{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,6,23]],"date-time":"2024-06-23T21:55:05Z","timestamp":1719179705481},"reference-count":13,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2018,1,1]],"date-time":"2018-01-01T00:00:00Z","timestamp":1514764800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["jpharmsci.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Pharmaceutical Sciences"],"published-print":{"date-parts":[[2018,1]]},"DOI":"10.1016\/j.xphs.2017.10.030","type":"journal-article","created":{"date-parts":[[2017,10,29]],"date-time":"2017-10-29T01:00:14Z","timestamp":1509238814000},"page":"412-418","update-policy":"http:\/\/dx.doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"title":["Overcoming the Challenges of Low Drug Solubility in the Intravenous Formulation of Solithromycin"],"prefix":"10.1016","volume":"107","author":[{"given":"Daniel","family":"Evans","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Samuel","family":"Yalkowsky","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sara","family":"Wu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Pereira","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Prabha","family":"Fernandes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.xphs.2017.10.030_bib1","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1586\/14787210.2016.1138857","article-title":"The role of solithromycin in the management of bacterial community-acquired pneumonia","volume":"14","author":"Van Bambeke","year":"2016","journal-title":"Expert Rev Anti Infect Ther"},{"key":"10.1016\/j.xphs.2017.10.030_bib2","doi-asserted-by":"crossref","first-page":"4961","DOI":"10.1128\/AAC.00860-10","article-title":"Binding and action of CEM-101, a new fluoroketolide antibiotic that inhibits protein synthesis","volume":"54","author":"Llano-Sotelo","year":"2011","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.xphs.2017.10.030_bib3","series-title":"Solubility and Solubilization in Aqueous Media","author":"Yalkowsky","year":"1999"},{"issue":"5","key":"10.1016\/j.xphs.2017.10.030_bib4","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1016\/j.ejps.2004.04.006","article-title":"Accuracy of calculated pH-dependent aqueous drug solubility","volume":"22","author":"Bergstr\u00f6m","year":"2004","journal-title":"Eur J Pharm Sci"},{"key":"10.1016\/j.xphs.2017.10.030_bib5","series-title":"Handbook of Pharmaceutical Salts Properties, Selection, and Use","author":"Stahl","year":"2002"},{"key":"10.1016\/j.xphs.2017.10.030_bib6","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/0378-5173(94)90118-X","article-title":"Precipitation of pH solubilized phenytoin","volume":"109","author":"Surakitbanharn","year":"1994","journal-title":"Int J Pharm"},{"issue":"7","key":"10.1016\/j.xphs.2017.10.030_bib7","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1021\/js980051i","article-title":"Formulation-related problems associated with intravenous drug delivery","volume":"87","author":"Yalkowsky","year":"1998","journal-title":"J\u00a0Pharm Sci"},{"key":"10.1016\/j.xphs.2017.10.030_bib8","series-title":"Scientific Tables","author":"Geigy","year":"1970"},{"key":"10.1016\/j.xphs.2017.10.030_bib9","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ijpharm.2010.03.040","article-title":"In\u00a0vitro methods to assess drug precipitation","volume":"393","author":"Dai","year":"2010","journal-title":"Int J Pharm"},{"key":"10.1016\/j.xphs.2017.10.030_bib10","doi-asserted-by":"crossref","first-page":"1574","DOI":"10.1002\/jps.10396","article-title":"Prediction of precipitation-induced phlebitis: a statistical validation of an in-vitro model","volume":"92","author":"Johnson","year":"2003","journal-title":"J\u00a0Pharm Sci"},{"key":"10.1016\/j.xphs.2017.10.030_bib11","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/j.ijpharm.2016.08.030","article-title":"Imaging of in\u00a0vitro parenteral drug precipitation","volume":"512","author":"Evans","year":"2016","journal-title":"Int J Pharm"},{"key":"10.1016\/j.xphs.2017.10.030_bib12","doi-asserted-by":"crossref","first-page":"987","DOI":"10.1021\/ed076p987","article-title":"A\u00a0general simulator for acid-base titrations","volume":"76","author":"de Levie","year":"1999","journal-title":"J\u00a0Chem Educ"},{"key":"10.1016\/j.xphs.2017.10.030_bib13","series-title":"The practices of medicinal chemistry","article-title":"Preparation of water soluble compounds through salt formation","author":"Anderson","year":"1996"}],"container-title":["Journal of Pharmaceutical Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022354917307293?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022354917307293?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,12,2]],"date-time":"2019-12-02T21:38:42Z","timestamp":1575322722000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022354917307293"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,1]]},"references-count":13,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2018,1]]}},"alternative-id":["S0022354917307293"],"URL":"https:\/\/doi.org\/10.1016\/j.xphs.2017.10.030","relation":{},"ISSN":["0022-3549"],"issn-type":[{"value":"0022-3549","type":"print"}],"subject":[],"published":{"date-parts":[[2018,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Overcoming the Challenges of Low Drug Solubility in the Intravenous Formulation of Solithromycin","name":"articletitle","label":"Article Title"},{"value":"Journal of Pharmaceutical Sciences","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.xphs.2017.10.030","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 American Pharmacists Association\u00ae. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}