":"In\u00a0vitro evaluation of chemosensitizers for clinical reversal of P-glycoprotein-associated Taxol resistance","author":"Lehnert","year":"1993","journal-title":"J\u00a0Natl Cancer Inst Monographs"},{"issue":"3","key":"10.1016\/j.xphs.2017.03.011_bib9","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1007\/s00280-012-1915-x","article-title":"Increased expression and function of P-glycoprotein in peripheral blood CD56+ cells is associated with the chemoresistance of non-small-cell lung cancer","volume":"70","author":"Han","year":"2012","journal-title":"Cancer Chemother Pharmacol"},{"issue":"12","key":"10.1016\/j.xphs.2017.03.011_bib10","doi-asserted-by":"crossref","first-page":"4486","DOI":"10.1073\/pnas.85.12.4486","article-title":"A\u00a0retrovirus carrying an MDR1 cDNA confers multidrug resistance and polarized expression of P-glycoprotein in MDCK cells","volume":"85","author":"Pastan","year":"1988","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"12","key":"10.1016\/j.xphs.2017.03.011_bib11","doi-asserted-by":"crossref","first-page":"1930","DOI":"10.2967\/jnumed.115.161273","article-title":"Breast cancer resistance protein and P-glycoprotein influence in\u00a0vivo disposition of 11C-erlotinib","volume":"56","author":"Traxl","year":"2015","journal-title":"J\u00a0Nucl Med"},{"issue":"3","key":"10.1016\/j.xphs.2017.03.011_bib12","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1038\/clpt.2013.208","article-title":"Interaction of the efflux transporters ABCB1 and ABCG2 with imatinib, nilotinib, and dasatinib","volume":"95","author":"Eadie","year":"2014","journal-title":"Clin Pharmacol Ther"},{"key":"10.1016\/j.xphs.2017.03.011_bib13","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1016\/j.phrs.2015.09.003","article-title":"Brain accumulation of the EML4-ALK inhibitor ceritinib is restricted by P-glycoprotein (P-GP\/ABCB1) and breast cancer resistance protein (BCRP\/ABCG2)","volume":"102","author":"Kort","year":"2015","journal-title":"Pharm Res"},{"issue":"6","key":"10.1016\/j.xphs.2017.03.011_bib14","doi-asserted-by":"crossref","first-page":"1484","DOI":"10.1002\/ijc.28475","article-title":"Increased oral availability and brain accumulation of the ALK inhibitor crizotinib by coadministration of the P-glycoprotein (ABCB1) and breast cancer\u00a0resistance protein (ABCG2) inhibitor elacridar","volume":"134","author":"Tang","year":"2014","journal-title":"Int J Cancer"},{"issue":"6672","key":"10.1016\/j.xphs.2017.03.011_bib15","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1038\/32433","article-title":"A\u00a0causal role for E-cadherin in the transition from adenoma to carcinoma","volume":"392","author":"Perl","year":"1998","journal-title":"Nature"},{"issue":"6","key":"10.1016\/j.xphs.2017.03.011_bib16","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1177\/1066896911414566","article-title":"Epithelial-mesenchymal transition (EMT) protein expression in a cohort of stage II colorectal cancer patients with characterized tumor budding and mismatch repair protein status","volume":"19","author":"Kevans","year":"2011","journal-title":"Int J Surg Pathol"},{"issue":"2","key":"10.1016\/j.xphs.2017.03.011_bib17","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1038\/sj.bjc.6605486","article-title":"Hypoxia potentiates Notch signaling in breast cancer leading to decreased E-cadherin expression and increased cell migration and invasion","volume":"102","author":"Chen","year":"2010","journal-title":"Br J Cancer"},{"issue":"3","key":"10.1016\/j.xphs.2017.03.011_bib18","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/j.ccr.2009.01.023","article-title":"Cancer metastasis is accelerated through immunosuppression during Snail-induced EMT of cancer cells","volume":"15","author":"Kudo-Saito","year":"2009","journal-title":"Cancer Cell"},{"issue":"14","key":"10.1016\/j.xphs.2017.03.011_bib19","doi-asserted-by":"crossref","first-page":"3151","DOI":"10.1242\/dev.01907","article-title":"The Snail genes as inducers of cell movement and survival: implications in development and cancer","volume":"132","author":"Barrallo-Gimeno","year":"2005","journal-title":"Development"},{"issue":"3","key":"10.1016\/j.xphs.2017.03.011_bib20","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1038\/nrm757","article-title":"The snail superfamily of zinc-finger transcription factors","volume":"3","author":"Nieto","year":"2002","journal-title":"Nat Rev Mol Cell Biol"},{"issue":"5","key":"10.1016\/j.xphs.2017.03.011_bib21","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1016\/S0092-8674(00)80862-4","article-title":"A\u00a0genetic link between morphogenesis and cell division during formation of the ventral furrow in Drosophila","volume":"101","author":"Grosshans","year":"2000","journal-title":"Cell"},{"issue":"5304","key":"10.1016\/j.xphs.2017.03.011_bib22","doi-asserted-by":"crossref","first-page":"1301","DOI":"10.1126\/science.275.5304.1301","article-title":"Control of vertebrate left-right asymmetry by a snail-related zinc finger gene","volume":"275","author":"Isaac","year":"1997","journal-title":"Science"},{"issue":"22","key":"10.1016\/j.xphs.2017.03.011_bib23","doi-asserted-by":"crossref","first-page":"6426","DOI":"10.1093\/emboj\/18.22.6426","article-title":"The mesoderm determinant snail collaborates with related zinc-finger proteins to control Drosophila neurogenesis","volume":"18","author":"Ashraf","year":"1999","journal-title":"EMBO J"},{"issue":"2","key":"10.1016\/j.xphs.2017.03.011_bib24","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/j.cell.2008.07.001","article-title":"TGFbeta in cancer","volume":"134","author":"Massague","year":"2008","journal-title":"Cell"},{"issue":"8","key":"10.1016\/j.xphs.2017.03.011_bib25","doi-asserted-by":"crossref","first-page":"1631","DOI":"10.1002\/cncr.20946","article-title":"Snail, Slug, and Smad-interacting protein 1 as novel parameters of disease aggressiveness in metastatic ovarian and breast carcinoma","volume":"103","author":"Elloul","year":"2005","journal-title":"Cancer"},{"issue":"1","key":"10.1016\/j.xphs.2017.03.011_bib26","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1007\/s10620-005-1275-z","article-title":"The transcriptional repressor SNAIL is overexpressed in human colon cancer","volume":"50","author":"Roy","year":"2005","journal-title":"Dig Dis Sci"},{"issue":"1","key":"10.1016\/j.xphs.2017.03.011_bib27","doi-asserted-by":"crossref","first-page":"12","DOI":"10.3350\/kjhep.2011.17.1.12","article-title":"Clinicopathologic significance of the expression of Snail in hepatocellular carcinoma","volume":"17","author":"Woo","year":"2011","journal-title":"Korean J Hepatol"},{"issue":"12","key":"10.1016\/j.xphs.2017.03.011_bib28","doi-asserted-by":"crossref","first-page":"1082","DOI":"10.1136\/thx.2009.115691","article-title":"Prognostic significance of hypoxia-inducible factor-1alpha, TWIST1 and Snail expression in resectable non-small cell lung cancer","volume":"64","author":"Hung","year":"2009","journal-title":"Thorax"},{"issue":"2","key":"10.1016\/j.xphs.2017.03.011_bib29","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1002\/ar.21523","article-title":"Prognostic evaluation of CapG, gelsolin, P-gp, GSTP1, and Topo-II proteins in non-small cell lung cancer","volume":"295","author":"Zhu","year":"2012","journal-title":"Anat Rec (Hoboken)"},{"issue":"17","key":"10.1016\/j.xphs.2017.03.011_bib30","doi-asserted-by":"crossref","first-page":"7559","DOI":"10.1128\/MCB.24.17.7559-7566.2004","article-title":"Aberrant expression of the transcription factors snail and slug alters the response to genotoxic stress","volume":"24","author":"Kajita","year":"2004","journal-title":"Mol Cell Biol"},{"issue":"1","key":"10.1016\/j.xphs.2017.03.011_bib31","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/0042-6822(68)90121-9","article-title":"The polypeptides of adenovirus. I. Evidence for multiple protein components in the virion and a comparison of types 2, 7A, and 12","volume":"36","author":"Maizel","year":"1968","journal-title":"Virology"},{"issue":"22","key":"10.1016\/j.xphs.2017.03.011_bib32","doi-asserted-by":"crossref","first-page":"10274","DOI":"10.1128\/JVI.74.22.10274-10286.2000","article-title":"Dependence of adenovirus infectivity on length of the fiber shaft domain","volume":"74","author":"Shayakhmetov","year":"2000","journal-title":"J\u00a0Virol"},{"issue":"2","key":"10.1016\/j.xphs.2017.03.011_bib33","doi-asserted-by":"crossref","first-page":"e88154","DOI":"10.1371\/journal.pone.0088154","article-title":"Drug-induced trafficking of p-glycoprotein in human brain capillary endothelial cells as demonstrated by exposure to mitomycin C","volume":"9","author":"Noack","year":"2014","journal-title":"PloS One"},{"issue":"1","key":"10.1016\/j.xphs.2017.03.011_bib34","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1471-4159.2006.04410.x","article-title":"Modulation of p-glycoprotein function by caveolin-1 phosphorylation","volume":"101","author":"Barakat","year":"2007","journal-title":"J\u00a0Neurochem"},{"issue":"50","key":"10.1016\/j.xphs.2017.03.011_bib35","doi-asserted-by":"crossref","first-page":"52132","DOI":"10.1074\/jbc.M409617200","article-title":"Src-mediated tyrosine phosphorylation of caveolin-1 induces its association with membrane type 1 matrix metalloproteinase","volume":"279","author":"Labrecque","year":"2004","journal-title":"J\u00a0Biol Chem"},{"issue":"10","key":"10.1016\/j.xphs.2017.03.011_bib36","first-page":"2575","article-title":"Overexpression of Snail accelerates adriamycin induction of multidrug resistance in breast cancer cells","volume":"12","author":"Li","year":"2011","journal-title":"Asian Pac J Cancer Prev"},{"issue":"1","key":"10.1016\/j.xphs.2017.03.011_bib37","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1074\/jbc.273.1.577","article-title":"SH2- and SH3-mediated interactions between focal adhesion kinase and Src","volume":"273","author":"Thomas","year":"1998","journal-title":"J\u00a0Biol Chem"},{"issue":"3","key":"10.1016\/j.xphs.2017.03.011_bib38","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1128\/MCB.00825-13","article-title":"Grb2 promotes integrin-induced focal adhesion kinase (FAK) autophosphorylation and directs the phosphorylation of protein tyrosine phosphatase alpha by the Src-FAK kinase complex","volume":"34","author":"Cheng","year":"2014","journal-title":"Mol Cell Biol"},{"issue":"9","key":"10.1016\/j.xphs.2017.03.011_bib39","doi-asserted-by":"crossref","first-page":"2059","DOI":"10.1002\/stem.154","article-title":"Snail and slug mediate radioresistance and chemoresistance by antagonizing p53-mediated apoptosis and acquiring a stem-like phenotype in ovarian cancer cells","volume":"27","author":"Kurrey","year":"2009","journal-title":"Stem Cells"},{"issue":"7579","key":"10.1016\/j.xphs.2017.03.011_bib40","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1038\/nature15748","article-title":"Epithelial-to-mesenchymal transition is not required for lung metastasis but contributes to chemoresistance","volume":"527","author":"Fischer","year":"2015","journal-title":"Nature"},{"issue":"7579","key":"10.1016\/j.xphs.2017.03.011_bib41","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1038\/nature16064","article-title":"Epithelial-to-mesenchymal transition is dispensable for metastasis but induces chemoresistance in pancreatic cancer","volume":"527","author":"Zheng","year":"2015","journal-title":"Nature"},{"issue":"2","key":"10.1016\/j.xphs.2017.03.011_bib42","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1016\/S0092-8674(00)00121-5","article-title":"TGFbeta signaling in growth control, cancer, and heritable disorders","volume":"103","author":"Massague","year":"2000","journal-title":"Cell"},{"issue":"Pt 10","key":"10.1016\/j.xphs.2017.03.011_bib43","doi-asserted-by":"crossref","first-page":"1959","DOI":"10.1242\/jcs.00389","article-title":"Regulation of tight junctions during the epithelium-mesenchyme transition: direct repression of the gene expression of claudins\/occludin by Snail","volume":"116","author":"Ikenouchi","year":"2003","journal-title":"J\u00a0Cell Sci"},{"issue":"42","key":"10.1016\/j.xphs.2017.03.011_bib44","doi-asserted-by":"crossref","first-page":"39209","DOI":"10.1074\/jbc.M206400200","article-title":"Snail induction of epithelial to mesenchymal transition in tumor cells is accompanied by MUC1 repression and ZEB1 expression","volume":"277","author":"Guaita","year":"2002","journal-title":"J\u00a0Biol Chem"},{"issue":"2","key":"10.1016\/j.xphs.2017.03.011_bib45","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1038\/35000025","article-title":"The transcription factor snail controls epithelial-mesenchymal transitions by repressing E-cadherin expression","volume":"2","author":"Cano","year":"2000","journal-title":"Nat Cell Biol"},{"issue":"23","key":"10.1016\/j.xphs.2017.03.011_bib46","doi-asserted-by":"crossref","first-page":"8184","DOI":"10.1128\/MCB.21.23.8184-8188.2001","article-title":"The mouse snail gene encodes a key regulator of the epithelial-mesenchymal transition","volume":"21","author":"Carver","year":"2001","journal-title":"Mol Cell Biol"},{"issue":"9","key":"10.1016\/j.xphs.2017.03.011_bib47","doi-asserted-by":"crossref","first-page":"1789","DOI":"10.1242\/dev.02837","article-title":"Multiple functions of Snail family genes during palate development in mice","volume":"134","author":"Murray","year":"2007","journal-title":"Development"},{"issue":"9","key":"10.1016\/j.xphs.2017.03.011_bib48","doi-asserted-by":"crossref","first-page":"998","DOI":"10.1038\/nm.3902","article-title":"Epithelial-to-mesenchymal transition induces cell cycle arrest and parenchymal damage in renal fibrosis","volume":"21","author":"Lovisa","year":"2015","journal-title":"Nat Med"}],"container-title":["Journal of Pharmaceutical Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022354917301685?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022354917301685?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,10,4]],"date-time":"2020-10-04T02:51:06Z","timestamp":1601779866000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022354917301685"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,9]]},"references-count":48,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2017,9]]}},"alternative-id":["S0022354917301685"],"URL":"https:\/\/doi.org\/10.1016\/j.xphs.2017.03.011","relation":{},"ISSN":["0022-3549"],"issn-type":[{"value":"0022-3549","type":"print"}],"subject":[],"published":{"date-parts":[[2017,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Snail-Induced Epithelial-to-Mesenchymal Transition Enhances P-gp-Mediated Multidrug Resistance in HCC827 Cells","name":"articletitle","label":"Article Title"},{"value":"Journal of Pharmaceutical Sciences","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.xphs.2017.03.011","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 American Pharmacists Association\u00ae. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}