{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T15:28:25Z","timestamp":1785770905290,"version":"3.56.0"},"reference-count":43,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2018,5,1]],"date-time":"2018-05-01T00:00:00Z","timestamp":1525132800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","award":["CM15\/00188"],"award-info":[{"award-number":["CM15\/00188"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["jpharmsci.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Pharmaceutical Sciences"],"published-print":{"date-parts":[[2018,5]]},"DOI":"10.1016\/j.xphs.2017.12.028","type":"journal-article","created":{"date-parts":[[2018,1,3]],"date-time":"2018-01-03T18:14:09Z","timestamp":1515003249000},"page":"1342-1351","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":48,"title":["Ophthalmic Econazole Hydrogels for the Treatment of Fungal Keratitis"],"prefix":"10.1016","volume":"107","author":[{"given":"Victoria","family":"D\u00edaz-Tom\u00e9","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Luaces-Rodr\u00edguez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jes\u00fas","family":"Silva-Rodr\u00edguez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Blanco-Dorado","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Garc\u00eda-Quintanilla","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9","family":"Llovo-Taboada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9","family":"Blanco-M\u00e9ndez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xurxo","family":"Garc\u00eda-Otero","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rub\u00e9n","family":"Varela-Fern\u00e1ndez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michel","family":"Herranz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda","family":"Gil-Mart\u00ednez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda Jes\u00fas","family":"Lamas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miguel","family":"Gonz\u00e1lez-Barcia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francisco J.","family":"Otero-Espinar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anxo","family":"Fern\u00e1ndez-Ferreiro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"3","key":"10.1016\/j.xphs.2017.12.028_bib1","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1111\/1469-0691.12126","article-title":"Mycotic keratitis: epidemiology, diagnosis and management","volume":"19","author":"Thomas","year":"2013","journal-title":"Clin Microbiol Infect"},{"issue":"3","key":"10.1016\/j.xphs.2017.12.028_bib2","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1128\/CMR.00113-16","article-title":"Bacterial and fungal endophthalmitis","volume":"30","author":"Durand","year":"2017","journal-title":"Clin Microbiol Rev"},{"issue":"11","key":"10.1016\/j.xphs.2017.12.028_bib3","first-page":"1676","article-title":"Review of clinical and basic approaches of fungal keratitis","volume":"9","author":"Wu","year":"2016","journal-title":"Int J Ophthalmol"},{"issue":"4","key":"10.1016\/j.xphs.2017.12.028_bib4","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1097\/01.ico.0000151539.92865.3e","article-title":"Comparison of topical itraconazole 1% with topical natamycin 5% for the treatment of filamentous fungal keratitis","volume":"24","author":"Kalavathy","year":"2005","journal-title":"Cornea"},{"key":"10.1016\/j.xphs.2017.12.028_bib5","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1186\/1471-2415-11-39","article-title":"Diagnosis and treatment outcome of mycotic keratitis at a tertiary eye care center in eastern India","volume":"11","author":"Rautaraya","year":"2011","journal-title":"BMC Ophthalmol"},{"issue":"8","key":"10.1016\/j.xphs.2017.12.028_bib6","doi-asserted-by":"crossref","first-page":"852","DOI":"10.1038\/sj.eye.6700557","article-title":"Fungal infections of the cornea","volume":"17","author":"Thomas","year":"2003","journal-title":"Eye"},{"issue":"3","key":"10.1016\/j.xphs.2017.12.028_bib7","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1007\/s12281-013-0150-1","article-title":"Current thoughts in fungal keratitis: diagnosis and treatment","volume":"7","author":"Ansari","year":"2013","journal-title":"Curr Fungal Infect Rep"},{"issue":"7","key":"10.1016\/j.xphs.2017.12.028_bib8","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1136\/bjo.2007.136515","article-title":"Voriconazole in the treatment of fungal eye infections: a review of current literature","volume":"92","author":"Hariprasad","year":"2008","journal-title":"Br J Ophthalmol"},{"issue":"10","key":"10.1016\/j.xphs.2017.12.028_bib9","doi-asserted-by":"crossref","first-page":"1235","DOI":"10.1136\/bjo.87.10.1235","article-title":"A\u00a0randomised clinical trial comparing 2% econazole and 5% natamycin for the treatment of fungal keratitis","volume":"87","author":"Prajna","year":"2003","journal-title":"Br J Ophthalmol"},{"issue":"647","key":"10.1016\/j.xphs.2017.12.028_bib10","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1136\/pgmj.55.647.625","article-title":"Recognition and chemotherapy of oculomycosis","volume":"55","author":"Jones","year":"1979","journal-title":"Postgrad Med J"},{"issue":"1","key":"10.1016\/j.xphs.2017.12.028_bib11","article-title":"Current use of antifungal eye drops and how to improve therapeutic aspects in keratomycosis","volume":"6","author":"Fernandez-Ferreiro","year":"2016","journal-title":"Fungal Genom Biol"},{"issue":"1-2","key":"10.1016\/j.xphs.2017.12.028_bib12","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/j.ijpharm.2011.04.031","article-title":"Chitosan\/sulfobutylether-\u03b2-cyclodextrin nanoparticles as a potential approach for ocular drug delivery","volume":"413","author":"Mahmoud","year":"2011","journal-title":"Int J Pharm"},{"issue":"5","key":"10.1016\/j.xphs.2017.12.028_bib13","doi-asserted-by":"crossref","first-page":"1197","DOI":"10.1007\/s11095-008-9694-0","article-title":"Recent perspectives in ocular drug delivery","volume":"26","author":"Gaudana","year":"2009","journal-title":"Pharm Res"},{"issue":"9","key":"10.1016\/j.xphs.2017.12.028_bib14","doi-asserted-by":"crossref","first-page":"3019","DOI":"10.1002\/jps.23077","article-title":"Cyclodextrins as functional excipients: methods to enhance complexation efficiency","volume":"101","author":"Loftsson","year":"2012","journal-title":"J\u00a0Pharm Sci"},{"issue":"4","key":"10.1016\/j.xphs.2017.12.028_bib15","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1016\/j.drudis.2013.10.001","article-title":"In situ gelling systems: a strategy to improve the bioavailability of ophthalmic pharmaceutical formulations","volume":"19","author":"Almeida","year":"2014","journal-title":"Drug Discov Today"},{"issue":"9","key":"10.1016\/j.xphs.2017.12.028_bib16","doi-asserted-by":"crossref","first-page":"1148","DOI":"10.1016\/j.addr.2013.04.016","article-title":"Crosslinked ionic polysaccharides for stimuli-sensitive drug delivery","volume":"65","author":"Alvarez-Lorenzo","year":"2013","journal-title":"Adv Drug Deliv Rev"},{"key":"10.1016\/j.xphs.2017.12.028_bib17","doi-asserted-by":"crossref","first-page":"341218","DOI":"10.1155\/2013\/341218","article-title":"Hp-\u03b2-CD-voriconazole in situ gelling system for ocular drug delivery: in\u00a0vitro, stability, and antifungal activities assessment","volume":"2013","author":"Pawar","year":"2013","journal-title":"Biomed Res Int"},{"issue":"7","key":"10.1016\/j.xphs.2017.12.028_bib18","doi-asserted-by":"crossref","first-page":"499","DOI":"10.3109\/10611860903508788","article-title":"Ion- and pH-activated novel in-situ gel system for sustained ocular drug delivery","volume":"18","author":"Gupta","year":"2010","journal-title":"J\u00a0Drug Target"},{"issue":"9","key":"10.1016\/j.xphs.2017.12.028_bib19","doi-asserted-by":"crossref","first-page":"574","DOI":"10.1089\/jop.2016.0084","article-title":"Enhancement of ocular in situ gelling properties of low acyl gellan gum by use of ion exchange","volume":"32","author":"Reed","year":"2016","journal-title":"J\u00a0Ocul Pharmacol Ther"},{"key":"10.1016\/j.xphs.2017.12.028_bib20","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1016\/j.ejpb.2015.06.003","article-title":"In\u00a0vitro and in\u00a0vivo ocular safety and eye surface permanence determination by direct and Magnetic Resonance Imaging of ion-sensitive hydrogels based on gellan gum and kappa-carrageenan","volume":"94","author":"Fern\u00e1ndez-Ferreiro","year":"2015","journal-title":"Eur J Pharm Biopharm"},{"issue":"1-2","key":"10.1016\/j.xphs.2017.12.028_bib21","doi-asserted-by":"crossref","first-page":"714","DOI":"10.1016\/j.ijpharm.2017.06.060","article-title":"Cysteamine polysaccharide hydrogels: study of extended ocular delivery and biopermanence time by PET imaging","volume":"528","author":"Luaces-Rodr\u00edguez","year":"2017","journal-title":"Int J Pharm"},{"key":"10.1016\/j.xphs.2017.12.028_bib22","series-title":"Advances in Analitycal Chemistry and Instrumentation","first-page":"117","article-title":"Phase-solubility techniques","author":"Higuchi","year":"1965"},{"issue":"4","key":"10.1016\/j.xphs.2017.12.028_bib23","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/S0928-0987(97)00277-7","article-title":"Interaction of clofibrate with cyclodextrin in solution: phase solubility, 1H NMR and molecular modelling studies","volume":"5","author":"Anguiano-Igea","year":"1997","journal-title":"Eur J Pharm Sci"},{"issue":"1","key":"10.1016\/j.xphs.2017.12.028_bib24","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/S0939-6411(02)00036-X","article-title":"Optimisation of carbomer viscous eye drops: an in\u00a0vitro experimental design approach using rheological techniques","volume":"54","author":"Ceulemans","year":"2002","journal-title":"Eur J Pharm Biopharm"},{"issue":"1","key":"10.1016\/j.xphs.2017.12.028_bib25","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1016\/j.ijpharm.2011.03.051","article-title":"Higuchi equation: derivation, applications, use and misuse","volume":"418","author":"Siepmann","year":"2011","journal-title":"Int J Pharm"},{"issue":"4","key":"10.1016\/j.xphs.2017.12.028_bib26","first-page":"110","article-title":"Analysis of Fickian and non-Fickian drug release from polymers","volume":"60","author":"Peppas","year":"1985","journal-title":"Pharm Acta Helv"},{"key":"10.1016\/j.xphs.2017.12.028_bib27","series-title":"Test No. 437: Bovine Corneal Opacity and Permeability Test Method for Identifying Ocular Corrosives and Severe Irritants","author":"OECD","year":"2009"},{"issue":"4","key":"10.1016\/j.xphs.2017.12.028_bib28","first-page":"300","article-title":"Analysis of ocular toxicity of fluconazole and voriconazole eyedrops using HET-CAM","volume":"38","author":"Fern\u00e1ndez-Ferreiro","year":"2014","journal-title":"Farm Hosp"},{"issue":"1-2","key":"10.1016\/j.xphs.2017.12.028_bib30","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/S0732-8893(01)00235-8","article-title":"Multi-laboratory assessment of the linezolid spectrum of activity using the Kirby-Bauer disk diffusion method: report of the Zyvox\u00ae Antimicrobial Potency Study (ZAPS) in the United States","volume":"40","author":"Jones","year":"2001","journal-title":"Diagn Microbiol Infect Dis"},{"key":"10.1016\/j.xphs.2017.12.028_bib31","author":"The Association for Research in Vision and Ophthalmology"},{"issue":"2","key":"10.1016\/j.xphs.2017.12.028_bib32","first-page":"772","article-title":"Positron emission Tomography for the development and characterization of corneal permanence of ophthalmic pharmaceutical formulations","volume":"58","author":"Fern\u00e1ndez-Ferreiro","year":"2017","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"3","key":"10.1016\/j.xphs.2017.12.028_bib33","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1016\/j.cmpb.2010.01.007","article-title":"PKSolver: an add-in program for pharmacokinetic and pharmacodynamic data analysis in Microsoft Excel","volume":"99","author":"Zhang","year":"2010","journal-title":"Comput Methods Programs Biomed"},{"issue":"1","key":"10.1016\/j.xphs.2017.12.028_bib34","first-page":"1","article-title":"Ophthalmic formulations new goals","volume":"40","author":"Fern\u00e1ndez-Ferreiro","year":"2016","journal-title":"Farm Hosp"},{"issue":"2","key":"10.1016\/j.xphs.2017.12.028_bib35","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1016\/j.ijpharm.2017.04.010","article-title":"Cyclodextrins and topical drug delivery to the anterior and posterior segments of the eye","volume":"531","author":"Loftsson","year":"2017","journal-title":"Int J Pharm"},{"issue":"2","key":"10.1016\/j.xphs.2017.12.028_bib36","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1002\/jps.21861","article-title":"Cyclodextrins as solubilizers: formation of complex aggregates","volume":"99","author":"Jansook","year":"2010","journal-title":"J\u00a0Pharm Sci"},{"issue":"1","key":"10.1016\/j.xphs.2017.12.028_bib37","doi-asserted-by":"crossref","first-page":"2903","DOI":"10.3762\/bjoc.10.308","article-title":"Cyclodextrin\u2013polysaccharide-based, in situ-gelled system for ocular antifungal delivery","volume":"10","author":"Fern\u00e1ndez-Ferreiro","year":"2014","journal-title":"Beilstein J Org Chem"},{"issue":"1","key":"10.1016\/j.xphs.2017.12.028_bib38","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1016\/j.ijpharm.2015.09.015","article-title":"Novel drug delivery strategies for improving econazole antifungal action","volume":"495","author":"Firooz","year":"2015","journal-title":"Int J Pharm"},{"key":"10.1016\/j.xphs.2017.12.028_bib39","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/j.ejpb.2017.04.007","article-title":"Microwave-assisted microemulsion technique for production of miconazole nitrate- and econazole nitrate-loaded solid lipid nanoparticles","volume":"117","author":"Shah","year":"2017","journal-title":"Eur J Pharm Biopharm"},{"issue":"1-2","key":"10.1016\/j.xphs.2017.12.028_bib40","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1023\/A:1008114411503","article-title":"Multicomponent systems of econazole with hydroxyacids and cyclodextrins","volume":"39","author":"Mura","year":"2001","journal-title":"J\u00a0Incl Phenom Macrocycl Chem"},{"issue":"5","key":"10.1016\/j.xphs.2017.12.028_bib41","doi-asserted-by":"crossref","first-page":"1795","DOI":"10.1208\/s12249-016-0609-9","article-title":"Improvement of the ocular bioavailability of econazole nitrate upon complexation with cyclodextrins","volume":"18","author":"Abd El-Gawad","year":"2016","journal-title":"AAPS PharmSciTech"},{"issue":"3","key":"10.1016\/j.xphs.2017.12.028_bib42","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1016\/j.ejps.2011.08.026","article-title":"In-vitro and in-vivo evaluation of carrageenan\/methylcellulose polymeric systems for transscleral delivery of macromolecules","volume":"44","author":"Thrimawithana","year":"2011","journal-title":"Eur J Pharm Sci"},{"issue":"2","key":"10.1016\/j.xphs.2017.12.028_bib43","doi-asserted-by":"crossref","first-page":"54","DOI":"10.4103\/2230-973X.100036","article-title":"Stimuli sensitive hydrogels for ophthalmic drug delivery: a review","volume":"2","author":"Kushwaha","year":"2012","journal-title":"Int J Pharm Investig"},{"issue":"11","key":"10.1016\/j.xphs.2017.12.028_bib44","doi-asserted-by":"crossref","first-page":"1420","DOI":"10.1136\/bjo.2009.158105","article-title":"Molecular imaging of the eye","volume":"94","author":"Eter","year":"2009","journal-title":"Br J Ophthalmol"}],"container-title":["Journal of Pharmaceutical Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022354917309103?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022354917309103?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,6,24]],"date-time":"2022-06-24T00:51:06Z","timestamp":1656031866000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022354917309103"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,5]]},"references-count":43,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2018,5]]}},"alternative-id":["S0022354917309103"],"URL":"https:\/\/doi.org\/10.1016\/j.xphs.2017.12.028","relation":{},"ISSN":["0022-3549"],"issn-type":[{"value":"0022-3549","type":"print"}],"subject":[],"published":{"date-parts":[[2018,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Ophthalmic Econazole Hydrogels for the Treatment of Fungal Keratitis","name":"articletitle","label":"Article Title"},{"value":"Journal of Pharmaceutical Sciences","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.xphs.2017.12.028","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 American Pharmacists Association\u00ae. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}