{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T00:05:01Z","timestamp":1785801901182,"version":"3.56.0"},"reference-count":42,"publisher":"Elsevier BV","issue":"10","license":[{"start":{"date-parts":[[2018,10,1]],"date-time":"2018-10-01T00:00:00Z","timestamp":1538352000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,10,1]],"date-time":"2018-10-01T00:00:00Z","timestamp":1538352000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["jpharmsci.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Journal of Pharmaceutical Sciences"],"published-print":{"date-parts":[[2018,10]]},"DOI":"10.1016\/j.xphs.2018.06.017","type":"journal-article","created":{"date-parts":[[2018,6,26]],"date-time":"2018-06-26T21:07:56Z","timestamp":1530047276000},"page":"2674-2685","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":32,"title":["Amphotericin B-Loaded Poly(lactic-co-glycolic acid) Nanofibers: An Alternative Therapy Scheme for Local Treatment of Vulvovaginal Candidiasis"],"prefix":"10.1016","volume":"107","author":[{"given":"Ramon Oliveira","family":"Souza","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tadeu","family":"Henrique de Lima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rodrigo Lambert","family":"Or\u00e9fice","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcelo Gonzaga","family":"de Freitas Ara\u00fajo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandra Aparecida","family":"de Lima Moura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juliana Teixeira","family":"Magalh\u00e3es","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gisele Rodrigues","family":"da Silva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"5","key":"10.1016\/j.xphs.2018.06.017_bib1","first-page":"443","article-title":"Comparison of enzymatic method rapid yeast plus system with RFLP-PCR for identification of isolated yeast from vulvovaginal candidiasis","volume":"14","author":"Moallaei","year":"2011","journal-title":"Iran J Basic Med Sci"},{"issue":"1","key":"10.1016\/j.xphs.2018.06.017_bib2","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1155\/2005\/401530","article-title":"Vaginal Candida parapsilosis: pathogen or bystander?","volume":"13","author":"Nyirjesy","year":"2005","journal-title":"Infect Dis Obstet Gynecol"},{"issue":"1","key":"10.1016\/j.xphs.2018.06.017_bib3","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.ajog.2015.06.067","article-title":"Recurrent vulvovaginal candidiasis","volume":"214","author":"Sobel","year":"2016","journal-title":"Am J Obstet Gynecol"},{"issue":"11","key":"10.1016\/j.xphs.2018.06.017_bib4","first-page":"3306","article-title":"Treatment of recurrent vulvovaginal candidiasis","volume":"61","author":"Ringdahl","year":"2000","journal-title":"Am Fam Physician"},{"key":"10.1016\/j.xphs.2018.06.017_bib5","doi-asserted-by":"crossref","first-page":"1368","DOI":"10.3390\/ijms17081368","article-title":"Syngonanthus nitens Bong. (Rhul.)-loaded nanostructured system for vulvovaginal candidiasis treatment","volume":"17","author":"Ramos","year":"2016","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.xphs.2018.06.017_bib6","series-title":"Sterol Biosynthesis Inhibitors","first-page":"480","article-title":"Azoles in the therapy of vaginal candidosis","author":"Mendling","year":"1988"},{"issue":"9577","key":"10.1016\/j.xphs.2018.06.017_bib7","doi-asserted-by":"crossref","first-page":"1961","DOI":"10.1016\/S0140-6736(07)60917-9","article-title":"Vulvovaginal candidosis","volume":"369","author":"Sobel","year":"2007","journal-title":"Lancet"},{"key":"10.1016\/j.xphs.2018.06.017_bib8","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/myc.12292","article-title":"Guideline: vulvovaginal candidosis (AWMF 015\/072), S2k (Excluding Chronic Mucocutaneous Candidosis)","volume":"58 Suppl 1","author":"Mendling","year":"2015","journal-title":"Mycoses"},{"key":"10.1016\/j.xphs.2018.06.017_bib9","doi-asserted-by":"crossref","first-page":"876","DOI":"10.1056\/NEJMoa033114","article-title":"Maintenance fluconazole therapy for recurrent vulvovaginal candidiasis","volume":"351","author":"Sobel","year":"2004","journal-title":"N\u00a0Engl J Med"},{"issue":"10","key":"10.1016\/j.xphs.2018.06.017_bib10","doi-asserted-by":"crossref","first-page":"1889","DOI":"10.1128\/EC.00151-07","article-title":"Genotypic evolution of azole resistance mechanisms in sequential Candida albicans isolates","volume":"6","author":"Coste","year":"2007","journal-title":"Eukaryot Cell"},{"issue":"11","key":"10.1016\/j.xphs.2018.06.017_bib11","doi-asserted-by":"crossref","first-page":"e0188567","DOI":"10.1371\/journal.pone.0188567","article-title":"In\u00a0vitro activity of Spirulina platensis water extract against different Candida species isolated from vulvo-vaginal candidiasis cases","volume":"12","author":"Marangoni","year":"2017","journal-title":"PLoS One"},{"issue":"8","key":"10.1016\/j.xphs.2018.06.017_bib12","first-page":"439","article-title":"PLGA implants containing vancomycin and dexamethasone: development, characterization and bactericidal effects","volume":"71","author":"Resende","year":"2016","journal-title":"Pharmazie"},{"issue":"4","key":"10.1016\/j.xphs.2018.06.017_bib13","doi-asserted-by":"crossref","first-page":"62","DOI":"10.3390\/pathogens6040062","article-title":"Liposomal and deoxycholate amphotericin B formulations: effectiveness against biofilm infections of Candida spp","volume":"6","author":"Rodrigues","year":"2017","journal-title":"Pathogens"},{"issue":"3","key":"10.1016\/j.xphs.2018.06.017_bib14","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1088\/0034-4885\/64\/3\/201","article-title":"Nanostructured material","volume":"64","author":"Moriarty","year":"2001","journal-title":"Rep Prog Phys"},{"key":"10.1016\/j.xphs.2018.06.017_bib15","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1016\/j.msec.2012.10.022","article-title":"Electrospun Fe3O4\/TiO2 hybrid nanofibers and their in\u00a0vitro biocompatibility: prospective matrix for satellite cell adhesion and cultivation","volume":"33","author":"Touseef","year":"2013","journal-title":"Mat Sci Eng C"},{"key":"10.1016\/j.xphs.2018.06.017_bib16","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.ejps.2015.03.003","article-title":"In\u00a0vitro and in\u00a0vivo ocular biocompatibility of electrospun poly(\u025b-caprolactone) nanofibers","volume":"73","author":"Da Silva","year":"2015","journal-title":"Eur J Pharm Sci"},{"key":"10.1016\/j.xphs.2018.06.017_bib17","series-title":"CD-ROM (Insight Publishing Productivity)","author":"The United States Pharmacopeia","year":"2006"},{"key":"10.1016\/j.xphs.2018.06.017_bib18","doi-asserted-by":"crossref","first-page":"1197","DOI":"10.1021\/acs.jmedchem.5b01862","article-title":"Novel water-soluble amphotericin B-PEG conjugates with low toxicity and potent in\u00a0vivo efficacy","volume":"59","author":"Halperin","year":"2016","journal-title":"J\u00a0Med Chem"},{"key":"10.1016\/j.xphs.2018.06.017_bib19","volume":"22","year":"2012"},{"key":"10.1016\/j.xphs.2018.06.017_bib20","doi-asserted-by":"crossref","first-page":"673","DOI":"10.3109\/13693786.2013.795294","article-title":"Evaluation of syngonanthus nitens (Bong.) Ruhl. extract as antifungal and in treatment of vulvovaginal candidiasis","volume":"51","author":"Ara\u00fajo","year":"2013","journal-title":"Med Mycol"},{"key":"10.1016\/j.xphs.2018.06.017_bib21","doi-asserted-by":"crossref","first-page":"2293","DOI":"10.1016\/S1452-3981(23)14309-4","article-title":"Preparation and in\u00a0vitro thermo-mechanical characterization of electrospun PLGA nanofibers for soft and hard tissue replacement","volume":"8","author":"Fouad","year":"2013","journal-title":"Int J Electrochem Sci"},{"key":"10.1016\/j.xphs.2018.06.017_bib22","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1007\/s00249-012-0842-4","article-title":"FTIR spectroscopic study of molecular organization of the antibiotic amphotericin B in aqueous solution and in DPPC lipid monolayers containing the sterols cholesterol and ergosterol","volume":"41","author":"Gago\u015b","year":"2012","journal-title":"Eur Biophys J"},{"key":"10.1016\/j.xphs.2018.06.017_bib23","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/j.colsurfb.2015.09.005","article-title":"PLGA nanofibers improves the\u00a0antitumoral effect of daunorubicin","volume":"136","author":"Guimar\u00e3es","year":"2015","journal-title":"Colloids Surf B Biointerfaces"},{"key":"10.1016\/j.xphs.2018.06.017_bib24","doi-asserted-by":"crossref","first-page":"3731","DOI":"10.1002\/jps.24569","article-title":"Methotrexate locally released from Poly(\u03b5-Caprolactone) implants: inhibition of the inflammatory angiogenesis response in a murine sponge model and the absence of systemic toxicity","volume":"104","author":"Oliveira","year":"2015","journal-title":"J\u00a0Pharm Sci"},{"issue":"3","key":"10.1016\/j.xphs.2018.06.017_bib25","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/j.diagmicrobio.2017.07.007","article-title":"In\u00a0vitro potency and fungicidal activity of CD101, a novel echinocandin, against recent clinical isolates of Candida spp","volume":"89","author":"Hall","year":"2017","journal-title":"Diagn Microbiol Infect Dis"},{"issue":"3","key":"10.1016\/j.xphs.2018.06.017_bib26","doi-asserted-by":"crossref","first-page":"139","DOI":"10.6118\/jmm.2017.23.3.139","article-title":"Probiotics in the prevention and treatment of postmenopausal vaginal infections: review article","volume":"23","author":"Kim","year":"2017","journal-title":"J\u00a0Menopausal Med"},{"issue":"4","key":"10.1016\/j.xphs.2018.06.017_bib27","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1007\/s10544-017-0215-y","article-title":"Fabrication and characterization of low-cost, bead-free, durable and hydrophobic electrospun membrane for 3D cell culture","volume":"19","author":"Moghadas","year":"2017","journal-title":"Biomed Microdevices"},{"issue":"11","key":"10.1016\/j.xphs.2018.06.017_bib28","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1007\/s10856-017-5957-9","article-title":"Investigating the performance of drug delivery system of fluconazole made of nano-micro fibers coated on cotton\/polyester fabric","volume":"28","author":"Semnani","year":"2017","journal-title":"J\u00a0Mater Sci Mater Med"},{"key":"10.1016\/j.xphs.2018.06.017_bib29","doi-asserted-by":"crossref","first-page":"1014","DOI":"10.1016\/j.msec.2010.05.003","article-title":"Fabrication and characterization of three-dimensional nanofiber membrane of PCL-MWCNTs by electrospinning","volume":"30","author":"Meng","year":"2010","journal-title":"Mater Sci Eng C"},{"issue":"132","key":"10.1016\/j.xphs.2018.06.017_bib30","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/j.colsurfb.2015.05.029","article-title":"Preparation and properties of PLGA nanofiber membranes reinforced with cellulose nanocrystals","volume":"1","author":"Mo","year":"2015","journal-title":"Colloids Surf B Biointerfaces"},{"issue":"41","key":"10.1016\/j.xphs.2018.06.017_bib31","doi-asserted-by":"crossref","first-page":"44073","DOI":"10.1002\/app.44073","article-title":"Influence of structure on release profile\u00a0of acyclovir loaded polyurethane nanofibers: monolithic and core\/shell structures","volume":"133","author":"Azizi","year":"2016","journal-title":"J\u00a0Appl Polym Sci"},{"key":"10.1016\/j.xphs.2018.06.017_bib32","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.jddst.2016.01.008","article-title":"Ocular inserts based on chitosan and brimonidine tartrate: development, characterization and biocompatibility","volume":"32","author":"De Souza","year":"2016","journal-title":"J\u00a0Drug Deliv Sci Technol"},{"issue":"6","key":"10.1016\/j.xphs.2018.06.017_bib33","doi-asserted-by":"crossref","first-page":"1852","DOI":"10.1128\/JCM.06440-11","article-title":"Detection of amphotericin B resistance in Candida haemulonii and closely related species by use of the Etest, Vitek-2 yeast susceptibility system, and CLSI and EUCAST broth microdilution methods","volume":"50","author":"Shin","year":"2012","journal-title":"J\u00a0Clin Microbiol"},{"key":"10.1016\/j.xphs.2018.06.017_bib34","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1590\/S1676-24442011000100004","article-title":"Compara\u00e7\u00e3o do perfil de suscetibilidade entre isolados cl\u00ednicos de Candida spp. orais e vulvovaginais no Sul do Brasil","volume":"47","author":"Dalazen","year":"2011","journal-title":"J\u00a0Bras Patol Med Lab"},{"issue":"116","key":"10.1016\/j.xphs.2018.06.017_bib35","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1016\/j.colsurfb.2014.01.011","article-title":"Formulation and evaluation in\u00a0vitro of coconut oil-core cationic nanocapsules intended for vaginal delivery of clotrimazole","volume":"1","author":"Santos","year":"2014","journal-title":"Colloids Surf B Biointerfaces"},{"key":"10.1016\/j.xphs.2018.06.017_bib36","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1016\/j.ijantimicag.2004.09.012","article-title":"Pharmacokinetic-pharmacodynamic modelling of antibacterial activity of cefpodoxime and cefixime in in\u00a0vitro kinetic models","volume":"25","author":"Liu","year":"2005","journal-title":"Int J Antimicrob Agents"},{"issue":"2","key":"10.1016\/j.xphs.2018.06.017_bib37","doi-asserted-by":"crossref","first-page":"239","DOI":"10.3390\/molecules23020239","article-title":"Immunomodulatory effect of tremella polysaccharides against cyclophosphamide-induced immunosuppression in mice","volume":"23","author":"Zhou","year":"2018","journal-title":"Molecules"},{"issue":"8","key":"10.1016\/j.xphs.2018.06.017_bib38","doi-asserted-by":"crossref","first-page":"1703","DOI":"10.3389\/fimmu.2017.01703","article-title":"Macrophage-microbe interactions: lessons from the zebrafish model","volume":"1","author":"Yoshida","year":"2017","journal-title":"Front Immunol"},{"issue":"111","key":"10.1016\/j.xphs.2018.06.017_bib39","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1016\/j.ejps.2017.10.002","article-title":"Surface-modified mucoadhesive microgels as a controlled release system for miconazole nitrate to improve localized treatment of vulvovaginal candidiasis","volume":"1","author":"Kenechukwu","year":"2018","journal-title":"Eur J Pharm Sci"},{"issue":"9","key":"10.1016\/j.xphs.2018.06.017_bib40","doi-asserted-by":"crossref","first-page":"1881","DOI":"10.1001\/archinte.1990.00390200073014","article-title":"The effect of prescribed daily dose frequency on patient medication compliance","volume":"150","author":"Eisen","year":"1990","journal-title":"Arch Intern Med"},{"issue":"115","key":"10.1016\/j.xphs.2018.06.017_bib41","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.ejps.2018.01.017","article-title":"Amphotericin B-albumin conjugates: synthesis, toxicity and anti-fungal activity","volume":"9","author":"Gurudevan","year":"2018","journal-title":"Eur J Pharm Sci"},{"key":"10.1016\/j.xphs.2018.06.017_bib42","doi-asserted-by":"crossref","DOI":"10.1136\/bcr-2013-202688","article-title":"Atrioventricular block related to liposomal amphotericin B","volume":"2014","author":"Sanches","year":"2014","journal-title":"BMJ Case Rep"}],"container-title":["Journal of Pharmaceutical Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022354918303514?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022354918303514?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,20]],"date-time":"2025-09-20T09:25:37Z","timestamp":1758360337000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022354918303514"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,10]]},"references-count":42,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2018,10]]}},"alternative-id":["S0022354918303514"],"URL":"https:\/\/doi.org\/10.1016\/j.xphs.2018.06.017","relation":{},"ISSN":["0022-3549"],"issn-type":[{"value":"0022-3549","type":"print"}],"subject":[],"published":{"date-parts":[[2018,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Amphotericin B-Loaded Poly(lactic-co-glycolic acid) Nanofibers: An Alternative Therapy Scheme for Local Treatment of Vulvovaginal Candidiasis","name":"articletitle","label":"Article Title"},{"value":"Journal of Pharmaceutical Sciences","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.xphs.2018.06.017","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 American Pharmacists Association\u00ae. Published by Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}