{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,28]],"date-time":"2026-06-28T10:54:41Z","timestamp":1782644081696,"version":"3.54.5"},"reference-count":42,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2018,3,1]],"date-time":"2018-03-01T00:00:00Z","timestamp":1519862400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["jpharmsci.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Pharmaceutical Sciences"],"published-print":{"date-parts":[[2018,3]]},"DOI":"10.1016\/j.xphs.2017.09.033","type":"journal-article","created":{"date-parts":[[2017,11,1]],"date-time":"2017-11-01T00:01:37Z","timestamp":1509494497000},"page":"863-869","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":12,"title":["Sustained Simultaneous Delivery of Metronidazole and Doxycycline From Polycaprolactone Matrices Designed for Intravaginal Treatment of Pelvic Inflammatory Disease"],"prefix":"10.1016","volume":"107","author":[{"given":"Meenakshi","family":"Pathak","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Allan G.A.","family":"Coombes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"BoMi","family":"Ryu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter J.","family":"Cabot","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark S.","family":"Turner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheryn","family":"Palmer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dongjie","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathryn J.","family":"Steadman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.xphs.2017.09.033_bib1","doi-asserted-by":"crossref","first-page":"561909","DOI":"10.1155\/2011\/561909","article-title":"Treatment of acute pelvic inflammatory disease","volume":"2011","author":"Sweet","year":"2011","journal-title":"Infect Dis Obstet Gynecol"},{"key":"10.1016\/j.xphs.2017.09.033_bib2","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1258\/ijsa.2011.011183","article-title":"A\u00a0National audit on the management of pelvic inflammatory disease in UK genitourinary medicine clinics","volume":"23","author":"Oroz","year":"2012","journal-title":"Int J STD AIDS"},{"key":"10.1016\/j.xphs.2017.09.033_bib3","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1097\/QCO.0b013e328334de21","article-title":"Current concepts in managing pelvic inflammatory disease","volume":"23","author":"Judlin","year":"2010","journal-title":"Curr Opin Infect Dis"},{"key":"10.1016\/j.xphs.2017.09.033_bib4","doi-asserted-by":"crossref","first-page":"990","DOI":"10.1086\/423963","article-title":"Bacterial vaginosis and anaerobic bacteria are associated with endometritis","volume":"39","author":"Haggerty","year":"2004","journal-title":"Clin Infect Dis"},{"key":"10.1016\/j.xphs.2017.09.033_bib5","first-page":"858","article-title":"Pelvic inflammatory disease","volume":"35","author":"Dayan","year":"2006","journal-title":"Aust Fam Physician"},{"key":"10.1016\/j.xphs.2017.09.033_bib6","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1016\/j.idc.2008.05.008","article-title":"Pelvic inflammatory disease and tubo-ovarian abscess","volume":"22","author":"Lareau","year":"2008","journal-title":"Infect Dis Clin North Am"},{"key":"10.1016\/j.xphs.2017.09.033_bib7","series-title":"The Hidden Epidemic: Confronting Sexually Transmitted Diseases","author":"Butler","year":"1997"},{"key":"10.1016\/j.xphs.2017.09.033_bib8","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1016\/j.jpag.2009.03.002","article-title":"Pelvic inflammatory disease","volume":"22","author":"Schnee","year":"2009","journal-title":"J\u00a0Pediatr Adolesc Gynecol"},{"key":"10.1016\/j.xphs.2017.09.033_bib9","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1053\/j.spid.2005.04.006","article-title":"Pelvic inflammatory disease in adolescents","volume":"16","author":"Banikarim","year":"2005","journal-title":"Semin Pediatr Infect Dis"},{"key":"10.1016\/j.xphs.2017.09.033_bib10","series-title":"Adherence to Long-Term Therapies: Evidence for Action","author":"World Health Organization","year":"2003"},{"key":"10.1016\/j.xphs.2017.09.033_bib11","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1128\/CMR.17.4.783-793.2004","article-title":"Treatment of infections caused by metronidazole-resistant Trichomonas vaginalis","volume":"17","author":"Cudmore","year":"2004","journal-title":"Clin Microbiol Rev"},{"key":"10.1016\/j.xphs.2017.09.033_bib12","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1093\/pch\/13.1.19","article-title":"Adherence to treatment in adolescents","volume":"13","author":"Taddeo","year":"2008","journal-title":"Paediatr Child Health"},{"key":"10.1016\/j.xphs.2017.09.033_bib13","first-page":"759","article-title":"Intravaginal drug delivery technologies","volume":"Chapter 63","author":"Woolfson","year":"2002"},{"key":"10.1016\/j.xphs.2017.09.033_bib14","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.addr.2015.09.006","volume":"92","year":"2015","journal-title":"Adv Drug Deliv Rev"},{"key":"10.1016\/j.xphs.2017.09.033_bib15","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1007\/s13346-015-0227-1","article-title":"Vaginal deployment and tenofovir delivery by microbicide gels","volume":"5","author":"Gao","year":"2015","journal-title":"Drug Deliv Transl Res"},{"key":"10.1016\/j.xphs.2017.09.033_bib16","doi-asserted-by":"crossref","first-page":"1479","DOI":"10.1097\/QAD.0000000000000280","article-title":"A\u00a0safety and pharmacokinetic trial assessing delivery of dapivirine from a vaginal ring in healthy women","volume":"28","author":"Nel","year":"2014","journal-title":"AIDS"},{"key":"10.1016\/j.xphs.2017.09.033_bib17","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1016\/j.jconrel.2006.08.014","article-title":"Gemeinhart, Cervical cancer treatment with a locally insertable controlled release delivery system","volume":"115","author":"Keskar","year":"2006","journal-title":"J\u00a0Control Release"},{"key":"10.1016\/j.xphs.2017.09.033_bib18","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1093\/humrep\/16.3.469","article-title":"Efficacy, tolerability and acceptability of a novel contraceptive vaginal ring releasing etonogestrel and ethinyl oestradiol","volume":"16","author":"Roumen","year":"2001","journal-title":"Hum Reprod"},{"key":"10.1016\/j.xphs.2017.09.033_bib19","doi-asserted-by":"crossref","first-page":"1775","DOI":"10.1007\/s10461-012-0215-0","article-title":"High acceptability of a vaginal ring intended as a microbicide delivery method for HIV prevention in African women","volume":"16","author":"van der Straten","year":"2012","journal-title":"AIDS Behav"},{"key":"10.1016\/j.xphs.2017.09.033_bib20","first-page":"62","article-title":"State of the art in intravaginal ring technology for topical prophylaxis of HIV infection","volume":"14","author":"Kiser","year":"2012","journal-title":"AIDS Rev"},{"key":"10.1016\/j.xphs.2017.09.033_bib21","doi-asserted-by":"crossref","first-page":"S30","DOI":"10.1016\/j.antiviral.2010.09.003","article-title":"Advances in microbicide vaginal rings","volume":"88 Suppl 1","author":"Malcolm","year":"2010","journal-title":"Antiviral Res"},{"key":"10.1016\/j.xphs.2017.09.033_bib22","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1016\/S0168-3659(02)00139-6","article-title":"Effect of supersaturation and crystallization phenomena on the release properties of a controlled release device based on EVA copolymer","volume":"82","author":"van Laarhoven","year":"2002","journal-title":"J\u00a0Control Release"},{"key":"10.1016\/j.xphs.2017.09.033_bib23","doi-asserted-by":"crossref","first-page":"1217","DOI":"10.1016\/j.progpolymsci.2010.04.002","article-title":"The return of a forgotten polymer\u2014polycaprolactone in the 21st century","volume":"35","author":"Woodruff","year":"2010","journal-title":"Progr Polym Sci"},{"key":"10.1016\/j.xphs.2017.09.033_bib24","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1177\/0885328214528256","article-title":"Evaluation of polycaprolactone matrices for the intravaginal delivery of metronidazole in the treatment of bacterial vaginosis","volume":"29","author":"Pathak","year":"2014","journal-title":"J\u00a0Biomater Appl"},{"issue":"2015","key":"10.1016\/j.xphs.2017.09.033_bib25","doi-asserted-by":"crossref","first-page":"4217","DOI":"10.1002\/jps.24652","article-title":"Investigation of polycaprolactone matrices for intravaginal delivery of doxycycline","volume":"104","author":"Pathak","year":"2015","journal-title":"J\u00a0Pharm Sci"},{"key":"10.1016\/j.xphs.2017.09.033_bib26","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1177\/0885328212437393","article-title":"Development of intra-vaginal matrices from polycaprolactone for sustained release of antimicrobial agents","volume":"28","author":"Dang","year":"2013","journal-title":"J\u00a0Biomater Appl"},{"key":"10.1016\/j.xphs.2017.09.033_bib27","doi-asserted-by":"crossref","first-page":"3725","DOI":"10.1002\/jps.23684","article-title":"An evaluation of polycaprolactone matrices for vaginal delivery of the antiviral, tenofovir, in\u00a0preventing heterosexual transmission of HIV","volume":"102","author":"Dang","year":"2013","journal-title":"J\u00a0Pharm Sci"},{"key":"10.1016\/j.xphs.2017.09.033_bib28","doi-asserted-by":"crossref","first-page":"2719","DOI":"10.1007\/s10856-013-5010-6","article-title":"Evaluation of microporous polycaprolactone matrices for controlled delivery of antiviral microbicides to the female genital tract","volume":"24","author":"Asvadi","year":"2013","journal-title":"J\u00a0Mater Sci Mater Med"},{"key":"10.1016\/j.xphs.2017.09.033_bib29","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1208\/s12248-009-9082-7","article-title":"Vaginal drug delivery systems for HIV prevention","volume":"11","author":"Rohan","year":"2009","journal-title":"AAPS J"},{"key":"10.1016\/j.xphs.2017.09.033_bib30","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/S0168-3659(97)00081-3","article-title":"Effect of polymer crystallinity on papaverine release from poly (L-lactic acid) matrix","volume":"49","author":"Miyajima","year":"1997","journal-title":"J\u00a0Control Release"},{"key":"10.1016\/j.xphs.2017.09.033_bib31","first-page":"1","article-title":"Fabrication of nanohydroxyapatite\/poly(caprolactone) composite microfibers using electrospinning technique for tissue engineering applications","volume":"2014","author":"Hassan","year":"2014","journal-title":"J\u00a0Nanomater"},{"key":"10.1016\/j.xphs.2017.09.033_bib32","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1039\/C4BM00242C","article-title":"mRNA delivery using non-viral PCL nanoparticles","volume":"3","author":"Palama","year":"2015","journal-title":"Biomater Sci"},{"key":"10.1016\/j.xphs.2017.09.033_bib33","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1177\/026119291103900403","article-title":"Vaginal irritation models: the current status of available alternative and in\u00a0vitro tests","volume":"39","author":"Costin","year":"2011","journal-title":"Altern Lab Anim"},{"key":"10.1016\/j.xphs.2017.09.033_bib34","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1095\/biolreprod.104.029603","article-title":"Interleukin (IL)-1, IL-6, and IL-8 predict mucosal toxicity of vaginal microbicidal contraceptives","volume":"71","author":"Fichorova","year":"2004","journal-title":"Biol Reprod"},{"key":"10.1016\/j.xphs.2017.09.033_bib35","doi-asserted-by":"crossref","first-page":"4610","DOI":"10.1172\/JCI57172","article-title":"Vaginal microbiome and sexually transmitted infections: an epidemiologic perspective","volume":"121","author":"Brotman","year":"2011","journal-title":"J\u00a0Clin Invest"},{"key":"10.1016\/j.xphs.2017.09.033_bib36","first-page":"13","article-title":"Liposomal oxytetracycline and doxycycline: studies on enhancement of encapsulation efficiency","volume":"3","author":"Budai","year":"2009","journal-title":"Drug Discov Ther"},{"key":"10.1016\/j.xphs.2017.09.033_bib37","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ijpharm.2004.10.015","article-title":"Stability of metronidazole, tetracycline HCl and famotidine alone and in combination","volume":"290","author":"Wu","year":"2005","journal-title":"Int J Pharm"},{"key":"10.1016\/j.xphs.2017.09.033_bib38","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1093\/jac\/16.2.189","article-title":"In-vitro and in-vivo activity of metronidazole against Gardnerella vaginalis, Bacteroides spp. and Mobiluncus spp. in bacterial vaginosis","volume":"16","author":"Jones","year":"1985","journal-title":"J\u00a0Antimicrob Chemother"},{"key":"10.1016\/j.xphs.2017.09.033_bib39","doi-asserted-by":"crossref","first-page":"S309","DOI":"10.1007\/BF01661303","article-title":"Clinical experience with ofloxacin in sexually transmitted disease","volume":"14 Suppl 4","author":"Judson","year":"1986","journal-title":"Infection"},{"key":"10.1016\/j.xphs.2017.09.033_bib40","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1517\/14656566.2015.999041","article-title":"Treatment of Chlamydial infections: 2014 update","volume":"16","author":"Kohlhoff","year":"2015","journal-title":"Expert Opin Pharmacother"},{"key":"10.1016\/j.xphs.2017.09.033_bib41","doi-asserted-by":"crossref","first-page":"1149","DOI":"10.3201\/eid1207.051558","article-title":"Azithromycin failure in Mycoplasma genitalium urethritis","volume":"12","author":"Bradshaw","year":"2006","journal-title":"Emerg Infect Dis"},{"key":"10.1016\/j.xphs.2017.09.033_bib42","first-page":"1801","article-title":"Development of polyether urethane intravaginal rings for the sustained delivery of hydroxychloroquine","volume":"8","author":"Chen","year":"2014","journal-title":"Drug Des Devel Ther"}],"container-title":["Journal of Pharmaceutical Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022354917307712?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022354917307712?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,10,5]],"date-time":"2019-10-05T08:04:03Z","timestamp":1570262643000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022354917307712"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,3]]},"references-count":42,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2018,3]]}},"alternative-id":["S0022354917307712"],"URL":"https:\/\/doi.org\/10.1016\/j.xphs.2017.09.033","relation":{},"ISSN":["0022-3549"],"issn-type":[{"value":"0022-3549","type":"print"}],"subject":[],"published":{"date-parts":[[2018,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Sustained Simultaneous Delivery of Metronidazole and Doxycycline From Polycaprolactone Matrices Designed for Intravaginal Treatment of Pelvic Inflammatory Disease","name":"articletitle","label":"Article Title"},{"value":"Journal of Pharmaceutical Sciences","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.xphs.2017.09.033","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Published by Elsevier Inc. on behalf of the American Pharmacists Association.","name":"copyright","label":"Copyright"}]}}